Adsorption of a promising bone tumor therapeutic agent 153Sm-EDTMP (ethylene diamine tetramethylene phosphonic acid) and effects of several coexisting substances on adsorption and desorption were investigated using HA...Adsorption of a promising bone tumor therapeutic agent 153Sm-EDTMP (ethylene diamine tetramethylene phosphonic acid) and effects of several coexisting substances on adsorption and desorption were investigated using HA (hydroxyapatite) as an in vitro model. The adsorption is quantitative up to total deposition of 40 μmol/g HA, while nonquantitative when the complex concentration is above 40μmol/g HA in the medium of pH=7.0±0.2. The uptake increases significantly with the Ca ions added. Desorption of the adsorped complexes is in the sequence of EDTMP DTPA > EDTA. Two modes of adsorption of 153Sm-EDTMP on HA are suggested, the first one ( 40μmol/g HA) quantitatively covers the available surface and the second, by which, is less efficient, additional complexes are adsorped. Non-qualltitative adsorption is attributed to Coulomb repulsion while the complex concentration ranging from 40 to 80 μmol/g HA.展开更多
文摘Adsorption of a promising bone tumor therapeutic agent 153Sm-EDTMP (ethylene diamine tetramethylene phosphonic acid) and effects of several coexisting substances on adsorption and desorption were investigated using HA (hydroxyapatite) as an in vitro model. The adsorption is quantitative up to total deposition of 40 μmol/g HA, while nonquantitative when the complex concentration is above 40μmol/g HA in the medium of pH=7.0±0.2. The uptake increases significantly with the Ca ions added. Desorption of the adsorped complexes is in the sequence of EDTMP DTPA > EDTA. Two modes of adsorption of 153Sm-EDTMP on HA are suggested, the first one ( 40μmol/g HA) quantitatively covers the available surface and the second, by which, is less efficient, additional complexes are adsorped. Non-qualltitative adsorption is attributed to Coulomb repulsion while the complex concentration ranging from 40 to 80 μmol/g HA.
