In this paper, the global and regional features of the seasonal variation of general circulation, and especially the Asian monsoon simulated by the Institute of Atmospheric Physics Two-level AGCM coupled with a sophis...In this paper, the global and regional features of the seasonal variation of general circulation, and especially the Asian monsoon simulated by the Institute of Atmospheric Physics Two-level AGCM coupled with a sophisticated land-surface model (IAP94-GCM) are presented and compared with the observation. The comparison is made by using the equilibrium multiyear seasonal cycle climate from a 100-year integration. In the integration sea surface temperature (SST) and sea ice are taken from the observed climatological data (with seasonal variation) because our purpose is to see the improvement of simulation due to the coupling with an advanced land surface model. Overall, the IAP94-GCM provides a reasonably realistic simulation of the interseasonal and intraseasonal climatology of the Asian monsoon and yields an important information that sheds light on the thermal underpinning and the thermodynamics of the seasonal and even multiscale variabilities associated with the Asian summer monsoon.展开更多
To improve the computational efficiency of the reliability-based design optimization(RBDO) of flexible mechanism, particle swarm optimization-advanced extremum response surface method(PSO-AERSM) was proposed by integr...To improve the computational efficiency of the reliability-based design optimization(RBDO) of flexible mechanism, particle swarm optimization-advanced extremum response surface method(PSO-AERSM) was proposed by integrating particle swarm optimization(PSO) algorithm and advanced extremum response surface method(AERSM). Firstly, the AERSM was developed and its mathematical model was established based on artificial neural network, and the PSO algorithm was investigated. And then the RBDO model of flexible mechanism was presented based on AERSM and PSO. Finally, regarding cross-sectional area as design variable, the reliability optimization of flexible mechanism was implemented subject to reliability degree and uncertainties based on the proposed approach. The optimization results show that the cross-section sizes obviously reduce by 22.96 mm^2 while keeping reliability degree. Through the comparison of methods, it is demonstrated that the AERSM holds high computational efficiency while keeping computational precision for the RBDO of flexible mechanism, and PSO algorithm minimizes the response of the objective function. The efforts of this work provide a useful sight for the reliability optimization of flexible mechanism, and enrich and develop the reliability theory as well.展开更多
Satellite-derived sea surface temperatures(SSTs) from the tropical rainfall measuring mission(TRMM)microwave imager(TMI) and the advanced microwave scanning radiometer for the earth observing system(AMSR-E) we...Satellite-derived sea surface temperatures(SSTs) from the tropical rainfall measuring mission(TRMM)microwave imager(TMI) and the advanced microwave scanning radiometer for the earth observing system(AMSR-E) were compared with non-pumped near-surface temperatures(NSTs) obtained from Argo profiling floats over the global oceans. Factors that might cause temperature differences were examined, including wind speed, columnar water vapor, liquid cloud water, and geographic location. The results show that both TMI and AMSR-E SSTs are highly correlated with the Argo NSTs; however, at low wind speeds, they are on average warmer than the Argo NSTs. The TMI performs slightly better than the AMSR-E at low wind speeds, whereas the TMI SST retrievals might be poorly calibrated at high wind speeds. The temperature differences indicate a warm bias of the TMI/AMSR-E when columnar water vapor is low, which can indicate that neither TMI nor AMSR-E SSTs are well calibrated at high latitudes. The SST in the Kuroshio Extension region has higher variability than in the Kuroshio region. The variability of the temperature difference between the satellite-retrieved SSTs and the Argo NSTs is lower in the Kuroshio Extension during spring. At low wind speeds, neither TMI nor AMSR-E SSTs are well calibrated, although the TMI performs better than the AMSR-E.展开更多
To reasonably implement the reliability analysis and describe the significance of influencing parameters for the multi-failure modes of turbine blisk, advanced multiple response surface method (AMRSM) was proposed for...To reasonably implement the reliability analysis and describe the significance of influencing parameters for the multi-failure modes of turbine blisk, advanced multiple response surface method (AMRSM) was proposed for multi-failure mode sensitivity analysis for reliability. The mathematical model of AMRSM was established and the basic principle of multi-failure mode sensitivity analysis for reliability with AMRSM was given. The important parameters of turbine blisk failures are obtained by the multi-failure mode sensitivity analysis of turbine blisk. Through the reliability sensitivity analyses of multiple failure modes (deformation, stress and strain) with the proposed method considering fluid-thermal-solid interaction, it is shown that the comprehensive reliability of turbine blisk is 0.9931 when the allowable deformation, stress and strain are 3.7 x 10(-3) m, 1.0023 x 10(9) Pa and 1.05 x 10(-2) m/m, respectively; the main impact factors of turbine blisk failure are gas velocity, gas temperature and rotational speed. As demonstrated in the comparison of methods (Monte Carlo (MC) method, traditional response surface method (RSM), multiple response surface method (MRSM) and AMRSM), the proposed AMRSM improves computational efficiency with acceptable computational accuracy. The efforts of this study provide the AMRSM with high precision and efficiency for multi-failure mode reliability analysis, and offer a useful insight for the reliability optimization design of multi-failure mode structure. (C) 2016 Chinese Society of Aeronautics and Astronautics. Production and hosting by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.展开更多
Pericytes have the potential to be developed as a cell therapy for the treatment of wounds;however,the efficacy of any cell therapy relies on the successful delivery of intact and functioning cells.Here,the effect of ...Pericytes have the potential to be developed as a cell therapy for the treatment of wounds;however,the efficacy of any cell therapy relies on the successful delivery of intact and functioning cells.Here,the effect of delivering pericytes on wound repair was assessed alongside the development of a surface-functionalized pericyte patch.Plasma polymerization(PP)was used to functionalize the surface of silicone patches with heptylamine(HA)or acrylic acid(AA)monomers.Human pericytes were subsequently delivered to murine excisional wounds by intradermal injection or using the pericyte-laden patches and the comparative effects on wound healing,inflammation and revascularization determined.The AA surface provided the superior transfer of the cells to de-epidermized dermis.Excisional murine wounds treated either with pericytes injected directly into the wound or with the pericyte-laden AA patches showed improved healing with decreased neutrophil infiltration and reduced numbers of macrophages in the wounds.Pericyte delivery also enhanced angiogenesis through a mechanism independent of VEGF signalling.Pericytes,when delivered to wounds,improved healing responses by dampening inflammation and promoting angiogenesis.Delivery of pericytes using PP-AA-functionalized patches was equally as effective as direct injection of pericytes into wounds.Pericyte-functionalized dressings may therefore be a clinically relevant approach for the treatment of wounds.展开更多
文摘In this paper, the global and regional features of the seasonal variation of general circulation, and especially the Asian monsoon simulated by the Institute of Atmospheric Physics Two-level AGCM coupled with a sophisticated land-surface model (IAP94-GCM) are presented and compared with the observation. The comparison is made by using the equilibrium multiyear seasonal cycle climate from a 100-year integration. In the integration sea surface temperature (SST) and sea ice are taken from the observed climatological data (with seasonal variation) because our purpose is to see the improvement of simulation due to the coupling with an advanced land surface model. Overall, the IAP94-GCM provides a reasonably realistic simulation of the interseasonal and intraseasonal climatology of the Asian monsoon and yields an important information that sheds light on the thermal underpinning and the thermodynamics of the seasonal and even multiscale variabilities associated with the Asian summer monsoon.
基金Projects(51275138,51475025)supported by the National Natural Science Foundation of ChinaProject(12531109)supported by the Science Foundation of Heilongjiang Provincial Department of Education,China+1 种基金Projects(XJ2015002,G-YZ90)supported by Hong Kong Scholars Program,ChinaProject(2015M580037)supported by Postdoctoral Science Foundation of China
文摘To improve the computational efficiency of the reliability-based design optimization(RBDO) of flexible mechanism, particle swarm optimization-advanced extremum response surface method(PSO-AERSM) was proposed by integrating particle swarm optimization(PSO) algorithm and advanced extremum response surface method(AERSM). Firstly, the AERSM was developed and its mathematical model was established based on artificial neural network, and the PSO algorithm was investigated. And then the RBDO model of flexible mechanism was presented based on AERSM and PSO. Finally, regarding cross-sectional area as design variable, the reliability optimization of flexible mechanism was implemented subject to reliability degree and uncertainties based on the proposed approach. The optimization results show that the cross-section sizes obviously reduce by 22.96 mm^2 while keeping reliability degree. Through the comparison of methods, it is demonstrated that the AERSM holds high computational efficiency while keeping computational precision for the RBDO of flexible mechanism, and PSO algorithm minimizes the response of the objective function. The efforts of this work provide a useful sight for the reliability optimization of flexible mechanism, and enrich and develop the reliability theory as well.
基金The National Basic Research Program(973 Program)of China under contract No.2013CB430301the National Natural Science Foundation of China under contract Nos 41440039,41206022 and 41406022the Public Science and Technology Research Funds Projects of Ocean under contract No.201305032
文摘Satellite-derived sea surface temperatures(SSTs) from the tropical rainfall measuring mission(TRMM)microwave imager(TMI) and the advanced microwave scanning radiometer for the earth observing system(AMSR-E) were compared with non-pumped near-surface temperatures(NSTs) obtained from Argo profiling floats over the global oceans. Factors that might cause temperature differences were examined, including wind speed, columnar water vapor, liquid cloud water, and geographic location. The results show that both TMI and AMSR-E SSTs are highly correlated with the Argo NSTs; however, at low wind speeds, they are on average warmer than the Argo NSTs. The TMI performs slightly better than the AMSR-E at low wind speeds, whereas the TMI SST retrievals might be poorly calibrated at high wind speeds. The temperature differences indicate a warm bias of the TMI/AMSR-E when columnar water vapor is low, which can indicate that neither TMI nor AMSR-E SSTs are well calibrated at high latitudes. The SST in the Kuroshio Extension region has higher variability than in the Kuroshio region. The variability of the temperature difference between the satellite-retrieved SSTs and the Argo NSTs is lower in the Kuroshio Extension during spring. At low wind speeds, neither TMI nor AMSR-E SSTs are well calibrated, although the TMI performs better than the AMSR-E.
基金co-supported by the National Natural Science Foundation of China (No. 51275138)the Science Foundation of Heilongjiang Provincial Department of Education (No. 12531109)+1 种基金the funding of Hong Kong Scholars Programs (Nos. XJ2015002 and G-YZ90)China’s Postdoctoral Science Funding (No. 2015M580037)
文摘To reasonably implement the reliability analysis and describe the significance of influencing parameters for the multi-failure modes of turbine blisk, advanced multiple response surface method (AMRSM) was proposed for multi-failure mode sensitivity analysis for reliability. The mathematical model of AMRSM was established and the basic principle of multi-failure mode sensitivity analysis for reliability with AMRSM was given. The important parameters of turbine blisk failures are obtained by the multi-failure mode sensitivity analysis of turbine blisk. Through the reliability sensitivity analyses of multiple failure modes (deformation, stress and strain) with the proposed method considering fluid-thermal-solid interaction, it is shown that the comprehensive reliability of turbine blisk is 0.9931 when the allowable deformation, stress and strain are 3.7 x 10(-3) m, 1.0023 x 10(9) Pa and 1.05 x 10(-2) m/m, respectively; the main impact factors of turbine blisk failure are gas velocity, gas temperature and rotational speed. As demonstrated in the comparison of methods (Monte Carlo (MC) method, traditional response surface method (RSM), multiple response surface method (MRSM) and AMRSM), the proposed AMRSM improves computational efficiency with acceptable computational accuracy. The efforts of this study provide the AMRSM with high precision and efficiency for multi-failure mode reliability analysis, and offer a useful insight for the reliability optimization design of multi-failure mode structure. (C) 2016 Chinese Society of Aeronautics and Astronautics. Production and hosting by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license.
基金This research was supported by the Cell Therapy Manufacturing Cooperative Research Centre(CTM CRC).Additionally,H.M.T.was supported through an Australian Post-Graduate Award scholarship and a top-up scholarship from the Playford Trust.P.A.received a University of South Australia President’s Postgraduate Scholarship,and A.J.C.is supported by a National Health and Medical Research Council(NHMRC)Senior Research Fellowship(GNT#1102617).
文摘Pericytes have the potential to be developed as a cell therapy for the treatment of wounds;however,the efficacy of any cell therapy relies on the successful delivery of intact and functioning cells.Here,the effect of delivering pericytes on wound repair was assessed alongside the development of a surface-functionalized pericyte patch.Plasma polymerization(PP)was used to functionalize the surface of silicone patches with heptylamine(HA)or acrylic acid(AA)monomers.Human pericytes were subsequently delivered to murine excisional wounds by intradermal injection or using the pericyte-laden patches and the comparative effects on wound healing,inflammation and revascularization determined.The AA surface provided the superior transfer of the cells to de-epidermized dermis.Excisional murine wounds treated either with pericytes injected directly into the wound or with the pericyte-laden AA patches showed improved healing with decreased neutrophil infiltration and reduced numbers of macrophages in the wounds.Pericyte delivery also enhanced angiogenesis through a mechanism independent of VEGF signalling.Pericytes,when delivered to wounds,improved healing responses by dampening inflammation and promoting angiogenesis.Delivery of pericytes using PP-AA-functionalized patches was equally as effective as direct injection of pericytes into wounds.Pericyte-functionalized dressings may therefore be a clinically relevant approach for the treatment of wounds.