The Popularization and Application of Cold Storage Red Blood Cells or Whole Blood at -80 ℃ of the Rh(D) Negative Patients in Surgical Operation

Summary: The efficiency of cold storage red blood cells (CSRBC) or whole blood at -80 ℃ used in 27 Rh(D) negative patients during surgical operation was reported. The Rh(D) negative patients received the transfusion of CSRBC or whole blood stored at -80 ℃ for 180 to 360 days. The changes in the indexes, such as blood TB, DB, K +, Na +, BUN, Cr, urine protein (URPO), UOB, Hb, HCT, serum total protein, relative to hemolytic reaction and blood volume before and after transfusion were observed. The results showed that after transfusion of CSRBC or whole blood 27 cases were negative for urine protein and UOB, and the levels of BUN and Cr were normal (P>0.05). Blood TB, DB, Hb, and HCT were increased, while pH, blood K + and blood Na + was normal with the difference being not significant before and after operation (P>0.05). Plasma protein was decreased, but there was no significant difference before and after operation (P>0.05). It was suggested that CSRBC or whole blood at -80 ℃ could be safely infused to the Rh(D) negative patients without side effects during the surgical operation.

<i>H</i>(.,.)<i>- φ - η -</i>Accretive Operators and Generalized Variational-Like Inclusions

In this paper, we generalize H(.,.) accretive operator introduced by Zou and Huang [1] and we call it H(.,.)- φ - η - accretive operator. We define the resolvent operator associated with H(.,.)- φ - η - accretive operator and prove its Lipschitz continuity. By using these concepts an iterative algorithm is suggested to solve a generalized variational-like inclusion problem. Some examples are given to justify the definition of H(.,.)- φ - η - accretive operator.

经营投资问责与国有企业风险防范--基于股价崩盘风险视角的实证研究

以股价崩盘风险为研究视角,采用交错双重差分模型考察经营投资问责制度对国有企业风险防范的影响。研究结果表明,经营投资问责制度实施之后,国有企业的股价崩盘风险显著降低,而提高投资决策稳健性、降低代理成本和改善信息不透明度是经营投资问责制度发挥作用的重要机制。拓展性研究发现,经营投资问责对股价崩盘风险的抑制作用在高管激励更强、法治环境更好和行政层级更高的企业中更明显。进一步的经济后果分析发现,经营投资问责缓解股价崩盘风险后显著提升了国有资本保值增值率。研究结论不仅为经营投资问责制度的有效性提供了新的证据,还为健全国有企业问责体系、防范化解金融风险提供了重要的政策启示。

Semi-Commutative Differential Operators Associated with the Dirac Opetator and Darboux Transformation

In the present paper, the semi-commutative differential oparators associated with the 1-dimensional Dirac operator are constructed. Using this results, the hierarchy of the mKdV (-) polynomials are expressed in terms of the KdV polynomials. These formulas give a new interpretation of the classical Darboux transformation and the Miura transformation. Moreover, the recursion operator associated with the hierarchy of the mKdV (-) polynomials is constructed by the algebraic method.

Loosely coordinating diluted highly concentrated electrolyte toward -60℃ Li metal batteries

Lithium metal batteries(LMBs) promise energy density over 400 Wh kg^(-1).However,they suffer severe electrochemical performance deterioration at sub-zero temperatures.Such failure behavior highly correlates to inferior lithium metal anode(LMA) compatibility and sluggish Li^(+) desolvation.Here,we demonstrate that cyclopentylmethyl ether(CPME) based diluted high-concentration electrolyte(DHCE)enables-60℃ LMBs operation.By leveraging the loose coordination between Li^(+) and CPME,such developed electrolyte boosts the formation of ion clusters to derive anion-dominant interfacial chemistry for enhancing LMA compatibility and greatly accelerates Li^(+) desolvation kinetics.The resulting electrolyte demonstrates high Coulombic efficiencies(CE),providing over 99.5%,99.1%,98.5% and 95% at 25,-20,-40,and-60℃respectively.The assembled Li-S battery exhibits remarkable cyclic stability in-20,and-40℃ at 0.2 C charging and 0.5 C discharging.Even at-60℃,Li-S cell with this designed electrolyte retains> 70% of the initial capacity over 170 cycles.Besides,lithium metal coin cell and pouch cell with10 mg cm^(-2) high S cathode loading exhibit cycling stability at-20℃.This work offers an opportunity for rational designing electrolytes toward low temperature LMBs.

The combined detection of carcinoembryonic antigen,carcinogenic antigen 125,and carcinogenic antigen 19-9 in colorectal cancer patients

BACKGROUND Hepatic metastases are common and difficult to treat after colorectal cancer(CRC)surgery.The predictive value of carcinoembryonic antigen(CEA),cancer antigen(CA)125 and CA19-9 combined tests for liver metastasis is unclear.AIM To evaluate predictive value of combined tests for CEA,CA125,and CA19-9 levels in patients with liver metastases of CRC.METHODS The retrospective study included patients with CRC alone(50 cases)and patients with CRC combined with liver metastases(50 cases)who were hospitalized between January 2021 and January 2023.Serum CEA,CA125 and CA19-9 levels were compared between the two groups,and binary logistic regression was used to analyze the predictive value of the combination of these tumor markers in liver metastasis.In addition,we performed receiver operating characteristic(ROC)curve analysis to assess its diagnostic accuracy.RESULTS The results showed that the serum CEA,CA125 and CA19-9 levels in the CRC with liver metastasis group were significantly higher than those in the CRC alone group.Specifically,the average serum CEA level in the CRC with liver metastasis group was 162.03±810.01 ng/mL,while that in the CRC alone group was 5.71±9.76 ng/mL;the average serum CA125 levels were 43.47±83.52 U/mL respectively.and 13.5±19.68 U/mL;the average serum CA19-9 levels were 184.46±473.13 U/mL and 26.55±43.96 U/mL respectively.In addition,binary logistic regression analysis showed that CA125 was significant in predicting CRC liver metastasis(P<0.05).ROC curve analysis results showed that the areas under the ROC curves of CEA,CA125 and CA19-9 were 0.607,0.692 and 0.586.CONCLUSION These results suggest that combined detection of these tumor markers may help early detection and intervention of CRC liver metastasis,thereby improving patient prognosis.

2003-2012年湖南省公共卫生机构经济运行状况及对策分析

目的:了解湖南省公共卫生机构2003-2012年经济运行状况。方法:通过卫生统计年报、卫生财务年报等资料收集相关数据,采用描述性统计方法进行分析。结果:我省公共卫生机构费用占卫生总费用的比例显著高于全国平均水平,但公共卫生机构整体效率水平显著低于医院和基层社区卫生服务机构;疾病控制、妇幼保健和采供血机构的人员经费不足以应付人员支出,其中妇幼保健机构人员经费缺口最大,人员支出基本需要自筹;各类公共卫生机构的收入和支出在2003-2012年间呈同步增长趋势,基本能够维持收支平衡、略有盈余。结论:可通过建立公共卫生投入法律保障制度,改善公共卫生机构人员工资待遇,以保证各类公卫机构良性经济运行。

加拿大体育非诉讼纠纷解决机制的运行特点及启示--以加拿大体育纠纷解决中心为例

加拿大体育非诉讼纠纷解决机制的运行具有教育性、经济性、灵活性、权威性、民间性、制度化等特点。要打破我国体育非诉讼纠纷解决机制建设的瓶颈,应借鉴加拿大体育非诉讼纠纷解决机制的先进经验,组建专门性体育非诉讼纠纷解决机构,加强体育非诉讼纠纷解决机制的监督和支持力度,完善体育非诉讼纠纷解决机制的立法工作,注重运动员体育纠纷相关法律知识的普法宣传与教育工作。

Comparative study of CEA and CA19-9 in esophageal,gastric and colon cancers individually and in combination(ROC curve analysis)

Objective： To determine the clinical serum levels of carcinoembryonic antigen （CEA） and carbohydrate antigen 19-9 （CA19-9）, individually and in combination, for the diagnosis of 50 healthy subjects and 150 cases of esophageal, gastric, and colon cancers. Methods： The sensitivities of the two markers were compared individually and in combination, with specificity set at 100%. Receiver operating characteristic （ROC） curves were plotted. Results： Serum CEA levels were significantly higher in cancer patients than in the control group. The sensitivity of CEA was determined： in esophageal cancer, sensitivity=28%, negative predictive value （NPV）=61.72%, and AUC=0.742 （SE=0.05）, with a significance level of P〈0.0001; in gastric cancer, sensitivity=30%, NPV=58.82%, and AUC=0.734 （SE=0.0S）, with a significance level of P〈0.0001; in colon cancer, sensitivity=74%, NPV=79.36%, and AUC=0.856 （SE=0.04）, with a significance level of P〈0.0001. The sensitivity of CA19-9 was also evaluated： in esophageal cancer, sensitivity=18%, NPV=54.94%, and AUC=0.573 （SE=0.05）, with a significance level of P=0.2054. In gastric cancer, sensitivity=42%, NPV=63.29%, and AUC=0.679 （SE=0.05）, with a significance level of P〈0.0011. In colon cancer, sensitivity=26%, NPV=57.47%, and AUC=0.S80 （SE=0.05）, with a significance level ofP=0.1670. The following were the sensitivities of CEA/CA19-9 combined： in esophageal cancer, sensitivity=42%, NPV=63.29%, SE=0.078 （95% CI： 0.0159-0.322）; gastric cancer, sensitivity=S8%, NPV=70.42%, SE=0.072 （9$% CI： -0.0866-0.198）; and colon cancer, sensitivity=72%, NPV=78.12%, SE=0.070 （9S% CI： 0.137-0.415）. Conclusion： CEA exhibited the highest sensitivity for colon cancer, and CA19-9 exhibited the highest sensitivity for gastric cancer. Combined analysis indicated an increase in diagnostic sensitivity in esophageal and gastric cancer compared with that in colon cancer.

Clinical value of serum CA19-9 levels in evaluating resectability of pancreatic carcinoma

AIM:To evaluate the clinical value of serum CA19-9 levels in predicting the respectability of pancreatic carcinoma according to receiver operating characteristic(ROC) curve analysis. METHODS:Serum CA19-9 levels were measured in 104 patients with pancreatic cancer which were possible to be resected according to the imaging. ROC curve was plotted for the CA19-9 levels. The point closest to the upper left-hand corner of the graph were chosen as the cut-off point. The sensitivity,specificity,positive and negative predictive values of CA19-9 at this cut-off point were calculated. RESULTS:Resectable pancreatic cancer was detected in 58(55.77%) patients and unresectable pancreatic cancer was detected in 46(44.23%) patients. The area under the ROC curve was 0.918 and 95% CI was 0.843-0.992. The CA19-9 level was 353.15 U/mL,and the sensitivity and specificity of CA19-9 at this cut-off point were 93.1% and 78.3%,respectively. The positive and negative predictive value was 84.38% and 90%,respectively. CONCLUSION:Preoperative serum CA19-9 level is a useful marker for further evaluating the resectability of pancreatic cancer. Obviously increased serum levels of CA19-9(> 353.15 U/mL) can be regarded as an ancillary parameter for unresectable pancreatic cancer.

Low noise,continuous-wave single-frequency 1.5-μm laser generated by a singly resonant optical parametric oscillator

We report a low noise continuous-wave （CW） single-frequency 1.5-μm laser source obtained by a singly resonant optical parametric oscillator （SRO） based on periodically poled lithium niobate （PPLN）. The SRO was pumped by a CW single-frequency Nd：YVO4 laser at 1.06μm. The 1.02 W of CW single-frequency signal laser at 1.5 μm was obtained at pump power of 6 W. At the output power of around 0.75 W, the power stability was better than ±l.5% and no mode-hopping was observed in 30 min and frequency stability was better than 8.5 MHz in 1 min. The signal wavelength could be tuned from 1.57 to 1.59 μm by varying the PPLN temperature. The 1.5-μm laser exhibits low noise characteristics, the intensity noise of the laser reaches the shot noise limit （SNL） at an analysis frequency of 4 MHz and the phase noise is less than 1 dB above the SNL at analysis frequencies above 10 MHz.

JVM16-125A新系列断路器的应用分析

基于塑壳研究设计的JVM16-125A断路器是具有短路与过载双重保护的限流型高分断断路器新产品,其适用于交流50/60Hz、额定电压400V及以下、额定电流125A及以下的电路中。它主要由塑料外壳、操作机构、灭弧系统、电磁系统、电热系统等组成,可用于正常情况下作为线路的不频繁的接通与分断之用途。

BOUNDEDNESS OF HIGHER ORDER COMMUTATORS OF GENERALIZED FRACTIONAL INTEGRAL OPERATORS ON HARDY SPACES

Let Tμ,b,m be the higher order commutator generated by a generalized fractional integral operator Tμ and a BMO function b. In this paper, we will study the boundedness of Tμ,b,m on classical Hardy spaces and Herz-type Hardy spaces.

A Comparative Analysis of the New -3(-n) - 1 Remer Conjecture and a Proof of the 3n + 1 Collatz Conjecture

This scientific paper is a comparative analysis of two mathematical conjectures. The newly proposed -3(-n) - 1 Remer conjecture and how it is related to and a proof of the more well known 3n + 1 Collatz conjecture. An overview of both conjectures and their respective iterative processes will be presented. Showcasing their unique properties and behavior to each other. Through a detailed comparison, we highlight the similarities and differences between these two conjectures and discuss their significance in the field of mathematics. And how they prove each other to be true.

商业信用融资对企业高质量发展的影响研究——基于创新与效率视角

利用2010-2021年我国沪深A股上市公司数据,实证检验商业信用融资对企业高质量发展的影响,并从创新与效率视角进行中介效应检验。研究发现,商业信用融资与企业高质量发展显著正相关,研发投入、营运能力和代理成本在其中发挥了部分中介作用,即商业信用融资有助于增加企业研发投入、提高企业营运能力和降低企业代理成本进而推动企业高质量发展。

异地商会与企业投资效率

以2004—2021年沪深A股上市公司为样本,考察参与异地商会对企业投资效率的影响。研究发现,参与异地商会能够显著提升企业投资效率,且该结论在经过一系列稳健性测试后仍然成立。作用机制检验结果表明,参与异地商会通过缓解融资约束、减少代理成本以及降低经营风险等路径提高了企业投资效率。拓展性研究显示,参与异地商会不仅能够缓解投资不足,而且可以抑制投资过度;企业通过出资或高管任职方式参与异地商会均能有效抑制企业非效率投资;在市场化程度较高的地区,参与异地商会对企业投资效率的改善效果更加明显。研究结论对于完善商会组织制度建设、促进企业高质量发展具有一定启示意义。

基于“多方协同”式项目化教学的“旅行社经营管理”课程改革——质性研究的视角

围绕项目化教学情景下营造“多方协同”育人目标,对“旅行社经营管理”进行了3年的持续课程教学改革研究与实践。以质性研究的方法,对2名教师、2名企业经营管理人员及8名学生在“多方协同”课程教学改革的元认知问题上进行了深入探讨,研究发现专业建设与课程发展、理论与实践教学内容重构、企业运作与课程任务设计、教与学过程中师生及学生相互之间需要协同,才能实现该门课程的人才培养特色,也为旅游管理专业特色化课程打造提供了一条建设思路。

面向现代化的政府运行保障体系建构

新时代政府运行保障体系需要转变传统机关事务发挥作用的路径依赖,建立系统高效的运行保障机制。这是推进国家治理体系和治理能力现代化的必然要求,对于破解政府内部治理难题,推动党政机关高质量发展具有重要意义。鉴于当前政府运行保障面临的实践困境,基于集中统一、节俭高效的目标,构建政府运行保障体系的分析框架,从坚持节俭高效导向、创新体制机制、加强资源统筹协调、深化开放多元四个维度构建政府运行保障的系统性治理模式,提升政府运行保障的效能性、专业性、协同性和示范性。

基于“岗课赛证”融通的旅行社经营管理课程教学实施探究——以“旅行社产品设计”为例

推进岗课赛证综合育人,成为高等职业院校深化“三教”改革、提高人才培养质量的重要抓手。课程团队积极开展岗课赛证融通的旅行社经营管理课程教学实践,以旅行社产品设计教学项目为例,从教学整体设计、教学策略、教学实施过程、学生学习效果、反思改进措施五个方面开展课堂教学设计。课程教学依托校内旅行社实训基地,结合红色旅游创意策划大赛和“1+X”证书,运用项目教学法进行深入探索与设计,以达到对接岗位、以赛促课和以证融课的教学目标,强化全过程多维度评价,实现课程思政教学效果,促进学生创新能力、专业技能和思政素养的提升。

分析师跟踪能否抑制企业杠杆操纵

杠杆操纵可能会阻碍企业可持续发展。文章以企业杠杆操纵为研究视角,运用混合最小二乘模型,通过2013-2022年A股上市企业数据研究探讨分析师跟踪对企业杠杆操纵的影响。研究发现:分析师跟踪对企业杠杆操纵起到显著的抑制作用,通过一系列稳健性检验后结论依然成立。传导机制表明,分析师跟踪通过抑制企业代理成本、缓解融资约束和提高企业内部控制水平来抑制企业杠杆操纵。异质性分析表明,分析师跟踪背景下,在信息透明度低和投资者保护指数低的样本中起到更为显著的效果。研究结论丰富了分析师跟踪效应的相关研究,同时也为抑制企业杠杆操纵提供了新的思路。