Combined modeling of cell aggregation and adhesion mediated by receptor–ligand interactions under shear flow

Blood cell aggregation and adhesion to endothelial cells under shear flow are crucial to many biological processes such as thrombi formation, inflammatory cascade, and tumor metastasis, in which these cellular interactions are mainly mediated by the underlying receptor-ligand bindings. While theoretical modeling of aggregation dynamics and adhesion kinetics of interacting cells have been well studied separately, how to couple these two processes remains unclear. Here we develop a combined model that couples cellular aggregation dynamics and adhesion kinetics under shear flow. The impacts of shear rate （or shear stress） and molecular binding affinity were elucidated. This study provides a unified model where the action of a fluid flow drives cell aggregation and adhesion under the modulations of the mechanical shear flow and receptor-ligand interaction kinetics. It offers an insight into understanding the relevant biological processes and functions.

Enhanced Cell-Edge Performance with Transmit Power-Shaping and Multipoint, Multiflow Techniques

In this paper, we present a technique called ＂fuzzy cells＂ that builds on the multicarrier features of Long Term Evolution-Advanced （LTE-A） and high-speed packet access （HSPA）. Multiple carriers are aggregated to create a larger system bandwidth, and these carriers are transmitted at different powers by each sector antenna. This creates a set of cell-edge locations that differ from one frequency to the next. System-level simulations are performed to estimate individual user and average throughput for a hexagonal deployment of 3-sector base stations. For moderately high loads, a fuzzy cell deployment can improve tenth percentile （cell-edge） user throughput by 100% and can improve average throughput by about 30% compared with a reuse 1 scheme. Fuzzy ceils reduce inter-cell interference in the same way as higher-order reuse schemes and allow users to access the full system bandwidth.

Coupling effect of Brownian motion and laminar shear flow on colloid coagulation:a Brownian dynamics simulation study

Simultaneous orthokinetic and perikinetic coagulations（SOPCs） are studied for small and large Peclet numbers（P e） using Brownian dynamics simulation.The results demonstrate that the contributions of the Brownian motion and the shear flow to the overall coagulation rate are basically not additive.At the early stages of coagulation with small Peclet numbers,the ratio of overall coagulation rate to the rate of pure perikinetic coagulation is proportional to P 1/2 e,while with high Peclet numbers,the ratio of overall coagulation rate to the rate of pure orthokinetic coagulation is proportional to P 1/2 e.Moreover,our results show that the aggregation rate generally changes with time for the SOPC,which is different from that for pure perikinetic and pure orthokinetic coagulations.By comparing the SOPC with pure perikinetic and pure orthokinetic coagulations,we show that the redistribution of particles due to Brownian motion can play a very important role in the SOPC.In addition,the effects of redistribution in the directions perpendicular and parallel to the shear flow direction are different.This perspective explains the behavior of coagulation due to the joint effects of the Brownian motion（perikinetic） and the fluid motion（orthokinetic）.

Hydrological Analysis and Ability Assessing of Flood Gating of Karaj Watershed According to the Form of the Watershed

The numeral trait of aquiferous zones in flowage studies and estimations is under most parts of nation. In this study Karaj aquiferous zone in Alborz province was surveyed from the view point of form, the agglomeration of drainage net length of channel and space. The orientation of hillside was specified as the affective factor on creating and streaming the flowage. A flow aggregating hydrological model for the studied zone was prepared and amount of the flow is mostly in which parts of the zone the delay and centralization time in the zone was evaluated and the related diagrams were derived. Finally, the zone was divided into 4 main subzones and their drainage nets were ranked and by 4 factors namely, space, length of canal, drainage aggregation and branch ratio affecting on performance of the zone from the view of from and appearance was surveyed. The factors interfering in SPSS software and their correlations were specified and specific coefficients stand in their related charts. By considering in the zone width and charts it is specified which of the sub zones has the most flowage potential from the view of the zones physical and numeral qualifications. All plots were prepared using GIS and WMS software and the studied zone’s hydrograph was depicted.