期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Genotype of ethanol metabolizing enzyme genes by oligonucleotide microarray in alcoholic liver disease in Chinese people 被引量:4
1
作者 虞朝辉 厉有名 +1 位作者 陈卫星 乐敏 《Chinese Medical Journal》 SCIE CAS CSCD 2002年第7期1085-1087,156+155,共3页
OBJECTIVE: To explore the relationship between genetic polymorphisms of the ethanol metabolizing enzymes and the occurrence of alcoholic liver disease (ALD). METHODS: Sixty-five healthy male controls and 165 alcoholis... OBJECTIVE: To explore the relationship between genetic polymorphisms of the ethanol metabolizing enzymes and the occurrence of alcoholic liver disease (ALD). METHODS: Sixty-five healthy male controls and 165 alcoholisms (including 122 ALD patients and 43 male alcohol abusers without liver complications defined as alcohol-dependent) were analyzed by polymerase chain reaction and hybridized with oligonucleotide microarray to detect the polymorphisms of the ethanol metabolizing enzymes genes. RESULTS: The frequencies of alcohol dehydrogenase gene 2 * 1 ( ADH2 * 1 ) allele were shown as 37.69%, 46.51% and 59.02% in control, alcohol-dependent and ALD groups respectively; while those of ADH2 * 2 allele were shown as 62.31 %, 53.49% and 40.98% respectively. No ADH2 * 3 was detected in any of the subjects. The frequency of ADH2 * 1 was significantly higher in alcoholisms (ALD group and alcohol-dependent group) than in healthy controls ( P 展开更多
关键词 Oligonucleotide Array Sequence Analysis Alcohol Dehydrogenase aldehyde oxidoreductases GENOTYPE Humans ISOENZYMES Liver Diseases Alcoholic MALE Polymorphism Genetic
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部