We have previously reported that the Ti complex generated from Cp2TiCl2 and LiBH4 serves as a catalyst for hydroboration of alkenes. Sodium borohydride can also be utilized as a reagent for hydroboration if reaction i...We have previously reported that the Ti complex generated from Cp2TiCl2 and LiBH4 serves as a catalyst for hydroboration of alkenes. Sodium borohydride can also be utilized as a reagent for hydroboration if reaction is carried out in the pre-展开更多
The direct iodination of polyfluorinated vinyl stannanes by tin-iodine exchange methodology was achieved giving （Z）-α-fluoro-β-trifluoromethyl vinyl iodides stereospecifically. Changing the substituent in R group ...The direct iodination of polyfluorinated vinyl stannanes by tin-iodine exchange methodology was achieved giving （Z）-α-fluoro-β-trifluoromethyl vinyl iodides stereospecifically. Changing the substituent in R group from the electron-withdrawing group to electron-donating group led to an increase in the yield from 78% to 90%, while it was moved from para to meta position the reaction did not afford a dramatic change in the yield （90% to 95%）. In addition, this reaction also can be applied to the vinyl stannane with heterocyclic group. The further coupling reaction of prepared vinyl iodide containing heterocyclic moiety with （Z）-α-fluoro-β-trifluoromethylstannanes gave polyfluorinated heterocyclic alkadienes with 2E,4E-selectivity.展开更多
文摘We have previously reported that the Ti complex generated from Cp2TiCl2 and LiBH4 serves as a catalyst for hydroboration of alkenes. Sodium borohydride can also be utilized as a reagent for hydroboration if reaction is carried out in the pre-
文摘The direct iodination of polyfluorinated vinyl stannanes by tin-iodine exchange methodology was achieved giving （Z）-α-fluoro-β-trifluoromethyl vinyl iodides stereospecifically. Changing the substituent in R group from the electron-withdrawing group to electron-donating group led to an increase in the yield from 78% to 90%, while it was moved from para to meta position the reaction did not afford a dramatic change in the yield （90% to 95%）. In addition, this reaction also can be applied to the vinyl stannane with heterocyclic group. The further coupling reaction of prepared vinyl iodide containing heterocyclic moiety with （Z）-α-fluoro-β-trifluoromethylstannanes gave polyfluorinated heterocyclic alkadienes with 2E,4E-selectivity.
