Main observation and conclusion High CO pressure(>40 bar)is usually needed in radical carbonylation reactions in the absence of metal catalyst.In this communication,we developed a transition-metal-free radical carb...Main observation and conclusion High CO pressure(>40 bar)is usually needed in radical carbonylation reactions in the absence of metal catalyst.In this communication,we developed a transition-metal-free radical carbonylation of activated alkylamines with phenols and alcohols under low CO pressure(1-6 bar).Various esters were obtained in moderate to excellent yields under simple reaction conditions with good functional group compatibility.展开更多
A simple approach to synthesize ZnO microstructures was reported using dodecylamine,hexadecylamine and oleylamine as template agents.The synthesized ZnO was characterized by XRD,FESEM,TEM,EDS mapping,FTIR,UV-vis DRS,R...A simple approach to synthesize ZnO microstructures was reported using dodecylamine,hexadecylamine and oleylamine as template agents.The synthesized ZnO was characterized by XRD,FESEM,TEM,EDS mapping,FTIR,UV-vis DRS,Raman spectroscopy and BET analysis.Hierarchical oriented ZnO microstructures were obtained.The photocatalytic performance of ZnO prepared with different types of alkylamines was evaluated by the degradation of methylene blue(MB)and methyl orange(MO).The results suggested that alkylamine control the nucleation,growth and morphology of ZnO.The photocatalytic properties of ZnO on the degradation of MB and MO decreased with increasing the alkyl chain length in alkylamine.展开更多
In this paper, an intercalation compound of layered α-ZrP with TMAPP was firstly synthesized by using the α-ZrP-BA pre-intercalation compound as intermediate. And we systemically investigated the intercala...In this paper, an intercalation compound of layered α-ZrP with TMAPP was firstly synthesized by using the α-ZrP-BA pre-intercalation compound as intermediate. And we systemically investigated the intercalation behavior of TMAPP into α-ZrP by XRD, visible spectrum and fluorescence spectrum.展开更多
Objective To test what length is needed for polyamine binding both intrinsic gate and pore docking site to block the cloned strong inwardly rectifying channel (Kir2.1 channel).Methods The effect of alkylamine analogue...Objective To test what length is needed for polyamine binding both intrinsic gate and pore docking site to block the cloned strong inwardly rectifying channel (Kir2.1 channel).Methods The effect of alkylamine analogues(DA5,DA8,DA10 and DA12) and the competitive interaction of polyamine toxin,philanthotoxin(PhTx),on expressed Kir 2.1channel in Xenopus oocytes were examined by using giant excised inside out patch clamp technique.Results The results showed that along with the increase of the length of DAs ,the value of Kd decreased and the high affinity binding increased gradually.However,PhTx had the strongest effect on interfering the DA10 binding between intrinsic gate and pore docking site and had a less effect on DA12.Conclusion DA10 may be the right length for polyamine to block the channel.And maybe there is a hydrophobic interaction between DA12 and C terminal domain of this channel, which then stabilize the DA12 binding between these two points and decrease the effect of PhTx on DA12.展开更多
Asymmetric reductive amination directly converts ketones and amines to alkylamines, which are important motifs in medicines.We report that cationic nickel complexes of chiral diphosphines promote enantioselective redu...Asymmetric reductive amination directly converts ketones and amines to alkylamines, which are important motifs in medicines.We report that cationic nickel complexes of chiral diphosphines promote enantioselective reductive amination of benzylic ketones with both arylamines and benzhydrazide. Isopropanol was used as a safe and cheap source of hydrogen instead of formic acid. The reaction can be readily applied to a concise synthesis of diarylethylamines, a class of neuroactive substances.展开更多
Shale hydration and swelling is the main obstacle to the development of shale gas utilizing water-based drilling fluids(WBDFs).In this work,the inhibition mechanism of alkylammonium inhibitor and alkylamine inhibitor ...Shale hydration and swelling is the main obstacle to the development of shale gas utilizing water-based drilling fluids(WBDFs).In this work,the inhibition mechanism of alkylammonium inhibitor and alkylamine inhibitor adsorbed on sodium bentonite(Na+Bent)are investigated using infrared spectroscopy(FT-IR),scanning electron microscopy(SEM),X-ray diffraction(XRD),zeta potential,particle size distribution tests,and thermogravimetry analysis(TGA).The results suggest that HTB and HMD can be inserted into the interlamination of Na+Bent and minimize the basal spacing compared to hydrated Na+Bent.HTB and HMD are inserted between the Na+Bent layers in a single-layer tiled manner and replace the sodium ions that are firmly fixed between the layers.Eventually,water molecules are removed from the interlayer Na+Bent.The interaction between the quaternary ammonium group and Na+Bent is more significant than between the primary amine group and Na+Bent.The inhibition performance suggests that HTB inhibits Na+Bent hydration and swelling more substantially than other inhibitors,indicating that the inhibition performance of the two quaternary ammonium groups is greater than that of the two primary amine groups.Therefore,HTB can be used as intercalation inhibition in WBDFs and has tremendous application value.展开更多
It is an unceasing goal for organic chemists to develop new catalytic methodologies for functional group transformations of widespread molecular structures. Amides are readily available from simple and reliable reacti...It is an unceasing goal for organic chemists to develop new catalytic methodologies for functional group transformations of widespread molecular structures. Amides are readily available from simple and reliable reactions, which are common structural units found in biologically active compounds. Consequently, they are attractive to be exploited in amine synthesis by reductive cross coupling. However, deoxygenative functionalization of amides is a long-standing challenge owing to the inertness of the resonance-stabilized amide C=O bond. In this work, a deoxygenative alkylation strategy was demonstrated, which combines amides and alkyl iodides to build structurally diverse tertiary alkylamines in a single step. Compared with previous deoxygenative alkylation of amides using organometallic reagents as functional partner, this work uses stable and easily available alkyl halides as functionalization reagents. The versatile and flexible strategy plus structural and functional diversity of readily available amides and alkyl iodides renders it highly appealing for the streamlined synthesis of tertiary amines and would be of much interest in areas such as pharmaceutical and agrochemical research.展开更多
Extraction of chromate ions from wastewater by tri alkylamine(R 3N) dissolved in kerosene was studied at 2560℃. 1 Octanol was used as the modifier to remove the third phase. The aqueous phase was a sulfuric acid...Extraction of chromate ions from wastewater by tri alkylamine(R 3N) dissolved in kerosene was studied at 2560℃. 1 Octanol was used as the modifier to remove the third phase. The aqueous phase was a sulfuric acid solution of Cr(Ⅵ) in the concentration range commonly encountered in the galvanizing industry, namely about 2.0 mol/L. Measurement of equilibrium behavior of Cr(Ⅵ) was carried out over wide concentration ranges of amine, Cr 2O 2- 7 and 1 octanol. Experimental results showed that the proper temperatures for extraction are 2540℃ , the [H +] of the aqueous phase is 2 mol/L, and the solvent composition is 30% R 3N, 64% kerosene, and 6% 1 octanol. Prediction and optimization of solvent extraction plant performance for variable industrial feed conditions are then possible. The influence of 1 octanol as the modifier to remove the third phase was also studied.展开更多
文摘Main observation and conclusion High CO pressure(>40 bar)is usually needed in radical carbonylation reactions in the absence of metal catalyst.In this communication,we developed a transition-metal-free radical carbonylation of activated alkylamines with phenols and alcohols under low CO pressure(1-6 bar).Various esters were obtained in moderate to excellent yields under simple reaction conditions with good functional group compatibility.
文摘A simple approach to synthesize ZnO microstructures was reported using dodecylamine,hexadecylamine and oleylamine as template agents.The synthesized ZnO was characterized by XRD,FESEM,TEM,EDS mapping,FTIR,UV-vis DRS,Raman spectroscopy and BET analysis.Hierarchical oriented ZnO microstructures were obtained.The photocatalytic performance of ZnO prepared with different types of alkylamines was evaluated by the degradation of methylene blue(MB)and methyl orange(MO).The results suggested that alkylamine control the nucleation,growth and morphology of ZnO.The photocatalytic properties of ZnO on the degradation of MB and MO decreased with increasing the alkyl chain length in alkylamine.
基金supported by the National Natural Science Foundation of China(No.20271074)
文摘In this paper, an intercalation compound of layered α-ZrP with TMAPP was firstly synthesized by using the α-ZrP-BA pre-intercalation compound as intermediate. And we systemically investigated the intercalation behavior of TMAPP into α-ZrP by XRD, visible spectrum and fluorescence spectrum.
基金Present address:Departm ent of CardiologyFirst Hosptial of Xi'an Jiaotong University+1 种基金Xi'an 710 0 6 China
文摘Objective To test what length is needed for polyamine binding both intrinsic gate and pore docking site to block the cloned strong inwardly rectifying channel (Kir2.1 channel).Methods The effect of alkylamine analogues(DA5,DA8,DA10 and DA12) and the competitive interaction of polyamine toxin,philanthotoxin(PhTx),on expressed Kir 2.1channel in Xenopus oocytes were examined by using giant excised inside out patch clamp technique.Results The results showed that along with the increase of the length of DAs ,the value of Kd decreased and the high affinity binding increased gradually.However,PhTx had the strongest effect on interfering the DA10 binding between intrinsic gate and pore docking site and had a less effect on DA12.Conclusion DA10 may be the right length for polyamine to block the channel.And maybe there is a hydrophobic interaction between DA12 and C terminal domain of this channel, which then stabilize the DA12 binding between these two points and decrease the effect of PhTx on DA12.
基金supported by the National Natural Science Foundation of China (22271007)the Peking University Shenzhen Graduate School,State Key Laboratory of Chemical Oncogenomics,Shenzhen Bay Laboratory,and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs。
文摘Asymmetric reductive amination directly converts ketones and amines to alkylamines, which are important motifs in medicines.We report that cationic nickel complexes of chiral diphosphines promote enantioselective reductive amination of benzylic ketones with both arylamines and benzhydrazide. Isopropanol was used as a safe and cheap source of hydrogen instead of formic acid. The reaction can be readily applied to a concise synthesis of diarylethylamines, a class of neuroactive substances.
基金supported by the Science and Technology Cooperation Project of the CNPC-SWPU Innovation Alliance(NO.2020CX040102,2020CX040201)National key R&D projects(No.2019YFA0708303)+3 种基金Sichuan Science and Technology Program(No.2020JDJQ0057)Sichuan Youth Science and technology innovation research team project(No.2020JDTD0018)Science and Technology Cooperation Project of the CNPC-SWPU Innovation Alliance(No.2020CX040102,2020CX040201)the Opening Project of Oil&Gas Field Applied Chemistry Key Laboratory of Sichuan Province(YQKF202101).
文摘Shale hydration and swelling is the main obstacle to the development of shale gas utilizing water-based drilling fluids(WBDFs).In this work,the inhibition mechanism of alkylammonium inhibitor and alkylamine inhibitor adsorbed on sodium bentonite(Na+Bent)are investigated using infrared spectroscopy(FT-IR),scanning electron microscopy(SEM),X-ray diffraction(XRD),zeta potential,particle size distribution tests,and thermogravimetry analysis(TGA).The results suggest that HTB and HMD can be inserted into the interlamination of Na+Bent and minimize the basal spacing compared to hydrated Na+Bent.HTB and HMD are inserted between the Na+Bent layers in a single-layer tiled manner and replace the sodium ions that are firmly fixed between the layers.Eventually,water molecules are removed from the interlayer Na+Bent.The interaction between the quaternary ammonium group and Na+Bent is more significant than between the primary amine group and Na+Bent.The inhibition performance suggests that HTB inhibits Na+Bent hydration and swelling more substantially than other inhibitors,indicating that the inhibition performance of the two quaternary ammonium groups is greater than that of the two primary amine groups.Therefore,HTB can be used as intercalation inhibition in WBDFs and has tremendous application value.
基金supported by the National Natural Science Foundation of China (22171278, 21821002)。
文摘It is an unceasing goal for organic chemists to develop new catalytic methodologies for functional group transformations of widespread molecular structures. Amides are readily available from simple and reliable reactions, which are common structural units found in biologically active compounds. Consequently, they are attractive to be exploited in amine synthesis by reductive cross coupling. However, deoxygenative functionalization of amides is a long-standing challenge owing to the inertness of the resonance-stabilized amide C=O bond. In this work, a deoxygenative alkylation strategy was demonstrated, which combines amides and alkyl iodides to build structurally diverse tertiary alkylamines in a single step. Compared with previous deoxygenative alkylation of amides using organometallic reagents as functional partner, this work uses stable and easily available alkyl halides as functionalization reagents. The versatile and flexible strategy plus structural and functional diversity of readily available amides and alkyl iodides renders it highly appealing for the streamlined synthesis of tertiary amines and would be of much interest in areas such as pharmaceutical and agrochemical research.
基金the National Natural Science Foundationof China(No.2 9836 130
文摘Extraction of chromate ions from wastewater by tri alkylamine(R 3N) dissolved in kerosene was studied at 2560℃. 1 Octanol was used as the modifier to remove the third phase. The aqueous phase was a sulfuric acid solution of Cr(Ⅵ) in the concentration range commonly encountered in the galvanizing industry, namely about 2.0 mol/L. Measurement of equilibrium behavior of Cr(Ⅵ) was carried out over wide concentration ranges of amine, Cr 2O 2- 7 and 1 octanol. Experimental results showed that the proper temperatures for extraction are 2540℃ , the [H +] of the aqueous phase is 2 mol/L, and the solvent composition is 30% R 3N, 64% kerosene, and 6% 1 octanol. Prediction and optimization of solvent extraction plant performance for variable industrial feed conditions are then possible. The influence of 1 octanol as the modifier to remove the third phase was also studied.