A Study on the Innovation of U-Education of Party Members from the Perspective of Big Data

Potential cognition of the social development system centered on economic construction has been changed. To a certain extent, it has formed the new concept of "world outlook and views on life and values" for the younger generation. It is imperative that innovation on the form of education of party members in the new era be enforced. In today's big data, problems in the education of party members can be concluded from the analysis of data collection and mining. To explore the U-Education methods and modes for special party members of a certain age group and create an "internet Party Construction platform +" can effectively deal with the shortcomings of the existing education, and through more convenient and quicker APP operation, widely used mobile phones can effectively conduct education and study, and data statistics function of the platform can be used for evaluation and analysis to seek a more perfect education mode.

MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1-extracellular signal-regulated kinase-1/2 axis

BACKGROUND MicroRNAs(miRNAs)regulate gene expression and play a critical role in cancer physiology.However,there is still a limited understanding of the function and regulatory mechanism of miRNAs in gastric cancer(GC).AIM To investigate the role and molecular mechanism of miRNA-145-5p(miR145-5p)in the progression of GC.METHODS Real-time polymerase chain reaction(RT-PCR)was used to detect miRNA expression in human GC tissues and cells.The ability of cancer cells to migrate and invade was assessed using wound-healing and transwell assays,respectively.Cell proliferation was measured using cell counting kit-8 and colony formation assays,and apoptosis was evaluated using flow cytometry.Expression of the epithelial-mesenchymal transition(EMT)-associated protein was determined by Western blot.Targets of miR-145-5p were predicated using bioinformatics analysis and verified using a dual-luciferase reporter system.Serpin family E member 1(SERPINE1)expression in GC tissues and cells was evaluated using RT-PCR and immunohistochemical staining.The correlation between SERPINE1 expression and overall patient survival was determined using Kaplan-Meier plot analysis.The association between SERPINE1 and GC progression was also tested.A rescue experiment of SERPINE1 overexpression was conducted to verify the relationship between this protein and miR-145-5p.The mechanism by which miR-145-5p influences GC progression was further explored by assessing tumor formation in nude mice.RESULTS GC tissues and cells had reduced miR-145-5p expression and SERPINE1 was identified as a direct target of this miRNA.Overexpression of miR-145-5p was associated with decreased GC cell proliferation,invasion,migration,and EMT,and these effects were reversed by forcing SERPINE1 expression.Kaplan-Meier plot analysis revealed that patients with higher SERPINE1 expression had a shorter survival rate than those with lower SERPINE1 expression.Nude mouse tumorigenesis experiments confirmed that miR-145-5p targets SERPINE1 to regulate extracellular signal-regulated kinase-1/2(ERK1/2).CONCLUSION This study found that miR-145-5p inhibits tumor progression and is expressed in lower amounts in patients with GC.MiR-145-5p was found to affect GC cell proliferation,migration,and invasion by negatively regulating SERPINE1 levels and controlling the ERK1/2 pathway.

新中国成立初期农村党员教育与农业互助合作运动的推进--以山东为中心的考察

新中国成立初期,为了消除农村党员对社会主义社会和共产主义社会的错误认识,打破“革命成功”的胜利情绪,农村基层党组织进行了一次较为系统的党员教育。通过农村党员教育,中国共产党在农村党的组织初步建立了党课制度,提高农民党员的思想觉悟和理论水平,改变部分党员存在的“个人生产、发家致富”的思想,划清党员干部先锋队与群众的界限,启发他们带头参加农村互助合作组织,并在其中发挥示范作用,有效推进了农业互助合作运动的进程。新中国成立初期,山东作为当时农村党员占比最多的省份,其农村党员教育积累了一定的经验,对当下党员干部教育有积极启示意义。

World Journal of Gastroenterology A Brief Introduction of Editorial Board Members 2004-2006

The World Journal of Gastroenterology Editorial Board consistsof 174 members,representing a team of worldwide experts ingastroenterology and hepatology.They are from 53 countriesincluding:Albania(1),Algeria(1),Argentina(2),Austria(1),Belarus(1),Belgium(1),Brazil(1),Bulgaria(1),Canada(1),China(40),Costa Rica(1),Croatia(1),Denmark(1),Egypt(1),Finland(1),France(1),Germany(7),Greece(1),Hungary(2),Iceland(1),India(2),Iran(1),Ireland(2),Israel(2),Italy(2),Japan(3),Latvia(1),Lithuania(1),Macedonia(1),Malaysia(2),Monaco(1),Netherlands(3),New Zealand(1),Pakistan(1),Philippines(1),Poland(2),Portugal(1),Romania(1),Russia(3),Singapore(1),SIovakia(1),Slovenia(2),South Africa(1),South Korea(2),Spain(1),Sri Lanka(1),Sweden(2),Switzerland(2),Thailand(1),Turkey(1),United Kingdom(6),United States(53),and Yugoslavia(1).

Verifying the Effects of an Education Program Leveraging Information Technology to Promote Cervical Cancer Screening in Women Aged 20 - 29—A One-Year Longitudinal Study

The purpose of this research is to implement an IT-based education program in order to promote cervical cancer screenings for women aged 20 - 29 years, as well as to examine the results of said program. This is a longitudinal/comparative study of two groups, one for which the program was implemented (the intervention group), and the other for which it was not (the control group). The program consisted of attending a health lecture and encouragement to be screened one month, six months, and one year later sent through IT-based methods. The target was unmarried women aged 20 - 29 who had neither previously given birth nor had been screened for cervical cancer in a period one year prior. They were divided into two groups, the intervention group (n = 142) and control group (n = 145). The effectiveness of the program was assessed via an initial survey and further surveys six months and one year later. Results were based on the Japanese version of the Health Belief Model Scale for Cervical Cancer and the Pap Smear Test (HBMSCCPST), knowledge scores in the categories of Healthy Lifestyles, Cervical Cancer, Cervical Cancer Screening, and screening behavior. A two-way ANOVA of the HBMSCCPST subscales and knowledge scores in the initial, six-month, and one-year surveys was performed, showing interaction in Cervical Cancer (p = 0.00). Main effects were observed in Cervical Cancer Screening (p = 0.00) and Healthy Lifestyles (p = 0.00). Regarding the amount of change from the initial survey, knowledge scores in the Cervical Cancer (p = 0.027) and Cervical Cancer Screening (p = 0.016) categories were significantly higher in the intervention group than in the control group. There was no significant difference in cervical cancer screening rates (p = 0.26) between the two groups. However, a small-degree effect size was observed for Benefits, Seriousness, and Susceptibility subscales in both examinees and non-examinees. Although the educational program of this study was effective in improving the knowledge of women in their twenties, there was little improvement in HBMSCCPST and it did not lead to the promotion of cervical cancer screening. In order to raise interest in cervical cancer screening, it is necessary to consider useful content to guide women to consult with healthcare professionals, a long-term population approach, and organizational structure of consultation.

高校网络思想政治教育载体创新研究--基于“三全育人”视域

从“三全育人”体系构建的角度分析当前高校网络思想政治教育面临的新形势、新机遇和现实困难,提出高校网络思想政治教育载体创新的基本遵循原则:要从有利于坚持主流意识形态主导、有利于落实立德树人根本任务、有利于贯彻以人为本根本理念出发,用网络思维和信息技术的“新”推动教育载体建设的“新”,并从加快思想政治工作队伍的角色重塑和转型升级、信息化建设与思想政治教育的深度融合、教育载体创新的系统性与精准性结合三个方面提出教育载体创新实践探索的相关思考。

Impact of Education on Productivity:A Model in China

Improving the quality of human resources through edu-cation and training is of great strategic significance.However, few people have done in depth and systematicstudies on the relationship between education and pro-ducttvity in China. This study developed an educationproductivity transform model and empirically tested themodel using data on the most districts of China. The ba-sic notion is that the effect depends both on the capabilityresulted from education, and on the environment inwhich this capability can be exercised, the effect is a re-sult of two factors combined.

MiR-16-5p plays an inhibitory role in human non-small cell lung cancer through Fermitin family member 2

Increasing evidence indicates that aberrant expressions of some microRNAs are associated with cancer progression.However,the roles and biological mechanisms of miRNA-16-5p in human non-small cell lung cancer(NSCLC)are not to be well studied.Here,we validated that the expression of miR-16-5p was decreased significantly in NSCLC samples and cell lines.The correlation between the clinicopathological features of NSCLC and the miR-16-5p expression showed that the expression of miR-16-5p in non-small cell lung cancer was linked with the advanced TNM stage,positive lymph node metastasis,with short overall survival(OS).Also,a negative correlation between miR-16-5p and Fermitin family member 2(FERMT2)was observed,implying there may be a potential link about their regulation.The hypothesis was further confirmed by in-silico analysis and dual-luciferase reporter assay.Moreover,we demonstrated that the transfections of miR-16-5p mimics could alter some biological characteristics of NSCLC cells remarkably accomplished by the expression variance of FERMT2 in vitro and in vivo assays.Summarily,this study demonstrated that miR-16-5p,as a tumor suppression factor in NSCLC by targeting FERMT2,could serve as one promising biomarker in the prediction for NSCLC patients.

公立医院党员教育管理实践探索

为适应公立医院高质量发展新要求,首都医科大学附属北京安贞医院党委坚持以党的政治建设为统领,夯实制度基础,落地调研指导,推进党建与业务工作深度融合。医院坚持以人民为中心,以党建服务品牌创建为抓手,深化党员学习教育内涵,构建了与医院发展目标相统一、着力服务人民健康的科学精准、务实创新的党员教育管理长效机制。

东北地区教学建筑侧窗导光构件形态模拟研究

目的 为解决东北地区教学建筑中自然光分布严重不均衡,而单纯依靠粗放式地提高窗地比采光计算方法无法改善,通过设置导光构件解决自然光分布不均衡的难题。方法 应用Ecotect软件建立典型教室空间和导光构件的参数化模型,分析导光构件内外位置、水平高度、截面尺寸、截面形态、透光度等参数变化对于采光系数、照度、采光均匀度等参数的影响。结果 通过对模拟数据的比较分析发现,导光板在位于侧窗室内一侧、高度为2 400 mm、截面宽度为1 050~1 200 mm、截面形态为弧形向下的情况下,采光照度和均匀度达到最佳平衡状态;导光百叶中的水平内倾百叶的综合性能优于其他类型。结论 横向比较,导光板最优方案在综合性能上优于导光百叶,是东北地区较为适用的导光构件。

伟大建党精神融入新时代学生党员教育的路径研究

伟大建党精神为学生党员教育提供了理论武器、价值导向、精神激励和情感归属,能够提升学生党员教育的系统性、说服力、贴近性和感染力。将伟大建党精神融入学生党员教育,要加强内容设计、注重实践导向、创新教育形式、优化机制建设,充分激发伟大建党精神的强大育人动能,涵育“有理想、敢担当、能吃苦、肯奋斗”的新时代学生党员。

“精准滴灌式”党员教育管理模式在高校学生社区中的实践运用

当前,高校要推进“一站式”学生社区综合管理工作必须紧紧围绕党建引领,将党建文化、专业学习、校园文化等内容充分融入到社区管理和活动之中,使学生社区切实成为融思想教育、行为导向、生活服务、文化熏陶为一体的“第二课堂”主阵地和学校立德树人的新高地。近年来,韶关学院积极探索“精准滴灌式”党员教育管理模式在高校学生社区的实践运用,尤其在强化党建引领、优化社区软硬件设施建设、凸显学生自我管理的主体作用与持续推进和完善制度建设等方面,为“一站式”学生社区综合管理的深入开展提供强有力的平台与保障,确保其在立德树人根本任务上发挥实效。

中华人民共和国成立初期山西省农村党员教育实践及历史启示(1949-1956)

农村党员教育是农村党支部建设的重要一环。中华人民共和国成立初期,山西省针对部分农村党员出现的思想文化水平偏低的现象,通过开办短期训练班、健全党课教育制度、建立农村党员教育网等方法,提高了农村党员的思想文化水平,保证了农村党组织的先进性和战斗力。因此,对中华人民共和国成立初期山西省农村党员教育工作的研究,能够为新时代农村党员的思想教育提供有益借鉴。

党建标杆院系创建视域下大学生党员先进性教育实践

新时代高校党建工作标杆院系创建要求必须加强大学生党员先进性教育,努力使大学生党员成为德智体美劳全面发展的新时代大学生的表率,这是全面从严治党、高校党建“双创”工作和为党育人、为国育才的内在要求。目前,大学生党员先进性教育面临外部多元化社会思潮和价值取向带来的负面影响以及内部党员发展工作本身存在的问题和不足。为此,新时代大学生党员先进性教育要在制度层面上健全和完善体制机制、内容和形式层面上创新和完善内容建设和载体方法、实现路径上严把党员发展过程中的“五关”,从而实现大学生党员的先进性。

习近平文化思想指引下党员干部教育创新路径研究

习近平文化思想在正本清源中举旗定向、在守正创新中全面发展、在系统谋划中科学总结,是我们党凝心聚力的“金钥匙”。在深刻理解习近平文化思想内涵和党员干部教育全局性作用的基础上,把握习近平文化思想融入党员干部教育的契合点,从意识形态教育、理想信念教育、“两个结合”教育三方面对党员干部教育问题进行探析并提出可参考性建议,切实发挥习近平文化思想在党员干部教育中的指导作用,以期实现党员干部教育提质增效。

以高水平教育培训推进高校党员干部和教师队伍建设研究

新时代新征程,新目标新任务,高校党校工作者必须持续加强党校工作能力建设,不断提升传道、授业、解惑的水平和质量;要以党性教育培训、理论教育培训、能力教育培训、作风教育培训、精神谱系教育培训、三大倡议教育培训这六项内容为工作重点,在加强课程建设及其课程教学之基础上,加强课堂建设及其课堂教学。为了强国建设、民族复兴新的伟大事业,高校党校要以高水平的教育培训工作实绩,造就足够多的党性坚强、理论深厚、能力高强、作风优良、精神高尚、胸怀宽广的高素质的党员干部和党员教师人才队伍,在中国式现代化进程中,推动新时代高校党校事业实现高质量发展。

新时代高校党员党性教育现状与对策研究

高校党性教育是党组织建设的重要组成部分,是不断壮大党的力量、强化党的领导,推进“党管教育事业”的基本工作。新时代推进高校党员党性教育是一个任重而道远的过程,但却普遍面临着重视程度不高、目标设置不强、党员主动性薄弱等问题,急需高校明确党性教育问题的基本原因,从斗争思维、整体思维、创新思维等维度出发,持续提升党员党性教育的实效性、规律性、紧迫性,从而办好社会主义大学,推动社会主义事业的现代化发展。

新时代党员教育对大学生创新创业精神的影响研究

新时代大学生创新创业精神对我国经济社会高质量发展至关重要。党员教育是立德树人的政治基础,创新创业精神是立德树人的重要抓手。从理论和实证层面探讨党员教育对大学生创新创业精神的影响,对湖南482名大学生党员的实证研究表明,党员教育对大学生创新创业精神有显著积极作用,大学生社会责任起到中介作用,党员发展质量起到调节作用。在此基础上,提出了通过党员教育促进大学生创新创业的建议。