Development of alexithymic personality features

The purpose of this paper is to review the current literature regarding the development of alexithymic personality features. Modern brain imaging technologies provide interesting data on the associations of alexithymia with different aberrations in brain function related to emotion regulation; however, the development of these deviations is poorly understood. A notable amount of research covers the relation of alexithymia to differentenvironmental factors. Many of these associations, for example, with low socio-economic status and general psychopathology in childhood, are well established. However, the retrospective and cross-sectional designs commonly used in these studies, as well as the use of self-report measures, hinder the ability to firmly establish causality. Certain individual developmental factors, such as lagging speech development and congenital cardiac malformations in childhood, have been associated with the development of alexithymia. Regarding the stability of alexithymia, a systematic review of the literature was conducted for this paper. In addition to being characterized as a personality feature in the general population, alexithymia also clearly has a state-like dimension that results in increases and decreases in alexithymic features in conjunction with mental disorder symptoms. An essential question is whether the alexithymic features in adulthood are, in fact, infantile features of a restricted ability to identify and describe emotions that simply persist in individuals through adolescence to adulthood. To firmly establish the roots of alexithymia development, longitudinal studies, particularly in younger populations, are needed. Furthermore, multifaceted study settings are encouraged.

An Exploration of Higher Vocational English Teachers’Professional Development on Students’Learning Ability in the Context of New Liberal Arts

The concept of New Liberal Arts,a multidisciplinary combined integrator with Chinese values at its core,has brought new challenges to the teaching methods and professional development of higher-level English teachers.Based on the evolving professional development process of higher vocational English teachers in the context of the New Liberal Arts,this article analyzes how English teachers can integrate multidisciplinary knowledge and adopt advanced educational technology in the teaching process.On this basis,it discusses the role of teachers’professional development in enhancing students’learning ability,such as through deepening disciplinary understanding,adopting innovative teaching strategies,and implementing personalized teaching.At the end of the article,based on a variety of pedagogical theories,we put forward suggestions,including continuous professional training,interdisciplinary cooperation,and the application of innovative teaching techniques,which are mainly aimed at helping higher vocational English teachers get rid of the dilemma of the new situation,adapt to the needs of the new liberal arts education as soon as possible,and then effectively improve students’abilities.

Development of College Students' Innovation and Entrepreneurship Ability under the Model of Personalized Education

The essence of personalized education is an innovative education that respects individual differences. With the continuous evolution of the times,the ability of innovation and entrepreneurship has become the key to reflecting comprehensive national strength. In response to the call of China to build " an innovative country",colleges and universities should cultivate students' individualized thinking and methods and abilities to solve problems on the basis of respecting the creativity and subjectivity of college students,and lay a solid foundation for students' future innovation and entrepreneurship. In this paper,the present situation of students' independent development promoted by personalized education at home and abroad was analyzed firstly,and the existing problems and solutions were pointed out. The study aims to contribute to the acceleration of China's innovation-driven development.

With Advantages,Development and Innovation Promote International Trade in All-round Way

In 2004, under the leadership of China Council for the Promotion of International Trade (CCPIT), CPC Shanghai Committee and Shanghai Municipal government, CCPIT Shanghai Sub-Council established scientific viewpoint of development, centered by export-oriented economy, strengthened active serving and innovation, raised service level which made great contributions to Shanghai's opening-up and economic development as well as drove the whole development of society.……

Relations Between China and Central Asian Countries Face Opportunity of All-Round Development

Since the establishment of diplomatic relations between China and its western neighbors - the Central Asian countries, the friendly and good-neighborly relationship between the two sides has kept a sound momentum of development. China’s policy of creating an amicable, secure and

Thoughts on Promoting the Development of Students’ Personality Using English Community

Language learning has certain difficulties,especially English as an important second language.Junior high school students will encounter certain obstacles in the process of learning.The establishment of English associations and the attraction of students to participate have a clear distinction due to classroom teaching and community activities.They are based on the interests of students,so they can motivate students to participate.This paper discusses the significance and methods of the English community to promote the development of students’personality.

Protecting the Rights of Disabled Persons——From the Perspective of Protecting Their Right to Development with Affirmative Action as the Core

Establishing and protecting the right to development of disabled persons is not only the important part of Xi Jinping’s thought on human rights, but also a reflection of Marxism’s idea of human rights and a requirement of the rule of law in China. It is necessary to promote the protection of the right to development of disabled persons in terms of affirmative action. The Chinese government’s affirmative action requires structural characteristics, including providing the institutional basis for the affirmative action by constructing legal and non-legal institutions, providing an environment conducive for the affirmative action by shaping a more aware social ecology and providing valid guarantees for affirmative action by increasing the responsibility of local governments.

Promoting the Personal Development of Children Through Art Education

With the arrival of the new era,the development of society changes with each passing day,innovative ability and creative thinking skills are increasingly valued by society.The development of innovative ability should start with children.The emergence of new educational concepts requires the school to cultivate students in a comprehensive way.In this case,art and music,which were once considered unimportant,are gradually changing the educational field and are returning to the public eye.Studies have shown that art education plays an important role in promoting personal development of children.Therefore,art education should not be neglected,and we should see that art education plays a certain role in improving children’s innovative abilities.However,there are still many problems in art education for children,which affects its role in promoting their personal development.Therefore,it is important to focus on how to promote children’s personal development through art education.This paper analyzes the problems faced in children’s art education and how to effectively maximize its role of art education to promote the development of children’s art education.

On All-round Development of Human Rights in China

In October 2003, the Third Plenary Session of the Sixteenth Central Committee of the Communist Party of China （CPC） called for adherence to ＂the outlook toward development based on the fundamental interests of the people, toward an all-round, balanced and sustainable development.＂ The session also proposed to the National People＇s Congress （NPC） that respect for and protection of human rights be written into the country＇s Constitution. And accordingly, the NPC adopted a decision to revise the Constitution the following year. The call and the proposal were inter-related. The call sets the guideline, the theoretical basis and the orientation for the development of human rights in China. The pro- posal subsequently resulted in a revision of-the Constitution, the fundamental state law, which came as a legal guarantee for respect for and protection of human rights. Then, the ＂task of promoting an all-round development of the human rights cause＂ was written down into the country＇s Eleventh Five-Year Program for National Economic and Social Development （2006-2010）, which was approved by the NPC in March 2006. This was the first time that the development of human rights was written into a national program for social development. This means that an even closer link has been forged between China＇s human rights cause on one hand and the country＇s political, economic, cultural and social welfare undertakings on the other, thus preparing China＇s human rights cause for faster and sustainable development. We are now safe to predict that in the future, there will be even more and better rights the Chinese people are able to enjoy.

Challenges and Demands for College English Teachers Raised by Training All-round Qualified Persons

The latest issue of College English Curriculum Requirements has posed challenges and demands for teachers in terms of linguistic competence, academic knowledge, language skills, professional morality, emotional and attitudinal qualifications, etc., which requires teachers to embrace and handle with active and open-minded responses. Hence, teachers ought to strive to develop and improve their own overall qualifications in collaboration with the long-term development of the subject and of the national higher education, with the need of qualified persons demanded by social development and the students＇ learning. Teachers also ought to form a notion of scientific development by keeping pace with the time, so as to discern the trend of subject development, to form appropriate judgments concerning the social development and to properly regulate their own development.

Breast Cancer MCF-7 Cell Spheroid Culture for Drug Discovery and Development

In vitro 3D cancer spheroids (tumoroids) exhibit a drug resistance profile similar to that found in solid tumors. 3D spheroid culture methods recreate more physiologically relevant microenvironments for cells. Therefore, these models are more appropriate for cancer drug screening. We have recently developed a protocol for MCF-7 cell spheroid culture, and used this method to test the effects of different types of drugs on this estrogen-dependent breast cancer cell spheroid. Our results demonstrated that MCF-7 cells can grow spheroid in medium using a low attachment plate. We managed to grow one spheroid in each well, and the spheroid can grow over a month, the size of the spheroid can grow over a hundred times in volume. Our targeted drug experimental results suggest that estrogen sulfotransferase, steroid sulfatase, and G protein-coupled estrogen receptor may play critical roles in MCF-7 cell spheroid growth, while estrogen receptors α and β may not play an essential role in MCF-7 spheroid growth. Organoids are the miniatures of in vivo tissues and reiterate the in vivo microenvironment of a specific organ, best fit for the in vitro studies of diseases and drug development. Tumoroid, developed from cancer cell lines or patients’ tumor tissue, is the best in vitro model of in vivo tumors. 3D spheroid technology will be the best future method for drug development of cancers and other diseases. Our reported method can be developed clinically to develop personalized drugs when the patient’s tumor tissues are used to develop a spheroid culture for drug screening.

Continuing professional development:progress beyond continuing medical education

Continuing medical education(CME)is rapidly evolving into competency-based continuing professional development(CPD)and this is driving change in self-directed CPD programs undertaken by individual practitioners as well as CPD programs or frameworks offered by CPD educators.This progression is being led by many factors including the rapid change in medical knowledge and medical practitioners along with changes in patients and society,healthcare systems,regulators and the political environment.We describe our experiences primarily concerning low-resource environments,in creating the International Council of Ophthalmology(ICO)Guide to Effective CPD/CME and in developing a CPD program for the Cambodian Ophthalmological Society(COS)twinned with the Royal Australian and New Zealand College of Ophthalmologists(RANZCO).At the conclusion of the project,47(100%)Cambodian practicing ophthalmologists were registered in the CPD program and 21(45%)were actively participating in the online COS-CPD program recording.We discuss challenges in CPD,propose solutions to overcome them and recommend developing research in CPD as needed to effectively enhance educational activities with impact in public health.

Predictive biomarkers in precision medicine and drug development against lung cancer

The molecular characterization of various cancers has shown that cancers with the same origins,histopathologic diagnoses,and clinical stages can be highly heterogeneous in their genetic and epigenetic alterations that cause tumorigenesis.A number of cancer driver genes with functional abnormalities that trigger malignant transformation and that are required for the survival of cancer cells have been identified.Therapeutic agents targeting some of these cancer drivers have been successfully developed,resulting in substantial improvements in clinical symptom amelioration and outcomes in a subset of cancer patients.However,because such therapeutic drugs often benefit only a limited number of patients,the successes of clinical development and applications rely on the ability to identify those patients who are sensitive to the targeted therapies.Thus,biomarkers that can predict treatment responses are critical for the success of precision therapy for cancer patients and of anticancer drug development.This review discusses the molecular heterogeneity of lung cancer pathogenesis;predictive biomarkers for precision medicine in lung cancer therapy with drugs targeting epidermal growth factor receptor(EGFR),anaplastic lymphoma kinase(ALK),c-ros oncogene 1 receptor tyrosine kinase[ROSl),and immune checkpoints;biomarkers associated with resistance to these therapeutics;and approaches to identify predictive biomarkers in anticancer drug development.The identification of predictive biomarkers during anticancer drug development is expected to greatly facilitate such development because it will increase the chance of success or reduce the attrition rate.Additionally,such identification will accelerate the drug approval process by providing effective patient stratification strategies in clinical trials to reduce the sample size required to demonstrate clinical benefits.

A Miracle of Human Development in China(1950-2030)

China has created an even more spectacular miracle in human development than in economic growth.From 1950 to 2015,China went through three stages of socio-economic development; the "extremely poor era",the "era of letting some people get rich first" and the "era of common prosperity",raising its human development to an increasingly higher level.With the world's fastestgrowing Human Development Index(HDI) during this period,China evolved from a very "low human development level" to a "high human development level".And it is expected to enter a new stage with a "very high human development level" around 2021.This human development miracle in China indicates that socialism with Chinese characteristics gains strength from being a major country and a late mover,as well as from its development path and socialist system.China,arguably contributing the most to the entirety of human development,can serve as a role model for developing countries and can lead the path for the all-round development of billions of people.

Research on Supplying Mechanisms of Rural Economic Able-person in Construction of New Countryside——Based on the Phenomenon of Intelligence Returning in Under-developed Agricultural Plain Area of Henan

From a perspective of the discussions on researches of economic able-person by researchers at home,it can be concluded that economic able-person has become the important mode promoting rural development.The research makes a discussion on the rural intelligence returning theory and points out that as a marketing action,rural intelligence returning functions directly and effectively on the supplying to rural economic able-person.The research also makes an analysis of the supplying mechanisms of rural able-person intelligence returning of the under-developed agricultural plain in Henan province.And results show that transferring of rural surplus labors takes place among provinces;farmers accelerate in returning to hometowns to make money and returning phenomena would tend to be normal.With more and more popular the intelligence returning phenomenon in rural areas,the under-developed agricultural plain in Henan province would make enough profits.

Religious Education in Authentic Human Development: A Theological-Ethical Consideration

From a theological ethical moral view,it seems obvious that adequate religious moral education is a sine qua non for authentic human development necessary for a solid nation-building.Although,state and religion are separated from each other,this should not imply a total dichotomy of religious influence on socio-political matters.A pure secularised world that has nothing to do with God,a society devoid of any form of religious affiliation,a society purely human having neither to do with God nor the spirits,such a society seems inconceivable and unrealistic and may not even be human.Experience shows that to be human demands some form of acknowledgment of a superior being,whose influence may inform one’s basic choices.The nature of the human person shows that there is nothing of the material that does not take its bearing from the religious-spiritual disposition of the person.Experience also confirms that a good moral life or virtuous life draws faith.St James the apostle implies this,when he says faith without good works or good moral life is dead(James 2:18).This can also be applicable to Abraham who is judged righteous because of his faith in God,i.e.,because he obeyed God’s command.Without faith,it is impossible to do God’s will,i.e.live a good moral life(Hebr 11:6).On the other hand,there are many forms of development,for instance:economic development,agricultural development,scientific,rural or urban development,which narrow into the human development that seems to determine their level.However,to have a solid sustainable development demands an adequate religious-moral education of the people,which functions both in the informal and formal forms of education.In as much as religious moral education gives solid grounding for adequate formation of the human person,the end result,and the development of the human person should at the same time reflect the national development.Development thus understood is holistic embracing the good of the individual as well as the nation.This article argues that authentic human development that may produce a national development worthy of the name draws from adequate religious moral education imparted on the citizens.It shows also that a worthy national development is a fore test of the development of the citizens of that nation,which in turn indicates their commitment to the common good.It is through the application of the common good that individuals reach their desired goals and so be able to contribute to the enrichment of the nation.This article suggests that good moral life is the manifestation of virtue learnt and practiced,which leads to adequate human development that eventually brings about solid national development.This type of development can be compared to what Pope Benedict XVI calls true social development,which respects the dignity of the all human beings.

Impact of taxes on the 2030 Agenda for Sustainable Development:Evidence from Organization for Economic Cooperation and Development(OECD)countries

Multiple ecological and socioeconomic problems have occurred worldwide,raising the awareness of sustainability.This study aims to examine the impact of taxes on Sustainable Development Goals(SDGs)in the context of Organization for Economic Co-operation and Development(OECD)countries.This research used effective average tax(EAT),tax on personal income(TPI),tax on corporate profits(TCP),and tax on goods and services(TGS)as the variables of taxes,and employed secondary data from 38 OECD countries covering 2000–2021.The study also used Breusch-Pagan Lagrange Multiplier(LM),Pesaran Scaled LM,Bias-Corrected Scaled LM,and Pesaran Cross-sectional dependence(CSD)tests to analyze the existence of crosssectional dependency.Then,we established the stationarity of variables through second-generation panel unit root tests(Cross-sectional Augmented Dickey-Fuller(CADF)and Cross-sectional Im,Pesaran,and Shin(CIPS)),and confirmed the long-run cointegration of the variables by using secondgeneration panel cointegration test(Westerlund cointegration test).The results showed that EAT,TPI,TCP,and TGS are positively associated with SDGs.However,the change in TPI has a smaller effect on SDGs than the change in EAT or TCP or TGS.The result of panel causality indicated that EAT,TPI,and TGS have a unidirectional causal relationship with SDGs.The study also found that TCP has a bi-directional causal relationship with SDGs.Moreover,the finding indicated that the OECD countries need to focus on tax policies to achieve the 2030 Agenda for Sustainable Development.This study is based on the theory of optimal taxation(TOT),which suggests that tax systems should be designed to maximize social welfare.Finally,we suggests the importance of taking a comprehensive approach for the managers and policy-makers when analyzing the impact of taxes on SDGs.

Research on the Virtuous Cycle Between the Right to Subsistence and the Right to Development

The right to subsistence and the right to development are the primary basic human rights,and there is a certain connection between the two.Although they refer to different things,they are mutually dependent and restricted.It is necessary to distinguish the right to development as a means and the right to development as an end.The former is the right to participate in,promote,and enjoy development,while the latter is the right of all people to enjoy free,comprehensive,and harmonious development.The protection of the right to subsistence and the right to development form an interacting virtuous cycle under certain conditions.The process of building a moderately prosperous society embodies this virtuous cycle.To build a modern socialist country in an all-round way,it is still necessary to keep on promoting the virtuous cycle between the right to subsistence and the right to development.

Personal voice in College English writing: Should it be developed or not?

Academic writing in College English Teaching is considered to be one of the most importanttopics. More important ly, the issue of personal voice in ESL writing attracts many second language researchers' attention recently. Through reviewing the supportive or opposite perspectives about using personal voice in writing, the paper aims to explore the barriers to expressing personal voice. The most significant part is to give some pedagogical implications for teaching academic writing.