In this study, the therapeutic effect of acupuncture and its effect on serum tumor necrosis factor apha (TNF-α) level was observed in 25 cases of allergic bronchial asthma patients. Acupoints used were Dazhui (GV 14)...In this study, the therapeutic effect of acupuncture and its effect on serum tumor necrosis factor apha (TNF-α) level was observed in 25 cases of allergic bronchial asthma patients. Acupoints used were Dazhui (GV 14), Feishu (BL 13), Dingchuan (EX-B 1), Pishu (BL 20), Tanzhong (CV 17), Shenshu (BL 23) and Fengchi (GB 20), supplemented with other acupoints according to syndrome differentiation. After 15 sessions of treatment, results showed that the total effective rate was 96% . Before treatment, serum TNF-oc activity was significantly higher than that of healthy subjects (25 cases, P<0.01). After treatment, TNF-α level reduced considerably in comparison with that of pre-treatment (P < 0. 05). These findings indicate that acupuncture can significantly improve allergic asthma patients' clinical symptoms and lower serum TNF-α activity.展开更多
Objective To explore the effect of ＂three-acupoint and five-needling method＂ on the expression level of p-ERK 1/2 protein in lung tissue of rats with allergic bronchial asthma.Methods Forty SPF-grade male SD rats we...Objective To explore the effect of ＂three-acupoint and five-needling method＂ on the expression level of p-ERK 1/2 protein in lung tissue of rats with allergic bronchial asthma.Methods Forty SPF-grade male SD rats were selected and randomly divided into four groups,including control group（group C）,model group（group M）,acupuncture group（group A） and blocker group（group PD）,with 10 rats in each group.After corresponding intervention was given,cell counting was conducted,and the expression level of p-ERK 1/2 protein in the lung tissue of rats was detected via immunohistochemical method and Western blot method.Results The number of leukocyte and eosinophil in the bronchoalveolar lavage fluid of rats in group A and group PD was smaller than that in group M,but larger than that in group C.It was shown based on the immunohistochemical test and Western blot test that the expression level of p-ERK1/2 protein in the lung tissue of rats in group M was higher than that in group C（P0.05）,while the expression level of p-ERK1/2 protein in group A and group PD was lower than that in group M（P0.05）.Conclusion ＂Threeacupoint and five-needling method＂ can effectively relieve the inflammatory response of rats with allergic bronchial asthma,and inhibit the expression level of p-ERK 1/2 protein in the lung tissue of rats with asthma.Acupuncture may alleviate the symptom of allergic bronchial asthma through inhibiting the expression level of p-ERK 1/2 protein.展开更多
文摘In this study, the therapeutic effect of acupuncture and its effect on serum tumor necrosis factor apha (TNF-α) level was observed in 25 cases of allergic bronchial asthma patients. Acupoints used were Dazhui (GV 14), Feishu (BL 13), Dingchuan (EX-B 1), Pishu (BL 20), Tanzhong (CV 17), Shenshu (BL 23) and Fengchi (GB 20), supplemented with other acupoints according to syndrome differentiation. After 15 sessions of treatment, results showed that the total effective rate was 96% . Before treatment, serum TNF-oc activity was significantly higher than that of healthy subjects (25 cases, P<0.01). After treatment, TNF-α level reduced considerably in comparison with that of pre-treatment (P < 0. 05). These findings indicate that acupuncture can significantly improve allergic asthma patients' clinical symptoms and lower serum TNF-α activity.
基金Supported by Project of National Natural Science Foundation of China:81303046Graduate innovation project of North China University of Science and Technology:2016S42
文摘Objective To explore the effect of ＂three-acupoint and five-needling method＂ on the expression level of p-ERK 1/2 protein in lung tissue of rats with allergic bronchial asthma.Methods Forty SPF-grade male SD rats were selected and randomly divided into four groups,including control group（group C）,model group（group M）,acupuncture group（group A） and blocker group（group PD）,with 10 rats in each group.After corresponding intervention was given,cell counting was conducted,and the expression level of p-ERK 1/2 protein in the lung tissue of rats was detected via immunohistochemical method and Western blot method.Results The number of leukocyte and eosinophil in the bronchoalveolar lavage fluid of rats in group A and group PD was smaller than that in group M,but larger than that in group C.It was shown based on the immunohistochemical test and Western blot test that the expression level of p-ERK1/2 protein in the lung tissue of rats in group M was higher than that in group C（P0.05）,while the expression level of p-ERK1/2 protein in group A and group PD was lower than that in group M（P0.05）.Conclusion ＂Threeacupoint and five-needling method＂ can effectively relieve the inflammatory response of rats with allergic bronchial asthma,and inhibit the expression level of p-ERK 1/2 protein in the lung tissue of rats with asthma.Acupuncture may alleviate the symptom of allergic bronchial asthma through inhibiting the expression level of p-ERK 1/2 protein.
