The effectiveness of traditional Chinese medicine (TCM) against various diseases urges more low cost, speed and sensitive analytical methods for investigating the phamacology of TCM and providing a theoretical basis f...The effectiveness of traditional Chinese medicine (TCM) against various diseases urges more low cost, speed and sensitive analytical methods for investigating the phamacology of TCM and providing a theoretical basis for clinical use. The potential of second-order calibration method was validated for the quantification of two effective ingredients of Schisandra chinensis in human plasma using spectrofluorimetry. The results obtained in the present study demonstrate the advantages of this strategy for multi-target determination in complex matrices. Although the spectra of the analytes are similar and a large number of interferences also exist, second-order calibration method could predict the accurate concentrations together with reasonable resolution of spectral profiles for analytes of interest owing to its ‘second-order advantage’. Moreover, the method presented in this work allows one to simply experimental procedure as well as reduces the use of harmful chemical solvents.展开更多
This paper analyzes some properties of the alternating separation (AS) and alternating projection (AP) algorithm. The analysis shows that AS converges to the optimal point steadily but slowly, while AP converges to th...This paper analyzes some properties of the alternating separation (AS) and alternating projection (AP) algorithm. The analysis shows that AS converges to the optimal point steadily but slowly, while AP converges to the optimal point quickly but is prone to immersing into the local extreme of the maximum likelihood (ML) criterion. To avoid their disadvantages and make use of their advantages, ASAP, which is the combination of AS and AP, is proposed. Simulation results show that the ASAP algorithm has the ability of estimating the direction of arrival more accurately and converging to optimal point more quickly.展开更多
基金the National Natural Science Foundation of China (Grant No. 21175041)the National Basic Research Program (Grant No. 2012CB910602)Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) for financial supports
文摘The effectiveness of traditional Chinese medicine (TCM) against various diseases urges more low cost, speed and sensitive analytical methods for investigating the phamacology of TCM and providing a theoretical basis for clinical use. The potential of second-order calibration method was validated for the quantification of two effective ingredients of Schisandra chinensis in human plasma using spectrofluorimetry. The results obtained in the present study demonstrate the advantages of this strategy for multi-target determination in complex matrices. Although the spectra of the analytes are similar and a large number of interferences also exist, second-order calibration method could predict the accurate concentrations together with reasonable resolution of spectral profiles for analytes of interest owing to its ‘second-order advantage’. Moreover, the method presented in this work allows one to simply experimental procedure as well as reduces the use of harmful chemical solvents.
文摘This paper analyzes some properties of the alternating separation (AS) and alternating projection (AP) algorithm. The analysis shows that AS converges to the optimal point steadily but slowly, while AP converges to the optimal point quickly but is prone to immersing into the local extreme of the maximum likelihood (ML) criterion. To avoid their disadvantages and make use of their advantages, ASAP, which is the combination of AS and AP, is proposed. Simulation results show that the ASAP algorithm has the ability of estimating the direction of arrival more accurately and converging to optimal point more quickly.
