A Retrospective Study of Treatment Efficacy of 65 Children with Ametroic Amblyopia

Purpose: To investigate relationship between treatment efficacy and the severity of ametropic amblyopia, the type of anisometropia and patient age. Methods:A total of 65 children with ametropic amblyopia undergoing clinical treatment in the ophthalmology department of Shaoguan Hygienic Hospital of Women and Children between June 2005 and November 2011 were enrolled in this study. The treatment efficacy for those subjects with different severities of ametropic amblyopia, types of anisometropia and ages was recorded. Results: The near-recovery/recovery rate, improvement rate and ineffectiveness rate were 70.8%, 16.9% and 12.3%, respectively. The recovery rates in mild-, moderate- and severe amblyopia groups were 97.1%, 61.1% and 8.3% respectively (P<0.05)..The recovery rate for patients with hyperopic-, astigmatic- and myopic anisometropia were 75.8%, 78.3% and 33.3% respectively. The recovery rates did not differ between hyperopic- and astigmatic- anisometropia children(P>0.05), whereas a statistically significant difference was noted between myopic children compared with their hyperopic and myopic-anisometropia counterparts (all P<0.05). The recovery rate for patients aged 3 to 6 years was 86.8% and 48.1% for those aged between 7 and 10 years (P<0.05). Conclusion: The treatment efficacy in ametropic amblyopia is associated with the severity of amblyopia, type of anisometropia and patient's age. Older patients with more severe amblyopia had poorer treatment efficacy. The efficacy in patients with hyperopic and astigmatic anisometropia was better than that for myopic anisometropia subjects.

Computerized tomography-guided therapeutic percutaneous puncture catheter drainage-combined with somatostatin for severe acute pancreatitis: An analysis of efficacy and safety

BACKGROUND Severe acute pancreatitis(SAP),a condition with rapid onset,critical condition and unsatisfactory prognosis,poses a certain threat to human health,warranting optimization of relevant treatment plans to improve treatment efficacy.AIM To evaluate the efficacy and safety of computerized tomography-guided the-rapeutic percutaneous puncture catheter drainage(CT-TPPCD)combined with somatostatin(SS)in the treatment of SAP.METHODS Forty-two SAP patients admitted to The Second Affiliated Hospital of Fujian Medical University from June 2020 to June 2023 were selected.On the basis of routine treatment,20 patients received SS therapy(control group)and 22 patients were given CT-TPPCD plus SS intervention(research group).The efficacy,safety(pancreatic fistula,intra-abdominal hemorrhage,sepsis,and organ dysfunction syndrome),abdominal bloating and pain relief time,bowel recovery time,hospital stay,inflammatory indicators(C-reactive protein,interleukin-6,and pro-calcitonin),and Acute Physiology and Chronic Health Evaluation(APACHE)II score of both groups were evaluated for comparison.RESULTS Compared with the control group,the research group had a markedly higher total effective rate,faster abdominal bloating and pain relief and bowel recovery,INTRODUCTION Pancreatitis,an inflammatory disease occurring in the pancreatic tissue,is classified as either acute or chronic and is associated with high morbidity and mortality,imposing a socioeconomic burden[1,2].The pathogenesis of this disease involves early protease activation,activation of nuclear factor kappa-B-related inflammatory reactions,and infiltration of immune cells[3].Severe acute pancreatitis(SAP)is a serious condition involving systemic injury and subsequent possible organ failure,accounting for 20%of all acute pancreatitis cases[4].SAP is also characterized by rapid onset,critical illness and unsatisfactory prognosis and is correlated with serious adverse events such as systemic inflammatory response syn-drome and acute lung injury,threatening the health of patients[5,6].Therefore,timely and effective therapeutic inter-ventions are of great significance for improving patient prognosis and ensuring therapeutic effects.Somatostatin(SS),a peptide hormone that can be secreted by endocrine cells and the central nervous system,is in-volved in the regulatory mechanism of glucagon and insulin synthesis in the pancreas[7].It has complex and pleiotropic effects on the gastrointestinal tract,which can inhibit the release of gastrointestinal hormones and negatively modulate the exocrine function of the stomach,pancreas and bile,while exerting a certain influence on the absorption of the di-gestive system[8,9].SS has shown certain clinical effectiveness when applied to SAP patients and can regulate the severity of SAP and immune inflammatory responses,and this regulation is related to its influence on leukocyte apoptosis and adhesion[10,11].Computerized tomography-guided therapeutic percutaneous puncture catheter drainage(CT-TPPCD)is a surgical procedure to collect lesion fluid and pus samples from necrotic lesions and perform puncture and drainage by means of CT image examination and precise positioning[12].In the research of Liu et al[13],CT-TPPCD applied to pa-tients undergoing pancreatic surgery contributes to not only good curative effects but also a low surgical risk.Baudin et al[14]also reported that CT-TPPCD has a clinical success rate of 64.6%in patients with acute infectious necrotizing pan-creatitis,with nonfatal surgery-related complications found in only two cases,suggesting that this procedure is clinically effective and safe in the treatment of the disease.In light of the limited studies on the efficacy and safety of SS plus CT-TPPCD in SAP treatment,this study performed a relevant analysis to improve clinical outcomes in SAP patients.

Effect of amblyopia training in regulating the amblyopic eye in children with ametropic amblyopia

Objective:To explore the effect of amblyopia training in regulating the amblyopic eye in children with ametropic amblyopia.Methods:A total of 50 children with ametropic amblyopia who were admitted in our hospital from March, 2012 to February, 2014 for amblyopia training were included in the study and served as the amblyopia group (n=90). The clinical efficacy and average time to enhance 1 line LogMAR vision in children with different degrees of amblyopia were recorded. The regulatory function indicators of amblyopic eye were detected. A total of 36 children with normal visions who came for physical examinations at the same stage were served as the control group (n=72).Results:The average time to enhance 1 line LogMAR vision for children with severe amblyopia in the amblyopia group was the shortest, secondly was the moderate amblyopia children, while the average time for children with mild amblyopia was the longest, and the comparison among each group was statistically significant. The accommodation amplitude and accommodation flexibility before and after treatment in the amblyopia group were significantly lower than those in the control group, while the accommodation lag was significantly higher than that in the control group. The accommodation amplitude and accommodation flexibility 3 months after treatment in the amblyopia group were significantly elevated, and those in children with mild and moderate amblyopia were significantly higher than those in children with severe amblyopia, while the accommodation lag was significantly reduced, and that in children with mild and moderate amblyopia was significantly lower than that in children with severe amblyopia.Conclusions:Amblyopia training for children with ametropic amblyopia can effectively improve the regulatory function, and is beneficial for the recovery.

Dual ligand-targeted Pluronic P123 polymeric micelles enhance the therapeutic effect of breast cancer with bone metastases

Bone metastasis secondary to breast cancer negatively impacts patient quality of life and survival.The treatment of bone metastases is challenging since many anticancer drugs are not effectively delivered to the bone to exert a therapeutic effect.To improve the treatment efficacy,we developed Pluronic P123(P123)-based polymeric micelles dually decorated with alendronate(ALN)and cancer-specific phage protein DMPGTVLP(DP-8)for targeted drug delivery to breast cancer bone metastases.Doxorubicin(DOX)was selected as the anticancer drug and was encapsulated into the hydrophobic core of the micelles with a high drug loading capacity(3.44%).The DOX-loaded polymeric micelles were spherical,123 nm in diameter on average,and exhibited a narrow size distribution.The in vitro experiments demonstrated that a pH decrease from 7.4 to 5.0 markedly accelerated DOX release.The micelles were well internalized by cultured breast cancer cells and the cell death rate of micelle-treated breast cancer cells was increased compared to that of free DOX-treated cells.Rapid binding of the micelles to hydroxyapatite(HA)microparticles indicated their high affinity for bone.P123-ALN/DP-8@DOX inhibited tumor growth and reduced bone resorption in a 3D cancer bone metastasis model.In vivo experiments using a breast cancer bone metastasis nude model demonstrated increased accumulation of the micelles in the tumor region and considerable antitumor activity with no organ-specific histological damage and minimal systemic toxicity.In conclusion,our study provided strong evidence that these pH-sensitive dual ligand-targeted polymeric micelles may be a successful treatment strategy for breast cancer bone metastasis.

Efficacy of recombinant human epidermal growth factor plus sodium hyaluronate eye drops in diabetic dry eye post-cataract surgery

BACKGROUND Dry eye syndrome(DES)after diabetic cataract surgery can seriously affect the patient’s quality of life.Therefore,effective alleviation of symptoms in patients with this disease has important clinical significance.AIM To explore the clinical effect of recombinant human epidermal growth factor(rhEGF)plus sodium hyaluronate(SH)eye drops on DES after cataract surgery in patients with diabetes.METHODS We retrospectively evaluated 82 patients with diabetes who experienced DES after cataract surgery at Tianjin Beichen Hospital,Affiliated Hospital of Nankai University between April 2021 and April 2023.They were classified into an observation group(42 cases,rhEGF+SH eye drops)and a control group(40 cases,SH eye drops alone),depending on the different treatment schemes.The therapeutic efficacy,dry eye symptom score,tear film breakup time(TFBUT),basic tear secretion score[assessed using Schirmer I test(SIt)],corneal fluorescein staining(FL)score,tear inflammatory markers,adverse reactions during treat-ment,and treatment satisfaction were compared between the two groups.RESULTS Therapeutic efficacy was higher in the observation group compared with the control group.Both groups showed improved TFBUT and dry eye,as well as improved SIt and FL scores after treatment,with a more pronounced improvement in the observation group.Although no marked differences in adverse reactions were observed between the two groups,treatment satisfaction was higher in the observation group.CONCLUSION rhEGF+SH eye drops rendered clinical benefits to patients by effectively ameliorating dry eye and visual impairment with favorable efficacy,fewer adverse reactions,and high safety levels.Thus,this treatment should be promoted in clinical practice.

Study on Effect of Chinese Herbal Medicine for Enhancing Therapeutic Efficacy on Refractory Drug Resistant Leukemia

The so-called multidrug resistance （MDR） of leukemic cells means the cross resistance of leukemic cells against multiple anti-tumor agents with different constitution and acting mechanism, which takes place simultaneous after resistance to a single contacted drug has been produced. Tumor cells with MDR would now show a low sensitivity to anti-tumor agents, making chemotherapy ineffective or of little effect. Moreover, MDR is one of the pathogenetic factors for inducing refractory leukemia.

Mining and Correlation Analysis of Association Rules between Properties and Therapeutic Efficacy of Chinese Materia Medica Based on Strategy Pattern

To the Editor:Chinese physicians often address the combination of the properties and therapeutic efficacy of Chinese materia medica(CMM).They believe that the properties and therapeutic efficacy of traditional Chinese medicines(TCMs)should be considered as an"organic whole.""Use based on therapeutic efficacy"can lead to omission of the properties of CMM.It also

Therapeutic Efficacy of Chinese Herbal Compound Preparation on Viral Diseases in Poultry

[Objective] To develop a new antiviral agent with high and long efficacy, wide spectrum, low toxicity and low cost from traditional Chinese herbal medicine and their compound. [ Method] The ＂Quxie＂ （ i. e. eliminating pathogenic factors） drugs including Hedyotis diffusa and Loni- cera japonica and ＂Fuzheng＂ （ i. e. strengthening body resistance） drugs including Radix astragali and Glycyrrhiza uralensis were taken to form an antiviral herbal compound preparation. Taking the astragalus polysaccharide monomer as control, the experiment was constructed by using the agent to treat some naturally occurring viral diseases, including Newcastle disease （ND）, infectious bursal disease （IBD）, duck viral hepatitis （DVH）, avian influenza （Al） H9 subtype and avian swollen head syndrome. [Ressult] The effective rates of the agent for treatment of the above- mentioned diseases were 87%, 87%, 69%, 100% and 100%, respectively, which were higher than that of astragalus polysaccharide monomer. The cure rates for these diseases were 33%, 37%, 13%, 69% and 75%, respectively, which were significantly higher than that of astragalus polysacchadde monomer （ P 〈 0.01 ）. The rates of poor therapeutic efficacy were 15%, 21%, 24%, 6% and 7%, respectively, which were significantly lower than that of astragalus polysaccharide monomer （P 〈 0.01 ）. [ Condusion] The Chinese herbal compound preparation shows good therapeutic effects on some avian viral diseases, which can decrease mortality rate and improve production performance of poultry more greatly than astragalus polysaccharide monomer.

Modified Therapeutic Antibodies: Improving Efficacy

The prosperity of the biotherapeutics market reflects the feasibility and effectiveness of therapeutic antibodies for the treatment of cancers,inflammatory disorders,and refractory infections.As drawbacks emerge in clinical trials and practice,such as impeded binding,reduced effector functions,and frequent adverse reactions,modifications of therapeutic antibodies are unprecedently burgeoning in research and development(R&D).These modifications include:①modified glycosylation;②fragment of crystallizable domain(Fc)amino acid alterations;③cross-isotype or cross-subclass exchanges;④antibody–drug conjugates(ADCs);⑤single chain of variable region fragment(scFv)for chimeric antigen receptor T(CAR-T)cells;and⑥bispecific antibodies(bsAbs)in order to promote binding affinity,half-life in circulation,effectiveness toward target cells and,ultimately,to achieve overall improved efficacy.While many achievements have been made around the world in the past decades,China has been playing an active role in this realm,with its great demand for biotherapeutics with R&D potential.This review recapitulates the international progress that has been achieved with modified therapeutic antibodies,and then focuses on that of China in an independent section.

Observation on therapeutic efficacy of ursodeoxycholic acid in Chinese patients with primary biliary cirrhosis:a 2-year follow-up study

The efficacy of ursodeoxycholic acid(UDCA)on long-term outcome of primary biliary cirrhosis(PBC)has been less documented in Chinese cohort.We aimed to assess the therapeutic effect of UDCA on Chinese patients with PBC.In the present study,67 patients with PBC were treated with UDCA(13–15 mg∙kg^(-1)∙day^(-1))and followed up for 2 years to evaluate the changes of symptoms,laboratory values and histological features.As the results indicated,fatigue and pruritus were obviously improved by UDCA,particularly in patients with mild or moderate symptoms.The alkaline phosphatase andγ-glutamyl transpetidase levels significantly declined at year 2 comparing to baseline values,with the most profound effects achieved in patients at stage 2.The levels of alanine aminotransferase and aspartate aminotransferase significantly decreased whereas serum bilirubin and immunoglobulin M levels exhibited no significant change.Histological feature was stable in patients at stages 1–2 but still progressed in patients at stages 3–4.The biochemical response of patients at stage 2 was much better than that of patients at stages 3–4.These data suggest that,when treated in earlier stage,patients in long-term administration of UDCA can gain favorable results not only on symptoms and biochemical responses but also on histology.It is also indicated that later histological stage,bad biochemical response and severe symptom may be indicators of poor prognosis for UDCA therapy.

二维超声联合剪切波弹性成像在老年肌少症诊断及疗效预测中的临床价值

目的探讨二维超声联合剪切波弹性成像在老年肌少症诊断及疗效预测中的临床应用价值。方法选取我院收治的84例老年肌少症患者(观察组)和同期42例健康老年人(对照组),两组均行二维超声和剪切波弹性成像检查,比较两组肌肉厚度、羽状角、肌束长度及收缩状态下腓肠肌杨氏模量平均值(以下简称杨氏模量值)的差异。观察组患者行常规药物治疗和弹力带训练,记录其治疗后总有效率,比较入院时与干预1、3、6个月后握力、四肢骨骼肌指数(ASMI)、简易躯体能力测试表(SPPB)评分的差异。绘制受试者工作特征(ROC)曲线分析二维超声和剪切波弹性成像参数单独及联合应用对老年肌少症诊断和疗效预测的效能。结果观察组肌肉厚度、羽状角、肌束长度及杨氏模量值均低于对照组,差异均有统计学意义(均P<0.05)。观察组患者治疗后总有效率86.90%(73/84);干预1、3、6个月后握力、ASMI、SPPB评分均高于入院时,差异均有统计学意义(均P<0.001)。ROC曲线分析显示,肌肉厚度、羽状角、肌束长度、杨氏模量值诊断老年肌少症的曲线下面积(AUC)分别为0.775、0.716、0.621、0.749,各参数联合应用的AUC为0.911,高于其单独应用,差异均有统计学意义(均P<0.05);肌肉厚度、羽状角、肌束长度、杨氏模量值预测老年肌少症疗效的AUC分别为0.805、0.846、0.785、0.775,各参数联合应用的AUC为0.889,高于单独应用,差异均有统计学意义(均P<0.05)。结论二维超声联合剪切波弹性成像在老年肌少症诊断及疗效预测中均有较好的临床应用价值,可为临床评估提供参考。

维多珠单抗治疗溃疡性结肠炎患者的长期疗效与安全性meta分析

目的 评价溃疡性结肠炎(UC)患者长期使用维多珠单抗(VDZ)的疗效及安全性。方法 检索Pub Med、Embase、ClinicalKey、Cochrane Library、Google Scholar数据库中建库至2023年6月30日,以缓解期UC患者为研究对象,以VDZ为干预条件的随机对照试验,检索语言仅限于英文。结果 最终共纳入7篇随机对照试验。与对照组比较,缓解期UC患者使用VDZ,可以获得更高的临床缓解率[RR=2.60,95%CI(1.92,3.52)]、临床反应率[RR=2.21,95%CI(1.75,2.78)]、黏膜愈合率[RR=2.51,95%CI(1.93,3.26)]、持久临床缓解率[RR=2.42,95%CI(1.88,3.12)]、无皮质类固醇缓解率[RR=3.23,95%CI(1.94,5.36)],差异有统计学意义(P <0.05)。两组不良事件[RR=1.00,95%CI(0.91,1.10)]和严重不良事件[RR=0.97,95%CI(0.72,1.29)]发生率比较,差异无统计学意义(P> 0.05)。结论 VDZ可使UC患者获得长久的内镜黏膜愈合,且不良反应少,适合临床UC患者长期使用。

咖啡因联合经鼻高流量氧疗治疗新生儿呼吸窘迫综合征的疗效观察

目的 分析咖啡因联合经鼻高流量氧疗治疗新生儿呼吸窘迫综合征(NRDS)的疗效。方法 前瞻性选取2020年3月—2023年6月亳州市人民医院收治的98例NRDS患儿,按随机数字表法分为对照组和研究组,每组49例。对照组给予经鼻高流量氧疗,研究组在对照组基础上另给予枸橼酸咖啡因治疗,治疗后7 d观察效果。对比两组无创通气时间、总用氧时间、呼吸暂停次数、血气指标、呼吸力学指标、临床疗效、炎症因子及并发症情况。结果 研究组无创通气时间、总用氧时间、呼吸暂停次数均低于对照组(P <0.05)。研究组与对照组治疗前、治疗后3和7 d的二氧化碳分压(PaCO_(2))、血氧分压(PaO_(2))比较,结果:(1)不同时间点PaO2、PaCO_(2)比较,差异均有统计学意义(F=7.961和8.038,均P=0.000);(2)研究组与对照组PaO_(2)、PaCO_(2)比较,差异均有统计学意义(F=7.958和6.987,均P=0.000);(3)两组PaO_(2)、PaCO_(2)变化趋势比较,差异均有统计学意义(F=8.057和8.136,均P=0.000)。研究组与对照组治疗前、治疗后3和7 d的气道阻力、内源性呼气末正压比较,结果:(1)不同时间点气道阻力、内源性呼气末正压比较,差异均有统计学意义(F=7.854和8.126,均P=0.000);(2)研究组与对照组气道阻力、内源性呼气末正压比较,差异均有统计学意义(F=8.236和7.958,均P=0.000);(3)两组气道阻力、内源性呼气末正压变化趋势比较,差异均有统计学意义(F=7.968和8.027,均P=0.000)。研究组总有效率高于对照组(P <0.05)。研究组治疗前后骨形态发生蛋白-7、Clara细胞分泌蛋白16、肿瘤坏死因子-α、C反应蛋白的差值均高于对照组(P <0.05)。两组总并发症发生率比较,差异无统计学意义(P>0.05)。结论 咖啡因联合经鼻高流量氧疗治疗NRDS疗效显著,可改善患儿血气及呼吸力学指标,抑制炎症反应,安全可靠。

扶正化浊汤联合甲状腺片治疗对甲状腺结节大小及疗效的影响

目的探讨扶正化浊汤治疗甲状腺结节(TN)对结节大小的影响。方法TN患者106例,随机均分为观察组和对照组,对照组给予左甲状腺素钠片常规治疗,观察组在对照组基础上同时增加扶正化浊汤治疗;于治疗前、治疗3个月时,对2组患者进行中医主症评分,采用彩色多普勒超声仪记录2组患者结节数目、最大直径、结节体积、血流阻力指数(RI)及搏动指数(PI),同时采集患者外周静脉血4 mL,检测促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离四碘甲腺原氨酸(FT4)及血管内皮生长因子(VEGF)水平,治疗3个月后评估2组患者的西医疗效,记录2组治疗期间恶心、呕吐、皮疹及口干等不良反应发生情况。结果治疗后3个月,2组中医主症评分均较治疗前下降,且观察组低于对照组(P<0.05);与对照组比较,2组TN患者治疗3个月后结节数目减少、结节最大直径和结节体积均降低,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后3个月,观察组TSH低于对照组,FT 3、FT 4高于对照组(P<0.05);治疗3个月后,观察组VEGF、RI、PI低于对照组(P<0.05);观察组西医疗效和中医证候疗效中的临床痊愈和总有效率均高于对照组,差异有统计学意义(P<0.05);比较观察组与对照组不良反应发生率比较,差异无统计学意义(P>0.05)。结论扶正化浊汤治疗TN疗效显著,可有效减轻患者症状,减小结节数目及大小,调节甲状腺功能,改善血流状况,降低VEGF表达,且安全性高。

超声造影联合miR-599水平在原发性肝癌TACE预后评估中的价值

目的:探讨超声造影(CEUS)联合血清微小RNA-599(miR-599)评估原发性肝癌(PHC)经导管动脉栓塞(TACE)术后疗效的价值。方法:采用回顾性研究方法,选取接受TACE治疗的80例PHC患者进行研究分析。根据实体瘤疗效标准(RECIST)将患者分为有效组54例和无效组26例,分别于TACE后第7天、14天、1月、2月时采用CEUS检查患者的肿瘤病灶灭活率,于术前及术后第7天、14天、1月、2月时检查患者血清miR-599水平,以患者TACE术后2月时的数字减影血管造影检查结果作为金标准,计算CEUS评估疗效的价值,并采用单因素分析方法及多因素Logistic回归模型分析血清miR-599与PHC患者TACE治疗效果的关系。结果:80例接受TACE治疗的PHC患者,在接受治疗2月后进行评价,其中完全缓解9例、部分缓解45例、疾病稳定22例、疾病进展4例;有效组患者的年龄、体质量指数、TACE次数、Childpugh分级、HBsAg结果与无效组比较,差异均无统计学意义(P>0.05);有效组患者与无效组患者的术前甲胎蛋白水平、病灶数目、最大病灶直径、病理学分期、是否使用索菲拉尼的情况比较,差异均具有统计学意义(P<0.05);术后1月时有效组的病灶灭活率为66.67%,术后2月时有效组患者的病灶灭活率为94.44%,有效组在术后1月、2月时的病灶灭活率显著高于无效组患者(P<0.05);无效组患者在术前及术后第7天、14天、1月、2月的血清miR-599水平均显著低于有效组患者(P<0.05);Logistic回归模型显示:术前miR-599低水平、术前AFP≥400μg/L、病灶直径≥5.0 cm、病理学分期为ⅢA期是TACE治疗PHC患者疗效不佳的独立危险因素(P<0.05),使用索菲拉尼有利于提高TACE治疗PHC患者的效果(P<0.05)。结论:应用TACE治疗的PHC患者,采用CEUS动态观察病灶变化情况,能较为准确地评估其临床治疗效果,而血清miR-599水平越低的PHC患者TACE治疗效果越差,可将CEUS病灶观察结果与血清miR-599检测结合,对PHC患者TACE的治疗效果进行综合评价。

腹腔镜结直肠癌根治术治疗结直肠癌的疗效

目的 探究分析腹腔镜结直肠癌根治术治疗结直肠癌的疗效。方法 选取2019年2月至2023年1月我院普外科收治的50例结直肠癌患者作为研究对象,随机分为对照组(开腹手术)与观察组(腹腔镜结直肠癌根治术),对比两组的治疗效果、临床相关指标、应激反应状态、炎症因子水平、胃动素与胃泌素水平、并发症发生率以及生活质量。结果 观察组治疗效果、临床相关指标、应激反应状态、炎症因子水平、胃动素与胃泌素水平、并发症发生率以及生活质量均优于对照组(P <0.05)。结论 腹腔镜结直肠癌根治术可显著改善患者病情状态、临床效果、并发症发生情况以及生活质量,安全可靠。

超声清创术+外用重组人粒细胞巨细胞刺激因子凝胶剂对糖尿病足WagnerⅡ、Ⅲ级溃疡治疗效果及愈合情况分析

目的探究超声清创术+外用重组人粒细胞巨细胞刺激因子凝胶剂在糖尿病足WagnerⅡ、Ⅲ级溃疡治疗中的应用效果。方法选取2023年2月—2024年2月江苏省靖江市人民医院内分泌科及烧伤整形科收治的70例糖尿病足WagnerⅡ、Ⅲ级溃疡患者为研究对象,以随机数表法分为参照组(35例,予以常规清创+胰岛素治疗)和研究组(35例,予以超声清创术+外用重组人粒细胞巨细胞刺激因子凝胶剂治疗)。比较两组溃疡面愈合率、炎症因子水平及治疗总有效率。结果治疗后2周,研究组溃疡创面愈合率略高于参照组,差异有统计学意义(P<0.05);治疗后1、2个月,研究组溃疡创面愈合率明显高于参照组,差异有统计学意义(P均<0.05)。治疗前,两组降钙素原、超敏C反应蛋白水平比较,差异无统计学意义(P均>0.05)。治疗后,两组降钙素原、超敏C反应蛋白水平均降低,且研究组显著低于参照组,差异有统计学意义(P均<0.05)。研究组WagnerⅡ、Ⅲ级溃疡治疗总有效率高于参照组,差异有统计学意义(P<0.05)。结论超声清创术联合外用重组人粒细胞巨细胞刺激因子凝胶剂可促进糖尿病足WagnerⅡ、Ⅲ级溃疡面愈合,控制血清炎症因子水平,整体疗效显著。

丁苯酞在急性缺血性脑卒中早期神经功能恶化中的效果观察

目的探讨丁苯酞在急性缺血性脑卒中早期神经功能恶化(END)中的运用价值。方法选取2021年9月至2023年5月廉江市人民医院收治的112例急性缺血性脑卒中END患者为研究对象,采用随机数表法将其分为对照组和观察组,每组各56例。对照组给予阿托伐他汀片+阿司匹林肠溶片+硫酸氢氯吡格雷片治疗。观察组在对照组的基础上给予丁苯酞治疗。比较两组疗效、血清细胞因子、凝血功能指标和不良反应发生情况。结果观察组疗效明显优于对照组,差异有统计学意义(P<0.05)。治疗后,两组超敏C反应蛋白、白细胞介素-6、神经丝轻链蛋白、D-二聚体浓度低于治疗前,且观察组低于对照组;两组部分活化凝血酶原时间长于治疗前,且观察组长于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论丁苯酞治疗急性缺血性脑卒中END可明显提高疗效,降低血清细胞因子水平和改善凝血功能指标,而且不增加不良反应的发生率。

加味桃红四物汤联合利伐沙班在髋关节置换术后的应用

目的探讨加味桃红四物汤联合利伐沙班在髋关节置换术后应用的效果,旨在评估其对术后血栓预防、炎症因子水平及并发症的影响。方法本研究为随机对照试验,前瞻性选取2019年11月至2023年11月在宝鸡市中医医院行髋关节置换手术的120例患者,采用随机数字表法将患者分为观察组(60例)和对照组(60例)。观察组男30例,女30例;年龄(65.25±10.33)岁;病程(4.72±1.15)年。对照组男28例,女32例;年龄(63.96±10.87)岁;病程(4.68±1.13)年。对照组采用利伐沙班治疗方案,观察组采用加味桃红四物汤与利伐沙班的联合治疗方案。比较两组在治疗前及治疗14 d后的凝血功能指标[血浆凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)及D-二聚体(D-D)]、血流变学指标(全血粘度、血浆粘度、红细胞比容、红细胞刚性指数及红细胞变形指数)、促炎性细胞因子指标[C反应蛋白(CRP)]、并发症及深静脉血栓(DVT)方面的差异。采用独立样本t检验、配对样本t检验和χ^(2)检验。结果治疗前,两组各项指标比较,差异均无统计学意义(均P>0.05)。治疗14 d后,观察组PT[(15.79±2.33)s]、TT[(19.05±3.12)s]和APTT[(30.21±4.07)s]均长于对照组[(14.01±2.67)s、(15.52±2.79)s、(27.33±3.49)s](均P<0.05);观察组FIB[(3.52±1.08)g/L]和D-D水平[(0.22±0.04)mg/L]均低于对照组[(4.09±1.06)g/L、(0.33±0.06)mg/L](均P<0.05)。治疗14 d后,观察组全血粘度[(4.07±1.28)mPa·S]、血浆粘度[(1.48±0.43)mPa·S]、红细胞比容[(37.56±2.79)%]、红细胞刚性指数(5.47±0.77)均低于对照组[(4.65±0.27)mPa·S、(2.02±0.39)mPa·S、(42.06±2.17)%、(6.23±0.84)](均P<0.05);观察组红细胞变形指数(0.84±0.03)高于对照组(0.74±0.07)(P<0.05)。治疗14 d后,观察组CRP水平[(4.25±1.09)mg/L]低于对照组[(7.97±2.14)mg/L](P<0.05)。治疗后14 d内,观察组并发症总发生率[13.33%(8/60)]和DVT阳性率[6.67%(4/60)]均低于对照组[25.00%(15/60)、20.00%(12/60)](均P<0.05)。结论加味桃红四物汤与利伐沙班的联合应用在预防髋关节或膝关节置换术后DVT的效果显著,能有效改善血流变学参数,抑制血液凝集,降低并发症发生率。

太原地区866例儿童慢性非特异性咳嗽病因及药物疗效随访分析

目的:对太原地区儿童慢性非特异性咳嗽常见病因构成特点及药物疗效进行随访、分析,为该地区慢性咳嗽患儿的经验性诊疗提供思路,提高治愈率。方法:采用回顾性研究方法,收集山西省儿童医院呼吸科门诊2021年12月-2023年12月收治的866例0~14岁慢性非特异性咳嗽患儿的临床资料,遵循国内儿童慢性咳嗽诊断与治疗指南作出诊断并予相应治疗,按时随访,评估药物疗效。结果:866例患儿年龄6个月~14岁,653例(75.4%)慢性咳嗽为单病因所致,213例(24.6%)为混合病因。病因依次为咳嗽变异性哮喘(CVA)697例(80.5%)、感染后咳嗽(PIC)190例(21.9%)、上气道咳嗽综合征(UACS)166例(19.2%)、过敏性咳嗽(AC)19例(2.2%)、心因性咳嗽(PC)11例(1.3%)、胃食管反流性咳嗽(GERC)2例(0.2%)。病因分布具有年龄、季节差异,而无性别差异。明确病因后进行对因治疗可取得较好疗效。结论:太原地区儿童慢性非特异性咳嗽常见病因为CVA、PIC和UACS,无性别差异;明确病因并根据病因进行药物干预是治疗儿童慢性咳嗽的关键。