We chose a definition of heatwaves (HWs) that has ~4-year recurrence frequency at world hot spots. We first examined the 1940-2022 HWs climatology and trends in lifespan, severity, spatial extent, and recurrence frequ...We chose a definition of heatwaves (HWs) that has ~4-year recurrence frequency at world hot spots. We first examined the 1940-2022 HWs climatology and trends in lifespan, severity, spatial extent, and recurrence frequency. HWs are becoming more frequent and more severe for extratropical mid- and low-latitudes. To euphemize HWs, we here propose a novel clean energy-tapping concept that utilizes the available nano-technology, micro-meteorology knowledge of temperature distribution within/without buildings, and radiative properties of earth atmosphere. The key points for a practical electricity generation scheme from HWs are defogging, insulation, and minimizing the absorption of infrared downward radiation at the cold legs of the thermoelectric generators. One sample realization is presented which, through relay with existing photovoltaic devices, provides all-day electricity supply sufficient for providing air conditioning requirement for a residence (~2000-watt throughput). The provision of power to air conditioning systems, usually imposes a significant stress on traditional city power grids during heatwaves.展开更多
Pyroptosis plays an important role in hemorrhagic stroke.Excessive endoplasmic reticulum stress can cause endoplasmic reticulum dysfunction and cellular pyroptosis by regulating the nucleotide-binding oligomerization ...Pyroptosis plays an important role in hemorrhagic stroke.Excessive endoplasmic reticulum stress can cause endoplasmic reticulum dysfunction and cellular pyroptosis by regulating the nucleotide-binding oligomerization domain and leucine-rich repeat pyrin domain-containing protein 3(NLRP3)pathway.However,the relationship between pyroptosis and endoplasmic reticulum stress after intraventricular hemorrhage is unclear.In this study,we established a mouse model of intraventricular hemorrhage and found pyroptosis and endoplasmic reticulum stress in brain tissue.Intraperitoneal injection of the selective GPR120 agonist TUG-891 inhibited endoplasmic reticulum stress,pyroptosis,and inflammation and protected neurons.The neuroprotective effect of TUG-891 appears related to inhibition of endoplasmic reticulum stress and pyroptosis activation.展开更多
Large areas of Artemisia ordosica Krasch., Caragana korshinskii Kom., and Caragana intermedia Kuang and H. C. Fu plantations were established on moving sand dunes in the Gonghe Basin (northeastern Tibetan Plateau) f...Large areas of Artemisia ordosica Krasch., Caragana korshinskii Kom., and Caragana intermedia Kuang and H. C. Fu plantations were established on moving sand dunes in the Gonghe Basin (northeastern Tibetan Plateau) for vegetation restoration. Elevating our understanding of the changes in soil characteristics after the establishment of different plantation types can be useful in the context of combating deserdfication. To assess the effects of these plantation types on the restoration of sandy land, we measured soil physical-chemical properties at four depths (0-5, 5-10, 10-20, and 20-50 cm) in each of the three plantation types and also in non-vegetated moving sand dunes (as control sites). Generally, the establishment of A. ordosica, C korshinskii and C intermedia plantations on sand dunes has greatly ameliorated soil quality in the Gonghe Basin. Specifically, relative to the moving sand dunes, shrub plantation has increased the silt and clay contents, total porosity and water holding capacity, soil organic matter, total nitrogen, total phosphorus and total potassium contents. The calculated soil quality index suggested that in the Gonghe Basin, C. intermedia is the best choice for soil amelioration. In all the three plantation types, soil amelioration mainly occurred in the shallow depths.展开更多
To investigate the effects of seabuckthorn(Hippophae rhamnoides)on soil amelioration,using the space replacement method,soil physical and chemical indexes as well as the microorganism quantity and soil enzyme activiti...To investigate the effects of seabuckthorn(Hippophae rhamnoides)on soil amelioration,using the space replacement method,soil physical and chemical indexes as well as the microorganism quantity and soil enzyme activities were analyzed.The results showed that:the soil bulk density of surface soil decreased and soil porosity and field capacity increased after afforestation with seabuckthorn.The plant was found to effectively reduce the soil pH,increase the soil conductivity,soil organic matters and available nutrients.Soil microorganism quantity,soil enzyme activities were both higher in 0-20 cm layer than in 20-40 cm layer.With the increase years of remediation with seabuckthorn,the quantity of soil microorganism and enzyme activities were increasing to a higher level 5 to 8 years later.Our study indicates that seabuckthorn can effectively improve soil physical and chemical properties,increase the quantity of soil microorganisms and enzyme activities,which is of great significance for the ecosystem restoration in mining areas.展开更多
The North China Plain (NCP) lying along the eastern coastal area withgeogriaphical coordinates 100°to 120°and 30° to 40°W, is one of the mostimportan agncultural ngons in China. A problem in soil s...The North China Plain (NCP) lying along the eastern coastal area withgeogriaphical coordinates 100°to 120°and 30° to 40°W, is one of the mostimportan agncultural ngons in China. A problem in soil salmization has beenfound in vast areas along the lower reaches of the Yellow hiver and north of it. After30 years of work on saline soil amelioration, 2.0 million ha has been improved,accounting for over 60 percen of the total ongnal saline soil area. Ths achievetnenthas ban obtained in close relation to water conservancy work. The author analyzessalthezation amelioration by using measures concerning subsuffoce water regulation.Ih addition to water conservancy measures, thes paper also descnbes acomprehensive way to ameliorate salthezation in northem NCP. Finally, the authorstresses the necessity of combining all measures together into a whole system forsolving salinization problems in northem NCP.展开更多
In order to ameliorate saline-alkaline soil, EM Bokashi has been applied to rice production in conjunction with subdrainage in Ningxia Autonomous Region and Zhejiang Province. The preliminary results can be summarized...In order to ameliorate saline-alkaline soil, EM Bokashi has been applied to rice production in conjunction with subdrainage in Ningxia Autonomous Region and Zhejiang Province. The preliminary results can be summarized as follows: EM Bokashi can increase soil organic matter content, improve soil porosity and permeability, and raise the soil's levels of available nutrients; and EM Bokashi combined with subdrainage treatment is more effective in controlling secondary soil salinization and raising the grain yield and quality than other treatments. The results suggest that EM Bokashi can reduce the necessary amount of chemical fertilizer application, thereby improving the agricultural environment, and that the introduction of EM Bokashi into systems of secondary soil salinization control systems has resulted in significant benefits.展开更多
A long-term field study was initiated during 1995 at Central Soil Salinity Research Institute, Regional Research Station, Lucknow (26047'58" N and 80°46'24" E) to analyze the effect of agroforestry systems ...A long-term field study was initiated during 1995 at Central Soil Salinity Research Institute, Regional Research Station, Lucknow (26047'58" N and 80°46'24" E) to analyze the effect of agroforestry systems on amelioration of alkali soils. Three agroforestry systems (pas- toral, silvipastoral and silvicultural) were compared with the control where no agroforestry system was introduced. Tree-based silvicultural and silvipastoral systems were characterized by tree species Prosopis juliflora and Acacia nilotica along with grass species Leptochloafusca, Panicum maximum, Trifolium alexandrium and Chloris gayana. Growth of ten-year-old Prosopis juliflora and Acacia nilotica planted in combi- nation with grasses was significantly higher over the silviculture system with the same species. Tree biomass yields of P. juliflora (77.20 t·ha-1) and A. nilotica (63.20 t·ha-1) planted under silvipastoral system were significantly higher than the sole plantation of (64.50 t·ha-1 and 52.75 t·ha-1). Fodder yield under the pastoral system was significantly higher than the silvipastoral system during initial years but it was at par with that of silvipastoral systems after eight years of plantation. The microbial biomass carbon in the soils of silvipastoral systems was significantly higher than in soils under sole plantation of trees and control systems. The Prosopis-based silvipastoral system proved more effective in reduc- ing soil pH, displacing Na+ from the exchange complex, increasing or- ganic carbon and available N, P and K. Improvement in soil physical properties such as bulk density, porosity, soil moisture and infiltration rate was higher in the Prosopis-based silvipastoral system than in the silviculture system or control On the basis of biomass production and improvement in soil health due to tree + grass systems, silvipastoral agroforestry system could be adopted for sustainable reclamation ofhighly alkali soils.展开更多
BACKGROUND A recent investigation showed that the prevalence of type 2 diabetes mellitus(T2DM)is 12.8%among individuals of Han ethnicity.Gut microbiota has been reported to play a central role in T2DM.Goto-Kakizaki(GK...BACKGROUND A recent investigation showed that the prevalence of type 2 diabetes mellitus(T2DM)is 12.8%among individuals of Han ethnicity.Gut microbiota has been reported to play a central role in T2DM.Goto-Kakizaki(GK)rats show differences in gut microbiota compared to non-diabetic rats.Previous studies have indicated that berberine could be successfully used to manage T2DM.We sought to understand its hypoglycaemic effect and role in the regulation of the gut microbiota.AIM To determine whether berberine can regulate glucose metabolism in GK rats via the gut microbiota.METHODS GK rats were acclimatized for 1 wk.The GK rats were randomly divided into three groups and administered saline(Mo),metformin(Me),or berberine(Be).The observation time was 8 wk,and weight,fasting blood glucose(FBG),insulin,and glucagon-like peptide-1(GLP-1)were measured.Pancreatic tissue was observed for pathological changes.Additionally,we sequenced the 16S rRNA V3-V4 region of the gut microbiota and analysed the structure.RESULTS Compared with the Mo group,the Me and Be groups displayed significant differences in FBG(P<0.01)and GLP-1(P<0.05).A significant decrease in weight and homeostatic model assessment-insulin resistance was noted in the Be group compared with those in the Me group(P<0.01).The pancreatic islets of the Me-and Be-treated rats showed improvement in number,shape,and necrosis compared with those of Mo-treated rats.A total of 580 operational taxonomic units were obtained in the three groups.Compared to the Mo group,the Me and Be groups showed a shift in the structure of the gut microbiota.Correlation analysis indicated that FBG was strongly positively correlated with Clostridia_UCG-014(P<0.01)and negatively correlated with Allobaculum(P<0.01).Body weight showed a positive correlation with Desulfovibrionaceae(P<0.01)and a negative correlation with Akkermansia(P<0.01).Importantly,our results demonstrated that Me and Be could significantly decrease Bacteroidetes(P<0.01)and the Bacteroidetes/Firmicutes ratio(P<0.01).Furthermore,Muribaculaceae(P<0.01;P<0.05)was significantly decreased in the Me and Be groups,and Allobaculum(P<0.01)was significantly increased.CONCLUSION Berberine has a substantial effect in improving metabolic parameters and modulating the gut microbiota composition in T2DM rats.展开更多
Hypoxia is a common pathological process in various clinical diseases and is characterized by abnormal changes in metabolism, function, and morphological structure of tissues resulting from insufficient oxygen supply ...Hypoxia is a common pathological process in various clinical diseases and is characterized by abnormal changes in metabolism, function, and morphological structure of tissues resulting from insufficient oxygen supply or oxygen barriers in tissues. In particular, hypoxia in vital organs such as the brain and heart is an important cause of death;. The prevention of tissue hypoxia and the展开更多
Objective:To study the potential ameliorating properties of cardamom Elettaria cardamomum (E.cardamomum) L.Maton against pan masala induced damage in lung of male Swiss mice. Methods:The experimental animals were divi...Objective:To study the potential ameliorating properties of cardamom Elettaria cardamomum (E.cardamomum) L.Maton against pan masala induced damage in lung of male Swiss mice. Methods:The experimental animals were divided into 3 groups(control,pan masala treated group and pan masala with cardamom treated group) to evaluate pan masala toxicity.The observations were substantiated with profound changes in the lung tissue as revealed in the histologic and transmission electron microscopic examinations.Results:Lung of pan masala treated group showed adenocarcinoma,edema,and inflammation with increased activity of acid phosphatase,alkaline phosphatase,and lactate dehydrogenase.The deleterious effects were seen to be less in cardamom treated group and the enzymatic activity also decreased significantly (P【0.05)\ in the ameliorating group.Conclusions:Thus,the present experiment exciting results are observed when cardamom is supplemented with pan masala,or when given alone.展开更多
Background : This study examined the ameliorative effect of D-3-O-methylchiroinositol, isolated from the stem bark of Piliostigma thonningii, on cadmium chloride-induced osteoporosis in male Wistar rats. Methods : Thi...Background : This study examined the ameliorative effect of D-3-O-methylchiroinositol, isolated from the stem bark of Piliostigma thonningii, on cadmium chloride-induced osteoporosis in male Wistar rats. Methods : Thirty-six rats were assigned to three treatment groups(n = 12). Group A(2 mL distilled water), group B:(2.5 mg/kg b.w. CdCl_2) and group C:(2.5 mg/kg b.w. CdCl_2 and D-3-O-methyl-chiroinositol 2 mg/kg b.w.). Bone ash, calcium, phosphate, magnesium, and zinc content, as well as bone histological changes were determined at the end of months 1, 2, and 3. Results : There were significant differences( P ≤ 0.05) in the weight of the cervical, tibia, and femoral bones in all groups. The serum concentration of CdCl_2 was significantly different across the three groups with time. There was significant variation( P < 0.005) in the mean bone ash across groups. The concentration of OH-proline was significantly different( P < 0.0001) across groups. There were significant differences( P < 0.0001) in bone calcium, magnesium, zinc, and phosphorus concentrations. Histology revealed high levels of bone mineralisation in the CdCl_2-treated group, indicative of osteoporosis with hypertrophied osteocytes, while the femur of Wistar rats treated with D-3-O-methyl-chiroinositol showed bone trabeculae and viable osteocytes. Conclusion : The study concluded that D-3-O-methyl-chiroinositol extract from Piliostigma thionningii stem bark ameliorated cadmium chloride-induced osteoporosis in male Wistar rats.展开更多
Type 2 diabetes mellitus(T2DM)is typified by the increment of chronic blood glucose levels that is caused by an absolute and/or a relative deficiency of insulin,accounts for 90%of diabetes and causes a range of compli...Type 2 diabetes mellitus(T2DM)is typified by the increment of chronic blood glucose levels that is caused by an absolute and/or a relative deficiency of insulin,accounts for 90%of diabetes and causes a range of complications[1].展开更多
Periodontitis is a widespread oral disease characterized by continuous inflammation of the periodontal tissue and an irreversible alveolar bone loss, which eventually leads to tooth loss. Four-octyl itaconate(4-OI) is...Periodontitis is a widespread oral disease characterized by continuous inflammation of the periodontal tissue and an irreversible alveolar bone loss, which eventually leads to tooth loss. Four-octyl itaconate(4-OI) is a cell-permeable itaconate derivative and has been recognized as a promising therapeutic target for the treatment of inflammatory diseases. Here, we explored, for the first time,the protective effect of 4-OI on inhibiting periodontal destruction, ameliorating local inflammation, and the underlying mechanism in periodontitis. Here we showed that 4-OI treatment ameliorates inflammation induced by lipopolysaccharide in the periodontal microenvironment. 4-OI can also significantly alleviate inflammation and alveolar bone loss via Nrf2 activation as observed on samples from experimental periodontitis in the C57BL/6 mice. This was further confirmed as silencing Nrf2 blocked the antioxidant effect of 4-OI by downregulating the expression of downstream antioxidant enzymes. Additionally, molecular docking simulation indicated the possible mechanism under Nrf2 activation. Also, in Nrf2-/-mice, 4-OI treatment did not protect against alveolar bone dysfunction due to induced periodontitis, which underlined the importance of the Nrf2 in 4-OI mediated periodontitis treatment.Our results indicated that 4-OI attenuates inflammation and oxidative stress via disassociation of KEAP1-Nrf2 and activation of Nrf2 signaling cascade. Taken together, local administration of 4-OI offers clinical potential to inhibit periodontal destruction,ameliorate local inflammation for more predictable periodontitis.展开更多
Rosiglitazone up-regulates caveolin-1 levels and has neuroprotective effects in both chronic and acute brain injury. Therefore, we postulated that rosiglitazone may ameliorate diffuse axonal injury via its ability to ...Rosiglitazone up-regulates caveolin-1 levels and has neuroprotective effects in both chronic and acute brain injury. Therefore, we postulated that rosiglitazone may ameliorate diffuse axonal injury via its ability to up-regulate caveolin-1, inhibit expression of amyloid-beta precursor protein, and reduce the loss and abnormal phosphorylation of tau. In the present study, intraperitoneal injection of rosiglitazone significantly reduced the levels of amyloid-beta precursor protein and hyperphosphorylated tau(phosphorylated at Ser^(404)(p-tau(S^(404))), and it increased the expression of total tau and caveolin-1 in the rat cortex. Our results show that rosiglitazone inhibits the expression of amyloid-beta precursor protein and lowers p-tau(S^(404)) levels, and it reduces the loss of total tau, possibly by up-regulating caveolin-1. These actions of rosiglitazone may underlie its neuroprotective effects in the treatment of diffuse axonal injury.展开更多
A pot experiment was conducted to investigate the effect of cow dung, rice husks, calcium chloride and gypsum on soil reclamation and compare the effect of organic and inorganic amendments on soil reclamation during t...A pot experiment was conducted to investigate the effect of cow dung, rice husks, calcium chloride and gypsum on soil reclamation and compare the effect of organic and inorganic amendments on soil reclamation during the period of 5th March to 20th April, 2017. The experiment was laid to fit a completely randomized design (CRD) with seven treatments [Reference soil (T0), Cow dung (T1), Rice husk (T2), Gypsum (T3), Calcium chloride (T4), Cow dung + Rice husk (T5) and Gypsum + Calcium chloride (T6)] each having three replications for this experiment. After incubation (45 days), the laboratory investigation was carried out in the Soil, Water and Environment Discipline, Khulna University, Khulna, Bangladesh. Results indicate that the individual or combined effect of gypsum (T3) was more effective in changing EC and SAR. Gypsum application in combination with calcium chloride (T6) improved the soil chemical properties by reducing the EC. Among the treatment, calcium chloride (T4) had a remarkable effect in reducing sodium adsorption ratio and gypsum had a remarkable effect in reducing pH. Cow dung (T1), rice husk (T2), combination of cow dung and rice husk (T5) were less effective to reduce EC, pH and SAR. It’s measured for soils of different soil amendments varied significantly展开更多
[Objectives]This study was conducted to clarify the improvement effects of different soil amelioration materials such as lime,green manure and bio-organic fertilizer on acidic tobacco-planting soil.[Methods]The dynami...[Objectives]This study was conducted to clarify the improvement effects of different soil amelioration materials such as lime,green manure and bio-organic fertilizer on acidic tobacco-planting soil.[Methods]The dynamic changes of soil pH,soil nutrients and enzyme activity were studied by applying lime,lime+green fertilizer,and lime+green fertilizer+biological organic fertilizer.[Results]①After the application of amelioration materials,the soil pH and available phosphorus content of tobacco-growing soil showed a stepwise change of first increasing and then decreasing,and became stable at 60 d after tobacco transplanting;the soil organic matter,alkali-hydrolyzable nitrogen and available potassium content showed a gradual change trend of"high-low-high";and the soil invertase and urease activity showed a gradual change trend of"low-high-low".②To 90 d after tobacco transplanting,the application of amelioration materials increased soil pH by 1.29-1.62 units,and increased organic matter content by 15.21%-20.86%,alkali-hydrolyzable nitrogen content by 6.83%-18.17%,available phosphorus content by 54.15%-217.85%,rapidly available potassium content by 11.42%-30.86%,soil invertase activity by 70.09%-18.93%,and soil urease activity by 64.07%-130.47%.③The combination of lime+green manure+alkaline microbial organic fertilizer had the best effect on the improvement of acidic tobacco-growing soil,and the effect of lime+green manure+acid microbial organic fertilizer on acidic soil was the second.[Conclusions]When applying lime,green fertilizer and alkaline bio-organic fertilizer should be applied to achieve sustainable improvement of strongly acidic soil.展开更多
Changes of word meanings in English are often achieved by the processes of generalization/specialization and pejoration/amelioration.By generalization or specialization,the literal meanings of a word are broadened or ...Changes of word meanings in English are often achieved by the processes of generalization/specialization and pejoration/amelioration.By generalization or specialization,the literal meanings of a word are broadened or narrowed.While by pejoration or amelioration,the associations of a word go downhill or rise.Trough supplying certain examples,a brief picture about meaning changes of words in English is drawn.展开更多
文摘We chose a definition of heatwaves (HWs) that has ~4-year recurrence frequency at world hot spots. We first examined the 1940-2022 HWs climatology and trends in lifespan, severity, spatial extent, and recurrence frequency. HWs are becoming more frequent and more severe for extratropical mid- and low-latitudes. To euphemize HWs, we here propose a novel clean energy-tapping concept that utilizes the available nano-technology, micro-meteorology knowledge of temperature distribution within/without buildings, and radiative properties of earth atmosphere. The key points for a practical electricity generation scheme from HWs are defogging, insulation, and minimizing the absorption of infrared downward radiation at the cold legs of the thermoelectric generators. One sample realization is presented which, through relay with existing photovoltaic devices, provides all-day electricity supply sufficient for providing air conditioning requirement for a residence (~2000-watt throughput). The provision of power to air conditioning systems, usually imposes a significant stress on traditional city power grids during heatwaves.
文摘Pyroptosis plays an important role in hemorrhagic stroke.Excessive endoplasmic reticulum stress can cause endoplasmic reticulum dysfunction and cellular pyroptosis by regulating the nucleotide-binding oligomerization domain and leucine-rich repeat pyrin domain-containing protein 3(NLRP3)pathway.However,the relationship between pyroptosis and endoplasmic reticulum stress after intraventricular hemorrhage is unclear.In this study,we established a mouse model of intraventricular hemorrhage and found pyroptosis and endoplasmic reticulum stress in brain tissue.Intraperitoneal injection of the selective GPR120 agonist TUG-891 inhibited endoplasmic reticulum stress,pyroptosis,and inflammation and protected neurons.The neuroprotective effect of TUG-891 appears related to inhibition of endoplasmic reticulum stress and pyroptosis activation.
基金supported by the Forestry Public Benefit Scientific Research Special Project of China(201504420)the National Science&Technology Pillar Program during the 12th Five-year Plan Period(2012BAD16B0102)
文摘Large areas of Artemisia ordosica Krasch., Caragana korshinskii Kom., and Caragana intermedia Kuang and H. C. Fu plantations were established on moving sand dunes in the Gonghe Basin (northeastern Tibetan Plateau) for vegetation restoration. Elevating our understanding of the changes in soil characteristics after the establishment of different plantation types can be useful in the context of combating deserdfication. To assess the effects of these plantation types on the restoration of sandy land, we measured soil physical-chemical properties at four depths (0-5, 5-10, 10-20, and 20-50 cm) in each of the three plantation types and also in non-vegetated moving sand dunes (as control sites). Generally, the establishment of A. ordosica, C korshinskii and C intermedia plantations on sand dunes has greatly ameliorated soil quality in the Gonghe Basin. Specifically, relative to the moving sand dunes, shrub plantation has increased the silt and clay contents, total porosity and water holding capacity, soil organic matter, total nitrogen, total phosphorus and total potassium contents. The calculated soil quality index suggested that in the Gonghe Basin, C. intermedia is the best choice for soil amelioration. In all the three plantation types, soil amelioration mainly occurred in the shallow depths.
基金supported by the Fund for 863 Program(2013AA102904)the central university basic research project(2009KD01).
文摘To investigate the effects of seabuckthorn(Hippophae rhamnoides)on soil amelioration,using the space replacement method,soil physical and chemical indexes as well as the microorganism quantity and soil enzyme activities were analyzed.The results showed that:the soil bulk density of surface soil decreased and soil porosity and field capacity increased after afforestation with seabuckthorn.The plant was found to effectively reduce the soil pH,increase the soil conductivity,soil organic matters and available nutrients.Soil microorganism quantity,soil enzyme activities were both higher in 0-20 cm layer than in 20-40 cm layer.With the increase years of remediation with seabuckthorn,the quantity of soil microorganism and enzyme activities were increasing to a higher level 5 to 8 years later.Our study indicates that seabuckthorn can effectively improve soil physical and chemical properties,increase the quantity of soil microorganisms and enzyme activities,which is of great significance for the ecosystem restoration in mining areas.
文摘The North China Plain (NCP) lying along the eastern coastal area withgeogriaphical coordinates 100°to 120°and 30° to 40°W, is one of the mostimportan agncultural ngons in China. A problem in soil salmization has beenfound in vast areas along the lower reaches of the Yellow hiver and north of it. After30 years of work on saline soil amelioration, 2.0 million ha has been improved,accounting for over 60 percen of the total ongnal saline soil area. Ths achievetnenthas ban obtained in close relation to water conservancy work. The author analyzessalthezation amelioration by using measures concerning subsuffoce water regulation.Ih addition to water conservancy measures, thes paper also descnbes acomprehensive way to ameliorate salthezation in northem NCP. Finally, the authorstresses the necessity of combining all measures together into a whole system forsolving salinization problems in northem NCP.
基金supported by the College Sci-Tech Achievements Industrialization Project of Jiangsu Education Department(Grant No.JH07-010)
文摘In order to ameliorate saline-alkaline soil, EM Bokashi has been applied to rice production in conjunction with subdrainage in Ningxia Autonomous Region and Zhejiang Province. The preliminary results can be summarized as follows: EM Bokashi can increase soil organic matter content, improve soil porosity and permeability, and raise the soil's levels of available nutrients; and EM Bokashi combined with subdrainage treatment is more effective in controlling secondary soil salinization and raising the grain yield and quality than other treatments. The results suggest that EM Bokashi can reduce the necessary amount of chemical fertilizer application, thereby improving the agricultural environment, and that the introduction of EM Bokashi into systems of secondary soil salinization control systems has resulted in significant benefits.
文摘A long-term field study was initiated during 1995 at Central Soil Salinity Research Institute, Regional Research Station, Lucknow (26047'58" N and 80°46'24" E) to analyze the effect of agroforestry systems on amelioration of alkali soils. Three agroforestry systems (pas- toral, silvipastoral and silvicultural) were compared with the control where no agroforestry system was introduced. Tree-based silvicultural and silvipastoral systems were characterized by tree species Prosopis juliflora and Acacia nilotica along with grass species Leptochloafusca, Panicum maximum, Trifolium alexandrium and Chloris gayana. Growth of ten-year-old Prosopis juliflora and Acacia nilotica planted in combi- nation with grasses was significantly higher over the silviculture system with the same species. Tree biomass yields of P. juliflora (77.20 t·ha-1) and A. nilotica (63.20 t·ha-1) planted under silvipastoral system were significantly higher than the sole plantation of (64.50 t·ha-1 and 52.75 t·ha-1). Fodder yield under the pastoral system was significantly higher than the silvipastoral system during initial years but it was at par with that of silvipastoral systems after eight years of plantation. The microbial biomass carbon in the soils of silvipastoral systems was significantly higher than in soils under sole plantation of trees and control systems. The Prosopis-based silvipastoral system proved more effective in reduc- ing soil pH, displacing Na+ from the exchange complex, increasing or- ganic carbon and available N, P and K. Improvement in soil physical properties such as bulk density, porosity, soil moisture and infiltration rate was higher in the Prosopis-based silvipastoral system than in the silviculture system or control On the basis of biomass production and improvement in soil health due to tree + grass systems, silvipastoral agroforestry system could be adopted for sustainable reclamation ofhighly alkali soils.
基金National Natural Science Foundation of China,No.81603574 and No.81774286National Key Research and Development Program,No.2018YFC1704202 and No.2020YFE0201800+1 种基金University Scientific Research Projects of Anhui,No.KJ2020A0401 and No.KJ2019A0442Province Science Foundation of Anhui,No.1708085QH213.
文摘BACKGROUND A recent investigation showed that the prevalence of type 2 diabetes mellitus(T2DM)is 12.8%among individuals of Han ethnicity.Gut microbiota has been reported to play a central role in T2DM.Goto-Kakizaki(GK)rats show differences in gut microbiota compared to non-diabetic rats.Previous studies have indicated that berberine could be successfully used to manage T2DM.We sought to understand its hypoglycaemic effect and role in the regulation of the gut microbiota.AIM To determine whether berberine can regulate glucose metabolism in GK rats via the gut microbiota.METHODS GK rats were acclimatized for 1 wk.The GK rats were randomly divided into three groups and administered saline(Mo),metformin(Me),or berberine(Be).The observation time was 8 wk,and weight,fasting blood glucose(FBG),insulin,and glucagon-like peptide-1(GLP-1)were measured.Pancreatic tissue was observed for pathological changes.Additionally,we sequenced the 16S rRNA V3-V4 region of the gut microbiota and analysed the structure.RESULTS Compared with the Mo group,the Me and Be groups displayed significant differences in FBG(P<0.01)and GLP-1(P<0.05).A significant decrease in weight and homeostatic model assessment-insulin resistance was noted in the Be group compared with those in the Me group(P<0.01).The pancreatic islets of the Me-and Be-treated rats showed improvement in number,shape,and necrosis compared with those of Mo-treated rats.A total of 580 operational taxonomic units were obtained in the three groups.Compared to the Mo group,the Me and Be groups showed a shift in the structure of the gut microbiota.Correlation analysis indicated that FBG was strongly positively correlated with Clostridia_UCG-014(P<0.01)and negatively correlated with Allobaculum(P<0.01).Body weight showed a positive correlation with Desulfovibrionaceae(P<0.01)and a negative correlation with Akkermansia(P<0.01).Importantly,our results demonstrated that Me and Be could significantly decrease Bacteroidetes(P<0.01)and the Bacteroidetes/Firmicutes ratio(P<0.01).Furthermore,Muribaculaceae(P<0.01;P<0.05)was significantly decreased in the Me and Be groups,and Allobaculum(P<0.01)was significantly increased.CONCLUSION Berberine has a substantial effect in improving metabolic parameters and modulating the gut microbiota composition in T2DM rats.
基金financially supported by 1226 major project [Grant no.AWS16J018]
文摘Hypoxia is a common pathological process in various clinical diseases and is characterized by abnormal changes in metabolism, function, and morphological structure of tissues resulting from insufficient oxygen supply or oxygen barriers in tissues. In particular, hypoxia in vital organs such as the brain and heart is an important cause of death;. The prevention of tissue hypoxia and the
文摘Objective:To study the potential ameliorating properties of cardamom Elettaria cardamomum (E.cardamomum) L.Maton against pan masala induced damage in lung of male Swiss mice. Methods:The experimental animals were divided into 3 groups(control,pan masala treated group and pan masala with cardamom treated group) to evaluate pan masala toxicity.The observations were substantiated with profound changes in the lung tissue as revealed in the histologic and transmission electron microscopic examinations.Results:Lung of pan masala treated group showed adenocarcinoma,edema,and inflammation with increased activity of acid phosphatase,alkaline phosphatase,and lactate dehydrogenase.The deleterious effects were seen to be less in cardamom treated group and the enzymatic activity also decreased significantly (P【0.05)\ in the ameliorating group.Conclusions:Thus,the present experiment exciting results are observed when cardamom is supplemented with pan masala,or when given alone.
文摘Background : This study examined the ameliorative effect of D-3-O-methylchiroinositol, isolated from the stem bark of Piliostigma thonningii, on cadmium chloride-induced osteoporosis in male Wistar rats. Methods : Thirty-six rats were assigned to three treatment groups(n = 12). Group A(2 mL distilled water), group B:(2.5 mg/kg b.w. CdCl_2) and group C:(2.5 mg/kg b.w. CdCl_2 and D-3-O-methyl-chiroinositol 2 mg/kg b.w.). Bone ash, calcium, phosphate, magnesium, and zinc content, as well as bone histological changes were determined at the end of months 1, 2, and 3. Results : There were significant differences( P ≤ 0.05) in the weight of the cervical, tibia, and femoral bones in all groups. The serum concentration of CdCl_2 was significantly different across the three groups with time. There was significant variation( P < 0.005) in the mean bone ash across groups. The concentration of OH-proline was significantly different( P < 0.0001) across groups. There were significant differences( P < 0.0001) in bone calcium, magnesium, zinc, and phosphorus concentrations. Histology revealed high levels of bone mineralisation in the CdCl_2-treated group, indicative of osteoporosis with hypertrophied osteocytes, while the femur of Wistar rats treated with D-3-O-methyl-chiroinositol showed bone trabeculae and viable osteocytes. Conclusion : The study concluded that D-3-O-methyl-chiroinositol extract from Piliostigma thionningii stem bark ameliorated cadmium chloride-induced osteoporosis in male Wistar rats.
基金supported by the National Nature Science Foundation of China[No.81872626]Science and Technology Foundation for Innovation Talent of Henan Province[No.154200510010]Science and Technology Plan of Henan Province[No.172102310029]。
文摘Type 2 diabetes mellitus(T2DM)is typified by the increment of chronic blood glucose levels that is caused by an absolute and/or a relative deficiency of insulin,accounts for 90%of diabetes and causes a range of complications[1].
基金supported by the National Natural Science Foundation of China (31971282 and 32071362)2019 Chongqing Graduate Tutor Team Construction Project (dstd201903)Scientific and Technological Research Program of Chongqing Municipal Education Commission (KJQN201900415)。
文摘Periodontitis is a widespread oral disease characterized by continuous inflammation of the periodontal tissue and an irreversible alveolar bone loss, which eventually leads to tooth loss. Four-octyl itaconate(4-OI) is a cell-permeable itaconate derivative and has been recognized as a promising therapeutic target for the treatment of inflammatory diseases. Here, we explored, for the first time,the protective effect of 4-OI on inhibiting periodontal destruction, ameliorating local inflammation, and the underlying mechanism in periodontitis. Here we showed that 4-OI treatment ameliorates inflammation induced by lipopolysaccharide in the periodontal microenvironment. 4-OI can also significantly alleviate inflammation and alveolar bone loss via Nrf2 activation as observed on samples from experimental periodontitis in the C57BL/6 mice. This was further confirmed as silencing Nrf2 blocked the antioxidant effect of 4-OI by downregulating the expression of downstream antioxidant enzymes. Additionally, molecular docking simulation indicated the possible mechanism under Nrf2 activation. Also, in Nrf2-/-mice, 4-OI treatment did not protect against alveolar bone dysfunction due to induced periodontitis, which underlined the importance of the Nrf2 in 4-OI mediated periodontitis treatment.Our results indicated that 4-OI attenuates inflammation and oxidative stress via disassociation of KEAP1-Nrf2 and activation of Nrf2 signaling cascade. Taken together, local administration of 4-OI offers clinical potential to inhibit periodontal destruction,ameliorate local inflammation for more predictable periodontitis.
基金funded by the New Century Supporting Programs to Excellent Talents in China,No.NCET-05-0831
文摘Rosiglitazone up-regulates caveolin-1 levels and has neuroprotective effects in both chronic and acute brain injury. Therefore, we postulated that rosiglitazone may ameliorate diffuse axonal injury via its ability to up-regulate caveolin-1, inhibit expression of amyloid-beta precursor protein, and reduce the loss and abnormal phosphorylation of tau. In the present study, intraperitoneal injection of rosiglitazone significantly reduced the levels of amyloid-beta precursor protein and hyperphosphorylated tau(phosphorylated at Ser^(404)(p-tau(S^(404))), and it increased the expression of total tau and caveolin-1 in the rat cortex. Our results show that rosiglitazone inhibits the expression of amyloid-beta precursor protein and lowers p-tau(S^(404)) levels, and it reduces the loss of total tau, possibly by up-regulating caveolin-1. These actions of rosiglitazone may underlie its neuroprotective effects in the treatment of diffuse axonal injury.
文摘A pot experiment was conducted to investigate the effect of cow dung, rice husks, calcium chloride and gypsum on soil reclamation and compare the effect of organic and inorganic amendments on soil reclamation during the period of 5th March to 20th April, 2017. The experiment was laid to fit a completely randomized design (CRD) with seven treatments [Reference soil (T0), Cow dung (T1), Rice husk (T2), Gypsum (T3), Calcium chloride (T4), Cow dung + Rice husk (T5) and Gypsum + Calcium chloride (T6)] each having three replications for this experiment. After incubation (45 days), the laboratory investigation was carried out in the Soil, Water and Environment Discipline, Khulna University, Khulna, Bangladesh. Results indicate that the individual or combined effect of gypsum (T3) was more effective in changing EC and SAR. Gypsum application in combination with calcium chloride (T6) improved the soil chemical properties by reducing the EC. Among the treatment, calcium chloride (T4) had a remarkable effect in reducing sodium adsorption ratio and gypsum had a remarkable effect in reducing pH. Cow dung (T1), rice husk (T2), combination of cow dung and rice husk (T5) were less effective to reduce EC, pH and SAR. It’s measured for soils of different soil amendments varied significantly
基金Supported by Science and Technology Project of Hunan Tobacco Monopoly Bureau(18-21Aa04).
文摘[Objectives]This study was conducted to clarify the improvement effects of different soil amelioration materials such as lime,green manure and bio-organic fertilizer on acidic tobacco-planting soil.[Methods]The dynamic changes of soil pH,soil nutrients and enzyme activity were studied by applying lime,lime+green fertilizer,and lime+green fertilizer+biological organic fertilizer.[Results]①After the application of amelioration materials,the soil pH and available phosphorus content of tobacco-growing soil showed a stepwise change of first increasing and then decreasing,and became stable at 60 d after tobacco transplanting;the soil organic matter,alkali-hydrolyzable nitrogen and available potassium content showed a gradual change trend of"high-low-high";and the soil invertase and urease activity showed a gradual change trend of"low-high-low".②To 90 d after tobacco transplanting,the application of amelioration materials increased soil pH by 1.29-1.62 units,and increased organic matter content by 15.21%-20.86%,alkali-hydrolyzable nitrogen content by 6.83%-18.17%,available phosphorus content by 54.15%-217.85%,rapidly available potassium content by 11.42%-30.86%,soil invertase activity by 70.09%-18.93%,and soil urease activity by 64.07%-130.47%.③The combination of lime+green manure+alkaline microbial organic fertilizer had the best effect on the improvement of acidic tobacco-growing soil,and the effect of lime+green manure+acid microbial organic fertilizer on acidic soil was the second.[Conclusions]When applying lime,green fertilizer and alkaline bio-organic fertilizer should be applied to achieve sustainable improvement of strongly acidic soil.
文摘Changes of word meanings in English are often achieved by the processes of generalization/specialization and pejoration/amelioration.By generalization or specialization,the literal meanings of a word are broadened or narrowed.While by pejoration or amelioration,the associations of a word go downhill or rise.Trough supplying certain examples,a brief picture about meaning changes of words in English is drawn.