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Design,delivery and efficacy testing of therapeutic nucleic acids used to inhibit hepatitis C virus gene expression in vitro and in vivo 被引量:9
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作者 Wolfgang H.Caselmann Matthias Serwe +3 位作者 Thomas Lehmann János Ludwig Brian S.Sproat Joachim W.Engels 《World Journal of Gastroenterology》 SCIE CAS CSCD 2000年第5期626-629,共4页
Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside analog ribavirin themajority of patients with chronic hepatitis C virus(HCV) infection cannot be ... Despite major achievements in the treatment ofchronic hepatitis C with the combination ofinterferons and the nucleoside analog ribavirin themajority of patients with chronic hepatitis C virus(HCV) infection cannot be treated effectively.Toimprove this response rate we used antisensetechnologies to inhibit HCV translation as possibleadditional option for experimental treatment.Antisense oligodeoxynucleotides(ODN) are 展开更多
关键词 hepatitis C-like viruses/therapy gene expression in VITRO in vivo nucleic acids/therapeutic use CYTOMEGALOVIRUS
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Therapeutic and Medicinal Uses of <i>Aloe vera</i>: A Review 被引量:5
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作者 Pankaj K. Sahu Deen Dayal Giri +5 位作者 Ritu Singh Priyanka Pandey Sharmistha Gupta Atul Kumar Shrivastava Ajay Kumar Kapil Dev Pandey 《Pharmacology & Pharmacy》 2013年第8期599-610,共12页
The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, ... The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, minerals, enzymes, amino acids, natural sugars and other bioactive compounds with emollient, purgative, anti-microbial, anti inflammatory, antioxidant, aphrodisiac, anti-helmenthic, antifungal, antiseptic and cosmetic values for health care. This plant has potential to cure sunburns, burns and minor cuts, and even skin cancer. The external use in cosmetic primarily acts as skin healer and prevents injury of epithelial tissues, cures acne and gives a youthful glow to skin, also acts as extremely powerful laxative. 展开更多
关键词 ALOE vera Antimicrobial therapeutic MEDICINAL useS Cosmetic Application
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Continuous Wear of Hydrogel Contact Lenses for Therapeutic Use
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作者 Daisuke Kudo Hiroshi Toshida +1 位作者 Toshihiko Ohta Akira Murakami 《Open Journal of Ophthalmology》 2012年第4期110-113,共4页
Purpose: To investigate the efficacy and complications of continuous wear of etafilcon A for therapeutic use. Materials and Methods: The subjects were 228 eyes of 219 outpatients prescribed contact lens (CL) for one w... Purpose: To investigate the efficacy and complications of continuous wear of etafilcon A for therapeutic use. Materials and Methods: The subjects were 228 eyes of 219 outpatients prescribed contact lens (CL) for one week of continuous therapeutic wear during 10 years. The reason for prescription of CLs, the primary disease, the duration of CL wear and the complications were assessed retrospectively. Results: The predominant reason for prescription of CLs was relief of pain or a foreign-body sensation (62.3%) and protection of the corneal epithelium (20.6%). The primary disease was post-penetrating keratoplasty (36.8%), followed by corneal epithelial erosion (14.5%), post-lamellar keratoplasty (14.0%) and bullous keratopathy (12.2%). The average duration of wearing single lens was 6.5 ± 3.2 days. The average duration of wearing CLs in total was 9.2 ± 10.7 months. The most frequent problem associated with continuous wear of CLs was their dropping out of CLs (12.3%). The complications associated with CLs included conjunctivitis with papillary hyperplasia, corneal erosion and superficial punctate keratitis, but corneal ulcer and corneal infiltrates were not found. Conclusion: Serious complications were not shown changing the lenses every week to keep to the prescribed time limit for continuous therapeutic wear, even if corneal epithelial barrier function is impaired. 展开更多
关键词 therapeutic use BANDAGE Soft Contact LENS CONTINUOUS WEAR COMPLICATION
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Comparison of long-lasting therapeutic effects between succimer and penicillamine on hepatolenticular degeneration 被引量:3
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作者 REN Ming Shan, ZHANG Zhi, WU Jun Xia, LI Fei, XUE Ben Chun and YANG Ren Min 《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第6期75-77,共3页
AIM To compare the long term effect of succimer (Suc) with that of penicillamine (Pen) in treating hepatolenticular degeneration (HLD). METHODS One hundred and twenty patients with HLD were divided into 2 groups. ... AIM To compare the long term effect of succimer (Suc) with that of penicillamine (Pen) in treating hepatolenticular degeneration (HLD). METHODS One hundred and twenty patients with HLD were divided into 2 groups. Group A ( n =60) received Suc 750mg , po. bid. Group B ( n =60) received Pen 250mg , po. qid. The period of maintenance treatment varied from 6 months to 3 years, averaging 1 5 years. Symptoms and therapeutic effects were evaluated by modified Goldstein scale. RESULTS The total effectiveness of group A in two different periods of treatment were 80% and 85% respectively, higher than those of group B (58% and 59% respectively) ( P <0 05). Suc also had obvious curative effects for the patients who failed in the use of Pen. There were fewer side effect in group A than in group B ( P <0 05). Suc and Pen could increase urinary copper excretion effectively and continually. CONCLUSION Suc is more effective and safer than Pen. Clinically, it can replace Pen as first choice drug for long term maintenance therapy of HLD. 展开更多
关键词 hepatolenticular degeneration/drug THERAPY succimer/therapeutic use penicillamine/therapeutic use
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Functional dyspepsia of ulcer-dysmotility type:clinical incidence and therapeutic strategy 被引量:3
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作者 WANG XiaoZhong and LIN GuZhen 《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第4期95-96,共2页
Functionaldyspepsiaofulcerdysmotilitytype:clinicalincidenceandtherapeuticstrategyWANGXiaoZhongandLINGuZhe... Functionaldyspepsiaofulcerdysmotilitytype:clinicalincidenceandtherapeuticstrategyWANGXiaoZhongandLINGuZhenSubjectheaadings... 展开更多
关键词 dyspepsia/drug therapy famotidine/therapeutic use cisapride/therapeutic use peptic ULCER gastrointestinal motility
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Therapeutic role of template-based lymphadenectomy in urothelial carcinoma of the upper urinary tract 被引量:5
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作者 Tsunenori Kondo Toshio Takagi Kazunari Tanabe 《World Journal of Clinical Oncology》 CAS 2015年第6期237-251,共15页
Lymphadenectomy for urothelial carcinoma of the upper urinary tract has attracted the attention of physicians. The mapping study of lymphatic spread has shown that a relatively wide area should comprise the regional n... Lymphadenectomy for urothelial carcinoma of the upper urinary tract has attracted the attention of physicians. The mapping study of lymphatic spread has shown that a relatively wide area should comprise the regional nodes for tumors of the right renal pelvis or the right upper two-thirds of the ureter. A prospective study showed that an anatomical templatebased lymphadenectomy significantly improved patient survival in tumors of the renal pelvis. This benefit was more evident for patients with p T2 stage tumors or higher. The risk of regional node recurrence is significant reduced by template-based lymphadenectomy,which is likely to be associated with improved patient survival. The removal of lymph node micrometastases is assumed to be the reason for therapeutic benefit following lymphadenectomy. The number of resected lymph nodes can be used to assess the quality of lymphadenectomy,but not to determine the extent of lymphadenectomy. The guidelines currently recommend lymphadenectomy for patients with muscle-invasive disease,even though the current recommendation grades are still low. The present limitation of lymphadenectomy is the lack of standardization of the extent of lymphadenectomy and the randomized trials. Further studies are warranted to collect the evidence to support lymphadenectomy. 展开更多
关键词 LYMPHADENECTOMY LYMPH node EXCISION UROTHELIAL carcinoma Treatment outcome therapeutic uses Diagnosis GUIDELINE
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Blastocystis hominis as a cause of chronic diarrhea in low-resource settings:A systematic review
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作者 Stephen Amoak Jonathan Soldera 《World Journal of Meta-Analysis》 2024年第3期30-41,共12页
BACKGROUND Blastocystis hominis(B.hominis),an anaerobic unicellular protist parasite,is known for its diverse clinical manifestations upon infecting the human gastrointestinal tract.Although globally distributed,it is... BACKGROUND Blastocystis hominis(B.hominis),an anaerobic unicellular protist parasite,is known for its diverse clinical manifestations upon infecting the human gastrointestinal tract.Although globally distributed,it is particularly prevalent in developing nations.Examining the symptoms and treatment outcomes of B.hominis infection in low-resource settings holds immense significance,providing healthcare practi-tioners with valuable insights to enhance patient care.AIM To synthesize existing evidence on the symptomatology and treatment outcomes of B.hominis infection in low-resource settings.METHODS Following the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines,a systematic review was conducted.The search spanned electronic databases including PubMed,Scopus,and Google Scholar.After a comprehensive screening process,a thorough examination of the papers,adhering to inclusion and exclusion criteria,and data extraction from eligible studies was conducted.The findings underwent summarization through simple descriptive analysis.RESULTS The search yielded 1200 papers,with 17 meeting inclusion criteria.Chronic diarrhea due to B.hominis infection was reported in only two studies,while abdominal pain,diarrhea,flatulence,constipation,and nausea/vomiting emerged as the most commonly documented symptoms.Recovery rates after one week of treatment ranged from 71.8%to 100%,and after two weeks,from 60%to 100%.CONCLUSION In low-resource settings,chronic diarrhea resulting from B.hominis infection is infrequent.Common symptoms include abdominal pain,diarrhea,flatulence,constipation,and nausea/vomiting.Post-treatment,clinical outcomes are notably favorable,supporting the recommendation for treatment.Metronidazole is advocated as the first-line agent,with consideration for switching to a second-line option in cases of treatment failure or poor response. 展开更多
关键词 Blastocystis infections Gastrointestinal diseases Treatment outcome Developing countries Metronidazole/therapeutic use
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Clinacanthus nutans:a review of the medicinal uses,pharmacology and phytochemistry 被引量:10
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作者 Md.Ariful Alam Sahena Ferdosh +4 位作者 Kashif Ghafoor Md.Abdul Hakim Abdul Shukor Juraimi Alfi Khatib Md.Zaidul I.Sarker 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2016年第4期393-399,共7页
Clinacanthus nutans Lindau is known as snake grass belonging to the Acanlhaceae family.This plant has diverse and potential medicinal uses in traditional herbal medicine for treating skin rashes,insects and snake bite... Clinacanthus nutans Lindau is known as snake grass belonging to the Acanlhaceae family.This plant has diverse and potential medicinal uses in traditional herbal medicine for treating skin rashes,insects and snake bites,lesions caused by herpes simplex virus,diabetes,and gout in Malaysia.Indonesia.Thailand and China.Phylochemieal investigations documented the varied contents of bioaclive compounds from litis plant namely flavonoids,glycosides,glycoglyeerolipids.cerebrosides and monoacylmonogalatosylglycerol.The pharmacological experiment proved that various types of extracts and pure compounds from this species exhibited a broad range of biological properties such as anti-inflammatory,antiviral,antioxidant,and anti-diabetic activities.The lindings of toxicity study showed that extracts from this plant did not show any toxicity thus it can be used as strong therapeutic agents for specific diseased conditions.However,further experiments on chemical components and their mode of action showing biological activities are required to elucidate the complete phytochemical profile and assess to confirm their suitability tor future drugs.This review summarizes the medicinal uses,phytochemistry and pharmacology of this plant in order to explore its therapeutic potential and gaps necessitating for prospected research work. 展开更多
关键词 Clinacanthus nutans MEDICINAL useS PHYTOCHEMICALS PHARMACOLOGY therapeutic potential
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High-intensity focused ultrasound extracorporeal ablation of liver tissuesin rabbits
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《World Journal of Gastroenterology》 SCIE CAS CSCD 1998年第2期16-16,共1页
HighintensityfocusedultrasoundextracorporealablationoflivertissuesinrabbitsCHENGShuQun1,ZHOUXinDa1,TANGZ... HighintensityfocusedultrasoundextracorporealablationoflivertissuesinrabbitsCHENGShuQun1,ZHOUXinDa1,TANGZhaoYou1,YUYao1,B... 展开更多
关键词 LIVER neoplasms experimental/therapy ultrasonic THERAPY iodized oil/therapeutic use liver/radiation effects randomized controlled trials
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Controversies regarding transplantation of mesenchymal stem cells
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作者 Tsvetelina Velikova Tereza Dekova Dimitrina Georgieva Miteva 《World Journal of Transplantation》 2024年第2期48-61,共14页
Mesenchymal stem cells(MSCs)have tantalized regenerative medicine with their therapeutic potential,yet a cloud of controversies looms over their clinical tran-splantation.This comprehensive review navigates the intric... Mesenchymal stem cells(MSCs)have tantalized regenerative medicine with their therapeutic potential,yet a cloud of controversies looms over their clinical tran-splantation.This comprehensive review navigates the intricate landscape of MSC controversies,drawing upon 15 years of clinical experience and research.We delve into the fundamental properties of MSCs,exploring their unique immuno-modulatory capabilities and surface markers.The heart of our inquiry lies in the controversial applications of MSC transplantation,including the perennial debate between autologous and allogeneic sources,concerns about efficacy,and lingering safety apprehensions.Moreover,we unravel the enigmatic mechanisms surro-unding MSC transplantation,such as homing,integration,and the delicate balance between differentiation and paracrine effects.We also assess the current status of clinical trials and the ever-evolving regulatory landscape.As we peer into the future,we examine emerging trends,envisioning personalized medicine and innovative delivery methods.Our review provides a balanced and informed perspective on the controversies,offering readers a clear understanding of the complexities,challenges,and potential solutions in MSC transplantation. 展开更多
关键词 Mesenchymal stem cells Transplantation controversies Regenerative medicine Autoimmune diseases Chronic inflammatory illnesses Tumor growth METASTASIS therapeutic potential Clinical use of mesenchymal stem cell
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USE OF CELL-BASED BIOASSAY FOR THE QUALITY CONTROL OF BOTANICAL THERAPEUTICS
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作者 Doo Suk Lee Min-Jung Bae Sunyoung Kim 《World Journal of Traditional Chinese Medicine》 2015年第4期91-91,共1页
The single most important factor in modernization efforts of traditional oriental medicines is the limited understanding of active compounds responsible for claimed therapeutic effects.Indeed,the unknown identity of b... The single most important factor in modernization efforts of traditional oriental medicines is the limited understanding of active compounds responsible for claimed therapeutic effects.Indeed,the unknown identity of biologically active molecules generates major difficulties associated with botanical therapeutics in general.This includes management of raw materials,poor understanding of 展开更多
关键词 use OF CELL-BASED BIOASSAY FOR THE QUALITY CONTROL OF BOTANICAL therapeuticS PG
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反相高效液相色谱法测定血浆中阿米替林及其代谢物去甲替林的总浓度和游离浓度 被引量:8
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作者 李金恒 许劲秋 +1 位作者 曹晓梅 陈东阳 《中国药理学通报》 CAS CSCD 北大核心 2001年第1期104-107,共4页
目的 建立灵敏、简便、适合临床监测阿米替林及其代谢物去甲替林总浓度与游离浓度的反相高效液相色谱法(RP HPLC)。方法 血样在碱性条件下 ,经一步液 液提取法后 ,在C 18柱上进行分离。流动相为乙腈∶水 =30∶70(V/V) ,其中含三乙胺 0... 目的 建立灵敏、简便、适合临床监测阿米替林及其代谢物去甲替林总浓度与游离浓度的反相高效液相色谱法(RP HPLC)。方法 血样在碱性条件下 ,经一步液 液提取法后 ,在C 18柱上进行分离。流动相为乙腈∶水 =30∶70(V/V) ,其中含三乙胺 0 5 %和磷酸 0 3%。血浆样品药物总浓度测定为RP HPLC ,游离药物测定为超滤离心 /RP HPLC。结果 阿米替林和去甲替林的标准曲线在 4~ 2 0 0μg·L-1(总浓度 )和 4~ 6 4μg·L-1(游离浓度 )范围内呈线性。两药的平均回收率分别为 10 2 0 %± 3 77%与 99 3 %± 7 13 % ;日内RSD分别为 2 40 %~ 4 39% ,3 0 2 %~4 2 8% ;日间RSD分别为 4 92 %~ 6 15 % ,6 35 %~7 48%。测定了 7例健康志愿者单剂量口服盐酸阿米替林片 5 0mg后 6h的血药浓度。血浆阿米替林总浓度为 18 0~ 2 7 2 μg·L-1,游离浓度为 1 4~ 2 5 μg·L-1。血浆去甲替林总浓度为 (2 0± 0 4) μg·L-1(1 5~ 2 5 μg·L-1)。阿米替林的血浆蛋白结合率在 89 8%~ 92 6 %之间。结论 本方法简便、快速 ,灵敏度与选择性高 ;成本低 。 展开更多
关键词 阿米替林 去甲替林 高效液相色谱法 游离药物 治疗药物监测
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马来酸氟吡汀联合阿米替林治疗脑卒中后丘脑痛的临床观察 被引量:14
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作者 赵艳 廖祖松 +2 位作者 邹耀兵 潘成德 江思德 《中国药房》 CAS 北大核心 2018年第9期1274-1277,共4页
目的:观察马来酸氟吡汀联合阿米替林治疗脑卒中后丘脑痛的疗效及安全性。方法:采用随机数字表法将我院2016年1月-2017年8月收治的70例脑卒中后丘脑痛患者随机分为对照组(34例)与观察组(36例),两组患者均给予脑卒中二级预防治疗,在此基础... 目的:观察马来酸氟吡汀联合阿米替林治疗脑卒中后丘脑痛的疗效及安全性。方法:采用随机数字表法将我院2016年1月-2017年8月收治的70例脑卒中后丘脑痛患者随机分为对照组(34例)与观察组(36例),两组患者均给予脑卒中二级预防治疗,在此基础上,对照组患者口服盐酸阿米替林片25 mg/次,tid,观察组患者在对照组治疗基础上口服马来酸氟吡汀胶囊0.1 g/次,tid,两组疗程均为4周。评价两组患者治疗前及治疗1、2、3、4周末视觉模拟疼痛(VAS)、汉密尔顿抑郁量表(HAMD17)和汉密尔顿焦虑量表(HAMA14)评分,观察两组患者临床疗效及不良反应发生情况。结果:治疗前,两组患者VAS、HAMD17、HAMA14评分比较,差异均无统计学意义(P>0.05)。观察组患者治疗1、2、3、4周末,对照组患者治疗2、3、4周末的VAS、HAMD17评分均显著低于治疗前,且观察组患者各治疗时段均显著低于对照组(P<0.05或P<0.01);两组患者治疗2、3、4周末HAMA14评分均显著低于治疗前,且观察组患者各治疗时段均显著低于对照组(P<0.05或P<0.01);观察组患者总有效率(91.67%)显著高于对照组(67.65%)(P<0.05),两组患者不良反应发生率(11.76%vs.11.11%)比较,差异无统计学意义(P>0.05)。结论:马来酸氟吡汀联合阿米替林能有效缓解脑卒中后丘脑痛症状,同时改善脑卒中后抑郁、焦虑情绪,均优于对照组且不良反应发生率与对照组相似。 展开更多
关键词 马来酸氟吡汀 阿米替林 脑卒中后丘脑痛 视觉模拟疼痛评分 汉密尔顿抑郁量表评分 汉密尔顿焦虑量表评分 疗效 安全性
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西酞普兰和阿米替林治疗抑郁症的对照研究 被引量:1
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作者 王秀娟 王金童 +1 位作者 张跃琴 马洁 《天津药学》 2004年第3期34-35,39,共3页
目的 :比较西酞普兰和阿米替林治疗抑郁症的疗效和安全性。方法 :将 6 0例抑郁症患者随机分成两组 ,分别服用西酞普兰和阿米替林 ,疗程 8周。用汉密尔顿抑郁量表 (HAMD)和药物副反应量表 (TESS)评价 ,比较两种药物的疗效和安全性。结果 ... 目的 :比较西酞普兰和阿米替林治疗抑郁症的疗效和安全性。方法 :将 6 0例抑郁症患者随机分成两组 ,分别服用西酞普兰和阿米替林 ,疗程 8周。用汉密尔顿抑郁量表 (HAMD)和药物副反应量表 (TESS)评价 ,比较两种药物的疗效和安全性。结果 :西酞普兰治疗抑郁症的疗效和阿米替林相似 ,但副反应明显较后者少 (P <0 .0 5 )。结论 :西酞普兰是一种安全有效的抗抑郁药。 展开更多
关键词 西酞普兰 阿米替林 抑郁症 疗效 安全性
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养血清脑颗粒联合西药治疗药源性头痛疗效观察 被引量:1
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作者 李玉莲 易飞 曾学文 《中国中医药现代远程教育》 2015年第22期55-56,共2页
目的探讨养血清脑颗粒联合阿米替林治疗药物过度使用性头疼患者的疗效。方法选取我院于2013年8月—2015年1月收治的48例药物过度使用性头疼患者,每次口服养血清脑颗粒4 g,每日3次,饭前口服,连用4周后停药;同时予以每晚口服阿米替林25 mg... 目的探讨养血清脑颗粒联合阿米替林治疗药物过度使用性头疼患者的疗效。方法选取我院于2013年8月—2015年1月收治的48例药物过度使用性头疼患者,每次口服养血清脑颗粒4 g,每日3次,饭前口服,连用4周后停药;同时予以每晚口服阿米替林25 mg,连用12周。记录治疗前后患者头痛发作频率、头痛持续时间、严重程度和治疗后药物不良反。结果养血清脑颗粒联合阿米替林治疗后,患者的头疼程度、头疼持续时间和头疼发作频率较治疗前明显改善(P<0.05);患者治疗后的不良反应发生率为8.4%,均为轻度不良反应。结论养血清脑颗粒联合阿米替林能有效缓解患者的头疼程度,缩短头疼持续时间,减少发作频率,具有良好的治疗效果,且安全性好,值得在临床上推广使用。 展开更多
关键词 养血清脑颗粒 阿米替林 药物过度使用性头痛 治疗效果
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氯米帕明和阿米替林治疗70例抑郁症的对照试验
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作者 赵靖平 陈远光 +2 位作者 张宏根 张淑云 丁杰豪 《中国新药与临床杂志》 CAS CSCD 北大核心 1991年第6期322-324,共3页
报道国产氯米帕明(男21例,女14例,年龄83±11yr)和阿米替林(男16例,女19例,年龄33±12yr)治疗70例抑郁症的对照试验。1wk内加至150-250mg/d共4wk。结果显示抗抑郁疗效2药间无显著差异。汉密顿抑郁量表总分的减分氯米帕明组大于... 报道国产氯米帕明(男21例,女14例,年龄83±11yr)和阿米替林(男16例,女19例,年龄33±12yr)治疗70例抑郁症的对照试验。1wk内加至150-250mg/d共4wk。结果显示抗抑郁疗效2药间无显著差异。汉密顿抑郁量表总分的减分氯米帕明组大于阿米替林组(分别为29±9,24±13,P<0.05)。2药主要副作用为口干、便秘、心悸、头晕等抗胆碱能作用,氯米帕明副作用略轻于阿米替林。 展开更多
关键词 氯米帕明/治疗应用 阿米替林/治疗应用 抑郁障碍症/药物疗法
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Combination of "low-dose" ribavirin and interferon alfa-2a therapy followed by interferon alfa-2a monotherapy in chronic HCV-infected nonresponders and relapsers after interferon alfa-2a monotherapy 被引量:19
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作者 Perdita Wietzke-Braun Volker Meier +1 位作者 Felix Braun Giuliano Ramadori 《World Journal of Gastroenterology》 SCIE CAS CSCD 2001年第2期222-227,共6页
AIM To report on the efficacy, safety and tolerability of interferon alfa-2a combined with a "low dose" of ribavirin for relapsers and non responders to alpha interferon monotherapy.METHODS Thirty-four chron... AIM To report on the efficacy, safety and tolerability of interferon alfa-2a combined with a "low dose" of ribavirin for relapsers and non responders to alpha interferon monotherapy.METHODS Thirty-four chronic hepatitis C virus-infected non-responders to interferon alfa2a monotherapy (a course of at least 3 months treatment) and 13 relapsers to interferon alfa 2a monotherapy (a dose of 3 to 6 million units three times per week for at least 20 weeks but not more than 18 months) were treated with the same dose of interferon alfa-2a used before (3 to 6 million units three times per week) and ribavirin (10 mg/ kg daily) for 6 months. In complete responders, interferon alfa-2a was administered for further 6 months at the same dose used before as monotherapy.RESULTS Seven (20.6%) of 34 non-responders stopped the combined therapy due to adverse events, including two patients with histological and clinical Child A cirrhosis. In 17/27 (63%)non-responders, the combined therapy was stopped after three months because of non-response. Ten of the 27 non-responders completed the 1;2-month treatment course. At a mean follow up of 28 months (16- 37 months)after the treatment, 4/10 (15%) previous non-responders still remained complete responders,All 13 previous relapsers completed the 12-month treatment course. At a mean follow up of 22months (9 - 36 months) after treatment, 6/13(46%) the previous relapsers were stillsustained complete responders.CONCLUSION Our treatment schedule of the combined therapy for 6 months of interferon alfa2a with a low dose of ribavirin (10 mg/kg/day)followed by 6 months of interferon alfa-2amonotherapy is able to induce a sustainedcomplete response rate in 15% of non-responders and 46% of relapsers with chronic hepatitis C virus-related liver diseases comparable to those obtained with the standarddoses of ribavirin 1000 - 1200 mg/day.Randomized prospective controlled trials using lower total amounts of ribavirin in combination with interferon should be performed. 展开更多
关键词 hepatitis C chronic/drug therapy INTERFERON alpha-2a/therapeutic use INTERFERON alpha-2a/administration & DOSAGE ribavirin/administration & DOSAGE ribavirin/therapeutic use
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Probiotic mixture VSL#3:An overview of basic and clinical studies in chronic diseases 被引量:11
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作者 Fang-Shu Cheng Dan Pan +2 位作者 Bing Chang Min Jiang Li-Xuan Sang 《World Journal of Clinical Cases》 SCIE 2020年第8期1361-1384,共24页
Probiotics are known as“live microorganisms”and have been proven to have a health effect on hosts at the proper dose.Recently,a kind of probiotic mixture including eight live bacterial strains,VSL#3,has attracted co... Probiotics are known as“live microorganisms”and have been proven to have a health effect on hosts at the proper dose.Recently,a kind of probiotic mixture including eight live bacterial strains,VSL#3,has attracted considerable attention for its combined effect.VSL#3 is the only probiotic considered as a kind of medical food;it mainly participates in the regulation of the intestinal barrier function,including improving tight junction protein function,balancing intestinal microbial composition,regulating immune-related cytokine expression and so on.The objective of this review is to discuss the treatment action and mechanism for the administration of VSL#3 in chronic diseases of animals and humans(including children).We found that VSL#3 has a therapeutic or preventive effect in various systemic diseases per a large number of studies,including digestive systemic diseases(gastrointestinal diseases and hepatic diseases),obesity and diabetes,allergic diseases,nervous systemic diseases,atherosclerosis,bone diseases,and female reproductive systemic diseases. 展开更多
关键词 VSL#3 INTESTINAL barrier function CHRONIC DISEASES INTESTINAL MICROBIAL balance CYTOKINES therapeutic use
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Medicinal plants with hepatoprotective activity in Iranian folk medicine 被引量:5
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作者 Majid Asadi-Samani Najme Kafash-Farkhad +3 位作者 Nafiseh Azimi Ali Fasihi Ebrahim Alinia-Ahandani Mahmoud Rafieian-Kopaei 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2015年第2期146-157,共12页
There are a number of medicinal combinations in the Iranian traditional medicine which are commonly used as tonic for liver.In this review,we have introduced some medicinal plants that are used mainly for the treatmen... There are a number of medicinal combinations in the Iranian traditional medicine which are commonly used as tonic for liver.In this review,we have introduced some medicinal plants that are used mainly for the treatment of liver disorders in Iranian folk medicine,with focus on their hepatoprotective effects particularly against CCI_4 agent.In this study,online databases including Web of Science.PubMed.Scopus,and Science Direct were searched for papers published from January 1970 to December 2013.Search terms consisted of medicinal plants,traditional medicine,folk medicine,hepatoprotective.Iran,liver,therapeutic uses,compounds,antioxidant.CCI_4.anti-inflammatory,and antihepatotoxic,hepatitis,alone or in combination.Allium hirtifolium Boiss..Apium graveolens L..Cynara scolyinus.Berberis vulgaris L..,Calendula officinalis,Nigella sativa L..Taraxacum officinale.Tragopogon porrifolius.Prangos ferulacea L..Allium sativum,Marribium vulgare,Ammi majus L..Citrullus lanatus Thunb.Agrimonia eupatoria L.and Primus armeniaca L.are some of the medicinal plants that have been used for the treatment of liver disorders in Iranian folk medicine.Out of several leads obtained from plants containing potential hepatoprotective agents,silymarin,P-sitosterol,betalain,neoandrographolide.phyllanthin.andrographolide.curcumin.picroside.hypophyllanlhin.kutkoside,and glycyrrhizin have been demonstrated to have potent hepatoprotective properties.Despite encouraging data on possibility of new discoveries in the near future,the evidence on treating viral hepatitis or other chronic liver diseases by herbal medications is not adequate. 展开更多
关键词 Medicinal plants Iran COMPOUNDS LIVER therapeutic uses CCl_4
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Treatment of rotaviral gastroenteritis with Qiwei Baizhu powder 被引量:7
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作者 Shuang-Teng He~1 Fei-Zhou He~2 Can-Rong Wu~3 Shun-Xiang Li~2 Wei-Xin Liu~4 Yong-Fang Yang~2 Shi-Sheng Jiang~2 Gang He~1 1 Institute of Combined Traditional Chinese and Western Medicine,Xiangya Hospital,Hunan Medical University,Changsha,410008,China2 Hunan Province Academy of Traditional Chinese Medicine,Changsha 410006,China3 Department of Microbiology,Hunan College of Traditional Chinese Medicine,Changsha 410007,China4 Department of Pediatrics,The Second Hospital of Shuangfeng County,Hunan Province,411700,China 《World Journal of Gastroenterology》 SCIE CAS CSCD 2001年第5期735-740,共6页
AIM To observe the effects of Qiwei Baizhu Powder ( QWBZP) on rotaviral gastroenteritis in children and in animal models.``METHODS Enrolled patients were divided into two groups, and one group was treated with oral re... AIM To observe the effects of Qiwei Baizhu Powder ( QWBZP) on rotaviral gastroenteritis in children and in animal models.``METHODS Enrolled patients were divided into two groups, and one group was treated with oral rehydration solution(ORS) and the other treated with oral liquid of QWBZP. Neonate mice were orally infected with 50 μLrotavirus suspension (4 × l0s PFU/mL) and treated with ORS or oral liquid of QWBZP, respectively.``RESULTS Eighty-three cases of rotaviral gastroenteritis treated with QWBZP revealed a better efficacy than that treated with ORS (x2 - 10.8T, P<0.05). The contents of sodium and glucose as well as number of patients with positive human rotavirus antigen in stool in QWBZP group were all less than that in ORS group. In animal models,QWBZP was found effective in treating rotavirus gastroenteritis in neonate NIH mice, as compared with control groups. In QWBZP group, the mortality of infected mice was decreased by 73.3%, the body weight of infected mice was increased, the contents of sodium and glucose as well as number of mice with positive rotavirus antigen in feces were significantly reduced, and the pathological changes such as damage of small intestinal mucosa and villi were also obviously alleviated.``CONCLUSION QWBZP has effects on improving the absorptive function of small intestine, shortening the duration of diarrhea and rotavirus shedding from stool and alleviating the pathological changes of small intestine induced by rotavirus. 展开更多
关键词 gastroenteritis/drug THERAPY ROTAVIRUS infectionsdrug therapy: Qiwei baizhu powder/therapeutic use disease models ANIMAL
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