Amplitude-integrated EEG (aEEG) is a popular method for monitoring cerebral function. Although various commercial aEEG recorders have been produced, a detailed aEEG algorithm currently is not available. The upper and ...Amplitude-integrated EEG (aEEG) is a popular method for monitoring cerebral function. Although various commercial aEEG recorders have been produced, a detailed aEEG algorithm currently is not available. The upper and lower margins in the aEEG tracing are the discriminating features for data inspection and tracing classification. However, most aEEG devices require that these margins be measured semi-subjectively. This paper proposes a step-by-step signal-processing method to calculate a compact aEEG tracing and the upper/lower margin using raw EEG data. The high accuracy of the algorithm was verified by comparison with a recognized commercial aEEG device based on a representative testing dataset composed of 72 aEEG data. The introduced digital algorithm achieved compact aEEG tracing with a small data size. Moreover, the algorithm precisely represented the upper and lower margins in the tracing for objective data interpretation. The described method should facilitate aEEG signal processing and further establish the clinical and experimental application of aEEG methods.展开更多
目的:探讨早产儿振幅整合脑电图(aEEG)评分、血清乳酸脱氢酶(LDH)水平与脑损伤严重程度相关性,并分析其对脑损伤发生的评估价值。方法:回顾性选取2021年1月至2023年6月于漯河市中心医院出生的早产儿212例为研究对象,依据出生后是否发生...目的:探讨早产儿振幅整合脑电图(aEEG)评分、血清乳酸脱氢酶(LDH)水平与脑损伤严重程度相关性,并分析其对脑损伤发生的评估价值。方法:回顾性选取2021年1月至2023年6月于漯河市中心医院出生的早产儿212例为研究对象,依据出生后是否发生脑损伤分为发生组86例、未发生组126例。比较两组aEEG评分、血清LDH水平及出生后5 min Apgar评分、新生儿神经学评分(NBNA)。依据脑损伤严重程度脑损伤发生组分为轻度27例、中度38例、重度21例,比较两组aEEG评分、血清LDH水平,从而分析aEEG评分、血清LDH水平与脑损伤严重程度、出生后5 min Apgar评分、NBNA评分相关性,分析脑损伤发生的影响因素,分析aEEG评分、血清LDH水平对脑损伤的评估价值。结果:发生组aEEG评分、出生后5 min Apgar评分、NBNA评分低于未发生组,血清LDH水平高于未发生组(P<0.05);aEEG评分与出生后5 min Apgar评分、NBNA评分呈正相关,而与脑损伤严重程度呈负相关,血清LDH水平与之相反(P<0.05);妊娠期高血压疾病、妊娠期糖尿病、血清LDH水平为脑损伤发生的独立危险因素,产前使用糖皮质激素、aEEG评分为脑损伤发生的独立保护因素(P<0.05);出生后12 h aEEG评分、血清LDH水平联合检测评估脑损伤发生的AUC大于单项指标评估(P<0.05)。结论:aEEG评分、血清LDH水平与早产儿脑损伤严重程度密切相关,联合检测对脑损伤发生具有一定评估价值。展开更多
文摘Amplitude-integrated EEG (aEEG) is a popular method for monitoring cerebral function. Although various commercial aEEG recorders have been produced, a detailed aEEG algorithm currently is not available. The upper and lower margins in the aEEG tracing are the discriminating features for data inspection and tracing classification. However, most aEEG devices require that these margins be measured semi-subjectively. This paper proposes a step-by-step signal-processing method to calculate a compact aEEG tracing and the upper/lower margin using raw EEG data. The high accuracy of the algorithm was verified by comparison with a recognized commercial aEEG device based on a representative testing dataset composed of 72 aEEG data. The introduced digital algorithm achieved compact aEEG tracing with a small data size. Moreover, the algorithm precisely represented the upper and lower margins in the tracing for objective data interpretation. The described method should facilitate aEEG signal processing and further establish the clinical and experimental application of aEEG methods.
文摘目的:探讨早产儿振幅整合脑电图(aEEG)评分、血清乳酸脱氢酶(LDH)水平与脑损伤严重程度相关性,并分析其对脑损伤发生的评估价值。方法:回顾性选取2021年1月至2023年6月于漯河市中心医院出生的早产儿212例为研究对象,依据出生后是否发生脑损伤分为发生组86例、未发生组126例。比较两组aEEG评分、血清LDH水平及出生后5 min Apgar评分、新生儿神经学评分(NBNA)。依据脑损伤严重程度脑损伤发生组分为轻度27例、中度38例、重度21例,比较两组aEEG评分、血清LDH水平,从而分析aEEG评分、血清LDH水平与脑损伤严重程度、出生后5 min Apgar评分、NBNA评分相关性,分析脑损伤发生的影响因素,分析aEEG评分、血清LDH水平对脑损伤的评估价值。结果:发生组aEEG评分、出生后5 min Apgar评分、NBNA评分低于未发生组,血清LDH水平高于未发生组(P<0.05);aEEG评分与出生后5 min Apgar评分、NBNA评分呈正相关,而与脑损伤严重程度呈负相关,血清LDH水平与之相反(P<0.05);妊娠期高血压疾病、妊娠期糖尿病、血清LDH水平为脑损伤发生的独立危险因素,产前使用糖皮质激素、aEEG评分为脑损伤发生的独立保护因素(P<0.05);出生后12 h aEEG评分、血清LDH水平联合检测评估脑损伤发生的AUC大于单项指标评估(P<0.05)。结论:aEEG评分、血清LDH水平与早产儿脑损伤严重程度密切相关,联合检测对脑损伤发生具有一定评估价值。
