Amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) coated on a kind of small particle silica gel was pre-pared. On this ADMPC chiral stationary phase (CSP), the direct enantiomeric separation of six novel chiral transi...Amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) coated on a kind of small particle silica gel was pre-pared. On this ADMPC chiral stationary phase (CSP), the direct enantiomeric separation of six novel chiral transi-tion metal tetrahedral clusters has firstly been achieved using n-hexane as the mobile phase containing various al-cohols as modifiers. The effect of mobile phase modifiers and the structural variation of the solutes on their reten-tion factors (k) and resolutions (Rs) were investigated. The result suggests that not only the structure and concentra-tion of alcohol in mobile phase, but also the structural differences in racemates can have a pronounced effect on enantiomeric separation. ADMPC-CSP is a suitable CSP for the optical resolution of chiral tetrahedral cluster by HPLC.展开更多
Amylose tris(3,5 dimethphenylcarbamate) was synthesized and used as the chiral stationary phase upon adsorption over silica gel. This stationary phase offered a practically useful chiral column with a high enantiomer ...Amylose tris(3,5 dimethphenylcarbamate) was synthesized and used as the chiral stationary phase upon adsorption over silica gel. This stationary phase offered a practically useful chiral column with a high enantiomer separability. Amylose was allowed to react with an excess of 3,5 dimethphenylcarbamate in pyridine for 48h. The obtained carbamate was dissolved and adsorbed on silica gel which has been treated with 3 aminopropyltriethoxysilane. The weight ratio of the carbamate to the silica gel was 0.45/2.55. The quizalofop was resoluted on amylose tris(3,5 dimethphenylcarbamate) chiral stationary phase. Separation was carried out with a hexane/2 propanol mixture at a flow rate of 0.5 mL·min -1 at room temperature. The effects of 2 propanol concentration on the retention and resolution had been investigated.展开更多
The influence of different alcohol modifiers in mobile phase on the chiral separation of 4-methoxyl flavanone, 5-methoxyl flavanone and 6-methoxyl flavanone on cellulose tris (3, 5-dimethylphenylcarbamate) (CDMPC) col...The influence of different alcohol modifiers in mobile phase on the chiral separation of 4-methoxyl flavanone, 5-methoxyl flavanone and 6-methoxyl flavanone on cellulose tris (3, 5-dimethylphenylcarbamate) (CDMPC) column was studied and the chiral recognition mechanism was discussed. Using hexane-tert-butanol (1.31 mol L-1) as the mobile phase, those three methoxyl flavanones were excellently separated on CDMPC chiral column.展开更多
基金Project supported by Chinese Academy of Science (No. KY95-S1-205).
文摘Amylose tris(3,5-dimethylphenylcarbamate) (ADMPC) coated on a kind of small particle silica gel was pre-pared. On this ADMPC chiral stationary phase (CSP), the direct enantiomeric separation of six novel chiral transi-tion metal tetrahedral clusters has firstly been achieved using n-hexane as the mobile phase containing various al-cohols as modifiers. The effect of mobile phase modifiers and the structural variation of the solutes on their reten-tion factors (k) and resolutions (Rs) were investigated. The result suggests that not only the structure and concentra-tion of alcohol in mobile phase, but also the structural differences in racemates can have a pronounced effect on enantiomeric separation. ADMPC-CSP is a suitable CSP for the optical resolution of chiral tetrahedral cluster by HPLC.
文摘Amylose tris(3,5 dimethphenylcarbamate) was synthesized and used as the chiral stationary phase upon adsorption over silica gel. This stationary phase offered a practically useful chiral column with a high enantiomer separability. Amylose was allowed to react with an excess of 3,5 dimethphenylcarbamate in pyridine for 48h. The obtained carbamate was dissolved and adsorbed on silica gel which has been treated with 3 aminopropyltriethoxysilane. The weight ratio of the carbamate to the silica gel was 0.45/2.55. The quizalofop was resoluted on amylose tris(3,5 dimethphenylcarbamate) chiral stationary phase. Separation was carried out with a hexane/2 propanol mixture at a flow rate of 0.5 mL·min -1 at room temperature. The effects of 2 propanol concentration on the retention and resolution had been investigated.
文摘The influence of different alcohol modifiers in mobile phase on the chiral separation of 4-methoxyl flavanone, 5-methoxyl flavanone and 6-methoxyl flavanone on cellulose tris (3, 5-dimethylphenylcarbamate) (CDMPC) column was studied and the chiral recognition mechanism was discussed. Using hexane-tert-butanol (1.31 mol L-1) as the mobile phase, those three methoxyl flavanones were excellently separated on CDMPC chiral column.
