Short anagen syndrome is a relatively recently described entity. This syndrome is an unusual condition where the anagen growth phase of hair follicles is shorter than normal. Its clinical characteristics and trichogra...Short anagen syndrome is a relatively recently described entity. This syndrome is an unusual condition where the anagen growth phase of hair follicles is shorter than normal. Its clinical characteristics and trichogram findings contribute to the diagnosis of this trichosis.展开更多
Introduction:Anagen effluvium (AE) is caused by impaired mitotic activity of matrix cells in the hair follicles.It presents with sudden loss of hair and myelosuppression.The diagnosis is based on the clinical history,...Introduction:Anagen effluvium (AE) is caused by impaired mitotic activity of matrix cells in the hair follicles.It presents with sudden loss of hair and myelosuppression.The diagnosis is based on the clinical history,trichoscopy,and trichogram.Case presentation:A 20-year-old woman presented with sudden loss of hair following treatment with oral azathioprine.Evaluation of the TPMT were within normal limits both in genotype and phenotype levels.Hair pull test was positive.Trichoscopy revealed yellow dots and multiple black dots,empty yellow dots,dark lines,upright regrowing hairs,and circle hairs.Azathioprine was stopped,and minoxidil 5% and oral multivitamin were started.Posttreatment trichoscopic analysis revealed terminal hairs and upright regrowing hairs.Discussion:AE is characterized by abrupt loss of anagen hairs due to impaired metabolic activity.Trichoscopy in AE shows coudability hairs,black dots,exclamation mark hairs,multiple broken shafts,and regrowing hairs.Empty yellow dots,yellow dots with black dots,pigtail hairs,and dark lines were additional features in this study.Conclusion:Trichoscopy assists in the accurate diagnosis of AE.Adverse effects of azathioprine can be observed even with normal TPMT levels.Weekly monitoring is therefore of prime importance.展开更多
<strong>Background:</strong> Androgenetic alopecia (AGA) is a most common condition of hair loss. Thus, the present study aimed to investigate the effect of Trichoxidil<sup>TM</sup>, a phytocom...<strong>Background:</strong> Androgenetic alopecia (AGA) is a most common condition of hair loss. Thus, the present study aimed to investigate the effect of Trichoxidil<sup>TM</sup>, a phytocomplex obtained from a blend of essential oils, in the treatment of hair loss caused by AGA. <strong>Methods:</strong> The CCD1072Sk cells were cultured for the 24-hour cell viability assessment and cytotoxicity of Trichoxidil<sup>TM</sup>. The expression of mRNA levels from KGF, IGF-1, and VEGF in fibroblasts was evaluated by RT-qPCR. Thirty-three volunteers, diagnosed with AGA, men and women, aged between 25 and 50 years, were divided into Control group, without treatment (n = 5);Trichosol<sup>TM</sup> vehicle group, without active (n = 5);Hydroalcoholic vehicle group, without active (n = 4);Trichosol<sup>TM</sup> vehicle group, with 2.5% minoxidil (n = 5);Hydroalcoholic vehicle group, with 2.5% minoxidil (n = 5);Trichosol<sup>TM</sup> group with 2.5% Trichoxidil<sup>TM</sup> (n = 5) and Hydroalcoholic vehicle group with 2.5% Trichoxidil<sup>TM</sup> (n = 4) to dermoscopic and histologic. <strong>Results:</strong> Fibroblasts exhibited higher proliferation when treated with higher concentrations of Trichoxidil<sup>TM</sup>. Trichoxidil<sup>TM</sup> significantly increased the expression of KGF, IGF-1, and VEGF mRNA in fibroblasts cells. Analysis of the capillary density showed that Trichoxidil<sup>TM</sup> associated with Trichosol<sup>TM</sup> vehicle, was the most effective association. In addition, it was observed an increased more effectively the percentage of anagen phase and reduction of the telogen when compared to other formulations. <strong>Conclusion:</strong> Trichoxidil<sup>TM</sup> promoted proliferative effects and positively modulated the expression of growth factors IGF-1, VEGF, and KGF, being a promising candidate for the treatment of hair loss caused by AGA.展开更多
文摘Short anagen syndrome is a relatively recently described entity. This syndrome is an unusual condition where the anagen growth phase of hair follicles is shorter than normal. Its clinical characteristics and trichogram findings contribute to the diagnosis of this trichosis.
文摘Introduction:Anagen effluvium (AE) is caused by impaired mitotic activity of matrix cells in the hair follicles.It presents with sudden loss of hair and myelosuppression.The diagnosis is based on the clinical history,trichoscopy,and trichogram.Case presentation:A 20-year-old woman presented with sudden loss of hair following treatment with oral azathioprine.Evaluation of the TPMT were within normal limits both in genotype and phenotype levels.Hair pull test was positive.Trichoscopy revealed yellow dots and multiple black dots,empty yellow dots,dark lines,upright regrowing hairs,and circle hairs.Azathioprine was stopped,and minoxidil 5% and oral multivitamin were started.Posttreatment trichoscopic analysis revealed terminal hairs and upright regrowing hairs.Discussion:AE is characterized by abrupt loss of anagen hairs due to impaired metabolic activity.Trichoscopy in AE shows coudability hairs,black dots,exclamation mark hairs,multiple broken shafts,and regrowing hairs.Empty yellow dots,yellow dots with black dots,pigtail hairs,and dark lines were additional features in this study.Conclusion:Trichoscopy assists in the accurate diagnosis of AE.Adverse effects of azathioprine can be observed even with normal TPMT levels.Weekly monitoring is therefore of prime importance.
文摘<strong>Background:</strong> Androgenetic alopecia (AGA) is a most common condition of hair loss. Thus, the present study aimed to investigate the effect of Trichoxidil<sup>TM</sup>, a phytocomplex obtained from a blend of essential oils, in the treatment of hair loss caused by AGA. <strong>Methods:</strong> The CCD1072Sk cells were cultured for the 24-hour cell viability assessment and cytotoxicity of Trichoxidil<sup>TM</sup>. The expression of mRNA levels from KGF, IGF-1, and VEGF in fibroblasts was evaluated by RT-qPCR. Thirty-three volunteers, diagnosed with AGA, men and women, aged between 25 and 50 years, were divided into Control group, without treatment (n = 5);Trichosol<sup>TM</sup> vehicle group, without active (n = 5);Hydroalcoholic vehicle group, without active (n = 4);Trichosol<sup>TM</sup> vehicle group, with 2.5% minoxidil (n = 5);Hydroalcoholic vehicle group, with 2.5% minoxidil (n = 5);Trichosol<sup>TM</sup> group with 2.5% Trichoxidil<sup>TM</sup> (n = 5) and Hydroalcoholic vehicle group with 2.5% Trichoxidil<sup>TM</sup> (n = 4) to dermoscopic and histologic. <strong>Results:</strong> Fibroblasts exhibited higher proliferation when treated with higher concentrations of Trichoxidil<sup>TM</sup>. Trichoxidil<sup>TM</sup> significantly increased the expression of KGF, IGF-1, and VEGF mRNA in fibroblasts cells. Analysis of the capillary density showed that Trichoxidil<sup>TM</sup> associated with Trichosol<sup>TM</sup> vehicle, was the most effective association. In addition, it was observed an increased more effectively the percentage of anagen phase and reduction of the telogen when compared to other formulations. <strong>Conclusion:</strong> Trichoxidil<sup>TM</sup> promoted proliferative effects and positively modulated the expression of growth factors IGF-1, VEGF, and KGF, being a promising candidate for the treatment of hair loss caused by AGA.
