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An Adaptive Control Strategy for Energy Storage Interface Converter Based on Analogous Virtual Synchronous Generator
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作者 Feng Zhao Jinshuo Zhang +1 位作者 Xiaoqiang Chen Ying Wang 《Energy Engineering》 EI 2024年第2期339-358,共20页
In the DC microgrid,the lack of inertia and damping in power electronic converters results in poor stability of DC bus voltage and low inertia of the DC microgrid during fluctuations in load and photovoltaic power.To ... In the DC microgrid,the lack of inertia and damping in power electronic converters results in poor stability of DC bus voltage and low inertia of the DC microgrid during fluctuations in load and photovoltaic power.To address this issue,the application of a virtual synchronous generator(VSG)in grid-connected inverters control is referenced and proposes a control strategy called the analogous virtual synchronous generator(AVSG)control strategy for the interface DC/DC converter of the battery in the microgrid.Besides,a flexible parameter adaptive control method is introduced to further enhance the inertial behavior of the AVSG control.Firstly,a theoretical analysis is conducted on the various components of the DC microgrid,the structure of analogous virtual synchronous generator,and the control structure’s main parameters related to the DC microgrid’s inertial behavior.Secondly,the voltage change rate tracking coefficient is introduced to adjust the change of the virtual capacitance and damping coefficient flexibility,which further strengthens the inertia trend of the DC microgrid.Additionally,a small-signal modeling approach is used to analyze the approximate range of the AVSG’s main parameters ensuring system stability.Finally,conduct a simulation analysis by building the model of the DC microgrid system with photovoltaic(PV)and battery energy storage(BES)in MATLAB/Simulink.Simulation results from different scenarios have verified that the AVSG control introduces fixed inertia and damping into the droop control of the battery,resulting in a certain level of inertia enhancement.Furthermore,the additional adaptive control strategy built upon the AVSG control provides better and flexible inertial support for the DC microgrid,further enhances the stability of the DC bus voltage,and has a more positive impact on the battery performance. 展开更多
关键词 Adaptive control analogous virtual synchronous generator DC/DC converter inertia of DC microgrid DC microgrid with PV and BES BATTERY DC bus voltage
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Network analysis of primary active compounds in Danqi analogous formulas for treating cardiovascular disease 被引量:1
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作者 Shichao Zheng Yanling Zhang Yanjiang Qiao 《Journal of Traditional Chinese Medical Sciences》 2016年第2期116-123,共8页
Objective:Used extensively to treat cardiovascular disease,Danqi analogous formulas(DQAF)include prescriptions for Danqi(DQ),Fufang Danshen(FFDS)and Qishen Yiqi(QSYQ).Differences in prescription compatibility result i... Objective:Used extensively to treat cardiovascular disease,Danqi analogous formulas(DQAF)include prescriptions for Danqi(DQ),Fufang Danshen(FFDS)and Qishen Yiqi(QSYQ).Differences in prescription compatibility result in varying emphases of DQAF in clinical application.Methods and results:Based on network analysis in this study,common and distinct mechanisms of DQAF actions on cardiovascular disease were analyzed at a systemic level.Components etargetsepathways models were developed by Cytoscape(http://www.cytoscape.org/);whereby,target information for active compounds was obtained based on the PharmMapper database(http://59.78.96.61/pharmmapper/),which was further used to search pathways using the Kyoto Encyclopedia of Genes and Genomes database(http://www.genome.jp/kegg/).Based on target and network analyses,we discovered RBP4 is a potential common target of DQAF,while mitogen-activated protein kinase 1(MAPK1)and glutathione S-transferase P were potential targets of FFDS and QSYQ,respectively.Furthermore,the potential of DQAF to treat cardiovascular disease occurs through effects on the endocrine,immune,and digestive systems,in addition to lipid,sugar and amino acid metabolic pathways.Whereas FFDS exhibits effects on Toll-like receptor,transforming growth factor beta and MAPK signaling pathways;QSYQ exerts effects on cyclic adenosine monophosphate signaling,as well as metabolism of glutathione and arachidonic acid. 展开更多
关键词 NETWORK Danqi analogous formulas DOCKING Cardiovascular diseases
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Quantum States Transfer by Analogous Bell States
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作者 MEI Di LI Chong YANG Guo-Hui SONG He-Shan 《Communications in Theoretical Physics》 SCIE CAS CSCD 2008年第2期347-350,共4页
Transmitting quantum states by channels of analogous Bell states is studied in this paper. We analyze the transmitting process. constructed the probabilitic unitary operator, and gain the largest successful transfer q... Transmitting quantum states by channels of analogous Bell states is studied in this paper. We analyze the transmitting process. constructed the probabilitic unitary operator, and gain the largest successful transfer quantum state probability. 展开更多
关键词 quantum state transfer analogous Bell state transfer quantum state probability
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Study on the Allosteric Modulators of Muscarinic M_2-Receptors Ⅱ: Synthesis of W84 Analogous with PiperazinylDithiocarbonate
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作者 RuntaoLi UlrikeHolzgrabe 《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 1999年第S1期451-451,共1页
关键词 Study on the Allosteric Modulators of Muscarinic M2-Receptors Synthesis of W84 analogous with PiperazinylDithiocarbonate
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Study on the Allosteric Modulators of Muscarinic M_2-Receptors: Synthesis of Unsymmetrical Analogous of W84
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作者 RuntaoLi UlrikeHolzgrabe 《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 1999年第S1期450-450,共1页
关键词 Study on the Allosteric Modulators of Muscarinic M2-Receptors Synthesis of Unsymmetrical analogous of W84
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Root Analogous Solid Waste Management System (RA-MSW for Biocells)
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作者 Ahmad Qasaimeh 《Journal of Environmental Protection》 2012年第8期760-766,共7页
Root Analogous Municipal Solid Waste System “RA-MSW” is a novel management system that manages waste, biogas, and leachate in bioreactor landfill. Different than conventional disposal at landfills, waste is penetrat... Root Analogous Municipal Solid Waste System “RA-MSW” is a novel management system that manages waste, biogas, and leachate in bioreactor landfill. Different than conventional disposal at landfills, waste is penetrated by synthetic roots that serve dual mission for biogas collection and leachate recirculation. RA-MSW roots are permeable hydropho- bic polymer material that are formed on-place or prefabricated at factory from recyclable material available on the dumping area. Since the material is hydrophobic, it does not contain water in the voids providing more space for gas transport and collection. The roots are also interchangeably used for leachate recirculation where the parameters of wa- ter content, nutrients, pH, and temperature are optimized to enhance biogas production simultaneously with leachate treatment. RA-MSW provides new approach of waste management and control;it has new virtues of landfill operation;new material medium for biogas collection;new biocell design configuration;new manipulation for leachate and biogas. The approach adds new merits for solid waste management, bio-energy utilization, and the concept of 5 R’s cycle for MSW management. 展开更多
关键词 ROOT ANALOGY RA Municipal Solid Waste Management Biogas LEACHATE Biocell 5 R’s Cycle
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The Hybrid Power Mean Involving the Character Sum of Polynomials and a Sum Analogous to Kloosterman Sum
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作者 LU Xingxing ZHANG Wenpeng 《数学进展》 CSCD 北大核心 2024年第6期1199-1209,共11页
The main purpose of this paper is using the properties of the classical Gauss sum and the analytic methods to study the computational problem of one kind of hybrid power mean involving the character sum of polynomials... The main purpose of this paper is using the properties of the classical Gauss sum and the analytic methods to study the computational problem of one kind of hybrid power mean involving the character sum of polynomials and a sum analogous to Kloosterman sum mod p,an odd prime,and give two sharp asymptotic formulae for them. 展开更多
关键词 character sum of polynomials a sum analogous to Kloosterman sum hybrid power mean the classical Gauss sum analytic method asymptotic formula
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Ti_(3)C_(2)T_(x)-TiSe_(2) analogous heterostructure for flexible zinc ion battery
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作者 Li Wen Junjie Shi +7 位作者 Qixiang Zhang Fei Wang Siliang Wang Shaojun Zhang Qiang Wang Ke Mao Fei Long Yihua Gao 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2023年第19期225-232,共8页
Exploring zinc-free anode materials is one of the effective strategies to get the zinc dendrites problem of flexible zinc ion battery(ZIB)solved.In this work,an analogous heterostructure(AHS)is constructed from the ex... Exploring zinc-free anode materials is one of the effective strategies to get the zinc dendrites problem of flexible zinc ion battery(ZIB)solved.In this work,an analogous heterostructure(AHS)is constructed from the excellent MXene(Ti_(3)C_(2)T_(x))and TiSe_(2) nanosheets.The AHS not only possesses numerous diffu-sion paths and Zn^(2+)storage sites but also possesses a stable conductive network to accelerate charge transfer in the electrode.As a collaborative advantage,electrochemical measurement results show that MXene/TiSe_(2) electrodes display an excellent specific capacity of 177.9 mAh g^(-1) at 0.10 A g^(-1) and a long-term cycling stability of 77.4%capacity retention after 400 cycles.DFT computations further demon-strate the excellent performance of MXene/TiSe_(2) electrodes including desirable electronic conductivity and low Zn^(2+)migration barriers.The assembled flexible ZIB not only delivers a good specific capacity of 42.2μAh cm^(-2) at 0.20 mA cm^(-2) and a competitive energy density of 37.4μWh cm^(-2) but also exhibits excellent flexibility and thermostability.Furthermore,after 400 cycles at 0.60 A g^(-1),flexible ZIB shows a capacity retention of 73.8%.This work gives a successful attempt to design 2D layered materials as Zn metal-free anode for flexible ZIB. 展开更多
关键词 Flexible zinc ion battery analogous heterostructure Zinc dendrite Zinc free metal anode MXene flakes TiSe_(2)nanosheets
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Advancements in medical treatment for pancreatic neuroendocrine tumors:A beacon of hope 被引量:1
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作者 Somdatta Giri Jayaprakash Sahoo 《World Journal of Gastroenterology》 SCIE CAS 2024年第12期1670-1675,共6页
This editorial highlights the remarkable advancements in medical treatment strategies for pancreatic neuroendocrine tumors(pan-NETs),emphasizing tailored approaches for specific subtypes.Cytoreductive surgery and soma... This editorial highlights the remarkable advancements in medical treatment strategies for pancreatic neuroendocrine tumors(pan-NETs),emphasizing tailored approaches for specific subtypes.Cytoreductive surgery and somatostatin analogs(SSAs)play pivotal roles in managing tumors,while palliative options such as molecular targeted therapy,peptide receptor radionuclide therapy,and chemotherapy are reserved for SSA-refractory patients.Gastrinomas,insul-inomas,glucagonomas,carcinoid tumors and VIPomas necessitate distinct thera-peutic strategies.Understanding the genetic basis of pan-NETs and exploring immunotherapies could lead to promising avenues for future research.This review underscores the evolving landscape of pan-NET treatment,offering renewed hope and improved outcomes for patients facing this complex disease. 展开更多
关键词 Pancreatic neuroendocrine tumor Medical management Somatostatin analog IMMUNOTHERAPY EVEROLIMUS
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Progress on Transition Metal Ions Dissolution Suppression Strategies in Prussian Blue Analogs for Aqueous Sodium-/Potassium-Ion Batteries 被引量:1
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作者 Wenli Shu Junxian Li +3 位作者 Guangwan Zhang Jiashen Meng Xuanpeng Wang Liqiang Mai 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第7期142-168,共27页
Aqueous sodium-ion batteries(ASIBs)and aqueous potassium-ion batteries(APIBs)present significant potential for large-scale energy storage due to their cost-effectiveness,safety,and environmental compatibility.Nonethel... Aqueous sodium-ion batteries(ASIBs)and aqueous potassium-ion batteries(APIBs)present significant potential for large-scale energy storage due to their cost-effectiveness,safety,and environmental compatibility.Nonetheless,the intricate energy storage mechanisms in aqueous electrolytes place stringent require-ments on the host materials.Prussian blue analogs(PBAs),with their open three-dimensional framework and facile synthesis,stand out as leading candidates for aqueous energy storage.However,PBAs possess a swift capacity fade and limited cycle longevity,for their structural integrity is compromised by the pronounced dis-solution of transition metal(TM)ions in the aqueous milieu.This manuscript provides an exhaustive review of the recent advancements concerning PBAs in ASIBs and APIBs.The dissolution mechanisms of TM ions in PBAs,informed by their structural attributes and redox processes,are thoroughly examined.Moreover,this study delves into innovative design tactics to alleviate the dissolution issue of TM ions.In conclusion,the paper consolidates various strategies for suppressing the dissolution of TM ions in PBAs and posits avenues for prospective exploration of high-safety aqueous sodium-/potassium-ion batteries. 展开更多
关键词 Prussian blue analogs Transition metal ions dissolution Suppression strategies Aqueous sodium-ion batteries Aqueous potassium-ion batteries
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STUDIES ON THE ANALOGOUS RHYTHM PHENOMENON IN COUPLED OCEANATMOSPHERE SYSTEM 被引量:3
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作者 黄建平 丑纪范 《Science China Chemistry》 SCIE EI CAS 1990年第7期851-860,共10页
In this paper, the dynamical forming mechanism of analogous rhythm phenomenon is studied by using a coupled ocean-atmosphere model in form of analogous discrepance. The results show that the analogous rhythm is non-un... In this paper, the dynamical forming mechanism of analogous rhythm phenomenon is studied by using a coupled ocean-atmosphere model in form of analogous discrepance. The results show that the analogous rhythm is non-uniform oscillation of analogous discrepance disturbance which is caused by the nonlinear coupled interaction of ocean-air system and the seasonal variation of monthly mean circulation. Then, the numerical simulations and sensitivity studies are conducted by using a global coupled ocean-atmosphere dynamical-statistical seasonal long-range numerical prediction model, the results not only prove the result of theoretical analysis, but also provide the basis of making seasonal long-range numerical prediction by using this model. 展开更多
关键词 analogous RHYTHM COUPLED OCEAN-ATMOSPHERE analogous discrepance
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Oilfield analogy and productivity prediction based on machine learning: Field cases in PL oilfield, China
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作者 Wen-Peng Bai Shi-Qing Cheng +3 位作者 Xin-Yang Guo Yang Wang Qiao Guo Chao-Dong Tan 《Petroleum Science》 SCIE EI CAS CSCD 2024年第4期2554-2570,共17页
In the early time of oilfield development, insufficient production data and unclear understanding of oil production presented a challenge to reservoir engineers in devising effective development plans. To address this... In the early time of oilfield development, insufficient production data and unclear understanding of oil production presented a challenge to reservoir engineers in devising effective development plans. To address this challenge, this study proposes a method using data mining technology to search for similar oil fields and predict well productivity. A query system of 135 analogy parameters is established based on geological and reservoir engineering research, and the weight values of these parameters are calculated using a data algorithm to establish an analogy system. The fuzzy matter-element algorithm is then used to calculate the similarity between oil fields, with fields having similarity greater than 70% identified as similar oil fields. Using similar oil fields as sample data, 8 important factors affecting well productivity are identified using the Pearson coefficient and mean decrease impurity(MDI) method. To establish productivity prediction models, linear regression(LR), random forest regression(RF), support vector regression(SVR), backpropagation(BP), extreme gradient boosting(XGBoost), and light gradient boosting machine(Light GBM) algorithms are used. Their performance is evaluated using the coefficient of determination(R^(2)), explained variance score(EV), mean squared error(MSE), and mean absolute error(MAE) metrics. The Light GBM model is selected to predict the productivity of 30 wells in the PL field with an average error of only 6.31%, which significantly improves the accuracy of the productivity prediction and meets the application requirements in the field. Finally, a software platform integrating data query,oil field analogy, productivity prediction, and knowledge base is established to identify patterns in massive reservoir development data and provide valuable technical references for new reservoir development. 展开更多
关键词 Data mining technique Analogy parameters Oilfield analogy Productivity prediction Software platform
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Trifunctional robust electrocatalysts based on 3D Fe/N-doped carbon nanocubes encapsulating Co4N nanoparticles for efficient battery-powered water electrolyzers
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作者 Hyung Wook Choi Hongdae Lee +8 位作者 Jun Lu Seok Bin Kwon Dong In Jeong Beum Jin Park Jiwon Kim Bong Kyun Kang Gun Jang Dae Ho Yoon Ho Seok Park 《Carbon Energy》 SCIE EI CAS CSCD 2024年第6期124-139,共16页
Herein,we have designed a highly active and robust trifunctional electrocatalyst derived from Prussian blue analogs,where Co_(4)N nanoparticles are encapsulated by Fe embedded in N-doped carbon nanocubes to synthesize... Herein,we have designed a highly active and robust trifunctional electrocatalyst derived from Prussian blue analogs,where Co_(4)N nanoparticles are encapsulated by Fe embedded in N-doped carbon nanocubes to synthesize hierarchically structured Co_(4)N@Fe/N-C for rechargeable zinc-air batteries and overall water-splitting electrolyzers.As confirmed by theoretical and experimental results,the high intrinsic oxygen reduction reaction,oxygen evolution reaction,and hydrogen evolution reaction activities of Co_(4)N@Fe/N-C were attributed to the formation of the heterointerface and the modulated local electronic structure.Moreover,Co_(4)N@Fe/N-C induced improvement in these trifunctional electrocatalytic activities owing to the hierarchical hollow nanocube structure,uniform distribution of Co_(4)N,and conductive encapsulation by Fe/N-C.Thus,the rechargeable zinc-air battery with Co_(4)N@Fe/N-C delivers a high specific capacity of 789.9 mAh g^(-1) and stable voltage profiles over 500 cycles.Furthermore,the overall water electrolyzer with Co_(4)N@Fe/N-C achieved better durability and rate performance than that with the Pt/C and IrO2 catalysts,delivering a high Faradaic efficiency of 96.4%.Along with the great potential of the integrated water electrolyzer powered by a zinc-air battery for practical applications,therefore,the mechanistic understanding and active site identification provide valuable insights into the rational design of advanced multifunctional electrocatalysts for energy storage and conversion. 展开更多
关键词 battery-powered electrolyzers hierarchical structure Prussian blue analog trifunctional electrocatalyst zinc-air battery
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Discovery of a geomorphological analog to Martian araneiforms in the Qaidam Basin, Tibetan Plateau
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作者 Shengxing Zhang Yiliang Li Wei Leng 《中国科学技术大学学报》 CAS CSCD 北大核心 2024年第5期1-9,I0006,共10页
Araneiforms are spider-like ground patterns that are widespread in the southern polar regions of Mars.A gas erosion process driven by the seasonal sublimation of CO_(2) ice was proposed as an explanation for their for... Araneiforms are spider-like ground patterns that are widespread in the southern polar regions of Mars.A gas erosion process driven by the seasonal sublimation of CO_(2) ice was proposed as an explanation for their formation,which cannot occur on Earth due to the high climatic temperature.In this study,we propose an alternative mechanism that attrib-utes the araneiform formation to the erosion of upwelling salt water from the subsurface,relying on the identification of the first terrestrial analog found in a playa of the Qaidam Basin on the northern Tibetan Plateau.Morphological analysis indicates that the structures in the Qaidam Basin have fractal features comparable to araneiforms on Mars.A numerical model is developed to investigate the araneiform formation driven by the water-diffusion mechanism.The simulation res-ults indicate that the water-diffusion process,under varying ground conditions,may be responsible for the diverse aranei-form morphologies observed on both Earth and Mars.Our numerical simulations also demonstrate that the orientations of the saltwater diffusion networks are controlled by pre-existing polygonal cracks,which is consistent with observations of araneiforms on Mars and Earth.Our study thus suggests that a saltwater-related origin of the araneiform is possible and has significant implications for water searches on Mars. 展开更多
关键词 araneiform landform subsurface water Qaidam Basin Mars analog fractal simulations
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Quantifying the chemical composition of weathering products of Hainan basalts with reflectance spectroscopy and its implications for Mars
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作者 Xing Wu JiaCheng Liu +5 位作者 WeiChao Sun Yang Liu Joseph Michalski Wei Tan XiaoRong Qin YongLiao Zou 《Earth and Planetary Physics》 EI CAS CSCD 2024年第6期854-867,共14页
With the development of the hyperspectral remote sensing technique,extensive chemical weathering profiles have been identified on Mars.These weathering sequences,formed through precipitation-driven leaching processes,... With the development of the hyperspectral remote sensing technique,extensive chemical weathering profiles have been identified on Mars.These weathering sequences,formed through precipitation-driven leaching processes,can reflect the paleoenvironments and paleoclimates during pedogenic processes.The specific composition and stratigraphic profiles mirror the mineralogical and chemical trends observed in weathered basalts on Hainan Island in south China.In this study,we investigated the laboratory reflectance spectra of a 53-m-long drilling core of a thick basaltic weathering profile collected from Hainan Island.We established a quantitative spectral model by combining the genetic algorithm and partial least squares regression(GA-PLSR)to predict the chemical properties(SiO2,Al2O3,Fe2O3)and index of laterization(IOL).The entire sample set was divided into a calibration set of 25 samples and a validation set of 12 samples.Specifically,the GA was used to select the spectral subsets for each composition,which were then input into the PLSR model to derive the chemical concentration.The coefficient of determination(R2)values on the validation set for SiO2,Al2O3,Fe2O3,and the IOL were greater than 0.9.In addition,the effects of various spectral preprocessing techniques on the model accuracy were evaluated.We found that the spectral derivative treatment boosted the prediction accuracy of the GA-PLSR model.The improvement achieved with the second derivative was more pronounced than when using the first derivative.The quantitative model developed in this work has the potential to estimate the contents of similar weathering basalt products,and thus infer the degree of alteration and provide insights into paleoclimatic conditions.Moreover,the informative bands selected by the GA can serve as a guideline for designing spectral channels for the next generation of spectrometers. 展开更多
关键词 reflectance spectroscopy weathered basalts terrestrial analog quantitative retrieval MARS
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A comprehensive review of lunar lava tube base construction and field research on a potential Earth test site
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作者 Yujie Feng Peng-Zhi Pan +3 位作者 Xuhai Tang Zhaofeng Wang Yuxin Li Altaf Hussain 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第9期1201-1216,共16页
The Moon,as the closest celestial body to the Earth,plays a pivotal role in the progression of deep space exploration,and the establishment of research outposts on its surface represents a crucial step in this mission... The Moon,as the closest celestial body to the Earth,plays a pivotal role in the progression of deep space exploration,and the establishment of research outposts on its surface represents a crucial step in this mission.Lunar lava tubes are special underground caves formed by volcanic eruptions and are considered as ideal natural shelters and scientific laboratories for lunar base construction.This paper begins with an in-depth overview of the geological origins,exploration history,and distribution locations of lunar lava tubes.Subsequently,it delves into the presentation of four distinctive advantages and typical concepts for constructing bases within lava tubes,summarizing the ground-based attempts made thus far in lunar lava tube base construction.Field studies conducted on a lava tube in Hainan revealed rock compositions similar to those found during the Apollo missions and clear lava tube structures,making it a promising analog site.Lastly,the challenges and opportunities encountered in the field of geotechnical engineering regarding the establishment of lunar lava tube bases are discussed,encompassing cave exploration technologies,in-situ testing methods,geomechanical properties under lunar extreme environments,base design and structural stability assessment,excavation and reinforcement techniques,and simulated Earth-based lava tube base. 展开更多
关键词 Lunar lava tube Lunar base construction Extraterrestrial cave exploration Earth analog site
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Michael Acceptor Pyrrolidone Derivatives and Their Activity against Diffuse Large B-cell Lymphoma
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作者 Bi-qiong ZHANG Feng-qing WANG +5 位作者 Jie YIN Xiao-tan YU Zheng-xi HU Liang-hu GU Qing-yi TONG Yong-hui ZHANG 《Current Medical Science》 SCIE CAS 2024年第5期890-901,共12页
Objective This study aimed to design and evaluate the efficacy of pyrrolidone derivatives as potential therapeutic agents against diffuse large B-cell lymphoma(DLBCL),a common and heterogeneous malignancy of the adult... Objective This study aimed to design and evaluate the efficacy of pyrrolidone derivatives as potential therapeutic agents against diffuse large B-cell lymphoma(DLBCL),a common and heterogeneous malignancy of the adult lymphohematopoietic system.Given the limitations of current therapies,there is a pressing need to develop new and effective drugs for DLBCL treatment.Methods A series of pyrrolidone derivatives were synthesized,and their antitumor activities were assessed,particularly against DLBCL cell lines.Structure-activity relationship(SAR)analysis was conducted to identify key structural components essential for activity.The most promising compound,referred to as compound 7,was selected for further mechanistic studies.The expression levels of relevant mRNA and protein were detected by RT-qPCR and Western blotting,and the expression of mitochondrial membrane potential and ROS was detected using flow cytometry for further assessment of cell cycle arrest and apoptosis.Results The compound 7 exhibited good antitumor activity among the synthesized derivatives,specifically in DLBCL cell lines.SAR analysis highlighted the critical role ofα,β-unsaturated ketones in the antitumor efficacy of these compounds.Mechanistically,compound 7 was found to induce significant DNA damage,trigger an inflammatory response,cause mitochondrial dysfunction,and disrupt cell cycle progression,ultimately leading to apoptosis of DLBCL cells.Conclusion The compound 7 has good antitumor activity and can induce multiple cellular mechanisms leading to cancer cell death.These findings warrant further investigation of the compound 7 as a potential therapeutic agent for DLBCL. 展开更多
关键词 pyrrolidone analogs Michael acceptor DNA damage mitochondrial dysfunction APOPTOSIS
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Balloon-based exposed payload designed for astrobiological research in Earth’s near space
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作者 YanQiu Wang JianXun Shen +4 位作者 Chao Wang WeiNing Li GaoHong Wang Wei Lin YuanDa Jiang 《Earth and Planetary Physics》 EI CAS CSCD 2024年第6期878-889,共12页
Earth’s near space,located in the region between 20 and 100 km above sea level,is characterized by extreme conditions,such as low temperature,low atmospheric pressure,harsh radiation,and extreme dryness.These conditi... Earth’s near space,located in the region between 20 and 100 km above sea level,is characterized by extreme conditions,such as low temperature,low atmospheric pressure,harsh radiation,and extreme dryness.These conditions are analogous to those found on the surface of Mars and in the atmosphere of Venus,making Earth’s near space a unique natural laboratory for astrobiological research.To address essential astrobiological questions,teams from the Chinese Academy of Sciences(CAS)have developed a scientific balloon platform,the CAS Balloon-Borne Astrobiology Platform(CAS-BAP),to study the effects of near space environmental conditions on the biology and survival strategies of representative organisms in this terrestrial analog.Here,we describe the versatile Biological Samples Exposure Payload(BIOSEP)loaded on the CAS-BAP with respect to its structure and function.The primary function of BIOSEP is to expose appropriate biological specimens to the harsh conditions of near space and subsequently return the exposed samples to laboratories for further analysis.Four successful flight missions in near space from 2019 to 2021 have demonstrated the high reliability and efficiency of the payload in communicating between hardware and software units,recording environmental data,exposing sample containers,protecting samples from external contamination,and recovering samples.Understanding the effects of Earth’s near space conditions on biological specimens will provide valuable insights into the survival strategies of organisms in extreme environments and the search for life beyond Earth.The development of BIOSEP and associated biological exposure experiments will enhance our understanding of the potential for life on Mars and the habitability of the atmospheric regions of other planets in the solar system and beyond. 展开更多
关键词 Earth’s near space biological sample exposure payload performance testing Mars analog ASTROBIOLOGY
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Experimental and computational optimization of Prussian blue analogues as high-performance cathodes for sodium-ion batteries:A review
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作者 Gwangeon Oh Junghoon Kim +4 位作者 Shivam Kansara Hyokyeong Kang Hun-Gi Jung Yang-Kook Sun Jang-Yeon Hwang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第6期627-662,I0015,共37页
In this review,we discuss the electrochemical properties of Prussian blue(PB)for Na^(+)storage by combining structural engineering and electrolyte modifications.We integrated experimental data and density functional t... In this review,we discuss the electrochemical properties of Prussian blue(PB)for Na^(+)storage by combining structural engineering and electrolyte modifications.We integrated experimental data and density functional theory(DFT)in sodium-ion battery(SIB)research to refine the atomic arrangements and crystal lattices and introduce substitutions and dopants.These changes affect the lattice stability,intercalation,electronic and ionic conductivities,and electrochemical performance.We unraveled the intricate structure-electrochemical behavior relationship by combining experimental data with computational models,including first-principles calculations.This holistic approach identified techniques for optimizing PB and Prussian blue analog(PBA)structu ral properties for SIBs.We also discuss the tuning of electrolytes by systematically adjusting their composition,concentration,and additives using a combination of molecular dynamics(MD)simulations and DFT computations.Our review offers a comprehensive assessment of strategies for enhancing the electrochemical properties of PB and PBAs through structural engineering and electrolyte modifications,combining experimental insights with advanced computational simulations,and paving the way for next-generation energy storage systems. 展开更多
关键词 Prussian blue analogs(PBAs) Sodium ion batteries(SIBs) Structural engineering Electrolyte modifications Experiments Density functional theory(DFT)
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Paravertebral block's effect on analgesia and inflammation in advanced gastric cancer patients undergoing transarterial chemoembolization and microwave ablation
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作者 Ying-Fen Xiong Ben-Zhong Wei +2 位作者 Yu-Feng Wang Xiao-Feng Li Cong Liu 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第1期196-204,共9页
BACKGROUND Transarterial chemoembolization(TACE)combined with microwave ablation(MWA)is an effective treatment strategy for patients with advanced gastric cancer and liver metastasis.However,it may cause severe postop... BACKGROUND Transarterial chemoembolization(TACE)combined with microwave ablation(MWA)is an effective treatment strategy for patients with advanced gastric cancer and liver metastasis.However,it may cause severe postoperative pain and inflammatory responses.The paravertebral block(PVB)is a regional anesthetic technique that provides analgesia to the thoracic and abdominal regions.AIM To evaluate the effect of PVB on postoperative analgesia and inflammatory response in patients undergoing TACE combined with MWA for advanced gastric cancer and liver metastasis.METHODS Sixty patients were randomly divided into PVB and control groups.The PVB group received ultrasound-guided PVB with 0.375%ropivacaine preoperatively,whereas the control group received intravenous analgesia with sufentanil.The primary outcome was the visual analog scale(VAS)score for pain at 6 h,12 h,24 h,and 48 h after the procedure.Secondary outcomes were the dose of sufentanil used,incidence of adverse events,and levels of inflammatory markers(white blood cell count,neutrophil percentage,C-reactive protein,and procalcitonin)before and after the procedure.RESULTS The PVB group had significantly lower VAS scores at 6 h,12 h,24 h,and 48 h after the procedure compared with the control group(P<0.05).The PVB group also had a significantly lower consumption of sufentanil and a lower incidence of nausea,vomiting,and respiratory depression than did the control group(P<0.05).Compared with the control group,the PVB group had significantly lower levels of inflammatory markers 24 h and 48 h after the procedure(P<0.05).CONCLUSION PVB can effectively reduce postoperative pain and inflammatory responses and improve postoperative comfort and recovery in patients with advanced gastric cancer and liver metastasis treated with TACE combined with MWA. 展开更多
关键词 Transarterial chemoembolization Microwave ablation Paravertebral block Visual analog scale SUFENTANIL Inflammatory markers
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