Simulation and Numerical Analysis on Anti-float Anchor by Field Rock and Soil Tests

This paper introduces the stress and deformation of anti floating anchor rod and explained the damage. Through field testing and numerical analysis, the article were studied the displacement and internal force of a basement tensile anti float anchor, results showed that： the axial force of bolt tension transfer is top-down transfer, axial force decreases, the stress concentrate on the end. When a force is applied to a certain load, end firstly generate damage, but with the deepening of the axial force, it is greatly reduced, which indicates that the anchor force is an effective length, rather than the longer the anchor pullout force is bigger; anchor group effect is a problem that can not be ignored, because the engineering community for its attention degree is not enough, so that the design of anti floating anchor the lack of a reliable basis, the test results can provide a reference for the future design of anti floating anchor. Prestressed anchors in the tension lock, prestressed loss are regularly.

A Genome‑Wide Association Study for Susceptibility to Axial Length in Highly Myopic Eyes

High myopia has long been highly prevalent worldwide with a largely yet unexplained genetic contribution.To identify novel susceptibility genes for axial length(AL)in highly myopic eyes,a genome-wide association study(GWAS)was performed using the genomic dataset of 350 deep whole-genome sequencing data from highly myopic patients.Top single nucleotide polymorphisms(SNPs)were functionally annotated.Immunofluorescence staining,quantitative polymerase chain reaction,and western blot were performed using neural retina of form-deprived myopic mice.Enrichment analyses were further performed.We identified the four top SNPs and found that ADAM Metallopeptidase With Thrombospondin Type 1 Motif 16(ADAMTS16)and Phosphatidylinositol Glycan Anchor Biosynthesis Class Z(PIGZ)had the potential of clinical signifi-cance.Animal experiments confirmed that PIGZ expression could be observed and showed higher expression level in form-deprived mice,especially in the ganglion cell layer.The messenger RNA(mRNA)levels of both ADAMTS16 and PIGZ were significantly higher in the neural retina of form-deprived eyes(p=0.005 and 0.007 respectively),and both proteins showed significantly upregulated expression in the neural retina of deprived eyes(p=0.004 and 0.042,respectively).Enrichment analysis revealed a significant role of cellular adhesion and signal transduction in AL,and also several AL-related pathways including circadian entrainment and inflammatory mediator regulation of transient receptor potential channels were proposed.In conclusion,the current study identified four novel SNPs associated with AL in highly myopic eyes and confirmed that the expression of ADAMTS16 and PIGZ was significantly upregulated in neural retina of deprived eyes.Enrichment analyses provided novel insight into the etiology of high myopia and opened avenues for future research interest.