Extravasated contrast volumetric assessment on computed tomography angiography in gastrointestinal bleeding:A useful predictor of positive angiographic findings

BACKGROUND Gastrointestinal bleeding(GIB)is a severe and potentially life-threatening condition,especially in cases of delayed treatment.Computed tomography angiography(CTA)plays a pivotal role in the early identification of upper and lower GIB and in the prompt treatment of the haemorrhage.AIM To determine whether a volumetric estimation of the extravasated contrast at CTA in GIB may be a predictor of subsequent positive angiographic findings.METHODS In this retrospective single-centre study,35 patients(22 men;median age 69 years;range 16-92 years)admitted to our institution for active GIB detected at CTA and further submitted to catheter angiography between January 2018 and February 2022 were enrolled.Twenty-three(65.7%)patients underwent endoscopy before CTA.Bleeding volumetry was evaluated in both arterial and venous phases via a semi-automated dedicated software.Bleeding rate was obtained from volume change between the two phases and standardised for unit time.Patients were divided into two groups,according to the angiographic signs and their concordance with CTA.RESULTS Upper bleeding accounted for 42.9%and lower GIB for 57.1%.Mean haemoglobin value at the admission was 7.7 g/dL.A concordance between positive CTA and direct angiographic bleeding signs was found in 19(54.3%)cases.Despite no significant differences in terms of bleeding volume in the arterial phase(0.55 mL vs 0.33 mL,P=0.35),a statistically significant volume increase in the venous phase was identified in the group of patients with positive angiography(2.06 mL vs 0.9 mL,P=0.02).In the latter patient group,a significant increase in bleeding rate was also detected(2.18 mL/min vs 0.19 mL/min,P=0.02).CONCLUSION In GIB of any origin,extravasated contrast volumetric analysis at CTA could be a predictor of positive angiography and may help in avoiding further unnecessary procedures.

Macular microvascular and structural changes on optical coherence tomography angiography in atypical optic neuritis

BACKGROUND Atypical optic neuritis,consisting of neuromyelitis optica spectrum disorders(NMOSD)or myelin oligodendrocyte glycoprotein antibody disease(MOGAD),has a very similar presentation but different prognostic implications and longterm management strategies.Vascular and metabolic factors are being thought to play a role in such autoimmune neuro-inflammatory disorders,apart from the obvious immune mediated damage.With the advent of optical coherence tomography angiography(OCTA),it is easy to pick up on these subclinical macular microvascular and structural changes.AIM To study the macular microvascular and structural changes on OCTA in atypical optic neuritis.METHODS This observational cross-sectional study involved 8 NMOSD and 17 MOGAD patients,diagnosed serologically,as well as 10 healthy controls.Macular vascular density(MVD)and ganglion cell+inner plexiform layer thickness(GCIPL)were studied using OCTA.RESULTS There was a significant reduction in MVD in NMOSD and MOGAD affected as well as unaffected eyes when compared with healthy controls.NMOSD and MOGAD affected eyes had significant GCIPL thinning compared with healthy controls.NMOSD unaffected eyes did not show significant GCIPL thinning compared to healthy controls in contrast to MOGAD unaffected eyes.On comparing NMOSD with MOGAD,there was no significant difference in terms of MVD or GCIPL in the affected or unaffected eyes.CONCLUSION Although significant microvascular and structural changes are present on OCTA between atypical optic neuritis and normal patients,they could not help in differentiating between NMOSD and MOGAD cases.

1-MCP与MT联合处理对芒果保鲜效果的影响

为探究1-甲基环丙烯(1-MCP)与褪黑素(MT)联合处理对芒果保鲜效果的影响,该研究用0.1 mg/L 1-MCP和0.2 mmol/L MT联合处理芒果后,于25℃贮藏10 d,每2 d取样测定相关指标。结果显示:1-MCP和MT联合处理可以延缓芒果果皮叶绿素降解和类胡萝卜素含量升高,在贮藏第10天,处理组的果皮叶绿素为0.078 mg/g,是对照组的5.27倍;延缓了果肉L*值的下降和a*、b*值的升高,抑制原果胶降解和可溶性果胶含量的升高,贮藏第6天处理组的原果胶含量比对照高2.53倍,而可溶性果胶含量比对照低44.04%,同时在贮藏前期显著抑制了多聚半乳糖醛酸酶(PG)和纤维素酶(Cx)活性,降低了β-半乳糖苷酶(β-Gal)活性,并且维持了果肉更完整的细胞结构,但果肉类黄酮含量在贮藏中期显著低于对照。综上,1-MCP和MT联合处理保持了芒果良好的外观品质,延缓了细胞壁物质的降解,提高了货架期品质。

50mT静磁场试验装置的研制和性能验证

为了满足有源植入式医疗器械标准中静磁场试验要求,研制了一款静磁场抗扰度试验装置。在输入电流约4.75 A条件下,该装置的磁通密度可以达到50 mT,且试验均匀域的磁通密度均匀性偏差达到2.8%。在0.055~50mT范围内,磁通密度的线性度达到了0.6%。该装置还可以实现对电压、电流、时间、温度以及电磁场曝露等参数进行有效地监控。该研究为有源植入式医疗器械的静磁场抗扰度试验提供了理论和技术支撑。

产教融合背景下基于MTS理论的金融知识学习及教学模式研究

在产教融合背景下,金融类课程的教学模式正向问题导向型转变。金融知识学习及教学通过产学协同,并匹配不同学生的学习特征和所要传授的知识特征,实现人才培养质量的提升。产教融合的模式中,混合型师资队伍建设是核心环节,通过案例研究,基于多团队系统理论,探讨产教融合背景下如何构建由校内教师、行业专家和学生组成的多元化教学团队,并分析其运行机制和效果;同时,基于学习模型的教学支持与模式创新,结合学生学习特征,对主要教学方法进行体系化梳理,并优化教学方法,形成教学方案。

基于VTI介质海洋CSEM和MT数据联合反演的黄海海相残留盆地深部结构研究

黄海海相残留盆地因其地层结构和深部地质构造的复杂性,一直是我国海洋地球科学的一项研究重点,虽然针对该研究区已开展了一系列的地球物理调查,但由于高速碳酸盐岩层对地震波存在着一定的屏蔽作用,致使该海域深部地震资料品质受到较大影响.海洋电磁法不受高速屏蔽层影响,有利于获得高速屏蔽层内部及其下方的深部结构信息.海洋可控源电磁法(Controlled source electromagnetic method,CSEM)和海洋大地电磁测深(Magnetotelleric,MT)能够提供海底电性结构的互补信息,较于单一的电磁方法,二者联合可获得更为准确的海底电性分布.本文提出了基于乘积目标函数的层状垂直各向异性(Vertical anisotropic,VTI)介质海洋可控源电磁和大地电磁资料联合反演方法,该方法在迭代过程中根据数据的拟合情况自适应调整CSEM和MT数据的权重和正则化因子的权重,反演参数包括海底介质的横向电阻率、垂向电阻率和地层厚度.以南黄海地质地球物理资料为例,建立浅水环境地电模型,并结合浅水环境的高噪声背景特点进行合成数据模型测试及分析.将本文所提出算法应用于理论模型合成数据和南黄海实测资料反演,结果表明,较于单独的海洋CSEM和MT反演,联合反演方法能够较准确地重构海底地层的电性分布,提高对海底地层各向异性电阻率的分辨能力.

Clinical profile and angiographic findings among patients with atrial fibrillation presenting for selective coronary angiography

Background: Coronary artery disease is the most common form of cardiovascular disease while Atrial fibrillation is the most common sustained arrhythmia. We set out to investigate the prevalence and clinical profile of patients with atrial fibrillation who present for selective coronary angiography and whether this has an effect on the angiogram findings and the treatment options offered to them. Methods and Results: This was a retrospectively collected database of 494 patients presenting for SCAG from 01.11.2010 to 30.11.2010 and 01.04.2010 to 30.04.2010. We collected and analyzed clinical characteristics of patients, their SCAG finding and modes of treatment offered up to discharge. 24.6% of patients had AF. They tended to be older, more commonly women, current or ex-smokers;presented with symptoms of atypical chest pain and were more likely to have a history of congestive heart failure or valvular heart disease. They had a longer hospital stay. Using CHADS-Vasc score, 83.6% were moderate to high risk for CVA. At SCAG, they were more likely to have non-significant coronary artery disease, and hence were more likely to be treated conservatively. Conclusion: AF patients presenting for SCAG constitute a unique subset of patients who despite having a higher likelihood of non-significant coronary stenosis are still prone to suffering from poorly-understood and under-appreciated myocardial ischemia.

基于调车工况的MT-2缓冲器容量需求仿真分析

为了分析MT-2缓冲器在调车连挂作业时的容量需求问题,基于摩擦式缓冲器非线性力学特性及车辆调车冲击受力特点,建立了铁道货车纵向冲击动力学模型,对调车过程中不同车辆质量、不同速度、不同编组方式及不同车体刚度等工况下MT-2缓冲器容量需求进行了分析。研究结果表明:缓冲器做功与车辆质量和连挂速度的平方成正比,冲击车和被冲击车数量都大于2辆时冲击面缓冲器的容量需求将与车辆数量无关。对同时考虑质量、速度、编组方式、车体刚度的缓冲器容量需求值进行了函数拟合,完成了比例系数κ、μ和λ的求解;不同车辆数量之间冲击时,不同车钩号的缓冲器做功值大小不一,在冲击面车钩号的缓冲器做功值均为最大,沿着冲击面前、后的车钩号逐渐递减,调车冲击时计算容量需求值时应不考虑车体刚度,以重车冲击重车模式时冲击面的缓冲器容量需求为准。

基于MT-CNN的矿井带式输送机输煤量检测技术

为实现矿井带式输送机输煤量检测的信息化、智能化,提出基于MT-CNN的矿井带式输送机输煤量检测技术。为了全面提升输煤量检测技术,从而提高矿井效益,选取了多任务卷积神经网络(MT-CNN)对检测目标进行多核心识别检测,优化了图像直线信息和边缘信息的提取效率,构建了良好的网络层次结构,优化了信息连接通道,从而全面提高图像识别分析和数据检测处理的效果。通过MT-CNN技术对输煤量的轮廓形态和荷载状态进行分析运算,经过图像样本数据训练获取矿井带式输送机输煤量的相关数据。研究结果表明,该技术能够有效提高输煤量图像识别的真实性,而检测时间缩短49%,计算结果准确率提高到98%,有效提高了输煤量检测的效率和准确度,具有较好的应用性能和良好的使用效果。加强矿井带式输送机的输煤量检测,可以为后续研究提供依据,很大程度上推动了相关技术发展,实现矿井信息化、智能化、现代化发展。

5G集约化VoLTE短信网关MT成功率提升方案研究

导致集约化VoLTE短信网关上线后MT成功率较割接前下降的三种主要原因,包括VoLTE网关对短信中心长会话保持参数识别错误、多业务处理机之间缺乏有效的协同机制、对MT短信ENUMDNS查询量过大。实施针对性改进措施后,成功率得到了显著提升。

基于MT7620A的智慧监控网关设计

针对网络摄像机不具备远程监控能力的问题,基于MT7620A设计了一种支持远程监控的智慧网关。网关使用MT7620A作为主控芯片,搭载OpenWrt系统。通过创建ONVIF客户端与同一局域网中支持ONVIF协议的监控设备进行通信,实现设备发现、信息获取、云台控制和视频流读取等功能;网关与云平台通过MQTT协议实现信令交互,云平台可以向网关发送设备管理、云台控制和视频流读取等命令;网关通过数据处理模块对命令进行解析和协议转换,实现对设备的管理,以及对监控设备云台的控制和视频流读取。网关在使用FFMPEG接口获取视频流之后,通过Socket TCP与云平台建立连接并发送视频流,保证视频流远程传输的稳定可靠。网关配有4G通信模块,避免了接入互联网受到有线网络通信的限制,双重通信方式更加有效地保障了网络传输。测试结果表明,所设计的网关能够支持云平台实现对设备的远程监控和控制。

Epidemiological, Clinical and Coronary Angiography Aspects of Acute Coronary Syndrome in the Cardiology Department of the Hospital Mother-Child “Le Luxembourg”Mali

Introduction: Cardiac catheterisation plays a fundamental role in the management of acute coronary syndrome. These explorations require heavy, complex and costly equipment and a large team of doctors, nurses and technicians with highly specialized training. Aims: To describe epidemiological, clinical and coronary angiography aspects of patients with acute coronary syndrome. Patients and Methods: Descriptive study from September 2019 to December 2023 in the Cardiology Department of the Hôpital Mère-Enfant of Bamako. Inclusion criteria were patients admitted for coronary angiography with the diagnosis of acute coronary syndrome. Results: During the study period, 1253 patients underwent coronary angiography, 596 of whom had acute coronary syndrome as an indication, representing a hospital frequency of 47%. Sex-ratio was 2.10. Mean age of patients was 58.5 ± 11.39 years. ST elevation acute coronary syndrome was the most common indication with 63.92% of cases. High blood pressure was the main cardiovascular risk factor with 58.7% of cases, and radial access approach was used in 98% of cases. Coronary angiography was pathological in 91.70% of cases (n = 548). Patients with lesions of anterior interventricular artery were 73.73% of cases. Tritruncal lesions accounted for 40.63% of cases. Conclusion: ST elevation acute coronary syndrome is the most frequent manifestation of acute coronary syndrome. Anterior interventricular artery is most often the culprit lesion for our patients.

Coronary Artery Patterns in Diabetic Patients Undergoing Diagnostic Coronary Angiography-Data from a Major Cardiac Center in Yemen

Background: Diabetes mellitus (DM) is independently associated with an increased risk of cardiovascular mortality and morbidity, including coronary artery disease (CAD). CAD is a shared burden disease and the leading cause of death in developed and developing countries. We aimed to assess the angiographic patterns of coronary arteries in patients with DM in a developing country (Yemen) as the first study. Methods: This study is a cross-sectional, prospective, observational study that includes a total of 250 patients who were admitted for elective diagnostic coronary angiography. Results: 96 (38.4%) patients were diabetics;68% were male;mean age was 57 ± 11 years. The incidence of three-vessel disease was 31.2% of patients. Considering the severity of lumen occlusion, (11.2%) of patients had non-significant lesions, (37.6%) of patients had significant lesions, and (32%) had total occlusive lesions. Lesions were of LAD in 76%, RCA in 60%, and LCX in 52% of the population. Among diabetics, two and 3-vessel diseases (33.3% vs. 20.8% & 50% vs. 19.5%, P = 0.001), left main lesion (10.4% vs. 2.6%, P = 0.012), significant stenosis (41.7% vs. 35.1%, P = 0.032), total occlusion of coronary arteries (43.8% vs. 19.5%, P = 0.032) and type C lesion (66.7% vs. 35.1%, P = 0.010) were more frequent than non-DM patients. Conclusion: The burden of significant and severe coronary lesions is more common among DM, which may be the major cause of morbidity and mortality of DM in developing countries.

The diagnostic yield for computed tomography pulmonary angiography in patients with anticoagulation

BACKGROUND:Patients who present to the emergency department(ED)for suspected pulmonary embolism(PE)are often on active oral anticoagulation(AC).However,the diagnostic yield of computed tomography pulmonary angiography(CTPA)in screening for PE in patients who present on AC has not been well characterized.We aim to investigate the diagnostic yield of CTPA in diagnosing PE depending on AC status.METHODS:We reviewed and analyzed the electronic medical records of patients who underwent CTPA for PE at a university hospital ED from June 1,2019,to March 25,2022.Primary outcome was the incidence of PE on CTPA depending on baseline AC status and indication for AC.RESULTS:Of 2,846 patients,242 were on AC for a history of venous thromboembolism(VTE),210 were on AC for other indications,and 2,394 were not on AC.The incidence of PE on CTPA was significantly lower in patients on AC for other indications(5.7%)when compared to patients on AC for prior VTE(24.3%)and patients not on AC at presentation(9.8%)(P<0.001).In multivariable analysis among the whole cohort,AC was associated with a positive CTPA(odds ratio[OR]0.26,95%confidence interval[CI]:0.15-0.45,P<0.001).CONCLUSION:The incidence of PE among patients undergoing CTPA in the ED is lower in patients previously on AC for indications other than VTE when compared to those not on AC or those on AC for history of VTE.AC status and indication for AC may affect pre-test probability of a positive CTPA,and AC status therefore warrants consideration as part of future diagnostic algorithms among patients with suspected PE.

CSAMT、MT等电磁法在矿山地质勘探中技术参数研究

目前,在矿山地质勘探中广泛采用CSAMT、MT等电磁法,但该类电磁法均存在电磁干扰影响因素,都存在其所对应地质条件的最佳工作技术参数,为了降低野外数据采集工作过程中电磁干扰并达到最佳工作目标任务要求,本文通过作者十几年来积累的关于CSAMT、MT在各种不同矿山地质条件下的工作经验及试验结论,总结得出该类电磁法在一定地质条件下的最佳工作技术参数,将为今后在不同矿山、不同地质条件下开展该相关方法提供参考示范。

抗肿瘤肽Mt5对人肝癌细胞增殖和凋亡的影响及机制

目的探讨抗肿瘤肽Mt5通过磷脂酰肌醇-3激酶(PI3K)/蛋白激酶B(AKT)信号通路对人肝癌细胞增殖与凋亡的影响。方法采用pymol构建Mt5的三维可视化结构示意图,Prot Param分析Mt5的正电荷和疏水性,NPS分析Mt5的α-螺旋所占比例;运用实时无标记细胞分析(RTCA)技术检测不同浓度Mt5(50 mg/L、100mg/L、200 mg/L、400 mg/L)作用后的HepG2细胞活力;通过实时荧光定量PCR法(qRT-PCR)法检测不同浓度Mt5(25 mg/L、50 mg/L、100 mg/L)作用后HepG2细胞中PI3K、AKT信使RNA(mRNA)表达;以Western blot法检测不同浓度Mt5(25 mg/L、50 mg/L、100 mg/L)作用后凋亡相关蛋白B细胞淋巴瘤-2蛋白(Bcl-2)、Bcl-2相关X蛋白(bax)和PI3K、AKT蛋白表达。结果生物学信息结果表明,Mt5的正电荷为+8,疏水性为0.588,α-螺旋度为84.62%;RTCA结果显示Mt5不同浓度处理组作用后,HepG2细胞指数随着Mt5浓度的增大和时间的延长逐渐降低至0以下;qPCR结果显示,Mt5组HepG2细胞中PI3K和AKT mRNA较阴性对照组表达降低(P<0.05),bax蛋白表达较阴性对照组升高(P<0.05),且呈浓度依赖性;Western blot结果显示,Mt5组HepG2细胞中Bcl-2、PI3K及AKT蛋白表达较阴性对照组降低(P<0.05),且呈浓度依赖性。结论Mt5可抑制人肝癌细胞增殖及诱导细胞凋亡,其机制可能与抑制PI3K/AKT信号通路有关。

0D-1D coupling model and 3D fluid-structure interaction model based on coronary CT angiography for displaying hemodynamic characteristics of coronary artery stenosis

Objective To observe value of 0D-1D coupling model and 3D fluid-structure interaction(FSI)model based on coronary CT angiography(CCTA)for displaying hemodynamic characteristics of coronary artery stenosis.Methods Based on CCTA data of the stenosed left anterior descending branch(LAD)in a patient with coronary heart disease,an 0D-1D coupling model and 3D FSI model were built,respectively.Then hemodynamic characteristic indexes,including the pressure,flow velocity and wall shear stress(WSS)were obtained in every 0.01 s during 1 s at 5 sampling points(i.e.sampling point 1—5)using these 2 models,respectively,and the consistencies of the results between models were evaluated with Spearman correlation coefficient r s.Results The time consuming for construction of 0D-1D coupling model and 3D FSI model was 0.033 min and 704 min,respectively.Both models showed basically distribution of the pressure,flow velocity and WSS of the stenosed LAD.For more details,the pressure at the stenosed segment of LAD and the proximal segment of stenosis were both higher,which gradually decreased at the distal segment of stenosis,and the flow velocity at the proximal segment of stenosis was in a relatively slow and uniform condition,with significantly increased flow velocity and WSS at the stenosed segment.Compared with 3D FSI model,0D-1D vascular coupling model was relatively unrefined and lack of distal flow lines when displaying blood flow velocity.For sampling point 2 at the stenosed segment of LAD,no significant consistency for pressure between 2 models was found(P=0.118),but strong consistency for the flow velocity and WSS(r s=0.730,0.807,both P<0.05).The consistencies of pressure,flow velocity and WSS between 2 models at the proximal and distal segment of stenosis,i.e.1,3—5 sampling points were week to moderate(r s=0.237—0.669,all P<0.05).Conclusion 0D-1D coupling model exhibited outstanding computational efficiency and might provide relatively reasonable results,while 3D FSI model showed higher accuracy for details and streamline when simulating LAD stenosis.

Automatic diagnosis of diabetic retinopathy using vision transformer based on wide-field optical coherence tomography angiography

Diabetic retinopathy(DR)is one of the major causes of visual impairment in adults with diabetes.Optical coherence tomography angiography(OCTA)is nowadays widely used as the golden criterion for diagnosing DR.Recently,wide-field OCTA(WF-OCTA)provided more abundant information including that of the peripheral retinal degenerative changes and it can contribute in accurately diagnosing DR.The need for an automatic DR diagnostic system based on WF-OCTA pictures attracts more and more attention due to the large diabetic population and the prevalence of retinopathy cases.In this study,automatic diagnosis of DR using vision transformer was performed using WF-OCTA images(12 mm×12 mm single-scan)centered on the fovea as the dataset.WF-OCTA images were automatically classified into four classes:No DR,mild nonproliferative diabetic retinopathy(NPDR),moderate to severe NPDR,and proliferative diabetic retinopathy(PDR).The proposed method for detecting DR on the test set achieves accuracy of 99.55%,sensitivity of 99.49%,and specificity of 99.57%.The accuracy of the method for DR staging reaches up to 99.20%,which has been proven to be higher than that attained by classical convolutional neural network models.Results show that the automatic diagnosis of DR based on vision transformer and WF-OCTA pictures is more effective for detecting and staging DR.

ZNT1 Involves Cuproptosis through Regulating MTF1-conduced Expression of MT1X under Copper Overload

Industrial activities such as smelting emissions,mineral combustion and industrial wastewater discharge might lead to copper pollution in the environment.This kind of copper pollution has harmful effects on aquatic o rganisms,plants and animals through direct or indirect exposure.However,the current understanding of the toxicity of copper is rather limited.Copper overload can perturb intracellular homeostasis and induce oxidative stress and e ven cell death.Recently,cuproptosis has been identified as a copper-dependent form of cell death induced by o xidative stress in mitochondria.We uncover here that zinc transporter 1(ZNT1)is an important regulator involved in cuproptosis.Firstly,we established the copper overload-induced cell death model with the overexpression of copper importer SLC31A1 in HeLa cells.Using this model,we conducted unbiased genome-wide CRISPR-Cas9 screens in cells treated with copper.Our results revealed a significant enrichment of ZNT1 gene in both library A and library B plasmids.Knocking out of ZNT1 in HeLa cells notably prevented cuproptosis.Subsequent knockout of metal transcription factor 1(MTF1)in ZNT1-deficient cells nearly abolished their ability to resist copper-induced cell death.However,overexpression of metallothionein 1X(MT1X)in the double-knockout cells could p artially restored the resistance to cuproptosis by loss of MTF1.Mechanistically,knockout of ZNT1 could promote MT1X expression by activating MTF1.As a consequence,the interaction between MT1X and copper was e nhanced,reducing the flow of copper into mitochondria and eliminating mitochondria damage.Taken together,this study reveals the important role of ZNT1 in cuproptosis and shows MTF1-MT1X axis mediated resistance to c uproptosis.Moreover,our study will help to understand the regulatory mechanism of cellular and systemic copper homeostasis under copper overload,and present insights into novel treatments for damages caused by both genetic copper overload diseases and environmental copper contamination.

Repeatability,interocular correlation and agreement of optic nerve head vessel density in healthy eyes:a sweptsource optical coherence tomographic angiography study

AIM:To assess the repeatability,interocular correlation,and agreement of quantitative swept-source optical coherence tomography angiography(OCTA)optic nerve head(ONH)parameters in healthy subjects.METHODS:Thir ty-three healthy subjects were enrolled.The ONH of both eyes were imaged four times by a swept-source-OCTA using a 3 mm×3 mm scanning protocol.Images of the radial peripapillary capillary were analyzed by a customized Matlab program,and the vessel density,fractal dimension,and vessel diameter index were measured.The repeatability of the four scans was determined by the intraclass correlation coefficient(ICC).The most well-centered optic disc from the four repeated scans was then selected for the interocular correlation and agreement analysis using the Pearson correlation coefficient,ICC and Bland-Altman plots.RESULTS:All swept-source-OCTA ONH parameters exhibited certain repeatability,with ICC>0.760 and coefficient of variation(CoV)≤7.301%.The obvious interocular correlation was observed for papillary vessel density(ICC=0.857),vessel diameter index(ICC=0.857)and fractal dimension(ICC=0.906),while circumpapillary vessel density exhibited moderate interocular correlation(ICC=0.687).Bland-Altman plots revealed an agreement range of-5.26%to 6.21%for circumpapillary vessel density.CONCLUSION:OCTA ONH parameters demonstrate good repeatability in healthy subjects.The interocular correlations of papillary vessel density,fractal dimension and vessel diameter index are high,but the correlation for circumpapillary vessel density is moderate.