The novel chitosan microspheres grafted with beta-cyclodextrins (CMGC) wereprepared by means of the reaction of chitosan microspheres and mono-(6-p-tosyl)- beta-cyclodextrins(beta-CD-OTs-6). beta-CD-OTs-6 were gained ...The novel chitosan microspheres grafted with beta-cyclodextrins (CMGC) wereprepared by means of the reaction of chitosan microspheres and mono-(6-p-tosyl)- beta-cyclodextrins(beta-CD-OTs-6). beta-CD-OTs-6 were gained by the reaction of p-toluenesul-fonyl chloride (TsCl) andbeta-cyclodextrins (beta-CDs). Their structures were proved by Fourier transform infrared spectralanalysis (FT-IR), X ray powder diffraction analysis, and ^(13)C NMR; the configuration of CMGC wascharacterized by scanning electron micrograph (SEM) and transmittance electron micrograph (TEM). Theinclusion complex of CMGC with iodine was prepared and its inclusion ability was studied. Theexperimental results showed that some iodine was included with CMGC and formed a stable inclusion.The stable complex of CMGC and iodine (CMGC-1) shows good antibacterial effect.展开更多
[Objective]This paper aimed to study the anti-bacterial effect of traditional Chinese medicine on cow recessive mastitis' s main pathogenic bacteria and provide basis for its clinical application.[Method]Plating and ...[Objective]This paper aimed to study the anti-bacterial effect of traditional Chinese medicine on cow recessive mastitis' s main pathogenic bacteria and provide basis for its clinical application.[Method]Plating and test-tube methods were used to determine the anti-bacterial diameter,minimum inhibitory concentration(MIC)and minimum bactericidal concentration(MBC)of 20 kinds of traditional Chinese medicine on dairy cow recessive mastitis' s clinically isolated main pathogenic bacteria,Staphylococcus aureus and Streptococcus agalactiae.[Conclusion]The results indicated that 7 kinds of traditional Chinese medicine,Herba Taraxaci,Rhizoma Coptidis,Fructus Forsythiae,Herba Andrographis,Radix Scutellar iae,Flos Carthami,Flos Chrysanthemi Indici had strong anti-bacterial effect.展开更多
1 Introduction Yuncheng Salt Lake is an old lake with a history of more than 5000 years,which locates in the margins of the central plains of China,with an area of about 130 km.It was an important resource of salt for...1 Introduction Yuncheng Salt Lake is an old lake with a history of more than 5000 years,which locates in the margins of the central plains of China,with an area of about 130 km.It was an important resource of salt for human consumption from early times.Major chemicals in Yuncheng Salt Lake contain Na Cl,Na2SO4 and Mg SO4(Gao et al.2007).In recent years,some halophilic bacteria and archaea were展开更多
The corrosion behavior of B30 Cu-Ni alloy in a sterile seawater and a SRB solution was investigated. The results show that the corrosion potential of specimen in the SRB solution is much lower than that in the sterile...The corrosion behavior of B30 Cu-Ni alloy in a sterile seawater and a SRB solution was investigated. The results show that the corrosion potential of specimen in the SRB solution is much lower than that in the sterile seawater. The polarization resistance of specimen in the SRB solution decreases quickly after a period immersion and becomes much lower than that in the sterile seawater. It is concluded that the SRB accelerates the corrosion process of B30 Cu-Ni alloy greatly. An anti-corrosion electroless Ni-P coating was produced and applied to the alloy. The results show that specimens coated with Ni-P plating exhibit favorable corrosion resistance property in SRB solution. Severe pitting corrosion appears on the uncoated specimens in the SRB solution when the coated specimens are still in good condition. The anti-corrosion mechanism of Ni-P plating was analyzed. It is concluded that coating the B30 Cu-Ni alloy with electroless Ni-P plating is an effective technique against the attack of SRB in marine environment.展开更多
Most patients with COVID-19 disease caused by the SARS-CoV-2 virus recover from this infection, but a significant fraction progress to a fatal outcome. As with some other RNA viruses, co-infection or activation of lat...Most patients with COVID-19 disease caused by the SARS-CoV-2 virus recover from this infection, but a significant fraction progress to a fatal outcome. As with some other RNA viruses, co-infection or activation of latent bacterial infections along with pre-existing health conditions in COVID-19 disease may be important in determining a fatal disease course. Mycoplasma spp. (M. pneumonaie, M. fermentans, etc.) have been routinely found as co-infections in a wide number of clinical conditions, and in some cases this has progressed to a fatal disease. Although preliminary, Mycoplasma pneumoniae has been identified in COVID-19 disease, and the severity of some signs and symptoms in progressive COVID-19 patients could be due, in part, to Mycoplasma or other bacterial infections. Moreover, the presence of pathogenic Mycoplasma species or other pathogenic bacteria in COVID-19 disease may confer a perfect storm of cytokine and hemodynamic dysfunction, autoimmune activation, mitochondrial dysfunction and other complications that together cannot be easily corrected in patients with pre-existing health conditions. The positive responses of only some COVID-19 patients to antibiotic and anti-malaria therapy could have been the result of suppression of Mycoplasma species and other bacterial co-infections in subsets of patients. Thus it may be useful to use molecular tests to determine the presence of pathogenic Mycoplasma species and other pathogenic bacteria that are commonly found in atypical pneumonia in all hospitalized COVID-19 patients, and when positive results are obtained, these patients should treated accordingly in order to improve clinical responses and patient outcomes.展开更多
This article reviews the latest developments in understanding the pathogenesis, detection and treatment of small intestinal damage and bleeding caused by nonsteroidal anti-inflammatory drugs (NSAIDs). With improvement...This article reviews the latest developments in understanding the pathogenesis, detection and treatment of small intestinal damage and bleeding caused by nonsteroidal anti-inflammatory drugs (NSAIDs). With improvements in the detection of NSAID-induced damage in the small intestine, it is now clear that this injury and the associated bleeding occurs more frequently than that occurring in the stomach and duodenum, and can also be regarded as more dangerous. However, there are no proven-effective therapies for NSAID-enteropathy, and detection remains a challenge, particularly because of the poor correlation between tissue injury and symptoms. Moreover, recent studies suggest that commonly used drugs for protecting the upper gastrointestinal tract (i.e., proton pump inhibitors) can significantly worsen NSAID-induced damage in the small intestine. The pathogenesis of NSAID-enteropathy is complex, but studies in animal models are shedding light on the key factors that contribute to ulceration and bleeding, and are providing clues to the development of effective therapies and prevention strategies. Novel NSAIDs that do not cause small intestinal damage in animal models offer hope for a solution to this serious adverse effect of one of the most widely used classes of drugs.展开更多
文摘The novel chitosan microspheres grafted with beta-cyclodextrins (CMGC) wereprepared by means of the reaction of chitosan microspheres and mono-(6-p-tosyl)- beta-cyclodextrins(beta-CD-OTs-6). beta-CD-OTs-6 were gained by the reaction of p-toluenesul-fonyl chloride (TsCl) andbeta-cyclodextrins (beta-CDs). Their structures were proved by Fourier transform infrared spectralanalysis (FT-IR), X ray powder diffraction analysis, and ^(13)C NMR; the configuration of CMGC wascharacterized by scanning electron micrograph (SEM) and transmittance electron micrograph (TEM). Theinclusion complex of CMGC with iodine was prepared and its inclusion ability was studied. Theexperimental results showed that some iodine was included with CMGC and formed a stable inclusion.The stable complex of CMGC and iodine (CMGC-1) shows good antibacterial effect.
基金Supported by Shijiazhuang Science and Technology Development Plan Project (08150132A)The Ministry of Science and Technology Spark Plan (2012GA6200025)
文摘[Objective]This paper aimed to study the anti-bacterial effect of traditional Chinese medicine on cow recessive mastitis' s main pathogenic bacteria and provide basis for its clinical application.[Method]Plating and test-tube methods were used to determine the anti-bacterial diameter,minimum inhibitory concentration(MIC)and minimum bactericidal concentration(MBC)of 20 kinds of traditional Chinese medicine on dairy cow recessive mastitis' s clinically isolated main pathogenic bacteria,Staphylococcus aureus and Streptococcus agalactiae.[Conclusion]The results indicated that 7 kinds of traditional Chinese medicine,Herba Taraxaci,Rhizoma Coptidis,Fructus Forsythiae,Herba Andrographis,Radix Scutellar iae,Flos Carthami,Flos Chrysanthemi Indici had strong anti-bacterial effect.
基金financially supported by National Natural Science Foundation of China (grants no. 31300002)Program for the Top Young Academic Leaders of Higher Learning Institutions of ShanxiPhD Start-up Foundation of Yuncheng University (grants no. YQ-2011043)
文摘1 Introduction Yuncheng Salt Lake is an old lake with a history of more than 5000 years,which locates in the margins of the central plains of China,with an area of about 130 km.It was an important resource of salt for human consumption from early times.Major chemicals in Yuncheng Salt Lake contain Na Cl,Na2SO4 and Mg SO4(Gao et al.2007).In recent years,some halophilic bacteria and archaea were
基金Project (2005JS5144904.01) supported by the State Key Laboratory for Marine Corrosion and Protection, China
文摘The corrosion behavior of B30 Cu-Ni alloy in a sterile seawater and a SRB solution was investigated. The results show that the corrosion potential of specimen in the SRB solution is much lower than that in the sterile seawater. The polarization resistance of specimen in the SRB solution decreases quickly after a period immersion and becomes much lower than that in the sterile seawater. It is concluded that the SRB accelerates the corrosion process of B30 Cu-Ni alloy greatly. An anti-corrosion electroless Ni-P coating was produced and applied to the alloy. The results show that specimens coated with Ni-P plating exhibit favorable corrosion resistance property in SRB solution. Severe pitting corrosion appears on the uncoated specimens in the SRB solution when the coated specimens are still in good condition. The anti-corrosion mechanism of Ni-P plating was analyzed. It is concluded that coating the B30 Cu-Ni alloy with electroless Ni-P plating is an effective technique against the attack of SRB in marine environment.
文摘Most patients with COVID-19 disease caused by the SARS-CoV-2 virus recover from this infection, but a significant fraction progress to a fatal outcome. As with some other RNA viruses, co-infection or activation of latent bacterial infections along with pre-existing health conditions in COVID-19 disease may be important in determining a fatal disease course. Mycoplasma spp. (M. pneumonaie, M. fermentans, etc.) have been routinely found as co-infections in a wide number of clinical conditions, and in some cases this has progressed to a fatal disease. Although preliminary, Mycoplasma pneumoniae has been identified in COVID-19 disease, and the severity of some signs and symptoms in progressive COVID-19 patients could be due, in part, to Mycoplasma or other bacterial infections. Moreover, the presence of pathogenic Mycoplasma species or other pathogenic bacteria in COVID-19 disease may confer a perfect storm of cytokine and hemodynamic dysfunction, autoimmune activation, mitochondrial dysfunction and other complications that together cannot be easily corrected in patients with pre-existing health conditions. The positive responses of only some COVID-19 patients to antibiotic and anti-malaria therapy could have been the result of suppression of Mycoplasma species and other bacterial co-infections in subsets of patients. Thus it may be useful to use molecular tests to determine the presence of pathogenic Mycoplasma species and other pathogenic bacteria that are commonly found in atypical pneumonia in all hospitalized COVID-19 patients, and when positive results are obtained, these patients should treated accordingly in order to improve clinical responses and patient outcomes.
基金Supported by A grant from the Canadian Institutes of Health Research
文摘This article reviews the latest developments in understanding the pathogenesis, detection and treatment of small intestinal damage and bleeding caused by nonsteroidal anti-inflammatory drugs (NSAIDs). With improvements in the detection of NSAID-induced damage in the small intestine, it is now clear that this injury and the associated bleeding occurs more frequently than that occurring in the stomach and duodenum, and can also be regarded as more dangerous. However, there are no proven-effective therapies for NSAID-enteropathy, and detection remains a challenge, particularly because of the poor correlation between tissue injury and symptoms. Moreover, recent studies suggest that commonly used drugs for protecting the upper gastrointestinal tract (i.e., proton pump inhibitors) can significantly worsen NSAID-induced damage in the small intestine. The pathogenesis of NSAID-enteropathy is complex, but studies in animal models are shedding light on the key factors that contribute to ulceration and bleeding, and are providing clues to the development of effective therapies and prevention strategies. Novel NSAIDs that do not cause small intestinal damage in animal models offer hope for a solution to this serious adverse effect of one of the most widely used classes of drugs.