Study the operating conditions on agglomeration of RDX particles in anti-solvent crystallization by using statistical optimization

The unfavorable growth and agglomeration of micro-particles of RDX explosive was almost observed in manufacture process. For preventing of growth of micro-particles and agglomeration in anti-solvent crystallization process, the effect of additives glucose, sucrose and poly ethylene glycol-2000 and wetting solvent of isopropyl alcohol were studied. Taguchi experimental design was used for optimization of the operating conditions. The type of additive, the amount of additive(%wt.), solvent of wetting and wetting time were selected for optimization of the conditions. By using 4 factor and 3 levels, 27 experiments were conducted(L27). Results showed that in the presence of 2 %wt. of sucrose additive and isopropyl alcohol solvent, the agglomerations of particles were decreased so that a decrease 30-50% in the average of particles size was seen. Addition additives were effective in storage container and for reduce the agglomeration of particles during storage. Also, the agglomeration rate of particles was reduced over time at optimized conditions. Imaging optical microscopy, scanning electron microscopy(SEM), and particle size analyzer(PSA) methods were used for particles size analyzing as a response in statistical optimization and quality control of the final product. The sensitivity to some mechanical and shock stimuli on the RDX in presence of sucrose additive was tested and the obtained results showed the insignificant effect of additive on the safety properties of pure RDX.

基于3,5-二溴水杨醛席夫碱镍配合物-氧化石墨烯电化学免疫传感器检测Anti-IgG含量的研究

应用物理吸附法将羊抗人IgG抗原直接固定于3,5-二溴水杨醛席夫碱镍配合物-氧化石墨烯修饰的金电极表面,制备电化学免疫传感器。采用循环伏安法和交流阻抗法对传感器进行表征,结果表明该传感器适合检测Anti-IgG浓度。同时探讨了缓冲液pH值、扫描速度、免疫反应温度、抗原与抗体配比对循环伏安峰电流的影响,结果表明在5-100mV/s扫速范围内,峰电流与扫速呈线性。孵育最优条件为25℃,h-IgG与Anti-IgG配比为1∶1。循环伏安法研究还表明Anti-IgG浓度在0.01-260μg/L范围内,线性关系良好,相关系数r^2=0.993,检出限（S/N=3）为0.006μg/L,据此建立了检测Anti-IgG浓度的新方法。

信号分子IRAK1/4在antiβ-2GPI/β2GPI复合物诱导THP-1细胞表达TF中的作用探讨

目的:探讨IRAK1和IRAK4在antiβ-2GPI/β2GPI复合物诱导单核细胞株THP-1表达组织因子(TF)中的作用。方法:利用荧光定量PCR(Real-time PCR)、TF活性试剂盒分别检测THP-1细胞表达TF mRNA及TF活性;Western blot检测anti-β2GPI/β2GPI复合物诱导THP-1细胞表达IRAK1、磷酸化-IRAK1(p-IRAK1)、IRAK4情况;观察IRAK1/4抑制物是否干预anti-β2GPI/β2GPI复合物诱导THP-1表达TF。结果:Antiβ-2GPI/β2GPI复合物(100μg/ml)诱导THP-1细胞表达TF显著增加(P<0.05 vs control);Antiβ-2GPI/β2GPI复合物(100μg/ml)刺激THP-1细胞表达IRAK1、p-IRAK1、IRAK4(蛋白)显著升高(P<0.05 vscontrol);IRAK1/4抑制物(50μmol/L)能够阻断antiβ-2GPI/β2GPI复合物(100μg/ml)诱导THP-1表达TF及IRAK1磷酸化的效应。结论:antiβ-2GPI/β2GPI复合物诱导THP-1细胞表达TF过程中,信号分子IRAK1/4被激活进而发挥重要作用。

三维Anti de Sitter空间中Lorentzian曲面的S_t^1×S_s^1-值光锥Gauss映射的奇点分类

利用Arnol'd的Legendrian理论,对三维Anti de Sitter空间中Lorentzian曲面进行了研究.引入光维高度函数概念研究了三维Anti de Sitter空间Lorentzian曲面的S1t×S1s-值、光锥Gauss映射的奇点,进行了奇点分类,揭示了类光Causs-kronecker曲率之间的关系;并研究了Lorentzian曲面的一些基本几何性质.

On the Construction of Deepening Anti - corruption Mechanism

It needs the foundation of system and the guarantee of organizational system for anti-corruption,but it is more necessary to build and form an effective anti-corruption mechanism,so that the anti-corruption can be really put into practice. Anti-corruption mechanism refers to a organic operation system of the interaction,interconnection and constraint between the constituent elements( parts) and elements of national anti-corruption,and as a system,anti-corruption mechanism should have the characteristics of system aticness,comprehensiveness,transparency,legalization,public participation,scientific dynam ic,and internationalism. The construction of deepening anti-corruption mechanism is the need for reconstructing the ruling legitimacy of the party and the governm ent. Adhering to the principle of treating both root causes and symptoms is necessary in the construction of anti-corruption m echanism,com bating and punishing corruption is an important part of anti-corruption,and the prevention and control of corruption is the basic project of anti-corruption. Therefore,the construction of prevention and control mechanism in the anti-corruption mechanism has a more far-reaching significance.

Anti-Bacterial and Flame Retardant for Cotton Fabric by One-Bath Finishing

A research on the process of cotton fabric flame-re-tarding,anti-bacterial finishing and one-bath finish-ing of anti-bacterial and flame-retarding is discussed.The flame retardant agent was phosphorous-contained,and the bacteriostatic finishing agent named SFR-1 wassynthesized.The flame retardancy of the fabric finishedcan meet the DOC FF3-71 Children Sleepwear Stan-dard.Its bacterial inhibiting capacity can meet and ex-ceed the requirements of similar products

Testing of Anti-stripping Property of Friction Spun Core Yarn

Friction spun core yarn has two components: filament core and staple fiber sheath. Under axial rubbing action, the failure mode of the core yarn is the stripping of the sheath from the core. This paper introduces a method to test the anti - stripping property of the core yarn. With a modified Universal Testing Machine, the stripping resistance of friction spun core yarn can be continuously measured. Some factors Influencing the measurements are discussed in detail. The testing results are compared with those from a Y731 Yarn Abrasion Tester and fur - ther confirmed by weaving practice.

创新要素集聚、反腐与创新效率提升

如何实现经济高速增长向高质量发展的动能转变是新时代中国特色社会主义经济亟待破解的重要命题。既有理论研究与实践经验表明,创新驱动是实现经济高质量发展的关键突破点,而创新要素的有效集聚则是实现创新驱动的必要条件。因此,现阶段从中央政府到地方政府均大力推进创新要素的有效集聚。从理论上看,在创新要素集聚过程中,政府扮演着十分重要的角色,而腐败作为一种阻碍资源有效配置的政府行为,可能不利于创新要素的有效集聚。文章将腐败行为引入创新要素集聚与创新效率的理论分析框架中,理论分析的结论初步表明创新要素集聚有利于创新效率提升,行政腐败则抑制了这一正向效应;当反腐力度加强时,这一抑制效应可能得到一定程度上的缓解。在理论分析的基础上,文章进一步基于2002—2016年我国省级面板数据,运用Tobit空间面板回归模型、IV-Tobit模型对上述结论进行了实证检验。实证结果表明,政府主导的创新要素集聚有效促进了创新效率的提升,而腐败行为的存在则抑制了这一正向效应。该研究结论在考虑内生性问题,并进行一系列稳健性检验后依然保持一致。同时,空间计量模型的分析结果显示创新要素集聚的空间溢出效应显著为负,即各地区之间存在“各自为政”的现象,缺乏区域协同创新。进一步研究发现,党的十八大之后反腐力度的加强有效地缓解了腐败所造成的负向效应,同时也使创新要素集聚的负向空间溢出效应得到了纠偏,表明党的十八大之后的反腐行动为“创新驱动发展战略”释放了制度红利,提供了有利于创新要素有效集聚与配置的生存土壤。以上研究发现对新发展阶段我国经济高质量发展的路径选择具有一定的参考价值。据此,文章认为腐败行为的创新抑制效应意味着加强反腐力度、简政放权能够改善创新要素集聚的制度环境。反腐虽然能够降低寻求政治关联的激励,提高创新效率,但市场机制扭曲才是腐败影响创新要素集聚的根源所在。因此,现阶段应从处理好政府与市场之间的关系入手,转变政府的职能,进一步完善市场机制,最终形成以市场配置为主、以政府引导为辅的创新要素集聚模式。

逆全球化背景下区域协同创新网络抗毁性评价——以长江经济带城市群为例

从结构抗毁性和功能抗毁性两个维度构建区域协同创新网络抗毁性评价指标体系,进而提出改进的AHPCRITIC组合赋权法确定指标权重,并采用TOPSIS方法对长江经济带3个城市群协同创新网络的抗毁性水平进行综合评价。结果表明,长三角城市群的协同创新网络抗毁性水平最强,成渝城市群次之,中游城市群最低;随着时间推移,长三角城市群的抗毁性持续增强,成渝城市群呈现“V”型减弱趋势,中游城市群呈现“V”型增强趋势;从结构抗毁性看,长三角城市群持续增强,成渝城市群与中游城市群呈现“V”型增强趋势但增幅较小;从功能抗毁性看,长三角城市群与中游城市群均呈现“V”型增强趋势,而成渝城市群呈现“V”型减弱趋势。

水合物阻聚剂研究进展

相较于传统的水合物生成抑制方式,向管线中添加低剂量抑制剂的水合物风险控制策略,在深水多相集输领域防控水合物堵塞中具有显著的优势,备受国内外学术与工业界的青睐。阻聚剂是一种能在更为苛刻的高过冷度工况下,仍具有良好阻聚效果的低剂量抑制剂,可保证多相混输流体内生成的水合物以浆液呈现可输送状态。本文重点阐述了影响阻聚剂性能的关键因素,梳理了阻聚剂存在体系内水合物生成及流动的宏微观特性。总体而言,阻聚剂的性能受加剂量、含水率、矿化度、pH、溶液乳化状态及应用工况过冷度等综合因素的影响;添加阻聚剂体系的水合物浆液内水合物生成量稳定适中、流动性越好,油气水混输系统内发生水合物堵塞的风险越低,其流动安全的保障可靠性越高。基于上述研究,本文总结了阻聚剂对水合物的作用机理,并给出了未来深入开展阻聚剂研究的建议。

生物聚合物对甲烷水合物动力学抑制作用研究

为保障海域天然气水合物安全高效钻井,针对常用的动力学抑制剂成本高、污染大的缺点,开展了可降解生物聚合物抑制剂对水合物的生成、分解抑制和防聚结效果实验研究。结果表明:1)羧甲基壳聚糖、黄原胶和果胶和壳聚糖盐酸盐对水合物的生成具有明显的动力学抑制作用,其中壳聚糖盐酸盐对水合物的抑制作用最强,可延长水合物诱导时间至40 min;2)羧甲基壳聚糖、黄原胶和果胶、壳聚糖盐酸盐、壳聚糖季铵盐对水合物分解具有抑制作用;3)相比于纯水,羧甲基壳聚糖和果胶的扭矩峰值更低,且无明显的聚结现象,可以作为无油体系防聚剂;4)羧甲基壳聚糖、黄原胶、果胶具有很好的耐低温性,可以在2.5%的盐浓度下将滤失量控制在15 ml内。以上成果认识可为海域水合物动力学抑制剂的合理选择提供借鉴。

高效液相色谱法测定抗体中葡聚糖硫酸钠含量

目的:建立高效液相色谱法测定葡聚糖硫酸钠含量的方法。方法:采用Sepax Zenix SEC-150色谱柱(300 mm×7.8 mm,3μm),以0.01 mol/L的十二水合磷酸氢二钠、0.09 mol/L的二水合磷酸二氢钠为流动相,等度洗脱,柱温50℃,流速1.2 mL/min,进样体积40μL,激发波长320 nm,发射波长400 nm。结果:在1~100μg/mL,葡聚糖硫酸钠与峰面积线性关系良好。定量限为0.5μg/mL,加标回收率在100.5%~110.0%,重复性实验的相对标准偏差为2.67%,稳定性实验的相对标准偏差为1.07%。结论:建立的高效液相色谱方法准确、可靠,可用于抗体中葡聚糖硫酸钠含量的测定。

透明摇晃-流动反应釜内水合物防聚剂性能测评研究

水合物容易在深水油气输送管道内形成并对管道流动安全构成极大威胁。向管道内加注水合物防聚剂,以此抑制水合物颗粒间的聚集并进而形成流动性良好的水合物浆,是防治水合物问题的常用措施。为了对道达尔公司(法国)提供的名为AA-D的水合物防聚剂(anti-agglomerant, AA)进行性能测评,使用透明摇晃-流动反应釜在不同晃动工况及AA-D浓度下开展了一系列水合物的生成及流动实验。实验中,使用网络摄像头分别记录水合物生成前、生成中及生成后的实验现象。同时,根据温度和压力曲线的变化计算出不同工况下水的转化率。根据实验结果,系统分析了防聚剂AA-D及晃动工况(摇晃角度和摇晃速率)对实验现象和水转化率的影响。结果表明:防聚剂AA-D在本实验条件下具有良好的水合物防治效果。研究成果可为水合物的防聚剂防治提供理论基础和借鉴。

Preparation of ultrafine α-Al_2O_3 powders by catalytic sintering of ammonium aluminum carbonate hydroxide at low temperature

The precursor of ammonium aluminum carbonate hydroxide was synthesized by using aluminum sulfate（Al2（SO4）3） and ammonium carbonate（（NH4）2CO3）. The effects of α-Al2O3 seeds and mixture composed of α-Al2O3 and ammonium nitrate, as well as multiplex catalysts （AT） on phase transformation of alumina in sintering process were investigated respectively. The results show that the α-Al2O3 seeds and the mixture of α-Al2O3 and ammonium nitrate can lower the phase transformation temperature of α-Al2O3 to different extents while the particles obtained agglomerate heavily. AT has great potential synergistic effects on the phase transformation of alumina and reduces the phase transformation temperature of α-Al2O3 and the trends of necking-formation between particles. Therefore the dispersion of powder particles is improved significantly.

<i>In Vivo</i>and <i>in Vitro</i>Evaluation of Anti Diabetic and Insulin Secretagogue Activities of <i>Capparis zeylanica</i>

Since ancient times, traditional medicines have been in the usage for the treatment of Diabetes mellitus. An edible fruit from traditional medicinal plant Capparis zeylanica (CZ) was studied for its anti diabetic, insulin secretagogue activities and mechanisms involved in it. In Streptozotocin induced diabetes rats, oral administration of Capparis zeylanica methanolic extract (CZME) (200 mg/kg body weight) for 28 days showed a significant reduction in blood glucose levels by 35.53% and enhanced circulating insulin levels by 81.82% than the diabetic control rats. The insulin secretagogue activity mechanisms of the extract were evaluated by using mouse insulinoma beta cell line (MIN6-β). The extract stimulated insulin release in dependent manner of glucose concentration (3 - 16.7 mM) and extract dose (5 - 500 μg/mL). The insulin releasing effect of the extract was significantly enhanced by 3-isobutyl-1-methyl xanthine, glibenclamide, elevated extracellular calcium and K+ depolarized media. This insulin release was significantly reduced in calcium blocking conditions (by nifedipine and EGTA), in the presence of potassium channel opener (diazoxide). Hence, anti diabetic activity of CZME might be a result of its stimulatory effect on insulin release from pancreatic beta cells via KATP channel dependent and independent ways. These results indicate that CZ fruits have the potential to use in diabetes therapy.

Exact Traveling Wave Solutions of Nano-Ionic Solitons and Nano-Ionic Current of MTs Using the exp(-φ (ξ ))-Expansion Method

In this work, the exp(-φ (ξ )) -expansion method is used for the first time to investigate the exact traveling wave solutions involving parameters of nonlinear evolution equations. When these parameters are taken to be special values, the solitary wave solutions are derived from the exact traveling wave solutions. The validity and reliability of the method are tested by its applications to Nano-ionic solitons wave’s propagation along microtubules in living cells and Nano-ionic currents of MTs which play an important role in biology.

气体水合物阻聚剂研究进展

由水合物生成与聚集引起的堵塞一直是深水油气流动安全保障领域面临的棘手问题。水合物阻聚剂(AAs)因可防止水合物颗粒聚集而成为降低水合物风险的有效方法之一。本文基于作者课题组在水合物抑制技术方面的研究工作,分别梳理表面活性剂型和固体颗粒型水合物阻聚剂的构效关系。同时,调研国内外宏观-微观-分子不同尺度的阻聚性能测试手段,包括高压搅拌反应釜、摇摆槽、流动轮和流动环路,以及微观力测试仪和分子动力学模拟。基于上述实验装置和分子模拟研究结果,总结了不同类型阻聚剂对水合物的作用机理,特别是乳化和吸附机理。最后分析现有水合物阻聚剂存在的问题,并展望了水合物阻聚剂的未来发展方向。这为将来适用于南海深水油气田的高效、绿色和经济水合物AAs的开发提供重要的技术支持。

油水体系中防聚剂对水合物形成的影响研究

防聚剂(AAs)可以降低深水油气输送管线和钻井作业中水合物堵塞风险。AAs吸附在水合物颗粒上使其分散从而防止聚集,但AAs对水合物的成核和生长影响尚不清楚。因此,本文研究了油水体系中一系列AAs对甲烷水合物形成动力学的影响,获得了体系中水合物的诱导时间、形成量和形成速率。结果表明,在纯水(100%)和高含水率(95%)油水体系中,AAs会促进水合物的形成;而在相对较低含水率(20%和60%)油水体系中,AAs会减缓甚至完全抑制水合物的成核和生长,这可能主要是由于AAs的传质位阻效应。该研究将有助于揭示AAs对水合物防聚的动力学抑制机制,对多相流混输和深水油气勘探的安全实施具有重要意义。

天然气水合物抑制剂研究进展

介绍了天然气水合物热力学抑制剂、动力学抑制剂、防聚剂的研究现状、作用基理、种类、应用范围以及存在的缺陷;针对现有的抑制剂的不足,提出了今后研究工作的发展方向。

硝酸铵的结块与防止

硝酸铵的吸湿性、多晶性造成了硝酸铵的结块。分析了影响松散型硝酸铵松散度降低并结块的主要原因是水分、造粒颗粒度、温度、松散添加剂、添加剂添加量、包装方式和储存条件,提出了提高硝酸铵松散度的具体改进措施。对防止硝酸铵结块的几种途径进行了讨论,介绍了防结块剂的应用情况,并介绍了五种硝酸铵专用防结块剂的特点及其应用情况。