Anti-Hypertensive Effects of Blended <i>Camellia oleifera</i>Abel Oil and Eucommia Extract on SHR Mice

In our study, we employed Camellia seed oil as the main ingredients blended with Eucommia Extract to investigate the effects of anti-hypertensive on mice by administrating mice with low dose, middle dose and high dose of Camellia seed oil complex for 4 weeks. The specific tests of studying effects of anti-hypertensive were body weight, blood systolic pressure (BSP), diastolic blood pressure (DBP), pm meam blood pressure (MBP) and heart rate (HR). And the results showed that appropriate level of Camellia seed oil complex could decrease the body weight and had an active effect on the cardiovascular system of mice, which significantly embodied the anti-hypertensive activity of Camellia seed oil complex.

Effects of anti-hypertensive drugs on esophageal body contraction

AIM:To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possi-ble relationship with gastro-esophageal reflux disease.METHODS:Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine,losartan,and atenolol,as well as without any drug administration.RESULTS:Peristaltic contractions by the esophageal body were separated into three segments by two troughs. The peak peristaltic pressures in the mid and lower segments of the esophageal body under atenolol administration were signifi cantly higher than those without medication in a supine position. On the other hand,peristaltic pressures under nifedipine administration were lower than those observed without drug ad-ministration. Losartan did not change esophageal body peristalsis. Atenolol elevated LES pressure and slowed peristaltic wave transition,while the effects of nifedip-ine were the opposite. CONCLUSION:Among the anti-hypertensive drugs tested,atenolol enhanced esophageal motor activity,which was in contrast to nifedipine.

Exploring the Anti-Hypertensive Properties of Medicinal Plants and Their Bioactive Metabolites: An Extensive Review

Medicinal plants are extensively used in traditional folk medicine. High blood pressure is associated with the risk of cardiovascular diseases (CVDs) and many other serious health complications resulting from it as a major concern of morbidity and mortality in health sector. Use of diuretics, angiotensin converting enzyme (ACE) inhibitors, beta adrenergic receptor antagonists (beta blockers), alpha adrenergic receptor antagonists (alpha blockers), calcium channel blockers (CCBs) etc. are not efficient enough to cure hypertension. Side effects regarding these medications lead to intolerance, impaired control of the disease, and also mismanagement of therapy. So, approach regarding quenching new potent therapeutic compounds from medicinal plants draws attention nowadays. For example, as a first-line therapeutic agent, an alkaloid is highly effective in lowering systolic blood pressure which is isolated from root extract of the plant of Rauwolfia serpentina species, namely reserpine. This article comes up with a list of 63 plant species from 37 families, compiling information related to plant parts used for making extracts, types of extract and animals used in these studies, antihypertensive effect of the extracts etc. It also refers to 74 chemically defined molecules, with in vitro and in vivo anti-hypertensive potential, isolated from these extracts along with their dosage and mechanism of action by using electronic searches of published articles from various databases and reference books. Our present work would be beneficial for researchers to investigate and invent novel antihypertensive therapy to treat hypertension.

Aliskiren Augments the Activities of Anti-Oxidant Enzymes in Liver Homogenates of DOCA Salt-Induced Hypertensive Rats

Hypertension is a serious problem that is recently thought to be associated with damaging effects on target organs partially via oxidative stress. On the other hand, there is accumulating literature describing some sort of therapeutic interaction between antioxidant enzymes in vital organs and hypertension. Therefore, the aim of this study is to investigate the possible effect of a direct renin inhibitor, aliskiren, used in treatment of hypertension via renin-angiotensin-aldosterone system (RAAS), on selected anti-oxidant enzymes in hepatic homogenates in DOCA salt-induced hypertesnive albino rats. Thirty male wister albino rats were assigned randomly into 3 groups (n = 10/ group). Group 1 received no treatement and serves as control. Group 2 received 0.5% carboxymethylcellulose sodium ip as a solvent of aliskiren, as a direct renin inhibitor (DRI). Group 3 received aliskiren 100 mg/kg/day ip for 4 weeks through gastric tube. Systolic blood pressure (SBP) was measured every week and its mean was recorded at the end of the study. Superoxide dismutase (SOD) enzyme in RBCs lysates, activities of catalase (CAT) and glutathione peroxidase enzymes and thiobarbituric acid reactive substance (TBARS), as a marker of lipid peroxidation, in hepatic homogenates were measured at the end of the study. DRI produced a marked reduction in mean SBP of hypertensive rats. It also significantly (p < 0.05) increased the activities of measured anti-oxidant enzymes while it significantly (p < 0.05) reduced TBARS in liver homogenates. These results indicated that renin possesses an oxidative effect in the liver in hypertensive rats. Aliskiren, in addition to its powerful anti-hypertensive effect, it could induce a great anti-oxidant effect in liver homogenates of DOCA salt-hypertensive rats.

Effects of autoantibodies against AT1-receptor and angiotensin Ⅱ on refractory hypertension

Objective The study will explore effects of the autoantibodies against AT1 receptor and angiotensin Ⅱ on the refractory hypertension. Methods Seventy-seven patients (46 men and 31 women) with essential hypertension were divided into groups of refractory hypertension (RH) and hypertension (HT) according to the 1999 WHO-ISH Guidelines for the Management of Hypertension. Forty normotensives (22 men) were recruited as controls. The mean age was 54. 3±13 years old in RH group, 53. 5±9 years old in HT group and 51. 2±11. 9 years old in normotensives (NT) group. The mean blood pressure was 154. 2±9. 4/98. 4± 8. 2 mmHg in RH group and 130. 1±7. 6/80. 5±6. 7 mmHg in HT group after combination drug therapy of hypertension for 4 weeks. Blood pressure in NT group was 120. 8±11. 7/76. 4 ± 7. 2 mmHg. The epitope of the 2nd extracellular loops of AT1 receptor was synthesized and used as antigens to screen the autoantibodies by ELISA. Plasma angiotensin (Ang) II were examined by a radioimmunoassay. Results The autoantibodies against AT1 receptor were positive in 18 (46. 15 %) patients with RH, in 4 (10. 5 % ) hypertension and in 3 (7. 5 % ) normotensives, P < 0. 01. Ang Ⅱwas 57. 01±52. 63 pmol/L in patients with RH. Both the autoantibodies positive and the Ang Ⅱ increasing were 4 (10. 3 % ) cases, both normal were 7 (17. 9 % ) cases, the autoantibodies positive or Ang II increasing was all of 14 (35. 9 % ) cases (x2 = 0. 09, P>0. 05) . There was no relationship between the autoantibodies against AT1 receptor and the angiotensin Ⅱ in refractory hypertension. Conclusion The autoantibodies against AT1 receptor and Ang Ⅱ might be two independent factors in developing of refractory hypertension. The findings suggest that AT1 receptor an-tagnist used in the treatment of refractory hypertension might have an important value.

The potential therapeutic effect DL0805-2 on experimental pulmonary hypertensive rats and the underlying mechanisms

Aim DL0805-2 is a novel Rho-kinases inhibitor which has been found to have potent cardiovascular effects. In the present research, we aimed to study the potential of DL0805-2 in the treatment of pulmonary arterial hypertension （PAH） and discuss the underlying mechanisms preliminarily. Methods A classical PAH animal model was used, which was established by single injection of 50 mg · kg^-1 monocrotaline （MCT）. One week later, the rats were administrated with 1, 3, 10 mg · kg^-1 DL0805-2 via intraperitoneal injection for 18 days. At the end of the experiment, the body weight and survival rate were recorded. Meanwhile, the respiration function, heart function, blood pressure and pulmonary artery pressure were detected. Serum was collected for biochemical index analysis. The weight of vital organs was used to calculate the organ index. Histopathology examination was em-ployed to observe the subtle changes in hearts, vessels and lungs. Furthermore, the mechanisms were studied main- ly by the method of western blotting. Results DL0805-2 did not show significant influence on body weight of PAH rats. But the survival rate of PAH rats treated with 3 and 10 mg · kg^-1 DL0805-2 was increased up to 90. 9% com- pared with the model group （68.2%）. DL0805-2 improved the pulmonary artery blood flow especially the maximal -1 -1 velocity （PV max） from 397.2 cm · s^-1 to 506.5, 540. 1 and 574.0 cm · s^-1 respectively. The results of echocar- diography and electrocardiogram show that DL0805-2 had little effect on left ventricle and systemic circulation but attenuated right ventricle injury and decreased the right ventricle pressure from 73.73 mmHg to 47.80, 42.64 and 46.45 mmHg respectively after DL0805-2 intervention. Disease markers of PAH including NT-proBNP in serum and ET-1 in lung tissue homogenate and serum biochemical indicators, ALT, AST and LDH, were reduced by DL0805-2. DL0805-2 also relieved edema of lungs and decreased inflammatory cytokines production. Through the examination on histopathologic slide of pulmonary main artery, right ventricle and lung, DL0805 derivatives were found to have significant protection effect on structural changes of organs induced by pulmonary hypertension. Ac- cording to the preliminary study on the mechanisms of DL0805-2 in PAH, Rho/ROCK pathway was significantly in- hibited by DL0805 derivatives. In addition, DL0805 derivatives showed effect on BMPRII/p-Smad pathway and ap- optosis related pathway. Conclusion DL0805-2 has showed potent treatment effect on the PAH rats. And the un- derlying mechanisms studies also indicated that RhoA/ROCK and BMPRII pathways were involved. This work will provide basis experimental data for the further research and development of DL0805-2.

基于3,5-二溴水杨醛席夫碱镍配合物-氧化石墨烯电化学免疫传感器检测Anti-IgG含量的研究

应用物理吸附法将羊抗人IgG抗原直接固定于3,5-二溴水杨醛席夫碱镍配合物-氧化石墨烯修饰的金电极表面,制备电化学免疫传感器。采用循环伏安法和交流阻抗法对传感器进行表征,结果表明该传感器适合检测Anti-IgG浓度。同时探讨了缓冲液pH值、扫描速度、免疫反应温度、抗原与抗体配比对循环伏安峰电流的影响,结果表明在5-100mV/s扫速范围内,峰电流与扫速呈线性。孵育最优条件为25℃,h-IgG与Anti-IgG配比为1∶1。循环伏安法研究还表明Anti-IgG浓度在0.01-260μg/L范围内,线性关系良好,相关系数r^2=0.993,检出限（S/N=3）为0.006μg/L,据此建立了检测Anti-IgG浓度的新方法。

信号分子IRAK1/4在antiβ-2GPI/β2GPI复合物诱导THP-1细胞表达TF中的作用探讨

目的:探讨IRAK1和IRAK4在antiβ-2GPI/β2GPI复合物诱导单核细胞株THP-1表达组织因子(TF)中的作用。方法:利用荧光定量PCR(Real-time PCR)、TF活性试剂盒分别检测THP-1细胞表达TF mRNA及TF活性;Western blot检测anti-β2GPI/β2GPI复合物诱导THP-1细胞表达IRAK1、磷酸化-IRAK1(p-IRAK1)、IRAK4情况;观察IRAK1/4抑制物是否干预anti-β2GPI/β2GPI复合物诱导THP-1表达TF。结果:Antiβ-2GPI/β2GPI复合物(100μg/ml)诱导THP-1细胞表达TF显著增加(P<0.05 vs control);Antiβ-2GPI/β2GPI复合物(100μg/ml)刺激THP-1细胞表达IRAK1、p-IRAK1、IRAK4(蛋白)显著升高(P<0.05 vscontrol);IRAK1/4抑制物(50μmol/L)能够阻断antiβ-2GPI/β2GPI复合物(100μg/ml)诱导THP-1表达TF及IRAK1磷酸化的效应。结论:antiβ-2GPI/β2GPI复合物诱导THP-1细胞表达TF过程中,信号分子IRAK1/4被激活进而发挥重要作用。

三维Anti de Sitter空间中Lorentzian曲面的S_t^1×S_s^1-值光锥Gauss映射的奇点分类

利用Arnol'd的Legendrian理论,对三维Anti de Sitter空间中Lorentzian曲面进行了研究.引入光维高度函数概念研究了三维Anti de Sitter空间Lorentzian曲面的S1t×S1s-值、光锥Gauss映射的奇点,进行了奇点分类,揭示了类光Causs-kronecker曲率之间的关系;并研究了Lorentzian曲面的一些基本几何性质.

Role of miR-21-5p/FilGAP axis in estradiol alleviating the progression of monocrotaline-induced pulmonary hypertension

Background:Aberrant expression of microRNAs(miRNAs)has been associated with the pathogenesis of pulmonary hypertension(PH).It is,however,not clear whether miRNAs are involved in estrogen rescue of PH.Methods:Fresh plasma samples were prepared from 12 idiopathic pulmonary arterial hypertension(IPAH)patients and 12 healthy controls undergoing right heart cath-eterization in Shanghai Pulmonary Hospital.From each sample,5μg of total RNA was tagged and hybridized on microRNA microarray chips.Monocrotaline-induced PH(MCT-PH)male rats were treated with 17β-estradiol(E_(2))or vehicle.Subgroups were cotreated with estrogen receptor(ER)antagonist or with antagonist of miRNA.Results:Many circulating miRNAs,including miR-21-5p and miR-574-5p,were mark-edly expressed in patients and of interest in predicting mean pulmonary arterial pres-sure elevation in patients.The expression of miR-21-5p in the lungs was significantly upregulated in MCT-PH rats compared with the controls.However,miR-574-5p showed no difference in the lungs of MCT-PH rats and controls.miR-21-5p was se-lected for further analysis in rats as E_(2) strongly regulated it.E_(2) decreased miR-21-5p expression in the lungs of MCT-PH rats by ERβ.E_(2) reversed miR-21-5p target gene FilGAP downregulation in the lungs of MCT-PH rats.The abnormal expression of RhoA,ROCK2,Rac1 and c-Jun in the lungs of MCT-PH rats was inhibited by E_(2) and miR-21-5p antagonist.Conclusions:miR-21-5p level was remarkably associated with PH severity in patients.Moreover,the miR-21-5p/FilGAP signaling pathway modulated the protective effect of E_(2) on MCT-PH through ERβ.

Mesenchymal Stem Cells Attenuate Vascular Remodeling in Monocrotaline-induced Pulmonary Hypertension Rats

Intravenous and intratracheal implantation of mesenchymal stem cells (MSCs) may offer ameliorating effects on pulmonary hypertension (PH) induced by monocrotaline (MCT) in rats. The aim of this study was to examine the anti-remodeling effect of intravenous MSCs (VMSCs) and intratracheal MSCs (TMSCs) in rats with PH, and the underlying mechanisms. MSCs were isolated from rat bone marrow and cultured. PH was induced in rats by intraperitoneal injection of MCT. One week after MCT administration, the rats were divided into 3 groups in terms of different treatments: VMSCs group (intravenous injection of MSCs), TMSCs group (intratracheal injection of MSCs), PH group (no treatment given). Those receiving saline instead of MCT served as negative control (control group). Pulmonary arterial structure was pathologically observed, pulmonary arterial dynamics measured, and remodeling-associated cytokines Smad2 and Smad3 detected in the lungs, three weeks after MCT injection. The results showed that PH group versus control group had higher pulmonary arterial pressure (PAP) and wall thickness index (WTI) 21 days after MCT treatment. The expression of phosphorylated (p)-Smad2 and the ratio of p-Smad2/Smad2 were much higher in PH group than in control group. Fluorescence-labeled MSCs were extensively distributed in rats’ lungs in VMSCs and TMSCs groups 3 and 14 days after transplantation, but not found in the media of the pulmonary artery. WTI and PAP were significantly lower in both VMSCs and TMSCs groups than in PH group three weeks after MCT injection. The p-Smad2 expression and the ratio of p-Smad2/Smad2 were obviously reduced in VMSCs and TMSCs groups as compared with those in PH group. In conclusion, both intravenous and intratracheal transplantation of MSCs can attenuate PAP and pulmonary artery remodeling in MCT-induced PH rats, which may be associated with the early suppression of Smad2 phosphorylation via paracrine pathways.

基于迷走-胆碱能抗炎通路探讨针刺治疗高血压病炎症反应作用机制

高血压病是临床常见心脑血管疾病之一。近年来,研究发现炎症反应与高血压病及靶器官损伤密切相关,炎症细胞浸润打破了自主神经系统的平衡,使外周交感神经过度激活,而交感神经活动的增强激活了免疫系统,促进了炎症的发生,从而形成恶性循环,而炎症反应的控制成为防治高血压病的新靶点。而迷走神经-胆碱能抗炎通路(cholinergic anti-inflammatory pathway,CAIP)是一条神经-免疫通路,研究发现其中关键信号分子的调节作用,可介导延缓高血压病炎症反应。针刺的抗炎效果为大家所共识,机制可能与调控胆碱能抗炎通路有密切联系,该文拟通过文献分析、汇总,总结针刺基于胆碱能抗炎通路调节高血压病机制:(1)耳穴迷走神经刺激可驱动抗炎反应;(2)针刺通过调节CAIP中乙酰胆碱(acetylcholine,ACh)的释放和乙酰胆碱受体7(α7nAChR)的表达激活信号转导通路;(3)针刺可调节CAIP细胞内分子信号转导途径从而抑制炎症因子的产生与发展。

Anti-Lipidemic Effect of Combined Leaf Extracts of <i>Moringa oleifera</i>and <i>Peristrophe bicalyculata</i>in Alloxan-Induced Diabetic Rats

In this study, the anti-lipidemic effects of combined extracts of Moringa oleifera and Peristrophe bicalyculata in allxoan-induced diabetic rats were investigated. Fifty four (54) adult male albino Wistar rats weighing between 140-180 g were shared into 5 parallel groups consisting of diabetic (DC) and non-diabetic (NC) groups. Each group consisted of 6 rats. Groups 2-5 were made diabetic using alloxan (150 mg/kg b.w in distil H2O). Except for groups 1 and 2, animals were gavaged at doses of 500 mg/kg b.w for the single dose of extract and 250 mg/kg for the combine extract treatment. Insulin served as a standard drug and was administered at 5IU/kg b.w. The control animal groups (NC, DC) received 0.2 ml of normal saline (placebo) for fourteen (14) consecutive days. Groups treated with extracts showed a significant (p < 0.05) increase in triglyceride (TG), total cholesterol (TC) levels, very low density lipoprotein (VLDL) and low density lipoprotein (LDL mg/dl) concentrations in all treated groups compared to the diabetic control group. No significant (p > 0.05) change was observed in HDL-C level in treated groups when compared to the normal control, diabetic control and insulin groups, suggesting a potential protection against cardiovascular diseases (CVDs) by these plants. No reduction in body weight was observed within the experimental period of 14 days. The results obtained in this study are in agreement with several other research results with these plants and claims by ethno-medical practitioners on the use of Moringa oleifera and Peristrophe bicalyculata in the treatment of hypertension and related CVDs.

On the Construction of Deepening Anti - corruption Mechanism

It needs the foundation of system and the guarantee of organizational system for anti-corruption,but it is more necessary to build and form an effective anti-corruption mechanism,so that the anti-corruption can be really put into practice. Anti-corruption mechanism refers to a organic operation system of the interaction,interconnection and constraint between the constituent elements( parts) and elements of national anti-corruption,and as a system,anti-corruption mechanism should have the characteristics of system aticness,comprehensiveness,transparency,legalization,public participation,scientific dynam ic,and internationalism. The construction of deepening anti-corruption mechanism is the need for reconstructing the ruling legitimacy of the party and the governm ent. Adhering to the principle of treating both root causes and symptoms is necessary in the construction of anti-corruption m echanism,com bating and punishing corruption is an important part of anti-corruption,and the prevention and control of corruption is the basic project of anti-corruption. Therefore,the construction of prevention and control mechanism in the anti-corruption mechanism has a more far-reaching significance.

VENTRICUAL ECTOPY IN PATIENTS WITH HYPERTENSIVE LEFT VENTRICULAR HYPERTOPHY

It has been noticed that patients with essential hypertension and left ventricular hypertrophy on EKG, are highly exposed to a risk of sudden death. LVH in arterial hypertension has repeatedly been documented to trigger or aggravate ventricular ectory. So we investigated the frequency of complex ventricular arrhythmia by means of 24-hour holter monitoring in 120 patients divided into 3 groups, the first group are 40 patients of essential hypetrtension with LVH, the second group are 40 patients with essential hypertension without LVH, and the third group are 40 normotensives without LVH as a control group. The three groups have been matched for age, sex and smoking habit, and the two hypertensive groups matched for blood pressure before and after antihypertensive therapy and duration of hypertension. Thirty hypertensive patients were examined for plasma norepinephrive on the day of holter monitoring, fifteen of those with LVH and the other fifteen without LVH. Nonsustained ventricular tahycardia, had been seen on five (12.5%)of the 40 patients with echocardiographic patten of LVH, and in no one of the 40 hypertensive patients without hyperophy and the 40 normotgnsive control group. Ninteen patients (47. 5%) with LVH had episodes of less than 30 premature ventricular contraction/hour. One patient (2.5%) with LVH has episodes of >30 premature ventricual contraction/hour, higher grade of ventricular ectopic activity such as coupled premature ventricular contractions was seen in two patiens (5%) and multifocal premature ventricular contractions in 11 patiens (27.5%) of the group with LVH. In this study all the data suggest that complex ventricular arrhythmia occur commonly in hypertensive patients with LVH, and map contribute the higher incidence of sudden death in these patients.

UPLC-DAD同时测定降血压类保健食品中20种非法添加化学药物

采用超高效液相色谱-二极管阵列检测器(UPLC-DAD)建立同时测定辅助降血压类保健食品中20种非法添加化学药物的方法。采用Luna UPLC C18色谱柱(2.1 mm×100 mm,1.6μm),以质量分数为0.2%的磷酸水溶液-乙腈为流动相进行梯度洗脱。流速为0.21 mL/min,柱温为35℃,DAD扫描,检测波长为220 nm,各剂型样品经甲醇提取,通过保留时间和紫外吸收光谱定性,峰面积外标法定量。结果表明:20种药物成分能完全分离,在4~80μg/mL内线性关系良好,回收率为92.3%~104.1%,相对标准偏差(RSD)为1.3%~2.9%。1批阳性样品检出奈比洛尔、乐卡地平、拉西地平,并通过UPLC-MS/MS得到确证。建立的方法操作简便,精密度、稳定性、重复性好,能够达到快速检测降压类保健食品中非法添加化学成分的目的。

C3 PHENOTYPE AND ALLELES，C3 HAV4－1 MONOCLONAL PHENOTYPE DISTRIBUTION IN HYPERTENSIVE PATIENTS WITH IgA GLOMERULONEPHRITIS

Using isoelective focusing in immobilized pH gradients and immunoblot, C3 phenotypes (F, FS, S) and C3 HAV4-1 monoclonal (F±S±) phenotypes were performed in 90 patients with IgA glomerulonephrits,(G.N.).including 49 IgA G. N.hypertensive (H.T.) patients and 41 IgA G. N. normotensive (N.T.) patients, and in 224 normal subjects (N.S.). A significant difference of C3 phenotype distribution between both IgA G. N.(hypertensive and normotensive) and N. S. was .found (P<0.01,P<0.01respectively).In monoclonal C3 HAV4-1(±) distribution significant difference between IgA H. T.and N.S.was observed (P<0.01). Furthermore, F and S allele .frequency of IgA G. N. including HT and NT is significantly. different (P<0.05). This data suggests that hypertensive patients with IgA G. N. seems to be related io the abnormal C3 genetic factors and if this gene distributions can be used as a predictor for the prognosis still needs futher investigations.

Anti-Bacterial and Flame Retardant for Cotton Fabric by One-Bath Finishing

A research on the process of cotton fabric flame-re-tarding,anti-bacterial finishing and one-bath finish-ing of anti-bacterial and flame-retarding is discussed.The flame retardant agent was phosphorous-contained,and the bacteriostatic finishing agent named SFR-1 wassynthesized.The flame retardancy of the fabric finishedcan meet the DOC FF3-71 Children Sleepwear Stan-dard.Its bacterial inhibiting capacity can meet and ex-ceed the requirements of similar products

血清Galectin-9和PD-L1蛋白水平与高血压脑出血病人病情严重程度及预后的相关性分析

目的探讨血清半乳糖凝集素-9(Galectin-9)和抗程序性死亡因子配体1(PD-L1)蛋白水平与高血压脑出血病人病情严重程度及预后的相关性。方法纳入2020年1月至2022年1月恩施土家族苗族自治州中心医院所收治的117例高血压脑出血病人作为研究对象,根据病人病情严重程度将其分为将分为轻型组(41例),中型组(54例)以及重型组(22例),并根据病人的预后状态将其分为预后良好组(76例)和预后不良组(41例)。采用酶联免疫吸附测定检测病人血清中Galectin-9,PD-L1的表达水平;采用logistic回归分析与高血压脑出血病人预后状态有关的影响因素;采用受试者操作特征曲线(ROC曲线)分析Galectin-9、PD-L1对高血压脑出血病人预后状态的预测价值。结果血清Galectin-9水平随病情严重程度的增加而升高,而血清PD-L1水平则随病情严重程度的增加逐渐降低(P<0.05);预后良好组病人血清Galectin-9水平(12.38±2.97)ng/L低于预后不良组(18.46±5.86)ng/L,而血清PD-L1水平(68.19±11.88)mg/L则高于预后不良组(53.23±9.76)mg/L(P<0.05);预后不良组中出血量≥30 mL、出血破入脑室以及美国国立卫生研究院卒中量表(NIHSS)评分≥20分的病人所占比例均高于预后良好组(P<0.05);出血量≥30 mL、出血破入脑室、NIHSS评分≥20分及Galectin-9≥15 ng/L均为高血压脑出血病人预后不良的危险因素,而PD-L1≥60 mg/L则为保护因素;血清Galectin-9和PD-L1预测高血压脑出血病人预后的曲线下面积(AUC)分别为0.88、0.82,二者联合预测的AUC为0.94,优于血清Galectin-9、PD-L1各自单独预测(Z_(二者联合-Galectin-9)=2.21、Z_(二者联合-PD-L1)=1.98,P=0.022、0.047)。结论血清Galectin-9和PD-L1表达水平与高血压脑出血病人病情严重程度密切相关,二者联合检测对病人的预后具有较好的预测效能。

Testing of Anti-stripping Property of Friction Spun Core Yarn

Friction spun core yarn has two components: filament core and staple fiber sheath. Under axial rubbing action, the failure mode of the core yarn is the stripping of the sheath from the core. This paper introduces a method to test the anti - stripping property of the core yarn. With a modified Universal Testing Machine, the stripping resistance of friction spun core yarn can be continuously measured. Some factors Influencing the measurements are discussed in detail. The testing results are compared with those from a Y731 Yarn Abrasion Tester and fur - ther confirmed by weaving practice.