Spontaneous or secondary to intravitreal injections of anti-angiogenic agents retinal pigment epithelial tears in age-related macular degeneration

·AIM:Toevaluatethevisualfunctionevolutionofretinal pigment epithelial(RPE) tears in patients with age-related macular degeneration(AMD) according to type of occurrence [spontaneous or secondary to anti-vascular endothelial growth factor(anti-VEGF) injection] and the topographic location of the tear after a two-year followup period.·METHODS: A total of 15 eyes of 14 patients with RPE tears in exudative AMD were analyzed retrospectively at the University Eye Clinic of Trieste. Inclusion criteria were: patient age of 50 or older with AMD and RPE tears both spontaneous occurring or post anti-VEGF treatment. Screening included: careful medical history,complete ophthalmological examination, fluorescein angiography(FA), indocyanine green angiography(ICG),autofluorescence and infrared imaging and optical coherence tomography(OCT). Patients were evaluated every month for visual acuity(VA), fundus examination and OCT. Other data reported were: presence of PED,number of injections before the tear, location of the lesion.·RESULTS:Meanfollow-up was24wk(SD±4wk). Atotal of 15 eyes were studied for RPE tear. In 6 cases(40%),the RPE tears occurred within two years of anti-VEGF injections the others occurred spontaneously. In 13cases(86.6%), the RPE tear was associated with pigment epithelial detachment(PED). In 7 cases(46.6%), the RPE tear occurred in the central area of the retina and involved the fovea. Two lesions were found in the parafoveal region, six in the extra-macular area. In all cases visual acuity decreased at the end of the follow-up period(P <0.01) independently of the type or the topographical location of the lesion.·CONCLUSION: RPE tear occurs in exudative AMD as a spontaneous complication or in relation to anti-VEGF injections. Visual acuity decreased significantly and gradually in the follow-up period in all cases. No correlation was found between visual loss and the type of onset or the topographic location of the tears.

基于3,5-二溴水杨醛席夫碱镍配合物-氧化石墨烯电化学免疫传感器检测Anti-IgG含量的研究

应用物理吸附法将羊抗人IgG抗原直接固定于3,5-二溴水杨醛席夫碱镍配合物-氧化石墨烯修饰的金电极表面,制备电化学免疫传感器。采用循环伏安法和交流阻抗法对传感器进行表征,结果表明该传感器适合检测Anti-IgG浓度。同时探讨了缓冲液pH值、扫描速度、免疫反应温度、抗原与抗体配比对循环伏安峰电流的影响,结果表明在5-100mV/s扫速范围内,峰电流与扫速呈线性。孵育最优条件为25℃,h-IgG与Anti-IgG配比为1∶1。循环伏安法研究还表明Anti-IgG浓度在0.01-260μg/L范围内,线性关系良好,相关系数r^2=0.993,检出限（S/N=3）为0.006μg/L,据此建立了检测Anti-IgG浓度的新方法。

信号分子IRAK1/4在antiβ-2GPI/β2GPI复合物诱导THP-1细胞表达TF中的作用探讨

目的:探讨IRAK1和IRAK4在antiβ-2GPI/β2GPI复合物诱导单核细胞株THP-1表达组织因子(TF)中的作用。方法:利用荧光定量PCR(Real-time PCR)、TF活性试剂盒分别检测THP-1细胞表达TF mRNA及TF活性;Western blot检测anti-β2GPI/β2GPI复合物诱导THP-1细胞表达IRAK1、磷酸化-IRAK1(p-IRAK1)、IRAK4情况;观察IRAK1/4抑制物是否干预anti-β2GPI/β2GPI复合物诱导THP-1表达TF。结果:Antiβ-2GPI/β2GPI复合物(100μg/ml)诱导THP-1细胞表达TF显著增加(P<0.05 vs control);Antiβ-2GPI/β2GPI复合物(100μg/ml)刺激THP-1细胞表达IRAK1、p-IRAK1、IRAK4(蛋白)显著升高(P<0.05 vscontrol);IRAK1/4抑制物(50μmol/L)能够阻断antiβ-2GPI/β2GPI复合物(100μg/ml)诱导THP-1表达TF及IRAK1磷酸化的效应。结论:antiβ-2GPI/β2GPI复合物诱导THP-1细胞表达TF过程中,信号分子IRAK1/4被激活进而发挥重要作用。

三维Anti de Sitter空间中Lorentzian曲面的S_t^1×S_s^1-值光锥Gauss映射的奇点分类

利用Arnol'd的Legendrian理论,对三维Anti de Sitter空间中Lorentzian曲面进行了研究.引入光维高度函数概念研究了三维Anti de Sitter空间Lorentzian曲面的S1t×S1s-值、光锥Gauss映射的奇点,进行了奇点分类,揭示了类光Causs-kronecker曲率之间的关系;并研究了Lorentzian曲面的一些基本几何性质.

Differential mRNA Expression of <i>COX</i>-2 and Proinflammatory Mediators in Patients with Rotator Cuff Tears and Osteoarthritis of the Hip

Purpose: Bursal inflammation is thought to be a major cause of pain in degenerative rotator cuff tears (RCTs). While the expression of proinflammatory mediators, such as COX-2, TNF-α, IL-1β, and IL-6, is crucial for the pathophysiology of osteoarthritis (OA), their role in degenerative RCTs remains unknown. The aim of this study was to determine the expression of COX-2 and proinflammatory mediators in the development of RCT-induced pain by comparing their levels in patients with hip OA or RCTs. Methods: We included samples obtained from 31 shoulders of 31 patients with RCTs and samples from 30 hips of 27 patients with hip OA. The mRNA levels of COX-2, TNF-α, IL-1β, and IL-6 were determined using RT-PCR, and were compared between the subacromial bursa and hip joints. We also analyzed IL-1β-induced COX-2 expression in the subacromial bursa and synovial blast of the hip. Results: COX-2, IL-1β, and IL-6 expression levels were significantly lower in the subacromial bursa of RCTs than in hip OA samples, while no significant difference was observed for TNF-α. No significant difference in the fold increase was observed between subacromial bursa and hip OA samples, even though IL-1β-induced COX-2 expression increased in both samples. Conclusion: Our findings suggest that the main mechanism underlying pain development differs between patients with RCTs and those with hip OA.

On the Construction of Deepening Anti - corruption Mechanism

It needs the foundation of system and the guarantee of organizational system for anti-corruption,but it is more necessary to build and form an effective anti-corruption mechanism,so that the anti-corruption can be really put into practice. Anti-corruption mechanism refers to a organic operation system of the interaction,interconnection and constraint between the constituent elements( parts) and elements of national anti-corruption,and as a system,anti-corruption mechanism should have the characteristics of system aticness,comprehensiveness,transparency,legalization,public participation,scientific dynam ic,and internationalism. The construction of deepening anti-corruption mechanism is the need for reconstructing the ruling legitimacy of the party and the governm ent. Adhering to the principle of treating both root causes and symptoms is necessary in the construction of anti-corruption m echanism,com bating and punishing corruption is an important part of anti-corruption,and the prevention and control of corruption is the basic project of anti-corruption. Therefore,the construction of prevention and control mechanism in the anti-corruption mechanism has a more far-reaching significance.

Anti-Bacterial and Flame Retardant for Cotton Fabric by One-Bath Finishing

A research on the process of cotton fabric flame-re-tarding,anti-bacterial finishing and one-bath finish-ing of anti-bacterial and flame-retarding is discussed.The flame retardant agent was phosphorous-contained,and the bacteriostatic finishing agent named SFR-1 wassynthesized.The flame retardancy of the fabric finishedcan meet the DOC FF3-71 Children Sleepwear Stan-dard.Its bacterial inhibiting capacity can meet and ex-ceed the requirements of similar products

Testing of Anti-stripping Property of Friction Spun Core Yarn

Friction spun core yarn has two components: filament core and staple fiber sheath. Under axial rubbing action, the failure mode of the core yarn is the stripping of the sheath from the core. This paper introduces a method to test the anti - stripping property of the core yarn. With a modified Universal Testing Machine, the stripping resistance of friction spun core yarn can be continuously measured. Some factors Influencing the measurements are discussed in detail. The testing results are compared with those from a Y731 Yarn Abrasion Tester and fur - ther confirmed by weaving practice.

<i>In Vivo</i>and <i>in Vitro</i>Evaluation of Anti Diabetic and Insulin Secretagogue Activities of <i>Capparis zeylanica</i>

Since ancient times, traditional medicines have been in the usage for the treatment of Diabetes mellitus. An edible fruit from traditional medicinal plant Capparis zeylanica (CZ) was studied for its anti diabetic, insulin secretagogue activities and mechanisms involved in it. In Streptozotocin induced diabetes rats, oral administration of Capparis zeylanica methanolic extract (CZME) (200 mg/kg body weight) for 28 days showed a significant reduction in blood glucose levels by 35.53% and enhanced circulating insulin levels by 81.82% than the diabetic control rats. The insulin secretagogue activity mechanisms of the extract were evaluated by using mouse insulinoma beta cell line (MIN6-β). The extract stimulated insulin release in dependent manner of glucose concentration (3 - 16.7 mM) and extract dose (5 - 500 μg/mL). The insulin releasing effect of the extract was significantly enhanced by 3-isobutyl-1-methyl xanthine, glibenclamide, elevated extracellular calcium and K+ depolarized media. This insulin release was significantly reduced in calcium blocking conditions (by nifedipine and EGTA), in the presence of potassium channel opener (diazoxide). Hence, anti diabetic activity of CZME might be a result of its stimulatory effect on insulin release from pancreatic beta cells via KATP channel dependent and independent ways. These results indicate that CZ fruits have the potential to use in diabetes therapy.

Exact Traveling Wave Solutions of Nano-Ionic Solitons and Nano-Ionic Current of MTs Using the exp(-φ (ξ ))-Expansion Method

In this work, the exp(-φ (ξ )) -expansion method is used for the first time to investigate the exact traveling wave solutions involving parameters of nonlinear evolution equations. When these parameters are taken to be special values, the solitary wave solutions are derived from the exact traveling wave solutions. The validity and reliability of the method are tested by its applications to Nano-ionic solitons wave’s propagation along microtubules in living cells and Nano-ionic currents of MTs which play an important role in biology.

抗撕裂树脂HN-807在工程机械轮胎胎面胶和胎侧胶中的应用

研究抗撕裂树脂HN-807在工程机械轮胎胎面胶和胎侧胶中的应用。结果表明:在工程机械轮胎胎面胶与胎侧胶中添加2份抗撕裂树脂HN-807,胶料的门尼粘度降低,工艺性能改善,强伸性能、弹性、炭黑分散性能和抗切割性能提高,生热降低,胎面胶的耐磨性能提高,胎侧胶的耐屈挠性能提高;成品轮胎的抗切割能力提高,使用寿命延长。

干眼症的药物治疗策略及研究进展

干眼症(DED)是一种复杂的多因素疾病,表现出不同的症状,这些症状可影响视觉功能,导致日常生活活动受限,工作效率降低,从而严重影响生活质量。本综述对目前临床上DED的治疗药物以及市场上正在开发的DED治疗策略进行总结,旨在对临床研究提供参考。

基于专利分析的撕裂式防盗指示装置技术发展研究

目前用于容器的防伪技术种类繁多、应用广泛,研究梳理容器的防伪技术有助于深入了解防伪封闭件的发展历程以及未来发展方向。文章介绍了容器设置撕裂式防盗指示装置进行防伪的防伪方式,检索并梳理了撕裂式防盗装置的相关专利,分析撕裂式防盗指示装置的发展技术分类,重点介绍非一体式撕裂条带防盗指示装置的技术发展情况,为相关人员提供参考。

缓释型抗冰冻混合料铺装路面抗凝冰效果及长效保持机制研究

【目的】针对冬季冰雪天气桥面结冰导致的交通安全问题,开展缓释型抗冰冻沥青混合料研究。【方法】通过融化试验、撕裂试验和电导率试验,对比评价SMA-13-国产和SMA-13-MFL的短期融冰和长期防冰效果。【结果】融化试验表明,进口MFL抗冰冻剂的融冰能力优于国产抗冰冻剂。撕裂试验表明,国产抗冰冻剂的融冰性能优于进口MFL抗冰冻剂。盐分融析电导率试验表明,进口MFL抗冰冻剂的析出速率大于国产抗冰冻剂;进口MFL抗冰冻的融雪除冰效果可持续2~3年,国产抗冰冻剂的融雪除冰效果可持续3~4年。【结论】缓释型抗冰冻混合料在桥面铺装中具有较好的推广应用前景。

欧加大厦出正负零六合一集束柱复杂节点加工工艺

欧加大厦项目结构形式为“钢框架+钢筋混凝土核心筒”,钢结构部分主要包括塔楼外框钢柱钢梁、核心筒内插钢柱钢结构,主要构件截面有圆管、H形、箱形,在出正负零标高底层转换处有各种截面组合成集束柱。制作难度大、结构复杂、要求精度高,并且行业内无类似工程结构项目借鉴,需要自行分析整合评审总结最佳加工制作工艺方案。

矿用输送带纵向撕裂原因分析及其预防

分析了矿用输送带纵向撕裂的原因,总结出了几种生产实践中常见的防止输送带撕裂的方法,以提高煤矿生产的安全。详细介绍了使用抗撕裂输送带防止撕裂的方法,同时介绍了抗撕裂输送带的结构和性能指标。

人工泪液联合非甾体抗炎药物治疗学龄前儿童干眼的临床观察

目的:探讨人工泪液联合非甾体抗炎药物治疗学龄前儿童干眼的临床疗效。方法:对确诊的儿童干眼患者32例64眼,给予人工泪液联合非甾体抗炎药物点眼治疗,在治疗前及治疗后1mo分别就临床症状、泪膜干涉图像等级及泪河高度做对比观察,进行统计学分析。结果:治疗1mo后,临床症状明显缓解,泪膜干涉图像等级及泪河高度均值较治疗前明显改善,差异有统计学意义(P<0.05)。结论:人工泪液联合非甾体抗炎药物可以明显改善儿童干眼患者的临床症状及干眼相关的实验室检查结果,临床疗效显著,用药安全,无不良反应。

眼用抗炎药联合人工泪液治疗儿童异常瞬目的临床观察

目的探讨眼用抗炎药联合人工泪液治疗儿童异常瞬目的临床疗效。方法 160例异常瞬目患儿,随机分为A组与B组,各80例。A组使用眼用抗炎药联合人工泪液治疗,B组单纯使用眼用抗炎药进行治疗。分别于治疗前及治疗后3、7、14 d就临床症状综合得分(CSCS)、泪膜破裂时间(BUT)、角膜荧光素染色(FL)做对比观察与综合评分并记录。结果 A组治疗异常瞬目的疗效优于B组,差异有统计学意义(P<0.05)。结论眼用抗炎药联合人工泪液对儿童异常瞬目的治疗有促进作用,值得在临床推广应用。

建筑结构用抗层状撕裂特厚板的焊接

宝钢开发的建筑用Q345GJ、Q420等抗层状撕裂低合金高强特厚钢板,满足国内日益增多的高层和超高层钢结构建筑与场馆建设需求。建筑用高强钢特厚板焊接是其应用的关键,宝钢开发了与该特厚板配套高效的埋弧焊接材料BH500J-III焊丝。采用高效的双丝埋弧焊接方法及其焊接材料,可达到所需的焊接接头强度和冲击韧性。

四元羧酸乙二硫醇二琥珀醚的合成及棉织物的抗皱整理

以马来酸和乙二硫醇为原料,通过硫醇的Michael加成反应合成了四元羧酸乙二硫醇二琥珀酸醚(MASESMA)。将MASESMA作为抗皱整理剂整理棉织物,探讨了焙烘温度、焙烘时间、整理剂和催化剂质量浓度对织物整理效果的影响。结果表明,优化的织物整理条件为:ρ(MASESMA)100 g/L,催化剂次亚磷酸钠与整理液中羧基物质的量比为0.5,即65 g/L,二浸二轧,80℃烘干3 min,160℃焙烘90 s。一次标准水洗后处理织物的折皱回复角为251°、撕破强力保留率53.9%、白度115.38。采用二浴法,添加20 g/L柔软剂可使织物折皱回复角达到275°,撕破强力保留率达69.3%。