α-Fe_(2)O_(3)/epoxy resin composite superhydrophobic coating was prepared withα-Fe_(2)O_(3) nanoparticles and epoxy resin by spin coating method.The coating without epoxy resin has higher contact angle(CA)and lower ...α-Fe_(2)O_(3)/epoxy resin composite superhydrophobic coating was prepared withα-Fe_(2)O_(3) nanoparticles and epoxy resin by spin coating method.The coating without epoxy resin has higher contact angle(CA)and lower ice adhesion strength(IAS),but the mechanical properties are poor.Theα-Fe_(2)O_(3)/epoxy resin composite superhydrophobic coating exhibits good mechanical durability.In addition,compared with the bare aluminum substrate,the Ecorr of the composite coating is positive and the Jcorr is lower.The inhibition efficiency of the composite coating is as high as 99.98%in 3.5 wt%NaCl solution.The difference in the microstructure caused by the two preparation methods leads to the changes in mechanical properties and corrosion resistance of composite superhydrophobic coating.展开更多
The formation of ice on the leading edge of aircraft engines is a serious issue,as it can have catastrophic consequences.The Swirl Anti-Icing(SAI)system,driven by ejection,circulates hot fluid within a 360°annula...The formation of ice on the leading edge of aircraft engines is a serious issue,as it can have catastrophic consequences.The Swirl Anti-Icing(SAI)system,driven by ejection,circulates hot fluid within a 360°annular chamber to heat the engine inlet lip surface and prevent icing.This study employs a validated Computational Fluid Dynamics(CFD)approach to study the impact of key geometric parameters of this system on flow and heat transfer characteristics within the anti-icing chamber.Additionally,the entropy generation rate and exergy efficiency are analyzed to assess the energy utilization in the system.The research findings indicate that,within the considered flow range,reducing the nozzle specific areaφfrom 0.03061 to 0.01083 can enhance the ejection coefficient by over 60.7%.This enhancement increases the air circulating rate,thereby intensifying convective heat transfer within the SAI chamber.However,the reduction inφalso leads to a significant increase in the required bleed air pressure and a higher entropy generation rate,indicating lower exergy efficiency.The nozzle angleθnotably affects the distribution of hot and cold spots on the lip surface of the SAI chamber.Increasingθfrom 0°to 20°reduces the maximum temperature difference on the anti-icing chamber surface by 60 K.展开更多
BACKGROUND Cat scratch disease(CSD)is the most common human infection caused by Barto-nella henselae(B.henselae).The main manifestation is self-limited lymphaden-opathy that primarily affects adolescents,and typically...BACKGROUND Cat scratch disease(CSD)is the most common human infection caused by Barto-nella henselae(B.henselae).The main manifestation is self-limited lymphaden-opathy that primarily affects adolescents,and typically resolves without treat-ment within 2-4 months.However,individuals with compromised immune systems or immunodeficiency require specific antibacterial therapy following diagnosis.Due to its low incidence,nonspecific clinical manifestations,and diagnostic limitations,this condition often poses challenges for clinicians in terms of missed diagnoses and misdiagnoses.CASE SUMMARY The child was ultimately diagnosed with CSD.The primary manifestations included nocturnal fever,enlargement of lymph nodes in the neck,axilla and groin,and suspected brucellosis;however,both brucellosis tests conducted during the course of the illness yielded negative results.Bone marrow cytology indicated stimulated proliferation.Lymph node biopsy indicated hyperplasia of lymphoid tissue in the cervical lymph nodes(right),with combined immunohisto-chemical findings indicating reactive hyperplasia.Immunohistochemical analysis revealed CD20 B(+),CD3 T(+),BCL-6(+),and BCL-2(-).CD21 FDC networks were present and Ki67 expression in the germinal center was~80%.Blood next-generation sequencing indicated B.henselae sequence number was 3.Serological test results demonstrated positive antibody response to B.henselae IgG(+),B.henselae IgM(+),Bartonella quintana(B.quintana)IgG(-)and B.quintana IgM(-),and the final diagnosis was CSD.CONCLUSION In patients presenting with fever at night and swollen lymph nodes of unknown origin,CSD should be considered.展开更多
BACKGROUND Syphilis is an infectious disease caused by Treponema pallidum that can invade the central nervous system,causing encephalitis.Few cases of anti-N-methyl-Daspartate receptor autoimmune encephalitis(AE)secon...BACKGROUND Syphilis is an infectious disease caused by Treponema pallidum that can invade the central nervous system,causing encephalitis.Few cases of anti-N-methyl-Daspartate receptor autoimmune encephalitis(AE)secondary to neurosyphilis have been reported.We report a neurosyphilis patient with anti-γ-aminobutyric acid-B receptor(GABABR)AE.CASE SUMMARY A young man in his 30s who presented with acute epileptic status was admitted to a local hospital.He was diagnosed with neurosyphilis,according to serum and cerebrospinal fluid(CSF)tests for syphilis.After 14 d of antiepileptic treatment and anti-Treponema pallidum therapy with penicillin,epilepsy was controlled but serious cognitive impairment,behavioral,and serious psychiatric symptoms were observed.He was then transferred to our hospital.The Mini-Mental State Examination(MMSE)crude test results showed only 2 points.Cranial magnetic resonance imaging revealed significant cerebral atrophy and multiple fluidattenuated inversion recovery high signals in the white matter surrounding both lateral ventricles,left amygdala and bilateral thalami.Anti-GABABR antibodies were discovered in CSF(1:3.2)and serum(1:100).The patient was diagnosed with neurosyphilis complicated by anti-GABABR AE,and received methylprednisolone and penicillin.Following treatment,his mental symptoms were alleviated.Cognitive impairment was significantly improved,with a MMSE of 8 points.Serum anti-GABABR antibody titer decreased to 1:32.The patient received methylprednisolone and penicillin after discharge.Three months later,the patient’s condition was stable,but the serum anti-GABABR antibody titer was 1:100.CONCLUSION This patient with neurosyphilis combined with anti-GABABR encephalitis benefited from immunotherapy.展开更多
基金Supported by the National Natural Science Foundation of China(No.51801058)the Special Program for Guiding Local Science and Technology Development by the Central Government of Hubei Province(No.2019ZYYD006)the Education and Teaching Research Project of Hubei Polytechnic University(No.2021B01)。
文摘α-Fe_(2)O_(3)/epoxy resin composite superhydrophobic coating was prepared withα-Fe_(2)O_(3) nanoparticles and epoxy resin by spin coating method.The coating without epoxy resin has higher contact angle(CA)and lower ice adhesion strength(IAS),but the mechanical properties are poor.Theα-Fe_(2)O_(3)/epoxy resin composite superhydrophobic coating exhibits good mechanical durability.In addition,compared with the bare aluminum substrate,the Ecorr of the composite coating is positive and the Jcorr is lower.The inhibition efficiency of the composite coating is as high as 99.98%in 3.5 wt%NaCl solution.The difference in the microstructure caused by the two preparation methods leads to the changes in mechanical properties and corrosion resistance of composite superhydrophobic coating.
基金Shenyang Key Laboratory of Aircraft Icing and Ice Protection,Grant Number XFX20220303Education Department of Hunan Province,China,Grant Number 23A0504National Natural Science Foundation of China,Grant Number 52275108.
文摘The formation of ice on the leading edge of aircraft engines is a serious issue,as it can have catastrophic consequences.The Swirl Anti-Icing(SAI)system,driven by ejection,circulates hot fluid within a 360°annular chamber to heat the engine inlet lip surface and prevent icing.This study employs a validated Computational Fluid Dynamics(CFD)approach to study the impact of key geometric parameters of this system on flow and heat transfer characteristics within the anti-icing chamber.Additionally,the entropy generation rate and exergy efficiency are analyzed to assess the energy utilization in the system.The research findings indicate that,within the considered flow range,reducing the nozzle specific areaφfrom 0.03061 to 0.01083 can enhance the ejection coefficient by over 60.7%.This enhancement increases the air circulating rate,thereby intensifying convective heat transfer within the SAI chamber.However,the reduction inφalso leads to a significant increase in the required bleed air pressure and a higher entropy generation rate,indicating lower exergy efficiency.The nozzle angleθnotably affects the distribution of hot and cold spots on the lip surface of the SAI chamber.Increasingθfrom 0°to 20°reduces the maximum temperature difference on the anti-icing chamber surface by 60 K.
基金Supported by Shaanxi Natural Science Foundation,No.2020SF-004.
文摘BACKGROUND Cat scratch disease(CSD)is the most common human infection caused by Barto-nella henselae(B.henselae).The main manifestation is self-limited lymphaden-opathy that primarily affects adolescents,and typically resolves without treat-ment within 2-4 months.However,individuals with compromised immune systems or immunodeficiency require specific antibacterial therapy following diagnosis.Due to its low incidence,nonspecific clinical manifestations,and diagnostic limitations,this condition often poses challenges for clinicians in terms of missed diagnoses and misdiagnoses.CASE SUMMARY The child was ultimately diagnosed with CSD.The primary manifestations included nocturnal fever,enlargement of lymph nodes in the neck,axilla and groin,and suspected brucellosis;however,both brucellosis tests conducted during the course of the illness yielded negative results.Bone marrow cytology indicated stimulated proliferation.Lymph node biopsy indicated hyperplasia of lymphoid tissue in the cervical lymph nodes(right),with combined immunohisto-chemical findings indicating reactive hyperplasia.Immunohistochemical analysis revealed CD20 B(+),CD3 T(+),BCL-6(+),and BCL-2(-).CD21 FDC networks were present and Ki67 expression in the germinal center was~80%.Blood next-generation sequencing indicated B.henselae sequence number was 3.Serological test results demonstrated positive antibody response to B.henselae IgG(+),B.henselae IgM(+),Bartonella quintana(B.quintana)IgG(-)and B.quintana IgM(-),and the final diagnosis was CSD.CONCLUSION In patients presenting with fever at night and swollen lymph nodes of unknown origin,CSD should be considered.
文摘BACKGROUND Syphilis is an infectious disease caused by Treponema pallidum that can invade the central nervous system,causing encephalitis.Few cases of anti-N-methyl-Daspartate receptor autoimmune encephalitis(AE)secondary to neurosyphilis have been reported.We report a neurosyphilis patient with anti-γ-aminobutyric acid-B receptor(GABABR)AE.CASE SUMMARY A young man in his 30s who presented with acute epileptic status was admitted to a local hospital.He was diagnosed with neurosyphilis,according to serum and cerebrospinal fluid(CSF)tests for syphilis.After 14 d of antiepileptic treatment and anti-Treponema pallidum therapy with penicillin,epilepsy was controlled but serious cognitive impairment,behavioral,and serious psychiatric symptoms were observed.He was then transferred to our hospital.The Mini-Mental State Examination(MMSE)crude test results showed only 2 points.Cranial magnetic resonance imaging revealed significant cerebral atrophy and multiple fluidattenuated inversion recovery high signals in the white matter surrounding both lateral ventricles,left amygdala and bilateral thalami.Anti-GABABR antibodies were discovered in CSF(1:3.2)and serum(1:100).The patient was diagnosed with neurosyphilis complicated by anti-GABABR AE,and received methylprednisolone and penicillin.Following treatment,his mental symptoms were alleviated.Cognitive impairment was significantly improved,with a MMSE of 8 points.Serum anti-GABABR antibody titer decreased to 1:32.The patient received methylprednisolone and penicillin after discharge.Three months later,the patient’s condition was stable,but the serum anti-GABABR antibody titer was 1:100.CONCLUSION This patient with neurosyphilis combined with anti-GABABR encephalitis benefited from immunotherapy.
