Looking up Prescriptions to Treat Infectious Disease:Anti-epidemic Books of Medical Formularies and Epidemic Prevention and Control in the Qing Dynasty

Copying,compiling,publishing,disseminating,and referencing anti-epidemic books of medical formularies were common activities during the outbreak of epidemics in the Qing dynasty.Its emergence,motivated by epidemic disease again and again,was important component parts of epidemic prevention and control.They played a unique role as media on affairs such as treating patients suffering from infectious diseases,mobilizing peoples to make contributions to anti-epidemic activities,integrating and popularizing knowledge of epidemic prevention.Anti-epidemic books of medical formularies were important to link peoples,things,and substances related with epidemic prevention and control,and were a kind of motivation to actively deal with the infectious disease,control the epidemic,and maintain health.Compared to other common measures,anti-epidemic books of medical formularies participated in many prevention and control practices deeply,which actually built a low cost,spontaneous,dispersed and non-institutional system to respond to epidemic,and the system had characteristics of stronger conductibility,bigger coverage area,and better external benefits.

Network Pharmacology, Molecular Docking and Experimental Exploring Molecular Mechanisms of Yinqiao Anti-Epidemic Formula in Regulating Mucosal Immune System of Respiratory Tract

[Objectives]To explore the molecular mechanisms of Yinqiao anti-epidemic formula(YQAEF)in regulating mucosal immune system of respiratory tract.[Methods]The active components of YQAEF were obtained from the TCMSP database,and RMIS targets were obtained from the GeneCards database.A"YQAEF components-RMIS targets-pathways"network was constructed by analyzing the above data to screen core targets for molecular docking verification.A mouse model of acute upper respiratory tract infection(AURI)was developed.Based on the experimental models,the key pathway target genes screened by network pharmacology were verified in vivo.[Results]The main active components of YQAEF involved in the regulation of the RMIS included quercetin,acetic acid,and raffinose.Key targets,such as angiotensin-converting enzyme(ACE),galactosidase alpha(GLA),matrix metalloproteinase 2(MMP2),Serpin Family E Member 1(SERPINE1),and myeloperoxidase(MPO)and important viral infection and endocrine resistance signaling pathways were included in the regulation of the RMIS with YQAEF.Molecular docking assays showed that the key targets had good binding activities with the components of YQAEF.Based on the results of network pharmacology,key target proteins in ACE,GLA,MMP2,SERPINE1,and MPO were selected for experimental verification.The results showed that ACE/ACE2 and MPO expressions were increased in the oral and throat mucosa of the AURI mice.Under YQAEF treatment,the expression levels of ACE/ACE2 and MPO were decreased.[Conclusions]This study revealed the mechanism of YQAEF in the regulation of RMIS,which is associated with multiple components,targets,and pathways.Further experiments confirmed that YQAEF interfered with MPO and ACE/ACE2 signaling pathways to regulate the RMIS in the oral and throat mucosa tissue of mice with AURI,and provide a new direction for exploring the potential antiviral mechanism of YQAEF.

China's Anti-epidemic Diplomacy Boosts Global Public Health Governance

In 2020 with a pandemic sweeping the world,global political and economic orders seriously disrupted and tens of millions of human lives threatened,the spread of the novel coronavirus is the world's number one challenge.China has efficiently organized domestic epidemic control and vigorously promoted international cooperation in the battle against the pandemic by advancing head-of-state diplomacy.In this ongoing crisis,China has actively led the way for global public health governance,promoted the building of a community with common health for mankind,and demonstrated the actions of a responsible major country.

The Logic of Self-Justification of China’s Anti-Epidemic Effectiveness

The COVID-19 outbreak in 2020 is a syndrome of economic,social and governance crises.It is not only a test of the medical and health system of a country or a region,but also a test of the emergency management system and the comprehensive governance capacity.Based on the complexity of epidemic prevention and control,no single factor can explain and respond to the"exceptional status"of epidemic prevention and control.Only by applying the"Theory of History Resultant Force",establishing systematic thinking,and comprehensively reviewing and analyzing can we comprehensively and objectively clarify its pros and cons.Having taken advantage of the party’s leadership,the nationwide system,and the Socialism with Chinese characteristics with a broad mass base and strong material support,China has achieved obvious results in a relatively short period of time in the process of epidemic prevention and control.It provides other countries or regions with Chinese experience,and Chinese wisdom for anti-epidemic efforts.

Acquisition and Dissemination of Anti-Epidemic Medical Prescriptions During the Outbreaks in the Qing Dynasty of China

During the epidemics in the Qing dynasty,many medical professionals,nonprofessionals,and social organizations collected and sorted medical prescriptions related to infectious diseases.These people also compiled,published,disseminated,and consulted related medical formularies.The above historical event can be viewed as the construction and dissemination of medical knowledge.They edited and published medical formularies on infectious diseases with lower cost and in flexible ways by taking the initiative and giving full scope to creativity.Diverse anti-epidemic medical prescriptions from these medical formularies can be used for infectious diseases in the event of the outbreaks.However,the therapeutic effects of classical prescriptions and folk recipes cannot be regarded as the same.The wide circulation of anti-epidemic medical prescriptions and medical formularies was essentially a process of epidemic prevention resource allocation.Not only did it enable many nonprofessionals to participate in epidemic prevention and control,but it also enhanced awareness,knowledge,and capacity for epidemic prevention at the individual level.At the same time,due to the uneven quality and individual differences in the physical fitness and condition of the prescriptions and formularies,they had the capacity of causing inconveniences to the readers or patients.

Discussing the Dietary Regimen and Disease Prevention and its Application as an Anti-epidemic Measure

This article discusses the role of dietary regimen in the traditional culture of Chinese medicine according to its origin.Dietary regimen is a technique that inherits die traditional culture of Chinese medicine.Through analysis of the characteristics of the dietary regimen and the discussion of the idea of disease prevention,the application of the dietary regimen in disease prevention is sought.Under the guidance of three key factors,the application of the dietary regimen in disease prevention is mainly manifested in two aspects,h irst,the dietary regimen can be used to guide the daily reasonable diet to maintain the human body in a balance of Yin and Yang,which could prevent the occurrence of diseases.Second,on the basis of minimizing health loss,it can be used for disease treatment,adjuvant treatment,and rehabilitation.Finally,taking preventive treatment as the guiding ideology,the application of a dietary regimen as an"anti-epidemic"was briefly discussed.

A Self-Powered Energy-Saving Epidemic Prevention Tent

The current situation of the epidemic is complex and changeable.Under the China adherence to the“dynamic zero clearance,”epidemic prevention and control is closely related to all walks of life,and epidemic prevention awning has become one of the essential basic epidemic prevention facilities.However,most of the epidemic awnings are manufactured for the isolation and protection from wind and rain,which could not meet the needs of electricity allocation during emergencies.Therefore,our goal is to design a new energy-saving epidemic prevention tent that is green,stable,and easy to shrink.It is equipped with multiple energy storage and multivariate methods to achieve self-supply of electric energy.First the“1+1”arrangement design of solar power panels on the anti-epidemic tent and pressure power panels combined with the design of pressure power panels under the tent can receive various energy inputs.At the same time,retractable brackets are designed under the four pillars,which are easy to fold and enhance the stability of the canopy.The utilization of energy is more diversified to achieve the purpose of energy conservation and emission reduction.Its market value is broad,and the development prospect is good.