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异种器官移植中HAR的机理与解决手段
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作者 朱学伟 李存保 《内蒙古医学院学报》 2005年第6期7-11,共5页
过急性排斥反应(hyperacute rejection,HAR)是目前异种移植发展的主要障碍之一,产生原因是非灵长类哺乳动物细胞表面的α-Gal表位与人体内天然存在的anti-gal的相互结合,继而引发补体的作用,导致移植物在数分钟内衰竭。目前清除人体内an... 过急性排斥反应(hyperacute rejection,HAR)是目前异种移植发展的主要障碍之一,产生原因是非灵长类哺乳动物细胞表面的α-Gal表位与人体内天然存在的anti-gal的相互结合,继而引发补体的作用,导致移植物在数分钟内衰竭。目前清除人体内anti-gal抗体,抑制补体的作用,下调移植物细胞表面α-Gal表位数量等方法被认为是解决过急性排斥反应的可行性手段。 展开更多
关键词 过急性排斥反应 特种器官移植 Galα(1 3)-Gal表位 anti-gal抗体
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Galling phenomena in metal forming 被引量:2
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作者 Kuniaki DOHDA Masahito YAMAMOTO +2 位作者 Chengliang HU Laurent DUBAR Kornel F.EHMANN 《Friction》 SCIE EI CAS CSCD 2021年第4期665-685,共21页
Galling phenomena in metal forming not only affect the quality of the engineered surfaces but also the success or failure of the manufacturing operation itself.This paper reviews the different galling conditions in sh... Galling phenomena in metal forming not only affect the quality of the engineered surfaces but also the success or failure of the manufacturing operation itself.This paper reviews the different galling conditions in sheet and bulk metal forming processes along with their evolution and the effects of temperature on galling.A group of anti-galling methods employed to prevent galling defects are also presented in detail.The techniques for quantitatively measuring galling are introduced,and the related prediction models,including friction,wear,and galling growth models,are presented to better understand the underlying phenomena.Galling phenomena in other processes similar to those occurring in metal forming are also examined to suggest different ways of further studying galling in metal forming.Finally,future research directions for the study of galling in metal forming are suggested. 展开更多
关键词 GALLING metal forming FRICTION WEAR ADHESION anti-galling
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