非痴呆型血管性认知障碍(vascular cognitive impairment no dementia,VCIND)是认知障碍的早期阶段,认知损害尚未达到痴呆的标准。本文从中医“虚、痰、瘀”的病因病机进行阐述,脾肾亏虚为发病基础,痰瘀互结为致病因素,导致髓海不足,清...非痴呆型血管性认知障碍(vascular cognitive impairment no dementia,VCIND)是认知障碍的早期阶段,认知损害尚未达到痴呆的标准。本文从中医“虚、痰、瘀”的病因病机进行阐述,脾肾亏虚为发病基础,痰瘀互结为致病因素,导致髓海不足,清窍失养,发为痴呆。胆碱能通路与认知障碍的发生发展密切相关,包括神经递质乙酰胆碱的缺乏、脑白质病变影响胆碱能通路的网络连接以及胆碱能抗炎通路等。探讨中医虚痰瘀的病机演变与胆碱能通路发病机制之间的关系,有助于进一步发掘中医中药治疗在胆碱能通路的作用。展开更多
The grand unified theory (GUT) originated in mathematics with this question: why are there long standing unsolved problems in mathematics, e.g., Fermat’s conjecture (also known as Fermat’s last theorem (FLT))? The a...The grand unified theory (GUT) originated in mathematics with this question: why are there long standing unsolved problems in mathematics, e.g., Fermat’s conjecture (also known as Fermat’s last theorem (FLT))? The answer came quickly: its underlying fields—foundations and the real number system—are defective. In particular, formal logic is inapplicable to mathematics (language of science) and the real number system is inconsistent. Critique-rectification of these fields was undertaken leading to a new mathematical methodology and the consistent new real number system that provides the main mathematics of GUT. Similar question was posed in physics: why are there long standing problems, e.g., the gravitational n-body and turbulence problems? The answer: the present methodology, quantitative modeling is inadequate and the remedy is a new methodology—qualitative mathematics and modeling that solved these problems and provided the initial formulation of GUT. This paper presents the basic logic of GUT and its fundamental concepts, particularly, the superstring or fundamental building block of matter.展开更多
文摘非痴呆型血管性认知障碍(vascular cognitive impairment no dementia,VCIND)是认知障碍的早期阶段,认知损害尚未达到痴呆的标准。本文从中医“虚、痰、瘀”的病因病机进行阐述,脾肾亏虚为发病基础,痰瘀互结为致病因素,导致髓海不足,清窍失养,发为痴呆。胆碱能通路与认知障碍的发生发展密切相关,包括神经递质乙酰胆碱的缺乏、脑白质病变影响胆碱能通路的网络连接以及胆碱能抗炎通路等。探讨中医虚痰瘀的病机演变与胆碱能通路发病机制之间的关系,有助于进一步发掘中医中药治疗在胆碱能通路的作用。
文摘The grand unified theory (GUT) originated in mathematics with this question: why are there long standing unsolved problems in mathematics, e.g., Fermat’s conjecture (also known as Fermat’s last theorem (FLT))? The answer came quickly: its underlying fields—foundations and the real number system—are defective. In particular, formal logic is inapplicable to mathematics (language of science) and the real number system is inconsistent. Critique-rectification of these fields was undertaken leading to a new mathematical methodology and the consistent new real number system that provides the main mathematics of GUT. Similar question was posed in physics: why are there long standing problems, e.g., the gravitational n-body and turbulence problems? The answer: the present methodology, quantitative modeling is inadequate and the remedy is a new methodology—qualitative mathematics and modeling that solved these problems and provided the initial formulation of GUT. This paper presents the basic logic of GUT and its fundamental concepts, particularly, the superstring or fundamental building block of matter.
