A new compound 8-chloro-7-（4-（3-chloropropanoyl）piperazin-1-yl）-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid（II, C20H20Cl2FN3O4, Mr = 456.08） was synthesized and characterized by 1H NMR, 1...A new compound 8-chloro-7-（4-（3-chloropropanoyl）piperazin-1-yl）-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid（II, C20H20Cl2FN3O4, Mr = 456.08） was synthesized and characterized by 1H NMR, 13 C NMR, HR MS and single-crystal X-ray diffraction. X-ray powder diffraction（XRPD）, thermal stabilities, UV-Vis spectrum, photoluminescent properties and absolute quantum yield of compound II were also investigated. The structure demonstrates that the crystal belongs to the triclinic system, space group P1 with a = 7.7339（3）, b = 10.2396（5）, c = 15.9076（8）A, α = 76.517（4）, β = 77.609（4）, γ = 80.320（4）°, V = 1187.22（9）A^3, Z = 2, Dc = 1.514 g/mm^3, μ = 4.901 mm^-1, F（000） = 556.0, R = 0.0534 and w R = 0.1447（I 〉 2σ（I））. The result reveals that fluoroquionolone moiety in this structure stacks with π×××π interactions to generate an infinite 1D chain, which can stabilize the whole framework of compound II. Delightfully, preliminary antibacterial activity in vitro against 4 cell strains uncovers that compound II has almost equal strong activity in comparison with Clinafloxacin, but stronger than Norfloxacin. These outcomes provide important information for further exploration of the structure-activity relationship（SAR） of compound II derivatives or analogs.展开更多
基金financially supported by the National Natural Science Foundation of China(No.21542003)
文摘A new compound 8-chloro-7-（4-（3-chloropropanoyl）piperazin-1-yl）-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid（II, C20H20Cl2FN3O4, Mr = 456.08） was synthesized and characterized by 1H NMR, 13 C NMR, HR MS and single-crystal X-ray diffraction. X-ray powder diffraction（XRPD）, thermal stabilities, UV-Vis spectrum, photoluminescent properties and absolute quantum yield of compound II were also investigated. The structure demonstrates that the crystal belongs to the triclinic system, space group P1 with a = 7.7339（3）, b = 10.2396（5）, c = 15.9076（8）A, α = 76.517（4）, β = 77.609（4）, γ = 80.320（4）°, V = 1187.22（9）A^3, Z = 2, Dc = 1.514 g/mm^3, μ = 4.901 mm^-1, F（000） = 556.0, R = 0.0534 and w R = 0.1447（I 〉 2σ（I））. The result reveals that fluoroquionolone moiety in this structure stacks with π×××π interactions to generate an infinite 1D chain, which can stabilize the whole framework of compound II. Delightfully, preliminary antibacterial activity in vitro against 4 cell strains uncovers that compound II has almost equal strong activity in comparison with Clinafloxacin, but stronger than Norfloxacin. These outcomes provide important information for further exploration of the structure-activity relationship（SAR） of compound II derivatives or analogs.
