Summary: Serum anticardiolipin antibody (ACA) was measured in 91 patients with cerebral infarction (CI), 42 patients with cerebral hemorrhage (CH) and 30 healthy controls. The results showed that the ACA in CI and CH ...Summary: Serum anticardiolipin antibody (ACA) was measured in 91 patients with cerebral infarction (CI), 42 patients with cerebral hemorrhage (CH) and 30 healthy controls. The results showed that the ACA in CI and CH patients was significantly higher than in controls and IgG ACA was the most important isotype. Stroke in ACA positive group tended to be recurrent and of multi focuses. Positive rate of IgG ACA reached its peak within the first week after stroke onset. The results suggested that ACA was an independent risk factor in CI and CH and might be valuable in stroke prediction.展开更多
Objective To investigate the relationship between cytomegalovirus (CMV) infection and the production of anticardiolipin antibody (ACA) in renal transplant recipients.Methods Polymerase chain reaction (PCR) was used qu...Objective To investigate the relationship between cytomegalovirus (CMV) infection and the production of anticardiolipin antibody (ACA) in renal transplant recipients.Methods Polymerase chain reaction (PCR) was used qualitatively for detection of CMV DNA in 146 renal transplant recipients.Meanwhile,enzyme linked immunosorbent assay (ELISA) was used for detection of ACA IgG in blood serum samples from these recipients and 32 healthy individuals. Results The ACA positive rate was 17.1% among the 146 renal transplant recipients,and that of the control group was 6.3%.There was no significant difference.However,the ACA positive rate of the renal transplant recipients infected with CMV was 31.2%.It was clearly higher than that of those with no infection of CMV and that of the control group ( P <0.005). Conclusion The production of ACA was closely related to CMV infection.It might be one of the factors of chronic angiopathy of the transplanted kidney due to CMV infection.展开更多
Obuective To determine the frequency and the clinical significance of anticardiolipin antibodies(ACA) in patients with systemic lupus erythematosus(SLE). Methods The serum ACA in 30 patients with SLE and 30 sera from ...Obuective To determine the frequency and the clinical significance of anticardiolipin antibodies(ACA) in patients with systemic lupus erythematosus(SLE). Methods The serum ACA in 30 patients with SLE and 30 sera from healthy volunteers was detected by the enzyme linked immunosorbend assay(ELISA). Results In normal group the binding index(BI)of IgG,IgM and IgA type of ACA was 1.48±0.43,1.46±0.43,1.00±0.33 respec-tively .In SLE groups the BI of IgG-ACA, IgA-ACA was 3.04±1.25,3.07±1.61,1.96±1.05 respectively with the differ-ences being significant(P<0.05).ACA had relations with part ofclinical manifestations such as blood vessel inflammation,thrombocy-topenia,renal lesions,Raynaud's phenomenon,damage of nerve center system and alboratory noms as low complement C3.There were linear correlation between ANA and IgG-ACA or IgM-ACA with r=0.912,0.870,0.758 respectively,all P<0.01.Conclusio ACA could be used as a marker to evaluate the activity of SLE.展开更多
文摘Summary: Serum anticardiolipin antibody (ACA) was measured in 91 patients with cerebral infarction (CI), 42 patients with cerebral hemorrhage (CH) and 30 healthy controls. The results showed that the ACA in CI and CH patients was significantly higher than in controls and IgG ACA was the most important isotype. Stroke in ACA positive group tended to be recurrent and of multi focuses. Positive rate of IgG ACA reached its peak within the first week after stroke onset. The results suggested that ACA was an independent risk factor in CI and CH and might be valuable in stroke prediction.
文摘Objective To investigate the relationship between cytomegalovirus (CMV) infection and the production of anticardiolipin antibody (ACA) in renal transplant recipients.Methods Polymerase chain reaction (PCR) was used qualitatively for detection of CMV DNA in 146 renal transplant recipients.Meanwhile,enzyme linked immunosorbent assay (ELISA) was used for detection of ACA IgG in blood serum samples from these recipients and 32 healthy individuals. Results The ACA positive rate was 17.1% among the 146 renal transplant recipients,and that of the control group was 6.3%.There was no significant difference.However,the ACA positive rate of the renal transplant recipients infected with CMV was 31.2%.It was clearly higher than that of those with no infection of CMV and that of the control group ( P <0.005). Conclusion The production of ACA was closely related to CMV infection.It might be one of the factors of chronic angiopathy of the transplanted kidney due to CMV infection.
文摘Obuective To determine the frequency and the clinical significance of anticardiolipin antibodies(ACA) in patients with systemic lupus erythematosus(SLE). Methods The serum ACA in 30 patients with SLE and 30 sera from healthy volunteers was detected by the enzyme linked immunosorbend assay(ELISA). Results In normal group the binding index(BI)of IgG,IgM and IgA type of ACA was 1.48±0.43,1.46±0.43,1.00±0.33 respec-tively .In SLE groups the BI of IgG-ACA, IgA-ACA was 3.04±1.25,3.07±1.61,1.96±1.05 respectively with the differ-ences being significant(P<0.05).ACA had relations with part ofclinical manifestations such as blood vessel inflammation,thrombocy-topenia,renal lesions,Raynaud's phenomenon,damage of nerve center system and alboratory noms as low complement C3.There were linear correlation between ANA and IgG-ACA or IgM-ACA with r=0.912,0.870,0.758 respectively,all P<0.01.Conclusio ACA could be used as a marker to evaluate the activity of SLE.
