A New Potent Inhibitor of Thrombin from the Leech Haemendipsa Yanyuanensis

Two components of anticoagulant protein were isolated from the leech Haemendipsa yanyuanensis by heparin agarose affinity chromatography and ultracentrifugation. The determination of anticoagulant activity and characterization analysis of the protein using the method of chromogenic substrate indicates that the anticoagulant protein is thrombin specific but not factor Xa specific. The results lay a foundation for the research of the anticoagulant mechanism and application of anticoagulant protein from H. yanyuanensis.

活化蛋白C研究进展

蛋白C在凝血酶-血栓调节蛋白复合物作用下形成的活化蛋白C(APC),具有抗凝、抗炎、促纤溶、抗凋亡和保护内皮细胞的功能,与人类多种疾病相关。现对APC的功能及与其相关疾病的研究进展做一综述,重点阐述APC对中枢神经系统的保护作用。