The serum of 40 normal subjects, 61 cases of various malignant diseases except pancreatic cancer,53 cases of various benign diseases and 33 cases of pancreatic cancer was examined with ELISA to determine the serum lev...The serum of 40 normal subjects, 61 cases of various malignant diseases except pancreatic cancer,53 cases of various benign diseases and 33 cases of pancreatic cancer was examined with ELISA to determine the serum level of pancreatic cancer-associated ant展开更多
INTRODUCTIONCarcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3]....INTRODUCTIONCarcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3].Carbohydrate antigen 19-9(CA19-9), obtained with a monoclonal antibody produced by immunizing a monoclonal antibody produced by immunizing a mouse with a colonic cancer cell line in 1979[4],is a ligand for E-selectin that plays an important role in the addhesion of cancer cells to endothelial cells [5,6].展开更多
【目的】探讨分析冠状动脉粥样硬化性心脏病（CHD）患者血清胱抑素C（CysC）、CA125和骨保护素（OPG）的水平变化及临床意义。【方法】选取本院158例经冠状动脉造影确诊的 CHD 患者作为观察组（CHD组），另选95例健康人作为健康对照组...【目的】探讨分析冠状动脉粥样硬化性心脏病（CHD）患者血清胱抑素C（CysC）、CA125和骨保护素（OPG）的水平变化及临床意义。【方法】选取本院158例经冠状动脉造影确诊的 CHD 患者作为观察组（CHD组），另选95例健康人作为健康对照组。分别应用免疫比浊法、化学免疫发光法和ELISA法比较不同组别和不同病变支数患者的CysC、CA125、OPG 水平。【结果】与健康对照组比较，CHD组CysC、CA125、OPG水平明显升高（ P ＜0．05或 P ＜0．01）；单支、双支、多支病变组3组血清CysC、CA125、OPG 水平逐渐升高，左室射血分数（LVEF）逐渐下降，且差异均有显著性（ P ＜0．05或 P ＜0．01）；NYHAⅠ级、Ⅱ级、Ⅲ级、Ⅳ级组血清CysC、CA125、OPG水平逐渐升高，LVEF逐渐下降，且差异均有显著性（ P＜0．05或 P＜0．01）。CysC、CA125、OPG 水平均与冠脉病变支数、心功能级别呈正相关（ P ＜0．01），与 LVEF呈负相关（ P ＜0．01）。【结论】联合检测血浆CysC、BMG、OPG 水平不仅能评价心功能受损程度，而且有助于早期发现CHD和有助于冠脉病变严重程度的判断及预后判断。展开更多
文摘The serum of 40 normal subjects, 61 cases of various malignant diseases except pancreatic cancer,53 cases of various benign diseases and 33 cases of pancreatic cancer was examined with ELISA to determine the serum level of pancreatic cancer-associated ant
基金This study was supported by the research grant from Administration of Key Disciplines for"Project 211"of Sun Yat-Sen University of Medical Sciences,Grant No.98097.
文摘INTRODUCTIONCarcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3].Carbohydrate antigen 19-9(CA19-9), obtained with a monoclonal antibody produced by immunizing a monoclonal antibody produced by immunizing a mouse with a colonic cancer cell line in 1979[4],is a ligand for E-selectin that plays an important role in the addhesion of cancer cells to endothelial cells [5,6].
文摘【目的】探讨分析冠状动脉粥样硬化性心脏病（CHD）患者血清胱抑素C（CysC）、CA125和骨保护素（OPG）的水平变化及临床意义。【方法】选取本院158例经冠状动脉造影确诊的 CHD 患者作为观察组（CHD组），另选95例健康人作为健康对照组。分别应用免疫比浊法、化学免疫发光法和ELISA法比较不同组别和不同病变支数患者的CysC、CA125、OPG 水平。【结果】与健康对照组比较，CHD组CysC、CA125、OPG水平明显升高（ P ＜0．05或 P ＜0．01）；单支、双支、多支病变组3组血清CysC、CA125、OPG 水平逐渐升高，左室射血分数（LVEF）逐渐下降，且差异均有显著性（ P ＜0．05或 P ＜0．01）；NYHAⅠ级、Ⅱ级、Ⅲ级、Ⅳ级组血清CysC、CA125、OPG水平逐渐升高，LVEF逐渐下降，且差异均有显著性（ P＜0．05或 P＜0．01）。CysC、CA125、OPG 水平均与冠脉病变支数、心功能级别呈正相关（ P ＜0．01），与 LVEF呈负相关（ P ＜0．01）。【结论】联合检测血浆CysC、BMG、OPG 水平不仅能评价心功能受损程度，而且有助于早期发现CHD和有助于冠脉病变严重程度的判断及预后判断。
