In order to resolve the increasing resistance phenomena of the Gram-negative bacteria against single chain quaternary ammonium salts （QAS）, lysine with a pedant fluorinated bis-ammonium salts was synthesized and its...In order to resolve the increasing resistance phenomena of the Gram-negative bacteria against single chain quaternary ammonium salts （QAS）, lysine with a pedant fluorinated bis-ammonium salts was synthesized and its antimicrobial properties were evaluated in this work. The novel fluorinated bis-ammonium salts shows similar activity with conventional single chain quaternary ammonium salts against Gram-positive bacteria but stronger activity against Gram-negative bacteria and yeast compared with the single chained counterpart.展开更多
An EPDDMAC-GE polymer （hydrophilic molecule） has been synthesized based on epoxypropyl dodecyl dimethyl ammonium chloride （EPDDMAC） and gelatin. A DEEPSAC-GE polymer （hydrophobic molecule） has been synthesized b...An EPDDMAC-GE polymer （hydrophilic molecule） has been synthesized based on epoxypropyl dodecyl dimethyl ammonium chloride （EPDDMAC） and gelatin. A DEEPSAC-GE polymer （hydrophobic molecule） has been synthesized based on diethyl-2,3-epoxypropyl-[3-methyldimethoxyl] silpropyl ammonium chloride （DEEPSAC） and gelatin. Compared with initial gelatin, the gelatin modified with quaternary ammonium salts containing epoxide groups exhibits stronger antibacterial activity.展开更多
A series of new norspermidine derivatives, both nonionic and cationic, have been obtained. Structures of the synthesized compounds have been estab-lished by FTIR, 1H NMR, 13C NMR, 2D NMR, mass spectrometry and element...A series of new norspermidine derivatives, both nonionic and cationic, have been obtained. Structures of the synthesized compounds have been estab-lished by FTIR, 1H NMR, 13C NMR, 2D NMR, mass spectrometry and elemental analyses. Physicochemical and anti-microbial properties have been discussed.展开更多
The abuse of antibiotics causes severe bacterial resistance, and the shortage of antibiotics has created a global public health crisis. This situation has prompted people to develop new antibacterial agents independen...The abuse of antibiotics causes severe bacterial resistance, and the shortage of antibiotics has created a global public health crisis. This situation has prompted people to develop new antibacterial agents independent of traditional antibiotics. Here, we created a series of photosensitive azobenzene-quaternary ammonium salt smart antibacterial agents by connecting azobenzene with amines with different chain lengths to improve the antibacterial selectivity of quaternary ammonium salt(QAS) and prevent the accumulation of active QAS in the environment. After trans-cis isomerization, the solubility of the title compound(compound 4) increased and the antibacterial property enhanced. The experimental results suggested that the antibacterial effect of compound 4 was significantly enhanced after 365 nm light irradiation, and it had photosensitive intelligent antibacterial activity and could be reused. Notably, we did not obtain any mutants of Staphylococcus aureus or Escherichia coli resistant to compound 4. In general,compound 4 has the advantages of high yield, photo-controllable antibacterial properties, reusability, and does not induce bacterial resistance. This photosensitive antibacterial compound provides a new idea for the construction of intelligent disinfectants and is expected to be a candidate for disinfectants in public facilities and medical architecture.展开更多
文摘In order to resolve the increasing resistance phenomena of the Gram-negative bacteria against single chain quaternary ammonium salts （QAS）, lysine with a pedant fluorinated bis-ammonium salts was synthesized and its antimicrobial properties were evaluated in this work. The novel fluorinated bis-ammonium salts shows similar activity with conventional single chain quaternary ammonium salts against Gram-positive bacteria but stronger activity against Gram-negative bacteria and yeast compared with the single chained counterpart.
基金supported by Shandong Provincial Natural Science Foundation (Nos. Y2008B35 and ZR2010BQ002)the Star Youth Science and Technology Plans Project of Ji’nan City (No. 20110103)
文摘An EPDDMAC-GE polymer （hydrophilic molecule） has been synthesized based on epoxypropyl dodecyl dimethyl ammonium chloride （EPDDMAC） and gelatin. A DEEPSAC-GE polymer （hydrophobic molecule） has been synthesized based on diethyl-2,3-epoxypropyl-[3-methyldimethoxyl] silpropyl ammonium chloride （DEEPSAC） and gelatin. Compared with initial gelatin, the gelatin modified with quaternary ammonium salts containing epoxide groups exhibits stronger antibacterial activity.
文摘A series of new norspermidine derivatives, both nonionic and cationic, have been obtained. Structures of the synthesized compounds have been estab-lished by FTIR, 1H NMR, 13C NMR, 2D NMR, mass spectrometry and elemental analyses. Physicochemical and anti-microbial properties have been discussed.
文摘利用三乙胺盐酸盐分别与双酚A型环氧树脂(E-44、E-51和E-54)和酚醛环氧树脂(F-51)发生反应,制备出4种不同的环氧树脂季铵盐.经测定环氧树脂的环氧值、环氧树脂季铵盐中的季铵盐离子,以及对三乙胺盐酸盐和环氧树脂季铵盐进行红外分析后发现,双酚A型环氧树脂的环氧基易于开启,而F-51的环氧基则具有较高的开启难度.经抑菌圈实验发现,F-51季铵盐表现出较强的杀菌效果.当F-51季铵盐浓度为0.5 mol/L时,其所形成的抑菌圈直径达到2.40 cm.
基金supported by grants from the National Natural Science Foundation of China (No. 21975165)Innovative Research Team Program of Sichuan Province (No. 2021JDTD0015)China Postdoctoral Science Foundation (No. 2021TQ0228)。
文摘The abuse of antibiotics causes severe bacterial resistance, and the shortage of antibiotics has created a global public health crisis. This situation has prompted people to develop new antibacterial agents independent of traditional antibiotics. Here, we created a series of photosensitive azobenzene-quaternary ammonium salt smart antibacterial agents by connecting azobenzene with amines with different chain lengths to improve the antibacterial selectivity of quaternary ammonium salt(QAS) and prevent the accumulation of active QAS in the environment. After trans-cis isomerization, the solubility of the title compound(compound 4) increased and the antibacterial property enhanced. The experimental results suggested that the antibacterial effect of compound 4 was significantly enhanced after 365 nm light irradiation, and it had photosensitive intelligent antibacterial activity and could be reused. Notably, we did not obtain any mutants of Staphylococcus aureus or Escherichia coli resistant to compound 4. In general,compound 4 has the advantages of high yield, photo-controllable antibacterial properties, reusability, and does not induce bacterial resistance. This photosensitive antibacterial compound provides a new idea for the construction of intelligent disinfectants and is expected to be a candidate for disinfectants in public facilities and medical architecture.
