This study is to investigate the potential of wolfberry water extracts for the treatment of Alzheimer’s disease(AD)and the relationship between their anti-AD property and the geographic locations in China.Total extra...This study is to investigate the potential of wolfberry water extracts for the treatment of Alzheimer’s disease(AD)and the relationship between their anti-AD property and the geographic locations in China.Total extracts of all wolfberry samples showed the potent to decrease self-induced Aβ1-42 aggregation and Cu2+-induced Aβ1-42 aggregation and the antioxidant capacity as well as the bioactivity for binding biometal.A transgenic drosophila model assay revealed that TE of S1 and S6(S1-TE and S6-TE)at 100μg/mL demonstrated the potent rescue effect on memory loss compared to the positive control memantine at 20μg/mL.Further study also revealed the polysaccharide extracts could contribute to their anti-AD property,and the anti-AD activity conspicuously depends on growing environment.Wolfberry samples S1 and S6 showed much more potent anti-AD property.Meanwhile this study demonstrated that the Chinese commonly consumed wolfberry in boiling water might have the beneficial function to prevent AD pathology.展开更多
Edible zein-based films containing lysozyme(LY) and ascorbic acid(AA) were developed in the presence of polyethylene glycol 400(PEG 400), the combined effects of LY and AA on the microstructure, mechanical properties ...Edible zein-based films containing lysozyme(LY) and ascorbic acid(AA) were developed in the presence of polyethylene glycol 400(PEG 400), the combined effects of LY and AA on the microstructure, mechanical properties and release properties of developed zein films were investigated in detail. The results of microstructure characterization indicated that zein-based films became compact and smooth, and LY aggregates were well distributed in the zein matrix because of the simultaneous addition of LY and AA. The results of mechanical tests showed that because of the synergistic effects of LY and AA on zein film, elongation at break of zein-based film could be up to 138%, which was 34.5 times higher than that of zein control film. LY release tests showed that when the concentration of AA was less than 3.1 mg·cm^(-2), the release rate of LY significantly decreased by 33.7%, and the total release increased by 80.6%. While the release profiles of AA showed that the release rate and total release of AA from the films containing LY increased by approximately 68.9% and 61.7% than the films without LY. Good antioxidant and sustained antimicrobial activities were found for the developed zein films.展开更多
基金National Natural Science Foundation of China(81673325 and 81711540311)。
文摘This study is to investigate the potential of wolfberry water extracts for the treatment of Alzheimer’s disease(AD)and the relationship between their anti-AD property and the geographic locations in China.Total extracts of all wolfberry samples showed the potent to decrease self-induced Aβ1-42 aggregation and Cu2+-induced Aβ1-42 aggregation and the antioxidant capacity as well as the bioactivity for binding biometal.A transgenic drosophila model assay revealed that TE of S1 and S6(S1-TE and S6-TE)at 100μg/mL demonstrated the potent rescue effect on memory loss compared to the positive control memantine at 20μg/mL.Further study also revealed the polysaccharide extracts could contribute to their anti-AD property,and the anti-AD activity conspicuously depends on growing environment.Wolfberry samples S1 and S6 showed much more potent anti-AD property.Meanwhile this study demonstrated that the Chinese commonly consumed wolfberry in boiling water might have the beneficial function to prevent AD pathology.
基金Supported by the National Natural Science Foundation of China(21476086)Guangdong Natural Science Foundation(2014A030312007)
文摘Edible zein-based films containing lysozyme(LY) and ascorbic acid(AA) were developed in the presence of polyethylene glycol 400(PEG 400), the combined effects of LY and AA on the microstructure, mechanical properties and release properties of developed zein films were investigated in detail. The results of microstructure characterization indicated that zein-based films became compact and smooth, and LY aggregates were well distributed in the zein matrix because of the simultaneous addition of LY and AA. The results of mechanical tests showed that because of the synergistic effects of LY and AA on zein film, elongation at break of zein-based film could be up to 138%, which was 34.5 times higher than that of zein control film. LY release tests showed that when the concentration of AA was less than 3.1 mg·cm^(-2), the release rate of LY significantly decreased by 33.7%, and the total release increased by 80.6%. While the release profiles of AA showed that the release rate and total release of AA from the films containing LY increased by approximately 68.9% and 61.7% than the films without LY. Good antioxidant and sustained antimicrobial activities were found for the developed zein films.
