Objective The alpha 2A-adrenergic receptor gene （ADRA2A） polymorphism in individuals antiplatelet response to sympathetic stimulation. The aim of this study was to investigate ADRA2A variants on platelet reactivity ...Objective The alpha 2A-adrenergic receptor gene （ADRA2A） polymorphism in individuals antiplatelet response to sympathetic stimulation. The aim of this study was to investigate ADRA2A variants on platelet reactivity in Chinese patients on dual antiplatelet therapy undergoing percutaneous coronary intervention （PCI）. modifies the the effect of （DAPT） after Methods From March 2011 to March 2013, 1,024 patients were enrolled in this prospective, single-center, observational study in China. Four single nucleotide polymorphisms （SNPs） of ADRA2A gene （rs11195419, rs3750625, rs13306146, and rs553668） and CYP2C19^＊2 were detected by ligase detection reaction （LDR）, and adenosine diphosphate （ADP） inhibition was detected by thromboelastography （TEG）. Results The minor allele frequencies of ADRA2A SNPs were common. Platelet ADP inhibition was significantly different among patients carrying rs11195419 （adjusted P = 0.022） and rs3750625 （adjusted P = 0.016）. The homozygous allele carriers had the lowest ADP inhibition. However, ADP inhibition was not significantly different in rs553668 and rs13306146. At the multivariate analysis, rs11195419 （P = 0.033）, rs3750625 （P = 0.020） and CYP2C19＂2 （P = 0.002） were independent predictors of ADP inhibition. Subgroups analysis based on sex showed rs11195419 （P = 0.003） and rs3750625 （P = 0.002） were significantly associated with ADP inhibition in males, but not in females. Conclusion ADRA2A genetic variations were associated with ADP-induced platelet aggregation during DAPT in Chinese patients undergoing PCI, and the effect was particularly more pronounced in males.展开更多
目的:观察有氧运动对冠心病经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后患者心肺功能、运动能力及生活质量的影响。方法:选取2020年1—6月三明市中西医结合医院收治的47例冠心病PCI术后患者为对照组,选取2020年7...目的:观察有氧运动对冠心病经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后患者心肺功能、运动能力及生活质量的影响。方法:选取2020年1—6月三明市中西医结合医院收治的47例冠心病PCI术后患者为对照组,选取2020年7—12月收治的47例冠心病PCI术后患者为试验组。两组均给予常规治疗,对照组给予双联抗血小板聚集治疗,试验组在对照组基础上进行有氧运动。比较两组治疗前与治疗1年后心肺功能指标、运动能力及生活质量。结果:治疗1年后,试验组左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)均明显低于对照组,左室射血分数(LVEF)明显高于对照组,差异有统计学意义(P<0.05)。治疗1年后,试验组最大通气量(maximum ventilation,MVV)、第1秒用力呼气容积(forced expiratory volume in one second,FEV1)、FEV1/用力肺活量(FVC)(FEV1/FVC%)均明显大于对照组,差异有统计学意义(P<0.05)。治疗1年后,试验组6 min步行试验(6 min walking test,6MWT)距离长于对照组,差异有统计学意义(P<0.05)。治疗1年后,试验组生理职能、生理功能、社会功能、情感职能、精力、躯体疼痛、精神健康及总体健康评分均明显高于对照组,差异有统计学意义(P<0.05)。结论:有氧运动可有效促进冠心病PCI术后患者心肺功能恢复,提高运动能力及生活质量,获得更好的康复效果。展开更多
基金supported by grant from the National Natural Science Foundation of China[81470486]
文摘Objective The alpha 2A-adrenergic receptor gene （ADRA2A） polymorphism in individuals antiplatelet response to sympathetic stimulation. The aim of this study was to investigate ADRA2A variants on platelet reactivity in Chinese patients on dual antiplatelet therapy undergoing percutaneous coronary intervention （PCI）. modifies the the effect of （DAPT） after Methods From March 2011 to March 2013, 1,024 patients were enrolled in this prospective, single-center, observational study in China. Four single nucleotide polymorphisms （SNPs） of ADRA2A gene （rs11195419, rs3750625, rs13306146, and rs553668） and CYP2C19^＊2 were detected by ligase detection reaction （LDR）, and adenosine diphosphate （ADP） inhibition was detected by thromboelastography （TEG）. Results The minor allele frequencies of ADRA2A SNPs were common. Platelet ADP inhibition was significantly different among patients carrying rs11195419 （adjusted P = 0.022） and rs3750625 （adjusted P = 0.016）. The homozygous allele carriers had the lowest ADP inhibition. However, ADP inhibition was not significantly different in rs553668 and rs13306146. At the multivariate analysis, rs11195419 （P = 0.033）, rs3750625 （P = 0.020） and CYP2C19＂2 （P = 0.002） were independent predictors of ADP inhibition. Subgroups analysis based on sex showed rs11195419 （P = 0.003） and rs3750625 （P = 0.002） were significantly associated with ADP inhibition in males, but not in females. Conclusion ADRA2A genetic variations were associated with ADP-induced platelet aggregation during DAPT in Chinese patients undergoing PCI, and the effect was particularly more pronounced in males.
文摘目的:观察有氧运动对冠心病经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后患者心肺功能、运动能力及生活质量的影响。方法:选取2020年1—6月三明市中西医结合医院收治的47例冠心病PCI术后患者为对照组,选取2020年7—12月收治的47例冠心病PCI术后患者为试验组。两组均给予常规治疗,对照组给予双联抗血小板聚集治疗,试验组在对照组基础上进行有氧运动。比较两组治疗前与治疗1年后心肺功能指标、运动能力及生活质量。结果:治疗1年后,试验组左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)均明显低于对照组,左室射血分数(LVEF)明显高于对照组,差异有统计学意义(P<0.05)。治疗1年后,试验组最大通气量(maximum ventilation,MVV)、第1秒用力呼气容积(forced expiratory volume in one second,FEV1)、FEV1/用力肺活量(FVC)(FEV1/FVC%)均明显大于对照组,差异有统计学意义(P<0.05)。治疗1年后,试验组6 min步行试验(6 min walking test,6MWT)距离长于对照组,差异有统计学意义(P<0.05)。治疗1年后,试验组生理职能、生理功能、社会功能、情感职能、精力、躯体疼痛、精神健康及总体健康评分均明显高于对照组,差异有统计学意义(P<0.05)。结论:有氧运动可有效促进冠心病PCI术后患者心肺功能恢复,提高运动能力及生活质量,获得更好的康复效果。
