Background Increased triglyceride （TG） occurs in patients with acute coronary syndrome （ACS）, and apolipoprotein AV （apoAV） has been shown to lower TG levels. In the present study, we investigated plasma apoAV l...Background Increased triglyceride （TG） occurs in patients with acute coronary syndrome （ACS）, and apolipoprotein AV （apoAV） has been shown to lower TG levels. In the present study, we investigated plasma apoAV level and its relationship with TG and C-reactive protein （CRP） in ACS patients. Methods A total of 459 subjects were recruited and categorized into control group （n=-116）, stable angina （SA） group （n=115）, unstable angina group （n=116） and acute myocardial infarction group （n=112）. Plasma apoAV level was measured by a sandwich ELISA assay. Results Compared with controls （（100.27±22.44） ng/ml）, plasma apoAV was decreased in SA patients （（76.54±16.91） ng/ml） but increased in patients with unstable angina （（330.89±66.48） ng/ml, P 〈0.05） or acute myocardial infarction （（368.66±60.53） ng/ml, P 〈0.05）. Inverse correlations between apoAV and TG were observed in the control or stable angina groups （r= -0.573 or-0.603, respectively, P 〈0.001）, whereas positive correlations were observed in the patients with unstable angina or acute myocardial infarction （r=0.696 or 0.690, respectively, P 〈0.001）. Furthermore, a positive relationship between apoAV and CRP was observed in the ACS patients but not in the non-ACS subjects. Conclusion The plasma apoAV concentration is increased and positively correlates with TG and CRP in ACS patients.展开更多
基金This study was supported by grants from the Key Clinical Projects for Affiliated Hospitals of Ministry of Health of China （2007-2009）, National Natural Science Foundation of China （No. 30770857） and Innovation Projects in Central South University （2008）.
文摘Background Increased triglyceride （TG） occurs in patients with acute coronary syndrome （ACS）, and apolipoprotein AV （apoAV） has been shown to lower TG levels. In the present study, we investigated plasma apoAV level and its relationship with TG and C-reactive protein （CRP） in ACS patients. Methods A total of 459 subjects were recruited and categorized into control group （n=-116）, stable angina （SA） group （n=115）, unstable angina group （n=116） and acute myocardial infarction group （n=112）. Plasma apoAV level was measured by a sandwich ELISA assay. Results Compared with controls （（100.27±22.44） ng/ml）, plasma apoAV was decreased in SA patients （（76.54±16.91） ng/ml） but increased in patients with unstable angina （（330.89±66.48） ng/ml, P 〈0.05） or acute myocardial infarction （（368.66±60.53） ng/ml, P 〈0.05）. Inverse correlations between apoAV and TG were observed in the control or stable angina groups （r= -0.573 or-0.603, respectively, P 〈0.001）, whereas positive correlations were observed in the patients with unstable angina or acute myocardial infarction （r=0.696 or 0.690, respectively, P 〈0.001）. Furthermore, a positive relationship between apoAV and CRP was observed in the ACS patients but not in the non-ACS subjects. Conclusion The plasma apoAV concentration is increased and positively correlates with TG and CRP in ACS patients.
