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Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations 被引量:3
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作者 Ian James Martins 《Advances in Aging Research》 2016年第1期9-26,共18页
Appetite regulation by nutritional intervention is required early in life that involves the anti-aging gene Sirtuin 1 (Sirt 1) with Sirt 1 maintenance of other cellular anti-aging genes involved in cell circadian rhyt... Appetite regulation by nutritional intervention is required early in life that involves the anti-aging gene Sirtuin 1 (Sirt 1) with Sirt 1 maintenance of other cellular anti-aging genes involved in cell circadian rhythm, senescence and apoptosis. Interests in anti-aging therapy with appetite regulation improve an individual’s survival to metabolic disease induced by gene-environment interactions by maintenance of the anti-aging genes connected to the metabolism of bacterial lipopolysaccharides, drugs and xenobiotics. Interventions to the aging process involve early calorie restriction with appetite regulation connected to appropriate genetic mechanisms that involve mitochondrial biogenesis and DNA repair in neurons. In the aging process as the anti-aging genes are suppressed as a result of transcriptional dysregulation chronic disease accelerations and connected to insulin resistance, non-alcoholic fatty liver disease (NAFLD) and neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease. Interests in the gene-environment interaction indicate that the anti-aging gene Sirt 1that regulates food intake has been repressed early in the aging process in various global populations. The connections between Sirt 1 and other anti-aging genes such as Klotho, p66Shc (longevity protein) and Forkhead box proteins (FOXO1/ FOXO3a) have been associated with programmed cell death and alterations in these anti-aging genesregulate glucose, lipid and amyloid beta metabolism that are important to various chronic diseases. 展开更多
关键词 Anti-Aging Genes appetite Environment NUTRITION SENESCENCE
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Effect of High-Protein Breakfast Meals on Within-Day Appetite and Food Intake in Healthy Men and Women 被引量:1
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作者 William Buosi David M. Bremner +2 位作者 Graham W. Horgan Claire L. Fyfe Alexandra M. Johnstone 《Food and Nutrition Sciences》 2015年第3期386-390,共5页
Breakfast is considered an important meal for daily appetite control. We examined the effect of high-protein breakfasts on within-day appetite sensations and subsequent ad libitum intake, in men and women. Twenty subj... Breakfast is considered an important meal for daily appetite control. We examined the effect of high-protein breakfasts on within-day appetite sensations and subsequent ad libitum intake, in men and women. Twenty subjects attended on 4 occasions, to consume in a randomised order high-protein (30% energy) breakfast meals, as, 1) maintenance (MTD) fed to energy requirements (2.67 MJ), 2) a weight-loss (WL) bacon-based meal breakfast (WL-B, 2.13 MJ), 3) a WL-chicken salad (WL-CS, 2.13 MJ) and 4) a WL-smoothie (WL-S, 2.08 MJ). The 3 HP-WL breakfasts elicited differences in hunger (p = 0.007), fullness (p = 0.029), desire to eat (p = 0.006) and prospective consumption (p = 0.020). The WL-B meal reduced hunger (p = 0.002) and enhanced fullness (p = 0.02), compared with the two other WL breakfasts. Although these differences were not reflected in ad libitum energy intake later in the day, a HP breakfast can modify morning satiety, which is important during dieting. 展开更多
关键词 PROTEIN appetite Weight Loss BREAKFAST Meals LUNCH INTAKE
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Association between Children’s Appetite Patterns and Maternal Feeding Practices 被引量:1
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作者 Tomomi Ainuki Rie Akamatsu 《Food and Nutrition Sciences》 2011年第3期228-234,共7页
This study explored associations between children’s appetites and maternal feeding practices. The participants, 614 parents of 3- to 6-year-old children from kindergartens in Tokyo, Japan, completed self-administered... This study explored associations between children’s appetites and maternal feeding practices. The participants, 614 parents of 3- to 6-year-old children from kindergartens in Tokyo, Japan, completed self-administered questionnaires. The children’s appetites were measured using the Enjoyment of Food (EF) and Food Responsiveness (FR) scales of the Child Eating Behaviour Questionnaire. Using cluster analysis, we examined three appetite patterns (“both low,” “high EF and low FR,” and “both high”). The three appetite patterns were associated with children’s obesity index. The “both low” pattern was associated with the highest maternal pressure to eat. The “high EF and low FR” patterns were related to an established snack time. The “both high” pattern was associated with higher maternal instrumental feeding compared with the “high EF and low FR” types. The results of this study will facilitate the development of targeted interventions and better parental guidance on maternal feeding practices and their association with children’s eating behaviours. 展开更多
关键词 appetite PRESCHOOL Children FEEDING PRACTICES
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Molecular Insights into Appetite Control and Neuroendocrine Disease as Risk Factors for Chronic Diseases in Western Countries 被引量:1
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作者 I. J. Martins Rhona Creegan +1 位作者 W. L. F. Lim R. N. Martins 《Open Journal of Endocrine and Metabolic Diseases》 2013年第5期11-33,共23页
Environmental factors such as stress, anxiety and depression are important to consider with the global increase in chronic diseases such as cardiovascular diseases, cancer, stroke, obesity, diabetes and neurodegenerat... Environmental factors such as stress, anxiety and depression are important to consider with the global increase in chronic diseases such as cardiovascular diseases, cancer, stroke, obesity, diabetes and neurodegenerative diseases. Brain metabolic diseases associated with conditions such as obesity and diabetes require early intervention with diet, lifestyle and drug therapy to prevent diseases to various organs such as the liver with non alcoholic fatty liver disease (NAFLD) and other organs such as the heart, lungs thyroid, pancreas, brain, kidneys and reproductive systems. Behavioural stress and the molecular mechanisms that are involved in neuroendocrine diseases such as insulin resistance in obesity require attention since associated inflammatory processes early in the disease process have been associated with neurodegenerative diseases. Molecular neuroendocrine disturbances that cause appetite dysregulation and hyperphagia are closely linked to hyperinsulinemia, dyslipidaemia and reduced lifespan. The origins of metabolic diseases that afflict various organs possibly arise from hypothalamic disturbances with loss of control of peripheral endocrine hormones and neuropeptides released from the brain. Diet and drug therapies that are directed to the autonomic nervous system, neuroendocrine and limbic systems may help regulate and integrate leptin and insulin signals involving various neuropeptides associated with chronic diseases such as obesity and diabetes. The understanding of brain circuits and stabilization of neuroanatomical structures in the brain is currently under investigation. Research that is involved in the understanding of diet and drugs in the stabilization of brain structures such as frontostriatal limbic circuits, hypothalamus brainstem circuits and parasympathetic nervous system is required. Information related to neuropeptides and neurotransmitters that are released from the brain and their regulation by therapeutic drugs requires further assessment. The promise of appropriate diets, lifestyle and drugs that target the CNS and peripheral tissues such as the adipose tissue, liver and pancreas may improve the prognosis of chronic diseases such as obesity and diabetes that are also closely associated with neurodegeneration. 展开更多
关键词 Stress METABOLIC Syndrome NEUROENDOCRINE DISEASE appetite FATTY Liver
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Effects of Pyridoxine on Selected Appetite Regulating Peptides mRNA Expression in Hypothalamic PVN/ARC Nuclei and Gastrointestinal Tract Tissues 被引量:1
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作者 Lei Liu Haoqi Wang +7 位作者 Haitao Sun Chunyan Fu Hongli Liu Yuqing Sun Xianghua Xu Weiji Chen Wenqiang Wu Fuchang Li 《Advances in Bioscience and Biotechnology》 2017年第9期273-282,共10页
An experiment was conducted to investigate the effect of dietary pyridoxine on the gene expression of appetite-regulating peptides in the hypothalamus and gastrointestinal tract of rabbits. Thirty-two rabbits were ran... An experiment was conducted to investigate the effect of dietary pyridoxine on the gene expression of appetite-regulating peptides in the hypothalamus and gastrointestinal tract of rabbits. Thirty-two rabbits were randomly divided into 2 treatments for 8 weeks (16 replicates/group and 1 rabbit/replicate). The treatments were fed a basal diet (control, measured pyridoxine content is 4.51 mg/kg) and the basal diet with a pyridoxine supplementation at 10 mg/kg (pyridoxine, measured pyridoxine content is 14.64 mg/kg). The results showed that dietary pyridoxine did not significantly alter the mRNA levels of neuropeptide Y, agouti related peptide, pro-opiomelanocortin and cocaine, amphetamine regulated transcript, peptide YY and cholecystokinin in arcuate nucleus, peptide YY in jejunum and ileum, and cholecystokinin in duodenum, jejunum and ileum (P > 0.05). Compared with the control, the mRNA levels of corticotropin-releasing hormone and melanocortin 4 receptor in paraventricular nuclei and peptide YY in duodenum were significantly decreased after pyridoxine treatment (P 0.05). In conclusion, the appetite genes of melanocortin 4 receptor and corticotropin-releasing hormone in paraventricular nuclei and peptide YY in duodenum are involved in the pyridoxine-caused hyperphagia. 展开更多
关键词 PYRIDOXINE Brain-Gut PEPTIDES appetite Control
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Low Salt Diet in Pregnant Mothers Is Associated with Enhanced Salt Appetite in Their Offspring of Dahl Salt-Sensitive Rats
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作者 Anna Hara Ranna Chow +2 位作者 Dong Dong Du Hiroe Sakuyama Yoshio Uehara 《Food and Nutrition Sciences》 2014年第19期1904-1913,共10页
Objectives: We investigated an influence of salt intake during gestation or lactation in salt preference of weaning Dahl salt sensitive (Dahl S) strain. Material and Methods: Nine-week-old female Dahl S rats, after ma... Objectives: We investigated an influence of salt intake during gestation or lactation in salt preference of weaning Dahl salt sensitive (Dahl S) strain. Material and Methods: Nine-week-old female Dahl S rats, after mated with the male, were divided into 1) high-salt group fed a 4% NaCl diet (high-salt mother) or 2) low-salt group fed a 0.3% NaCl diet (low-salt mother) during gestation or lactation periods. Using 0.4%, 0.6% and 0.8% (w/v) saline solutions, we assessed salt preference in their offspring after weaning. Systolic blood pressure (SBP) was determined by tail cuff method. Results: Both the male and female offspring from low-salt mothers during gestation consumed equal amounts of any saline solution. However, the amount of each saline solution was higher in the offspring of low-salt mothers than those of high-salt mothers. This resulted in a significant increase of salt intake in both the male and female offspring of low-salt mothers compared with those of high-salt mothers. In contrast, both the male and female offspring from low-mothers during lactation rather preferred the lower concentration of saline solution, and this resulted in less salt intake in the offspring of low-salt mothers than those of high-salt mothers. Conclusions: We demonstrated that low salt diet in pregnant mothers increased salt intake of their offspring. The offspring of mothers fed a low salt diet during lactation had less salt than those of high-salt mothers. The influence of salt intake of mothers in their offspring varies along with the growth stage of their babies. 展开更多
关键词 SALT appetite NEONATE Salt-Sensitive Hypertension Dahl Rat Programming GESTATION LACTATION
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Informing Primary School Nutritional Policy: Effects of Mid-Morning Snacks on Appetite and Energy Control
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作者 Penny L. S. Rumbold Caroline J. Dodd-Reynolds Emma J. Stevenson 《Food and Nutrition Sciences》 2013年第5期529-537,共9页
The purpose of this research was to inform primary school nutritional policy by identifying which mid-morning snack would be more beneficial to consume from an appetite control perspective. During morning break 14 gir... The purpose of this research was to inform primary school nutritional policy by identifying which mid-morning snack would be more beneficial to consume from an appetite control perspective. During morning break 14 girls and 11 boys were provided with 160 ml of semi-skimmed milk or153 gof apple in a randomised crossover manner. Visual analogue scales were used to record hunger, prospective food consumption and fullness, immediately before and after breakfast, immediately before and after the mid-morning snack, and every 60 min until 21:00 on each day. School dinner/packed lunch energy intakes were assessed 90 min following the mid-morning snacks, in addition to evening energy intake. Children felt less hungry and could eat less when apple was consumed, however lunch and evening energy intakes were not different. Fluctuations in appetite did not translate into differences in energy intake therefore both milk and fruit should be promoted as mid-morning snacks in primary schools. 展开更多
关键词 Primary School POLICY Mid-Morning SNACKS Milk Fruit appetite Energy Intake
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Ethnobotanical Survey of Appetite Suppressant Plants Used in Hauts-Bassins Areas of Burkina Faso
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作者 Emmanuel Zongo Roland Nâg-Tiero Meda +8 位作者 Yaya Gnanou Yaya Gnanou Sami Eric Kam Benjamin Kouliga Koama Pataréyaoba Alassane Ouedraogo Eliasse Zongo Ollo Da Dramane Paré Georges Anicet Ouedraogo 《Food and Nutrition Sciences》 CAS 2022年第12期1001-1014,共14页
This study aimed to list the medicinal plants used as an appetite suppressant in Hauts-Bassins areas of Burkina Faso. An ethnobotanical survey was undertaken from September to November 2021 using a semi-structured que... This study aimed to list the medicinal plants used as an appetite suppressant in Hauts-Bassins areas of Burkina Faso. An ethnobotanical survey was undertaken from September to November 2021 using a semi-structured questionnaire. To determine well-known families and species, some indices such as Family Importance Value (FIV) and Relative Frequency of Citation (RFC) were calculated respectively. Sixty-seven traditional healers (41 men and 26 women) have been interviewed. The age group from 41 to 60 years old was more represented (47.76%). Fifty-eight (58) plant species belonging to 29 families and 53 genera were recorded to have appetite suppressant properties. Fabaceae family (25%) was the most mentioned followed by Combretaceae (12%). The most mentioned species were Guierasenegalensis (7.64%), Parkiabiglobosa (6.18%), Annona senegalensis and Gardenia erubescens (5.35% for both). Leaves and fruits had the highest frequencies of use with 41% and 25% respectively. The decoction (49.62%) was the main preparation method. The oral route was the only mode of drug administration. These results would contribute to strengthening the database on the medicinal plants used as an appetite suppressant by the traditional healers in Burkina Faso. 展开更多
关键词 Ethnobotanical Survey appetite Suppressant Plants Hauts-Bassins Areas Burkina Faso
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Study on the Relationship Between Tableware Color and Consumers’Appetite
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作者 HUANG Yafen LIN Xiaoqing 《Psychology Research》 2022年第5期289-293,共5页
In order to explore the relationship between the color of tableware and appetite,random samples were selected from the network survey.The results show that the vast majority of people will pay attention to the color o... In order to explore the relationship between the color of tableware and appetite,random samples were selected from the network survey.The results show that the vast majority of people will pay attention to the color of tableware,and think that the color of tableware will have an impact on appetite:Most of the respondents prefer the warm color of tableware.Finally,according to the survey results,some suggestions and ideas are put forward to the catering operators:Catering operators need to improve their aesthetic artistry;pay attention to the collocation of different colors;according to the tableware function deployment tableware color;and so on. 展开更多
关键词 color of tableware appetite warm tones DIFFERENCES aesthetic artistry tableware function
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Global Risk Appetite,US Economic Policy Uncertainties and Cross-Border Capital Flow
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作者 谭小芬 曹倩倩 赵茜 《China Economist》 2022年第5期2-18,共17页
Based on the global asset portfolio model,this paper created a panel threshold model using EPFR fund data to empirically test the non-linear spillover effects of US economic policy uncertainties on cross-border capita... Based on the global asset portfolio model,this paper created a panel threshold model using EPFR fund data to empirically test the non-linear spillover effects of US economic policy uncertainties on cross-border capital flow for emerging economies.Our study led to the following findings:(1)When the level of global investor risk tolerance is high,rising US EPU will induce a capital inflow into emerging economies,as manifested in the“portfolio rebalancing effect.”When the level of global investor risk tolerance is below a critical threshold,this gives rise to risk aversion and emerging economies will experience net capital outflow,i.e.the“flight to quality effect”.(2)Equity fund investors have a lower risk tolerance threshold than bond fund investors.(3)According to our heterogeneity analysis,more attention should be paid to monitoring capital flow through actively managed funds,ETF funds,and retail investor funds.The economy should increase financial efficiency and economic resiliency to mitigate capital outflow pressures from the external environment. 展开更多
关键词 Cross-border fund capital flow global risk appetite US economic policy uncertainty panel threshold model
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A Cross-Sectional Study on Appetite, Nutritional Status and Nutritional Support of Hospitalized Patients
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作者 Youdi Cai Meinong Zhong +5 位作者 Ya Jiang Xueling Zhou Xiaolan He Qian Luo Xiaoling Li Shiju Huang 《Open Journal of Nursing》 2021年第11期1002-1014,共13页
<strong>Objective: </strong>To understand the appetite and nutritional status of hospitalized patients in a tertiary A general hospital in Guangzhou, Guangdong Province. <strong>Methods:</strong&g... <strong>Objective: </strong>To understand the appetite and nutritional status of hospitalized patients in a tertiary A general hospital in Guangzhou, Guangdong Province. <strong>Methods:</strong> A cross-sectional survey of appetite and nutritional status assessment on inpatients in 44 wards of the hospital was conducted. Taking all “conscious patients hospitalized for more than 48 hours” in the hospital on November 25, 2020 as the survey subjects, the patients’ appetite, dietary intake, nutrition and nutritional support in the past week were investigated. <strong>Results: </strong>A total of 890 cases were investigated, among which 25 cases (2.81%) with missing data were excluded, and thus 865 investigated cases were considered effective. The incidence of nutritional risk was 28.67%, malnutrition 13.29%, external tube feeding nutrition 3.24%, parenteral nutrition 7.05%, and oral nutritional supplement 10.40%. The average score of appetite assessment was (6.99 ± 2.43) points. Among them, cases with appetite assessment scores < 5 points accounted for 15.84%, and 52 patient cases utilized appetite-improving drugs. Among the 137 patients with appetite scores < 5, only 7 patients utilized appetite-improving drugs. The patients’ dietary self-evaluation scores were averagely (4.08 ± 1.16) points, and the daily intake compliance rate of patients was 85.78%. Appetite assessment score was correlated with dietary intake score (<em>r</em> = 0.548) and daily intake compliance rate (<em>r</em> = 0.263) (<em>p</em> < 0.01). The differences in body weight, BMI, grip strength, albumin, and hemoglobin concentration of patients with different appetite states were statistically different (<em>p</em> < 0.01). Appetite was an influencing factor of weight change (<em>β</em> = <span style="white-space:nowrap;">&#8722;</span>0.079, <em>p</em> = 0.023). The difference between the appetite assessment scores and the daily intake compliance rates of patients with different nutritional support methods was statistically significant (<em>p</em> < 0.05);the individualized diet group had the highest appetite assessment score (8.57 ± 1.70), while the parenteral nutrition group had the lowest appetite assessment score (4.90 ± 2.99);the individualized diet group had the highest daily intake rate of 100%, followed by the parenteral nutrition group with 96.72%, and the regular diet group had the lowest rate of 84.02%. <strong>Conclusion: </strong>The appetite of hospitalized patients is closely related to nutritional status, and therefore, attention should be paid to the appetite status and nutritional status of hospitalized patients. Inpatients with different nutritional support methods should be given individualized appetite and nutritional interventions. 展开更多
关键词 Cross-Sectional Study appetite Nutritional Status Nutritional Support
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Neuroimaging and neuroendocrine insights into foodcravings and appetite interventions in obesity
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作者 Jin Huang Chen Wang +3 位作者 Hang-Bin Zhang Hui Zheng Tao Huang Jian-Zhong Di 《Psychoradiology》 2023年第1期95-106,共12页
This article reviews the previous studies on the distinction between food cravings and appetite,and how they are regulated by hor-mones and reflected in brain activity.Based on existing research,food cravings are defi... This article reviews the previous studies on the distinction between food cravings and appetite,and how they are regulated by hor-mones and reflected in brain activity.Based on existing research,food cravings are defined as individual preferences influenced by hormones and psychological factors,which differ from appetite,as they are not necessarily related to hunger or nutritional needs.The article also evaluates the neuroimaging findings about food cravings,and interventions to reduce food cravings,such as mindfulness training,alternative sweeteners,non-invasive brain stimulation techniques,cognitive-behavioral therapy,and imaginal retraining,and points out their advantages,disadvantages,and limitations.Furthermore,the article delves into the potential future directions in the field,emphasizing the need for a neuroendocrine perspective,considerations for associated psychiatric disorders,innovative clinical interventions,and emerging therapeutic frontiers in obesity management.The article outlines the neuro-endocrine basis of food cravings,including ghrelin,leptin,melanocortin,oxytocin,glucagon-like peptide-1,baclofen,and other hormones and their brain regions of action.The article argues that food cravings are an important target for obesity,and more research is needed to explore their complex characteristics and mechanisms,and how to effectively interact with their neuro-endocrine pathways.The article provides a new perspective and approach to the prevention and treatment of obesity. 展开更多
关键词 food cravings fMRI appetite OBESITY neuro-endocrine
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Geomagnetic field absenee reduces adult body weight of a migratory insect by disrupt!ng feeding behavior and appetite regulation 被引量:1
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作者 Gui-Jun Wan Shou-Lin Jiang +5 位作者 Ming Zhang Jing-Yu Zhao Ying-Chao Zhang Wei-Dong Pan Gregory A.Sword Fa-Jun Chen 《Insect Science》 SCIE CAS CSCD 2021年第1期251-260,共10页
The geomagnetic field(GMF)is well documented for its essential role as a cue used in animal orientation or navigation.Recent evidence indicates that the absence of GMF(mimicked by the near-zero magnetic field,NZMF)can... The geomagnetic field(GMF)is well documented for its essential role as a cue used in animal orientation or navigation.Recent evidence indicates that the absence of GMF(mimicked by the near-zero magnetic field,NZMF)can trigger stress-like responses such as reduced body weight,as we have previously shown in the brown planthopper,Nilaparvata lugens.In this study,we found that consistent with the significantly decreased body weight of newly emerged female(—14.67%)and male(—13.17%)adult N.lugens,the duration of the phloem ingestion feeding waveform was significantly reduced by 32.02%in 5th instar nymphs reared under the NZMF versus GMF.Interestingly,5th instar nymphs that exhibited reduced feeding had significantly higher glucose levels(+16.98%and+20.05%;24 h and 48 h after molting),which are associated with food aversion,and expression patterns of their appetite-related neuropeptide genes(neuropeptide F,dow regulated overall;short neuropeptide F,dowregulated overall;adipokinetic hormone up-regulated overall;and adipokinetic hormone receptor,down-regulated overall)were also altered under the absence of GMF in a manner consistent with diminishing appetite.Moreover,the expressions of the potential magnetosensor croptochromes(Crys)were found significantly altered under the absence of GMF,indicating the likely upstream signaling of the Cry-mediated magnetoreception mechanisms.These findings support the hypothesis that strong changes in GMF intensity can reduce adult body weight through affecting insect feeding behavior and underlying regulatory processes including appetite regulation.Our results highlight that GMF could be necessary for the maintenanee of energy homeostasis in insects. 展开更多
关键词 appetite body weight feeding behavior geomagnetic field MAGNETORECEPTION Nilaparvata lugens
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Appetite control: why we fail to stop eating even when we are full?
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作者 Kristen DAVIS Young-Jai YOU 《Frontiers in Biology》 CAS CSCD 2014年第3期169-174,共6页
We often eat more than our body needs. We live in an environment where high calorie food is abundant and physical activities are limited. Living in this environment, maintaining healthy bodyweight becomes challenging ... We often eat more than our body needs. We live in an environment where high calorie food is abundant and physical activities are limited. Living in this environment, maintaining healthy bodyweight becomes challenging and obesity becomes a social burden. Why do we continue to eat even after the metabolic needs are satisfied? Feeding is an ancient behavior essential to survive. Thus the mechanisms to regulate appetite, energy expenditure, and energy storage are well conserved throughout animals. Based on this conservation, we study why we fail to control appetite using a simple genetic model system C. elegans. We have discovered certain genetic components that when misregulated have animals eat more and store more fat. In this review we discuss how these genes work in the appetite control circuit to ultimately understand overall appetite control behavior. We will also briefly discuss how social influence affects feeding regardless of the metabolic status of an animal. 展开更多
关键词 cGMP TGFI3 C. elegans SATIETY appetite obesity
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Propionate stimulates the secretion of satiety hormones and reduces acute appetite in a cecal fistula pig model
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作者 Yanan Zhang Xuan Li +5 位作者 Guowen Huang Haifeng Wang Huizi Chen Yong Su Kaifan Yu Weiyun Zhu 《Animal Nutrition》 SCIE CSCD 2022年第3期390-398,共9页
Short-chain fatty acids(SCFA)can regulate appetite by stimulating the secretion of satiety hormones.However,the impact of short-chain fatty acid propionate on the release of gut satiety hormones and appetite regulatio... Short-chain fatty acids(SCFA)can regulate appetite by stimulating the secretion of satiety hormones.However,the impact of short-chain fatty acid propionate on the release of gut satiety hormones and appetite regulation in pigs is not completely understood.In this study,16 pigs were infused with saline or sodium propionate through a fistula in the caecum during a 28-day experimental period.We characterized the effects of propionate administration on peptide YY(PYY)and glucagon-like peptide 1(GLP-1)secretion from colonic tissue,and investigated the role of propionate infusion on the expression of appetite-related genes in the colon and hypothalamus.Further,the direct impact of propionate administration on the expression of orexigenic neuropeptide agouti-related protein(AgRP)in hypothalamic N38 cells was also examined.The results showed that intra-cecal infusion of propionate reduced the short-term feed intake(P<0.05)but not the long-term feed intake in pigs(P>0.05).Propionate administration stimulated PYY and GLP-1 release from colon tissue in vivo and ex vivo(P<0.05).It also upregulated PYY expression in the colonic mucosa(P<0.05).Meanwhile,the GLP-1 and PYY levels in the blood were increased after intra-cecal infusion of propionate at d 28(P<0.05).Additionally,intra-cecal infusion of propionate upregulated the mRNA and protein expression of free fatty acid receptor 2/3(FFAR2/FFAR3)in the colonic mucosa(P<0.05).Propionate infusion also downregulated the orexigenic AgRP mRNA expression(P<0.05)and upregulated the anorexigenic cocaine-and amphetamine-regulated transcript(CART)mRNA expression(P=0.09)in the hypothalamus.Moreover,propionate administration directly downregulated AgRP expression in hypothalamic N38 cells in a dose-dependent manner(P<0.05).Collectively,these findings demonstrated that cecal propionate stimulated colonic secretion of satiety hormones and suppressed appetite to reduce the short-term feed intake in pigs.This study highlights that microbial-derived propionate exerts an important role in regulating the physical functions of the host. 展开更多
关键词 PROPIONATE Gut hormones appetite HYPOTHALAMUS Pig
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APPETITE FOR READING
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作者 TANG YUANKAI 《Beijing Review》 2007年第23期26-28,共3页
The success of Harry Potter has sparked a growing children’s book industry in China Four years ago 9-year-old Bian Jinyang, like many Chinese children, finished reading his first Harry
关键词 appetite FOR READING
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A Growing Appetite for Art
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作者 CHEN WEN 《Beijing Review》 2010年第15期40-41,共2页
Chinese as well as international buyers are showing great interest in collecting There was no sign of economic depression at Sotheby’s auction,"Fine Chinese Ceramics and Works of Art",held in New York in Ma... Chinese as well as international buyers are showing great interest in collecting There was no sign of economic depression at Sotheby’s auction,"Fine Chinese Ceramics and Works of Art",held in New York in March.The 1692 masterpiece,Two Mynas 展开更多
关键词 A Growing appetite for Art
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Intelligent option portfolio model with perspective of shadow price and risk‑free profit
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作者 Fengmin Xu Jieao Ma 《Financial Innovation》 2023年第1期2137-2164,共28页
Since Markowitz proposed modern portfolio theory,portfolio optimization has been being a classic topic in financial engineering.Although it is generally accepted that options help to improve the market,there is still ... Since Markowitz proposed modern portfolio theory,portfolio optimization has been being a classic topic in financial engineering.Although it is generally accepted that options help to improve the market,there is still an improvement for the portrayal of their unique properties in portfolio problems.In this paper,an intelligent option portfolio model is developed that allows selling options contracts to earn option fees and considers the high leverage of options in the market.Deep learning methods are used to predict the forward price of the underlying asset,making the model smarter.It can find an optimal option portfolio that maximizes the final wealth among the call and put options with multiple strike prices.We use the duality theory to analyze the marginal contribution of initial assets,risk tolerance limit,and portfolio leverage limit for the final wealth.The leverage limit of the option portfolio has a significant impact on the return.To satisfy the investors with different risk preferences,we also give the conditions for the option portfolio to gain a risk-free return and replace the Conditional Value-at-Risk.Numerical experiments demonstrate that the intelligent option portfolio model obtains a satisfactory out-of-sample return,which is significantly positively correlated with the volatility of the underlying asset and negatively correlated with the forecast error of the forward price.The risk-free option model is effective in achieving the goal of no drawdown and gaining satisfactory returns.Investors can adjust the balance point between returns and risks according to their risk preference. 展开更多
关键词 Option portfolio Linear programming Deep learning Risk appetite
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Effect of Helicobacter pylori eradication on serum ghrelin and obestatin levels 被引量:5
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作者 Celal Ulasoglu Banu Isbilen +3 位作者 Levent Doganay Filiz Ozen Safak Kiziltas Ilyas Tuncer 《World Journal of Gastroenterology》 SCIE CAS 2013年第15期2388-2394,共7页
AIM: To investigate changes in serum ghrelin and obestatin levels before and after Helicobacter pylori (H. pylori ) eradication. METHODS: A total of 92 patients presenting with symptoms of dyspepsia were enrolled in t... AIM: To investigate changes in serum ghrelin and obestatin levels before and after Helicobacter pylori (H. pylori ) eradication. METHODS: A total of 92 patients presenting with symptoms of dyspepsia were enrolled in the study. Upper endoscopy was performed on all patients and used to diagnose H. pylori infection according to the presence of characteristic histopathological findings; seventy patients were diagnosed with H. pylori infection and the remaining 22 non-infected patients were classified as healthy controls. H. pylori eradication was accomplished by administering the classical triple therapy drug regimen, consisting of lansoprazole 30 mg bid , amoxicillin 1 g bid , and clarithromycin 500 mg tid for 14 d. The eradication of H. pylori was assessed with C14-urea breath test, which was performed at eight weeks after treatment. Levels of serum active ghrelin and obestatin were assessed at beginning of the study (prior to treatment) and after eight weeks. The levels were comparatively analyzed between the H. pylori negative control group, the H. pylori eradicated group, and the H. pylori non-eradicated group. RESULTS: A total of 92 patients, 50 females and 42 males with a mean age of 38.2 ± 11.9 years (range: 19-64), were analyzed. H. pylori eradication success was achieved in 74.3% (52/70) of H. pylori positive patients. The initial levels of ghrelin in the H. pylori positive and control cases were 63.6 ± 19.8 pg/mL and 65.1 ± 19.2 pg/mL (P=0.78), respectively, and initial obestatin levels were 771±427 pg/mL and 830 ± 296 pg/mL (P=0.19), respectively. The difference between the initial levels and the week 8 levels of ghrelin and obestatin in the control group was insignificant [4.5% (P=0.30) and -0.9% (P=0.65), respectively]. The difference between the initial and week 8 levels of ghrelin and obestatin in the H. pylori non-eradicated group were also insignificant [0.9% (P=0.64) and 5.3% (P=0.32), respectively]. The H. pylori eradicated group had a greater change in obestatin levels when compared to the control and the non-eradicated groups (148 ± 381 pg/mL vs -12±138 pg/mL and -72.8±203 pg/mL, respectively, P=0.015), while decreases in ghrelin levels were insignificant (-7.2 pg/mL vs -1.4 pg/mL and -1.9 pg/mL, respectively, P=0.52). The ghrelin/obestatin ratio for the initial and week 8 levels changed significantly in only the H. pylori eradicated group (0.11 vs 0.08, respectively, P=0.015). For overweight patients (as designated by body mass index), we observed significant increases in obestatin levels in the eradicated group as compared to non-eradicated group (201 ± 458 pg/mL vs -5 ± 81 pg/mL, respectively, P=0.02). In the H. pylori-eradicated group, the levels did not differ between the sexes for ghrelin (-6.3 ± 26.9 pg/mL vs -8.0 ± 24.0 pg/mL, respectively, P=0.97) or obestatin (210 ± 390 pg/mL vs 96 ± 372 pg/mL, respectively, P=0.23).CONCLUSION: Serum levels of ghrelin decreased while obestatin levels increased in H. pylori eradicated subjects, especially in overweight and male patients. 展开更多
关键词 GHRELIN OBESTATIN HELICOBACTER PYLORI Gastric PEPTIDES appetite
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Effects of a 3-month vigorous physical activity intervention on eating behaviors and body composition in overweight and obese boys and girls 被引量:4
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作者 María Martín-García Luis M.Alegre +3 位作者 Beatriz Garcia-Cuartero Eleanor J.Bryant Bernard Gutin Ignacio Ara 《Journal of Sport and Health Science》 SCIE 2019年第2期170-176,共7页
Purpose: This study aims to analyze the effects of a 3-month vigorous physical activity(VPA) intervention on eating behavior and body composition in overweight and obese children and adolescents.Methods: Forty-seven p... Purpose: This study aims to analyze the effects of a 3-month vigorous physical activity(VPA) intervention on eating behavior and body composition in overweight and obese children and adolescents.Methods: Forty-seven participants(7–16 years) took part in the study: 28 were assigned to the intervention group(IG)(10 boys and 18 girls) and19 in a control group(CG)(8 boys and 11 girls). Body composition(dual-energy X-ray absorptiometry), anthropometrics(body mass, height, and body mass index(BMI)), and eating behavior traits(Three-Factor Eating Questionnaire-R21 C) were determined before and after the VPA intervention.Results: A decrease in the percentage of body fat and BMI(-2.8% and-1.8%, respectively), and an increase in most lean mass variables were found in the IG(all p ≤ 0.05). In relation to the eating behavior traits, IG subjects showed a 14% reduction in the Emotional Eating score(p = 0.04),while Cognitive Restraint score did not change after the VPA intervention. The baseline factors of the questionnaire predicted changes in body mass and fat mass variables only in the CG.Conclusion: A 3-month VPA intervention influenced eating behaviors of overweight or obese young, especially the Emotional Eating factor, in the presence of favorable body composition changes. 展开更多
关键词 appetite Children Exercise Obesity TFEQ-R21 Young
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