ESMO2023:恩扎卢胺联合雄激素剥夺治疗对比安慰剂联合雄激素剥夺治疗在中国转移性激素敏感性前列腺癌患者中的疗效和安全性(中国ARCHES)

2019年发表的全球ARCHES试验(NCT02677896)结果显示,与安慰剂(placebo,PBO)+雄激素剥夺治疗(androgen deprivation therapy,ADT)相比,恩扎卢胺+ADT延长了转移性激素敏感性前列腺癌(metastatic hormone-sensitive prostate cancer,mHSPC)患者的总生存期和放射影像学无进展生存期(radiographic progression-free survival,rPFS)^([1])。然而,该试验无中国患者入组。欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)2023年会议报道了中国ARCHES研究(NCT04076059)的初步结果,这是一项评估恩扎卢胺+ADTvs.PBO+ADT在中国m HSPC患者中的疗效和安全性的多中心、随机、双盲、PBO对照的Ⅲ期试验^([2])。

Mechanical properties and influence mechanism of confined concrete arches in high-stress tunnels

Deep underground projects(e.g., coal mines), are often faced with complex conditions such as high stress and extremely soft rock. The strength and rigidity of the traditional support system are often insufficient,which makes it difficult to meet the requirements of ground control under complex conditions. As a new support form with high strength and rigidity, the confined concrete arch plays an important role in controlling the rock deformation under complex conditions. The section shape of the tunnel has an important impact on the mechanical properties and design of the support system. However, studies on the mechanical properties and influence mechanism of the new confined concrete arch are rarely reported. To this end, the mechanical properties of traditional U-shaped steel and new confined concrete arches are compared and comparative tests on arches of circular and straight-leg semicircular shapes in deep tunnels are conducted. A large mechanical testing system for underground engineering support structure is developed. The mechanical properties and influence mechanism of confined concrete arches with different section shapes under different loading modes and cross-section parameters are systematically studied. Test results show that the bearing capacity of the confined concrete arch is 2.10 times that of the U-shaped steel arch, and the bearing capacity of the circular confined concrete arch is 2.27 times that of the straight-leg semicircular arch. Among the various influencing factors and their engineering parameters,the lateral stress coefficient has the greatest impact on the bearing capacity of the confined concrete arch,followed by the steel pipe wall thickness, steel strength, and core concrete strength. Subsequently, the economic index of bearing capacity and cost is established, and the optimization design method for the confined concrete arch is proposed. Finally, this design method is applied to a high-stress tunnel under complex conditions, and the deformation of the surrounding rock is effectively controlled.

Elastic responses of underground circular arches considering dynamic soil-structure interaction:A theoretical analysis

Due to the wide applications of arches in underground protective structures, dynamic analysis of circular arches including soil-structure interactions is important. In this paper, an exact solution of the forced vibration of circular arches subjected to subsurface denotation forces is obtained. The dynamic soil-structure interaction is considered with the introduction of an interfacial damping between the structure element and the surrounding soil into the equa- tion of motion. By neglecting the influences of shear, rotary inertia and tangential forces and assuming the arch incompressible, the equations of motion of the buried arches were set up. Analytical solutions of the dynamic responses of the protective arches were deduced by means of modal super- position. Arches with different opening angles, acoustic impedances and rise-span ratios were analyzed to discuss their influences on an arch. The theoretical analysis suggests blast loads for elastic designs and predicts the potential failure modes for buried protective arches.

Measurement of vibration frequencies of ties in masonry arches by means of a robotic total station

Measurement of the vibration frequencies of eight ties set in masonry arches of a church by means of a robotic total station is described.The instrument made continuous recordings(up to ten per second)of the three-dimensional positions of a reflector situated at 1/2 or 1/4 of the length of the tie during vertical oscillation induced by an impulsive load.The recording slips,vibration amplitudes(and their accuracy),hourly diagram and experimental spectra of vibrations,and the corresponding frequencies were calculated.The results were verified by comparing them with the vibration frequencies and indirectly the tension and fixed support constraint calculated from accelerometric measurements.The study provides interesting information on the accuracies of the reflector′s three-dimensional coordinates,but highlighted certain limits in the application of robotized total stations for measuring vibration frequencies of ties in masonry arches.

Mechanical behaviour analysis and support system field experiment of confined concrete arches

Soft rock control is a big challenge in underground engineering.As for this problem,a high-strength support technique of confined concrete(CC)arches is proposed and studied in this paper.Based on full-scale mechanical test system of arch,research is made on the failure mechanism and mechanical properties of CC arch.Then,a mechanical calculation model of circular section is established for the arches with arbitrary section and unequal rigidity;a calculation formula is deduced for the internal force of the arch;an analysis is made on the influence of different factors on the internal force of the arch;and a calculation formula is got for the bearing capacity of CC arch through the strength criterion of bearing capacity.With numerical calculation and laboratory experiment,the ultimate bearing capacity and internal force distribution is analyzed for CC arches.The research results show that:1)CC arch is 2.31 times higher in strength than the U-shaped steel arch and has better stability;2)The key damage position of the arch is the two sides;3)Theoretical analysis,numerical calculation and laboratory experiment have good consistency in the internal force distribution,bearing capacity,and deformation and failure modes of the arch.All of that verifies the correctness of the theoretical calculation.Based on the above results,a field experiment is carried out in Liangjia Mine.Compared with the U-shaped steel arch support,CC arch support is more effective in surrounding rock deformation control.The research results can provide a basis for the design of CC arch support in underground engineering.

Design and Construction of Composite Tubular Arches with Network Suspension System： Recent Undertakings and Trends

The use of Network hanger arrangement, a development of the classical Nielsen V-hanger system, in steel bowstring arch bridges allows for important steel saving, with very slender main elements, owing to the remarkable reduction of bending stresses in the arches and tie beams. The present paper describes the main features of the design and construction of several long-span arch bridges of this typology in Spain： the three pedestrian footbridges for the Madrid cycling ring track, with spans of 52, 60 and 80 m, the Bridge over River Deba in Guipuzcoa with a span of 110 m and Palma del Rio Bridge over River Guadalquivir in Cordoba, 130 m long. In all cases, two inclined arches linked at the crown were implemented, a very effective disposition to reduce the out-of-plane buckling length. The multiple crossings of the hanger system, consisting of prestressed bars in the case of Deba Bridge and the footbridges, and locked coil cables for Palma del Rio Bridge, were dealt with by means of crossing devices which led to a technically satisfactory solution with minimal visual impact. An innovative approach to bowstring arches was introduced in Valdebebas Bridge over M-12 motorway in Madrid, next to the new T-4 Terminal of Barajas Airport, with a span of 162 m, where the hangers are replaced by a structural steel mesh -diagrid- which acts as the web of a simply-supported beam whose compression head is the arch and the tie beam is the deck.

Elastic stability of shallow pin-ended parabolic arches subjected to step loads

Buckling could be induced when shallow arches were subjected to vertical step loads. In-plane static and dynamic buckling of shallow pin-ended parabolic arches with a horizontal cable was investigated. Based on the equations of motion derived from Hamilton's principle, nonlinear equilibrium equations and static buckling equilibrium equations were deduced. Through the pseudo-static analysis, approximate solutions to the lower and upper dynamic buckling loads under step loads were obtained, for shallow parabolic arches. The results show that dynamic buckling and snap-through buckling are impossible when modified slenderness ratio λ<λc and λ>λs, where λc and λs denote critical slenderness ratios of bucking and snap-through buckling, respectively; effects of the stiffness of the horizontal cable on the dynamic buckling are significant; and the dynamic buckling loads under a equivalent central concentrated step load are lower than the loads under a distributed load appreciably.

Nonlinear dynamic behaviors of viscoelastic shallow arches

The nonlinear dynamic behaviors of nonlinear viscoelastic shallow arches sub- jected to external excitation are investigated. Based on the d＇Alembert principle and the Euler-Bernoulli assumption, the governing equation of a shallow arch is obtained, where the Leaderman constitutive relation is applied. The Galerkin method and numerical in- tegration are used to study the nonlinear dynamic properties of the viscoelastic shallow arches. Moreover, the effects of the rise, the material parameter and excitation on the nonlinear dynamic behaviors of the shallow arch viscoelastic shallow arches may appear to have a are investigated. The results show that chaotic motion for certain conditions.

In-Plane Creep Buckling of Concrete-Filled Steel Tubular Arches

The creep-induced deformation of the arch rib of concrete-filled steel tubular （CFST） arches under a sustained load can increase the bending moment, which may lead to earlier stability failure called creep buckling. To investigate the influences of concrete creep on the buckling strength of arches, a theoretical analysis for the creep buckling of CFST circular arches under distributed radial load is performed. The simplified Arutyunyan-Maslov （AM） creep law is used to model the creep behavior of concrete core, and the creep integral operator is introduced. The analytical solutions of the time-dependent buckling strength under the sustained load are achieved and compared with the existing formula based on the age-adjusted effective modulus method （AEMM）. Then the solutions are used to determine the influences of the steel ratio and the first loading age on the creep buckling of CFST arches. The results show that the analytical solutions are of good accuracy and applicability. For CFST arches, the steel ratio and the first loading age have significant influences on creep buckling. An approximate log-linear relationship between the decreased degrees of the creep buckling strength and the first loading age is found. For the commonly used parameters, the maximum loss of the buckling strength induced bv concrete creen is close to 40%

Application of a Machine Learning Algorithm for the Structural Optimization of Circular Arches with Different Cross-Sections

Arches are employed for bridges. This particular type of structures, characterized by a very old use tradition, is nowadays, widely exploited because of its strength, resilience, cost-effectiveness and charm. In recent years, a more conscious design approach that focuses on a more proper use of the building materials combined with the increasing of the computational capability of the modern computers, has led the research in the civil engineering field to the study of optimization algorithms applications aimed at the definition of the best design parameters. In this paper, a differential formulation and a MATLAB code for the calculation of the internal stresses in the arch structure are proposed. Then, the application of a machine learning algorithm, the genetic algorithm, for the calculation of the geometrical parameters, that allows to minimize the quantity of material that constitute the arch structures, is implemented. In this phase, the method used to calculate the stresses has been considered as a constraint function to reduce the range of the solutions to the only ones able to bear the design loads with the smallest volume. In particular, some case studies with different cross-sections are reported to prove the validity of the method and to compare the obtained results in terms of optimization effectiveness.

In-Plane Elastic Stability of Arches under a Radial Concentrated Load

This paper is concerned with the in-plane elastic stability of arches subjected to a radial concentrated load. The equilibrium equation for pin-ended circular arches is established by using energy method, and it is proved that the axial force is nearly a constant along the circumference of the circular arches. Based on force method, the equation for the primary eigen function is derived and solved, and the approximate analytical solution of critical instability load is obtained. Numerical examples are given and discussed.

股票市盈率波动有偏性对投资者股票交易量的影响研究--基于沪深300指数

有着独特波动规律的股票市盈率,会对投资者的股票交易产生影响。从市盈率波动有偏性的角度出发,以沪深300指数的市盈率数据为研究样本,构建回归模型,实证检验市盈率波动有偏性对股票交易量的影响,结果表明:沪深300指数市盈率波动相对于正常波动水平存在明显右偏性;沪深300指数市盈率波动的持续时间较长且具有非对称性;沪深300指数市盈率波动右偏性对股票成交量具有显著的反向影响,并且这种影响受到经济增长、出口量、利率、汇率、居民消费价格指数和货币供应量的非对称约束。要稳定股市交易量,就需要综合考虑上述因素的影响,并根据市场变动灵活调整政策措施。

Nonlinear Bending Analysis of Functionally Graded CNT-Reinforced Shallow Arches Placed on Elastic Foundations

This research explores the nonlinear bending behaviors of functionally graded carbon nanotube-reinforced(FG-CNTR)shallow arches with unmovable simply supported ends and clarnped-clamped ends;these arches are subjected to a uniform radial pressure and rest on a nonlinear elastic foundation.The temperature-dependent material properties of the arches are considered.Within the framework of Reddy shear deformation theory possessing von Karman nonlinearity,the motion equations and boundary conditions for the FG-CNTR arches are determined by the Euler-Lagrange variational principle.Then,a two-step perturbation technique is adopted to determine the load-deflection relationship analytically.To verify the validity of the developed model and related perturbation solutions,a numerical investigation is conducted for shallow arches with five distribution patterns of carbon nanotube(CNT)reinforcements uniaxially aligned in the axial direction.Finally,the influences of various factors,including the elastic foundation,layout type,and volume fraction of CNTs and geometric factors,on the nonlinear behaviors of FG-CNTR shallow arches are examined.The obtained results show that the load deflection curves exhibit less snap-through instability as the CNT volume fraction increases.The transverse shear stress versus the thickness of FG-CNTR shallow arches is markedly affected by the layout type and content of reinforcements.

Recent Construction Technology Innovations and Practices for Large-Span Arch Bridges in China

Arch bridges provide significant technical and economic benefits under suitable conditions.In particular,concrete-filled steel tubular(CFST)arch bridges and steel-reinforced concrete(SRC)arch bridges are two types of arch bridges that have gained great economic competitiveness and span growth potential due to advancements in construction technology,engineering materials,and construction equipment over the past 30 years.Under the leadership of the author,two record-breaking arch bridges—that is,the Pingnan Third Bridge(a CFST arch bridge),with a span of 560 m,and the Tian’e Longtan Bridge(an SRC arch bridge),with a span of 600 m—have been built in the past five years,embodying great technological breakthroughs in the construction of these two types of arch bridges.This paper takes these two arch bridges as examples to systematically summarize the latest technological innovations and practices in the construction of CFST arch bridges and SRC arch bridges in China.The technological innovations of CFST arch bridges include cable-stayed fastening-hanging cantilevered assembly methods,new in-tube concrete materials,in-tube concrete pouring techniques,a novel thrust abutment foundation for nonrocky terrain,and measures to reduce the quantity of temporary facilities.The technological innovations of SRC arch bridges involve arch skeleton stiffness selection,the development of encasing concrete materials,encasing concrete pouring,arch rib stress mitigation,and longitudinal reinforcement optimization.To conclude,future research focuses and development directions for these two types of arch bridges are proposed.

Roof collapse mechanism of weak surrounding rock for deep-buried tunnels under high geostress conditions

High geostress,a typical attribute of tunnels located at significant depths,is crucial in causing stress-induced failure and influencing the stability of the tunnel crown.This study developed an analytical method for the failure mechanism that occurs in deep-buried tunnel roofs,taking into account the influence of geostress.The limit analysis theory was utilized for deriving analytical solutions about the geometry of the collapsing surface and the limit supporting pressure.The collapsing surface obtained by the analytical solution was validated by the findings of the physical model test,which shows a high level of agreement with the actual one.An extensive investigation was done to explore the effects of the lateral pressure coefficients,the tunnel buried depth,the geological conditions of the surrounding rock,the long-short axis ratio,and the size of the tunnel profile.The findings indicate that an increase in the lateral pressure coefficient from 0.5 to 1.5 results in a reduction in the height of the collapsing zone by 2.08 m and the width of the collapsing zone by 1.15 m,while simultaneously increases the limit supporting pressure by 18.9%.The proposed upper bound method accurately determines the limit supporting pressure and the geometry of the collapsing surface,which aligns well with the results acquired through numerical modelling and on-site monitoring in actual engineering applications.The proposed analytical method can serve as a reference for similar crown failure issues of deep-buried tunnels.

Health diagnosis of ultrahigh arch dam performance using heterogeneous spatial panel vector model

Currently,more than ten ultrahigh arch dams have been constructed or are being constructed in China.Safety control is essential to long-term operation of these dams.This study employed the flexibility coefficient and plastic complementary energy norm to assess the structural safety of arch dams.A comprehensive analysis was conducted,focusing on differences among conventional methods in characterizing the structural behavior of the Xiaowan arch dam in China.Subsequently,the spatiotemporal characteristics of the measured performance of the Xiaowan dam were explored,including periodicity,convergence,and time-effect characteristics.These findings revealed the governing mechanism of main factors.Furthermore,a heterogeneous spatial panel vector model was developed,considering both common factors and specific factors affecting the safety and performance of arch dams.This model aims to comprehensively illustrate spatial heterogeneity between the entire structure and local regions,introducing a specific effect quantity to characterize local deformation differences.Ultimately,the proposed model was applied to the Xiaowan arch dam,accurately quantifying the spatiotemporal heterogeneity of dam performance.Additionally,the spatiotemporal distri-bution characteristics of environmental load effects on different parts of the dam were reasonably interpreted.Validation of the model prediction enhances its credibility,leading to the formulation of health diagnosis criteria for future long-term operation of the Xiaowan dam.The findings not only enhance the predictive ability and timely control of ultrahigh arch dams'performance but also provide a crucial basis for assessing the effectiveness of engineering treatment measures.

Early clinical outcome with lens position adjustment following implantable collamer lens surgery

AIM:To observe early clinical outcome with lens position adjustment following the implantable collamer lens(ICL)surgery.METHODS:Sixty patients were selected for this retrospective study.One eye from each patient received Toric ICL for astigmatism correction,and the other received non-astigmatic ICL surgery using horizontal position.Patients with higher postoperative arch height were selected,and their non-astigmatic eye clinical outcome were observed after ICL surgery at 1wk,1,and 3mo.The clinical measurements included uncorrected visual acuity(UCVA),intraocular pressure(IOP),refractive state,corneal endothelium cell count,and arch height.Three months later,the ICL in each patient’s non-astigmatic eye was adjusted to the vertical from the horizontal position.The results were compared before and 1wk,1,and 3mo after adjustment.RESULTS:UCVA and IOP were significantly reduced 1wk after position adjustment compared to 1wk after ICL implantation(P<0.05).The patients demonstrated significantly reduced arch height and corneal endothelium cell count 1wk,1,and 3mo after adjusting position compared to 1wk,1,and 3mo after ICL implantation(P<0.05).However,there was no significant difference in refraction between 1wk,1,and 3mo after ICL implantation and position adjustment(P>0.05).CONCLUSION:Early positioning adjustment postphakic ICL implantation can benefit patients with adjusted arch height or higher IOP.Despite the good clinical effects,the doctors should pay attention to the potential for adverse effects on UCVA and corneal endothelium cells following early position adjustment after posterior chamber phakic ICL implantation.

Numerical Simulation Analysis of Welded Joints in Arch Ribs of Large Span Steel Pipe Arch Bridges

In order to study the residual stress distribution law of welded joints of arch ribs of large-span steel pipe concrete arch bridges,numerical simulation of temperature,stress and strain fields based on ABAQUS for welded joints of arch-ribbed steel tubes using 7-,8-and 9-layer welds is carried out and its accuracy is demonstrated.The steel pipe welding temperature changes,residual stress distribution,different processes residual stress changes in the law,the prediction of post-weld residual stress distribution and deformation are studied in this paper.The results show that the temperature field values and test results are more consistent with the accuracy of numerical simulation of welding,the welding process is mainly in the form of heat transfer;Residual high stresses are predominantly distributed in the Fusion zone(FZ)and Heat-affected zone(HAZ),with residual stress levels tending to decrease from the center of the weld along the axial path,the maximum stress appears in the FZ and HAZ junction;The number of welding layers has an effect on the residual stress distribution,the number of welding layers increases,the residual stress tends to decrease,while the FZ and HAZ high stress area range shrinks;Increasing the number of plies will increase the amount of residual distortion.

Effects of comprehensive nursing with cognitive behavioral therapy in orthodontic osteodilated arch treatment

BACKGROUND This work explored the effects of cognitive behavior therapy(CBT)-based comprehensive nursing intervention(CNI)mode in arch expansion to treat patients with orthodontic osteodilated arch(OOA).AIM To explore the application effect of CBT-based CNI model in orthodontic expansion arch treatment.METHODS Using convenient sampling method,81 patients with OOA were selected and rolled into a control group(Ctrl group,40 cases)and an observation group(Obs group,41 cases).During the treatment,patients in the Ctrl group received routine nursing intervention mode,and the those in the Obs group received CBT mode on the basis of this.Before and after intervention,the incidence of oral mucositis,the mastery rate of correct arch expansion method,self-rating anxiety scale score,soft scale index,and plaque index were compared for patients in different groups.In addition,satisfaction and complications were comparatively analyzed.RESULTS Incidence of oral mucositis in the Obs group was lower(14.6%vs 38.5%),and the mastery rate of correct arch expansion method was obviously higher(90.2%vs 55.0%)was obviously higher(all P<0.05).Meanwhile,the soft scale index and plaque index in the Obs group were much lower(P<0.05).The compliance(90.24%)and satisfaction(95.12%)in the Obs group were greatly higher(P<0.05).CONCLUSION The CBT-based CNI mode greatly improved the mastery rate of correct arch expansion method during arch expansion in treating patients with OOA and enhanced the therapeutic effect of arch expansion and the oral health of patients,improving the patient compliance.

基于政策利率时间序列分析的硅谷银行破产启示

加息超调背景下的硅谷银行破产事件引起广泛关注,研究选取美国纳斯达克100指数、标准普尔500指数、硅谷银行股价数据进行时间序列的ARCH效应分析,发现美联储低利率刺激以及2022年6月起始的加息超调使两种指数与硅谷银行股价时间序列产生了波动聚集反应,并存在异常值。采用多元时间序列VAR模型进行格兰杰因果检验以及脉冲响应分析,发现政策利率调整对硅谷银行股价造成了冲击。基于研究结果,提出顺周期效应具备客观性及前瞻性,央行相机抉择要精准;银行业需要重视市场存在的异动和相关指标检测;面对风险新形态需采用前沿管理技术;避免业务模式单一化和集中化等风险管理建议。