Rare incidence of mucosa-associated lymphoid tissue lymphoma presenting as buccal fat pad tumor:A case report

BACKGROUND Mucosa-associated lymphoid tissue(MALT)lymphoma,a type of non-Hodgkin lymphoma,originates in the mucosal lining of body organs and internal cavities,including the nose,mouth,lungs,and digestive tract.The lymphoma develops when the body produces abnormal B lymphocytes.These lymphomas develop at the edge of the lymphoid tissue,called the marginal zone,and,hence,are classified as a type of marginal zone lymphomas.They are the most common type of marginal zone lymphomas although their occurrence is rare.To date,no previous cases of MALT lymphoma in the buccal fat pad have been reported.CASE SUMMARY We report the case of a patient who presented with a mass on the frontal cheek.Magnetic resonance imaging revealed a tumor in the buccal fat pad,and histopathological and immunohistochemical findings confirmed the diagnosis of MALT lymphoma.The patient had a history of Helicobacter pylori and hepatitis C virus infection,suggesting an association between these infective agents and MALT lymphoma.CONCLUSION Consideration of MALT lymphoma is essential in the differential diagnosis of frontal cheek masses.

Primary mucosal-associated lymphoid tissue extranodal marginal zone lymphoma of the bladder from an imaging perspective: A case report

BACKGROUND Mucosal-associated lymphoid tissue extranodal marginal zone(MALT)lymphoma is a low-grade tumor that rarely occurs in the urinary bladder.There is currently no consensus on the common imaging findings or most appropriate treatment in MALT lymphoma in the urinary bladder due to the limited number of reports.CASE SUMMARY A 48-year-old woman was admitted to the hospital with a 1-year history of macroscopic hematuria.Imaging showed a large homogeneous mass with an unclear boundary and an irregular morphology in the bladder.The mass had an abundant blood supply.For further diagnosis,transurethral cystoscopic biopsy and bone marrow biopsy was performed,and the patient was finally diagnosed with primary MALT lymphoma of the bladder.R-CHOP chemotherapy was carried out.After three cycles of chemotherapy,the mass disappeared and the bladder wall thickness was only 4 mm,which indicated excellent therapeutic response to the chemotherapy.To date,the patient remains asymptomatic and she visits our hospital regularly for the completion of the remaining chemotherapy cycles.CONCLUSION Primary MALT lymphoma of the bladder is rare,and there are certain characteristics in the ultrasonographic findings.Imaging findings play an important role in evaluating the therapeutic efficacy and are critical during long-term follow-up after therapy.

Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis

BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(H.pylori)-induced chronic gastritis.Clinical practice guidelines currently recommend H.pylori eradication as the preferred initial treatment for early-stage GML.To determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is imperative.AIM To perform a meta-analysis to assess the rate of complete remission(CR)of H.pylori-positive early-stage GML following bacterial eradication.METHODS We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September 2022.Prospective and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in H.pylori-positive patients.The risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal Tools.The pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects model.Heterogeneity and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P<0.01 and I²>50%,respectively.Subgroup and meta-regression analyses were conducted to explore potential sources of heterogeneity.RESULTS The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text reading.Finally,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational studies.The overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 H.pylori-positive early-stage GML patients,in whom H.pylori was successfully eradicated,were included in the analysis.The pooled CR of H.pylori-positive early-stage GML after bacterial eradication was 75.18%(95%CI:70.45%-79.91%).P-MA indicated the substantial heterogeneity in CR reported across studies(I2=92%;P<0.01).Meta-regression analysis identified statistically significant effect modifiers,including the proportion of patients with t(11;18)(q21;q21)-positive GML and the risk of bias in each study.CONCLUSION Comprehensive synthesis of available evidence suggests that H.pylori eradication is effective as the sole initial therapy for early-stage GML.Although the substantial heterogeneity observed across studies limits the interpretation of the pooled overall CR,the present study is a relevant to informing clinical practice.

Marginal zone lymphoma with severe rashes: A case report

BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial symptom.CASE SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent discharge.First-line treatment with rituximab combined with zanubrutinib had poor effects.However,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes disappeared.CONCLUSION For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be considered.This approach may provide a new perspective in the treatment of MZL.

Role of non-Helicobacter pylori gastric Helicobacters in helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma

Marginal zone lymphomas rank as the third most prevalent form of non-Hodgkin B-cell lymphoma,trailing behind diffuse large B-cell lymphoma and follicular lymphoma.Gastric mucosa-associated lymphoid tissue lymphoma(GML)is a low-grade B-cell neoplasia frequently correlated with Helicobacter pylori(H.pylori)-induced chronic gastritis.On the other hand,a specific subset of individuals diagnosed with GML does not exhibit H.pylori infection.In contrast to its H.pylori-positive counterpart,it was previously believed that H.pylori-negative GML was less likely to respond to antimicrobial therapy.Despite this,surprisingly,increasing evidence supports that a considerable proportion of patients with H.pylori-negative GML show complete histopathological remission after bacterial eradication therapy.Nonetheless,the precise mechanisms underlying this treatment responsiveness are not yet fully comprehended.In recent years,there has been growing interest in investigating the role of non-H.pylori gastric helicobacters(NHPHs)in the pathogenesis of H.pylori-negative GML.However,additional research is required to establish the causal relationship between NHPHs and GML.In this minireview,we examined the current understanding and proposed prospects on the involvement of NHPHs in H.pylori-negative GML,as well as their potential response to bacterial eradication therapy.

Role of Helicobacter pylori in gastric mucosa-associated lymphoid tissue lymphomas

Mucosa-associated lymphoid tissue (MALT) lymphoma is an indolent extranodal marginal zone B-cell lymphoma, originating in acquired MALT that is induced in mucosal barriers as part of a normal adaptive immune response to a chronic immunoinflammatory stimulus, most notably chronic infection by Helicobacter pylori (H. pylori). This antigenic stimulation initially leads to lymphoid hyperplasia; the acquisition of additional genetic aberrations culminates in the activation of intracellular survival pathways, with disease progression due to proliferation and resistance to apoptosis, and the emergence of a malignant clone. There are descriptions of MALT lymphomas affecting practically every organ and system, with a marked geographic variability partially attributable to the epidemiology of the underlying risk factors; nevertheless, the digestive system (and predominantly the stomach) is the most frequently involved location, reflecting the gastrointestinal tract’s unique characteristics of contact with foreign antigens, high mucosal permeability, large extension and intrinsic lymphoid system. While early-stage gastric MALT lymphoma can frequently regress after the therapeutic reversal of the chronic immune stimulus through antibiotic eradication of H. pylori infection, the presence of immortalizing genetic abnormalities, of advanced disease or of eradication-refractoriness requires a more aggressive approach which is, presently, not consensual. The fact that MALT lymphomas are rare neoplasms, with a worldwide incidence of 1-1.5 cases per 105 population, per year, limits the ease of accrual of representative series of patients for robust clinical trials that could sustain informed evidence-based therapeutic decisions to optimize the quality of patient care.

Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene

AIM To identify the clinical features of gastric mucosaassociated lymphoid tissue(MALT) lymphoma with extra copies of MALT1.METHODS This is a multi-centered,retrospective study. We reviewed 146 patients with MALT lymphoma in the stomach who underwent fluorescence in situ hybridization analysis for t(11;18) translocation. Patients were subdivided into patients without t(11;18) translocation or extra copies of MALT1(Group A,n = 88),patients with t(11;18) translocation(Group B,n = 27),and patients with extra copies of MALT1(Group C,n = 31). The clinical background,treatment,and outcomes of each group were investigated.RESULTS Groups A and C showed slight female predominance,whereas Group B showed slight male predominance. Mean ages and clinical stages at lymphoma diagnosis were not different between groups. Complete response was obtained in 61 patients in Group A(69.3%),22 in Group B(81.5%),and 21 in Group C(67.7%). Helicobacter pylori(H. pylori) eradication alone resulted in complete remission in 44 patients in Group A and 13 in Group C. In Group B,14 patients underwent radiotherapy alone,which resulted in lymphoma disappearance. Although the difference was not statistically significant,event-free survival in Group C tended to be inferior to that in Group A(P = 0.10).CONCLUSION Patients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication,similar to patients without t(11;18) translocation or extra copies of MALT1.

Relationships between lymphomas linked to hepatitis C virus infection and their microenvironment

The relationships between lymphomas and their microenvironment appear to follow 3 major patterns:(1)an independent pattern;(2)a dependent pattern on deregulated interactions;and(3)a dependent pattern on regulated coexistence.Typical examples of the third pattern are hepatitis C virus(HCV)-associated marginal zone lymphomas(MZLs)and mucosa-associated lymphoid tissue lymphomas.In these lymphomas,a regulated coexistence of the malignant cells and the microenvironmental factors usually occurs.At least initially,however,tumor development and cell growth largely depend on external signals from the microenvironment,such as viral antigens,cytokines,and cell-cell interactions.The association between HCV infection and B-cell lymphomas is not completely defined,although this association has been demonstrated by epidemiological studies.MZL and diffuse large B-cell lymphoma are the histotypes most frequently associated with HCV infection.Many mechanisms have been proposed for explaining HCV-induced lymphomagenesis;antigenic stimulation by HCV seems to be fundamental in establishing B-cell expansion as observed in mixed cryoglobulinemia and in B-cell lymphomas.Recently,antiviral treatment has been proved to be effective in the treatment of HCV-associated indolent lymphomas.Importantly,clinically responses were linked to the eradication of the HCV-RNA,providing a strong argument in favor of a causative link between HCV and lymphoproliferation.

原发性眼附属器非霍奇金淋巴瘤的特征

目的:探讨原发于眼附属器非霍奇金淋巴瘤的临床表现与病理特征。方法:对18例住院手术并经病理学检查确认为原发于眼附属器非霍奇金淋巴瘤患者的临床资料进行回顾性分析,对该病发生部位、临床及影像学表现、病理学特征进行总结。结果:全部患者均表现为眼部占位性病变,其中发生于眼眶者12例(含泪腺3例),占66.7%;发生于结膜者3例,占16.7%;发生于下睑者3例,占16.7%。全部病例中,8例患者被临床和影像学检查误诊为"炎性假瘤"。8例被诊为眼部占位性病变性质待查。经病理学检查,16例(88.9%)诊断为黏膜相关淋巴组织型的结外边缘带B细胞淋巴瘤,2例诊断为NK/T细胞性非霍奇金淋巴瘤。结论:原发于眼附属器的非霍奇金淋巴瘤主要表现为无痛性肿块,多发生于眼眶,临床和影像学确诊难度大,大多数糖皮质激素治疗有效,容易被误诊为"炎性假瘤"。黏膜相关淋巴组织B细胞淋巴瘤是最常见的病理类型。

眼结膜黏膜相关淋巴组织边缘带B细胞淋巴瘤临床病理分析

目的 探讨眼结膜黏膜相关淋巴组织边缘带B细胞淋巴瘤（marginal zone B cell lymphoma of mucosa-associated lymphoidtissue）（简称为MALT淋巴瘤）的临床病理特征、治疗及预后。方法 对15例眼结膜MALT淋巴瘤患者的临床病理资料进行回顾性分析及随访,复查和完善HE及免疫组化染色切片,4例进行Ig基因重排克隆性分析。结果 （1）15例患者中,男性5例,女性10例,中位年龄42岁,病史平均20个月。（2）病理形态：黏膜下大量密集淋巴样细胞弥漫浸润,并有模糊淋巴滤泡样结节。浸润细胞多为小～中等大小的淋巴样细胞及单核样B细胞。（3）免疫表型：浸润细胞CD20、CD79a、BCL-2均（＋）,CD3、CD5、CD10、Cyclin D1、TdT均（-）。（4）Ig基因克隆性分析：4例均呈单克隆。（5）随访：随访时间2～35个月,截止随访日期,所有患者均生存,且病变无复发。结论 眼结膜MALT淋巴瘤好发于中年女性,结膜红肿突起为主要特征,镜下以小细胞样边缘带B细胞为主,具有典型MALT淋巴瘤的免疫表型和惰性临床经过,预后良好。

原发性皮肤边缘区B细胞淋巴瘤临床病理特征

目的探讨原发皮肤边缘区B细胞淋巴瘤(PCMZL)的临床和病理学特征,诊断和鉴别诊断。方法对2例PCMZL和1例皮肤淋巴组织增生(CLP)病例进行临床特征、组织形态学、免疫表型及PCRIgH基因重排分析。结果免疫组化示2例PCMZL的小淋巴细胞CD20和CD79α(),bcl-2、BOB.1和Oct-2(),MUM-1(+),CD5、CD10、bcl-6和CD23(-);浆细胞CD138、MUM-1(),限制性表达轻链kappa。1例CLP的小淋巴细胞CD20、CD3和bcl-2(),MUM1(+);浆细胞同时表达κ及λ。IgH扩增2例PCMZL呈单克隆性,1例CLP显示多克隆性。结论PCMZL属MALT-L家族,形态学上肿瘤细胞由异源性小淋巴细胞组成,免疫学上显示后生发中心标记。浆细胞轻链限制性和B细胞抗原受体基因克隆性重排对诊断有非常重要的帮助。

Fc受体样4蛋白在唾液腺黏膜相关淋巴组织结外边缘区B细胞淋巴瘤中的表达及意义

目的:通过检测唾液腺黏膜相关淋巴组织结外边缘区B细胞淋巴瘤(extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue B cell lymphoma,MALT淋巴瘤)中Fc受体样4(Fc receptor-like 4,FCRL4)蛋白的表达,分析其表达及分布特点与临床病理指标、预后等的相关性。方法:筛选2005—2013经病理确诊为唾液腺MALT淋巴瘤的病例作为实验组;以唇腺良性淋巴上皮病(benign lymphoepithelial lesions,BLEL)、大唾液腺BLEL及弥漫性大B细胞淋巴瘤(diffuse large B cell lymphoma,DLBCL)作为对照组。免疫组织化学(immunohistochemistry,IHC)法检测FCRL4蛋白表达。采用SPSS 17.0软件对FCRL4在实验组、对照组的表达及其与临床病理指标之间的关系进行分析,应用Kaplan-Meier法分析FCRL4表达与总体生存率之间的关系。结果:共收集到72例唾液腺MALT淋巴瘤。FCRL4表达主要定位于淋巴细胞的细胞膜和细胞浆,阳性细胞主要分布在上皮巢内及周边,且在唾液腺MALT淋巴瘤中的表达率显著高于唇腺BLEL(P=0.013)、大唾液腺BLEL(P=0.003)及DLBCL(P=0.001)。FCRL4蛋白表达与临床病理指标、总体生存率之间均无明显相关性(P>0.05)。结论:唾液腺MALT淋巴瘤中FCRL4主要表达于邻近上皮的淋巴细胞中,该类细胞可能与唾液腺MALT淋巴瘤的发生相关,可作为该肿瘤辅助诊断的指标。

免疫组织化学双染技术在唾液腺淋巴上皮性病变中的应用评价

目的:根据抗体阳性表达的不同部位(细胞核、细胞质和细胞膜)、染色顺序及匹配不同的显色系统,探讨免疫组织化学双染技术在唾液腺淋巴上皮性病变诊断中的最佳染色方法。方法:挑选良性淋巴上皮病(benign lymphoepithelial lesion,BLEL)、淋巴上皮癌(lymphoepithelial carcinoma,LEC)和黏膜相关淋巴组织结外边缘区B细胞淋巴瘤(extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue,MALT淋巴瘤)各20例,分别进行AE1/AE3、Ki-67、CD20cy抗体的免疫组织化学单染和两两组合的双染检测。每个病例依据不同抗体的表达部位(细胞核、细胞质及细胞膜)、不同的抗体染色顺序和显色剂,分别采用3种双染方法检测,即①先Ki-67(DAB显色),再AE1/AE3或CD20cy(AEC显色);②先AE1/AE3或CD20cy(DAB显色),再Ki-67(AEC显色);③先Ki-67(AEC显色),再AE1/AE3或CD20cy(BCIP/NBT显色)。所得结果均与单染相比较,采用SPSS 17.0软件包对数据进行χ^2检验和配对t检验,分析染色强度和阳性比率有无差异。结果:所有双染方法中抗体定位均准确,但方法 1中各抗体染色强度(P=0.765)和阳性比率(P>0.05)均无显著差异,而方法 2和方法 3中抗体的阳性比率和染色强度均有不同程度下降(P<0.05)。结论:免疫组织化学双染技术在唾液腺淋巴上皮性病变中的最佳染色方法为先进行阳性定位于细胞核如Ki-67的染色,配合使用DAB显色剂,后进行阳性定位于细胞膜或细胞质如AE1/AE3或CD20cy的染色,配合使用AEC显色剂。

以胸腔积液首发误诊的黏膜相关淋巴组织结外边缘区淋巴瘤1例并文献复习

目的:探讨以胸腔积液首发的黏膜相关淋巴组织结外边缘区淋巴瘤的临床表现、影像学特征、病理特点及诊断治疗、预后等,以提高对该病的认识。方法:回顾总结了1例以胸腔积液首发误诊的边缘区淋巴瘤MALT型的诊治过程,并在PubMed数据库检索了1999年1月1日~2020年11月31日发表的英文文献12例,最后对共13例进行了分析总结。结果:首发为胸腔积液的MALT淋巴瘤较少见,临床表现不特异,容易误诊漏诊。文献中病例以个案病例报道为多。以胸腔积液首发的MALT常见症状为气短(8/13)、胸痛(6/13)、咳嗽(3/13)。影像学可表现为胸腔积液、胸膜团块影等。大部分治疗为化疗、外科切除或观察治疗等,其预后总体尚好。结论:以胸腔积液首发的MALT淋巴瘤较少见且容易误诊,应及时行穿刺检查、尽早病理诊断。

眼附属器淋巴造血组织增生性疾病临床病理分析

目的探讨眼附属器淋巴造血组织增生性疾病的临床病理学特征。方法回顾性分析210例首都医科大学附属北京同仁医院眼附属器淋巴造血组织增生性疾病患者的临床资料和临床病理资料。结果 1该组眼附属器淋巴造血组织增生性疾病中最常见的是非霍奇金淋巴瘤(100例,47.6%),其次为炎性假瘤(45例,21.4%)和良性淋巴上皮病变(Mikuliczs病,41例,19.5%)。2该组病变部分类型在发病年龄和性别上有特点,组织病理学上的表现有交叉。3该部位非霍奇金淋巴瘤中最常见的为结外黏膜相关组织边缘区B细胞淋巴瘤(74例),眼附属器的结外黏膜相关组织边缘区B细胞淋巴瘤有其不同于其他解剖部位的该肿瘤的特点。4免疫组织化学染色在该部位淋巴造血组织增生性疾病的诊断和鉴别诊断中有非常重要的作用。5眼附属器的Ig G4相关性疾病(10例)的诊断和临床病理表现有其独有的特征。结论眼附属器淋巴造血组织增生性疾病是一类比较常见的疾病,其在发病年龄、性别等临床表现和组织学类型上都具有明显的临床病理学特征,掌握这些对临床病理诊断将提供较大的帮助。

消化系统多器官粘膜相关淋巴组织淋巴瘤1例报道并文献复习

目的：探讨一例消化系统多器官粘膜相关淋巴组织淋巴瘤的临床病理特点，并复习有关文献。方法：结合有关临床资料，复习本病例所有HE切片，应用免疫组化法标记CD20、CD3、CD5、CD10、CD23、Cyclin D1、bcl-2和KI-67。结果：免疫表型CD20＋、bcl-2＋、CD23＋／-、KI-67＋，CD3-、CD-、CD10-、CyclinD1-，诊断为粘膜相关淋巴瘤。结论：结外粘膜相关淋巴瘤是一种低度恶性的B细胞淋巴瘤，其临床行为受淋巴细胞归巢的影响。

肝脏原发黏膜相关淋巴组织结外边缘区淋巴瘤一例

患者女,59岁,因"间断性右上腹胀痛2周"于2020年8月26日入兰大二院,无发热、寒战,无恶心、呕吐,无腹泻、便秘。查体:全身皮肤黏膜、巩膜无黄染,浅表淋巴结未扪及肿大。右上腹轻度压痛,腹部触及包块,腹式呼吸减弱,无腹壁静脉曲张。实验室检查,甲胎蛋白(alpha fetoprotein,AFPAFP)、癌胚抗原(carcinoembryonic antigen,CEACEA)、糖类抗原(carbohydrate antigen,CA125、CA199CA125、CA199)均为阴性。

眼附属器黏膜相关淋巴组织结外边缘区B细胞淋巴瘤(MALT)临床病理分析

目的:探讨6例眼附属器黏膜相关淋巴组织结外边缘区B细胞淋巴瘤(MALT)患者的临床病理特点及预后。方法:收集2010年01月至2019年01月病理学检查确诊的6例眼附属器MALT患者的临床资料及治疗方案、形态学特点及免疫组化表达,FISH检测MALT1基因断裂,电话随访,分析总结其临床病理特点及预后。结果:临床表现为眼部不适,眼睑肿胀及视物模糊等。镜下可见肿瘤由形态多样的小B细胞组成,包括边缘带细胞(中心细胞样细胞)、单核样细胞、小淋巴细胞,也可见散在的免疫母细胞和中心母细胞样细胞,部分细胞有浆细胞样分化。5例肿瘤细胞CD20(+)、CD3(-)、BCL2(+)、Ki67约10%~25%,3例BCL10及AEG1阳性,1例伴浆细胞分化,免疫组化表现为CD20(-)、CD79α(+)、CD38(+)、CD138(+)、MUM1(+)、Kappa、Lambda呈限制性表达,2例FISH检测结果阳性。结论:眼附属器MALT淋巴瘤常CD20、BCL2、BCL10、AEG1阳性,FISH可作为辅助诊断。

眼睑黏膜相关淋巴组织结外边缘区淋巴瘤二例

目的探讨眼睑黏膜相关淋巴组织结外边缘区B细胞淋巴瘤的临床病理学特征。方法对2例眼睑黏膜相关淋巴组织结外边缘区淋巴瘤的临床表现、组织学形态及免疫表型进行分析,并复习相关文献。结果镜检下2例均表现为小圆形肿瘤细胞结节状或弥漫浸润生长,肿瘤细胞浸润至横纹肌组织及睑板腺周围,并见淋巴上皮病变,部分区域见滤泡植入现象。高倍镜下细胞大小不等,细胞核呈类圆形及圆形,核凹陷或扭曲,核深染,染色质分布不均,核仁不明显,胞质少,淡染或部分处呈透明状。肿物组织免疫组化表达结果:CD20弥漫(+)、CD79a弥漫(+)、Bcl-2 1例阳性,1例弱阳性、Ki-6710%~20%(+)。结论眼睑黏膜相关淋巴组织结外边缘区淋巴瘤罕见,熟悉其临床病理学特征及免疫表型,有助于正确诊断。

肝脏原发结外黏膜相关淋巴组织边缘区淋巴瘤1例

1病例资料患者,女,55岁,半月前体检发现肝脏占位,患者自觉一般状态良好,无特殊症状,为确诊及治疗收入我院。实验室结果显示甲胎蛋白、糖类抗原(包括CA199、CA125、CA153)及癌胚抗原均为阴性。影像学:CT扫描(图1A):肝左内叶团块状低密度影,边界清晰。MRI平扫:肝左内叶见稍长T_(1)WI(图1B),稍长T_(2)WI信号(图1C)影。