Prevalence of post-traumatic stress disorder and depressive symptoms among civilians residing in armed conflict-affected regions:a systematic review and meta-analysis

Background Globally,populations afflicted by armed conflict are known to have high rates of mental health disorders.Aims This meta-analysis aims to estimate the prevalence of post-traumatic stress disorder(PTSD)and depressive symptoms among civilians residing in armed conflictaffected regions.Methods This meta-analysis was conducted in accordance with the Preferred Reporting Items forSystematic Reviews and Meta-Analyses.A literature search employing MEDLINE(R),Embase Classic+Embase,APA PsyclNFO,Ovid Healthstar,Journal@Ovid Full Text,Cochrane,PTSDpubs and CINAHL was conducted from inception until 19 March 2024 to identify relevant studies.Quality assessment was performed using the Joanna Briggs Institute Critical Appraisal Checklist for Prevalence Studies,and a Comprehensive Meta-Analysiswas usedto conduct the statistical analysis.Results The search yielded 38595 articles,of which 57 were considered eligible for inclusion.The included studies comprised data from 64596 participants.We estimated a prevalence of 23.70%(95%CI 19.50%to28.40%)forPTSD symptomsand 25.60%(95%Cl 20.70%to 31.10%)for depressive features among war-afflicted civilians.The subgroup analysis based on time since the war and the country's economic status revealed the highest prevalence for both PTSD and depressive symptoms was present during the years of war and in low/middle-incomecountries.Conclusions The results of this study provide conclusive evidence of the detrimental impacts of armed conflict on mental health outcomes.Hence,it is crucial to emphasise the significance of both physical and mental health in the aftermath of war and take appropriate humanistic measures to overcome challenges in the management of psychiatric illnesses.

Application of Newcastle disease virus in the treatment of colorectal cancer

Colorectal cancer (CRC) is one of the main reasons of tumor-related deaths worldwide.At present,the main treatment is surgery,but the results are unsatisfactory,and the prognosis is poor.The majority of patients die due to liver or lung metastasis or recurrence.In recent years,great progress has been made in the field of tumor gene therapy,providing a new treatment for combating CRC.As oncolytic viruses selectively replicate almost exclusively in the cytoplasm of tumor cells and do not require integration into the host genome,they are safer,more effective and more attractive as oncolytic agents.Newcastle disease virus (NDV) is a natural RNA oncolytic virus.After NDV selectively infects tumor cells,the immune response induced by NDV’s envelope protein and intracellular factors can effectively kill the tumor without affecting normal cells.Reverse genetic techniques make NDV a vector for gene therapy.Arming the virus by inserting various exogenous genes or using NDV in combination with immunotherapy can also improve the anti-CRC capacity of NDV,and good results have been achieved in animal models and clinical treatment trials.This article reviews the molecular biological characteristics and oncolytic mechanism of NDV and discusses in vitro and in vivo experiments on NDV anti-CRC capacity and clinical treatment.In conclusion,NDV is an excellent candidate for cancer treatment,but more preclinical studies and clinical trials are needed to ensure its safety and efficacy.

Performance of risk stratification systems for gastrointestinal stromal tumors: A multicenter study

BACKGROUND Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumor type in the gastrointestinal system. Presently, various classification systems to prognosticate GISTs have been proposed.AIM To evaluate the application value of four different risk stratification systems for GISTs.METHODS Patients who were diagnosed with GISTs and underwent surgical resection at four hospitals from 1998 to 2015 were identified from a database. Risk of recurrence was stratified by the modified National Institute of Health(NIH)criteria, the Armed Forces Institute of Pathology(AFIP) criteria, the Memorial Sloan Kettering Cancer Center(MSKCC) prognostic nomogram, and the contour maps. Receiver operating characteristic(ROC) curves were established to compare the four abovementioned risk stratification systems based on the area under the curve(AUC).RESULTS A total of 1303 patients were included in the study. The mean age of the patients was 55.77 ± 13.70 yr; 52.3% of the patients were male. The mean follow-up period was 64.91 ± 35.79 mo. Approximately 67.0% the tumors were located in the stomach, and 59.5% were smaller than 5 cm; 67.3% of the patients had a mitotic count ≤ 5/50 high-power fields(HPFs). Thirty-four tumors ruptured before and during surgery. Univariate analysis demonstrated that tumor size > 5 cm(P <0.05), mitotic count > 5/50 HPFs(P < 0.05), non-gastric location(P < 0.05), and tumor rupture(P < 0.05) were significantly associated with increased recurrence rates. According to the ROC curve, the AFIP criteria showed the largest AUC(0.754).CONCLUSION According to our data, the AFIP criteria were associated with a larger AUC than the NIH modified criteria, the MSKCC nomogram, and the contour maps, which might indicate that the AFIP criteria have better accuracy to support therapeutic decision-making for patients with GISTs.

The Russian‐Ukrainian armed conflict will push back the sustainable development goals

The Russian-Ukrainian armed conflict is a dramatic world event. Apart from the loss of life, the present conflicthas tremendous impacts on the environment, economy, and society. The conflict provoked a ripple of events withimplications at the global level, especially in energy and food. The escalation of this conflict is imposing severethreats to achieving the United Nations (UN) Sustainable Development Goals (SDGs) not only to the countries di-rectly involved in the conflict but also to other countries, especially the developing ones that are more vulnerableto the economic crisis. In this editorial, we assessed the impacts of the Russian-Ukrainian conflict on BiophysicalSDGs, Social SDGs, Economic SDGs and Partnership for the Goals SDG that consider all the previous dimensions.The Russian-Ukrainian conflict’s impact on the SDGs is variable. Biodiversity SDGs are mainly affected at theregional level (Russia, Ukraine, surrounding and European Union countries). Society SDGs are affected at local(e.g., SDG3 good health and wellbeing;SDG4 quality education) and global (e.g., SDG2 zero hunger) levels. Fi-nally, the Russian-Ukrainian armed conflict has world-level implications for the economic SDGs. Nevertheless,the ongoing conflict’s impacts are not entirely understood, and several uncertainties exist. Peace is needed toachieve the UN’s SDGs in 2030.

Stigma and its impact on the families of former soldiers of the German Armed Forces: An exploratory study

Background: Military families who have a family member with a mental illness see themselves confronted with many demands. Stigmatization is one of these challenges. Stigmatization affects not only the individual who suffers from a mental illness but also other family members via stigma by association and vicarious stigma. Stigma by association occurs when mental illness stigma spills over to individuals associated with an individual with a mental illness. Vicarious stigma describes the suffering of family members when they note the impact of stigma on their relative with mental illness. As a societal phenomenon, stigma plays out in social interactions and might therefore influence the social networks of families. It is also associated with healthcare utilization.Methods: Narrative interviews were conducted with 15 family members(partners, spouses, parents and children) of former soldiers of the German Armed Forces with a service-induced mental illness. The transcribed interview data were analyzed using a thematic analysis approach, in which codes were formed and emerging themes were systemized. Relationships between stigma, the families’ reactions to it, its effects on their social relationships and its interference with their healthcare utilization were analyzed.Results: This study provides a detailed description of how relatives of former German soldiers with mental health problems experience stigma by association and vicarious stigma. Their perceptions are shown in a model that describes stigma-related attitudes, reactions to them and their effects on the social relationships of former soldiers’ families. These families felt stigmatized because of the former soldiers’ mental illness(mental illness stigma) and the military context in which it occurred(former soldier stigma). They reacted with nondisclosure, anger, acceptance and self-blame. Stigma was associated with smaller and weaker social networks that were characterized by social exclusion, self-segregation and conflicts with extended family, friends and colleagues. Stigma also affected the families’ healthcare utilization.Conclusions: Urgently needed anti-stigma campaigns, particularly in the civilian context, should address the stigmatization of both mental illness and the military participation of the families affected. They should consider the needs of both former soldiers with a mental illness and their families.

Rationale and design of the cardiorespiratory fitness and hospitalization events in armed forces study in Eastern Taiwan

AIM To investigate the association between cardiorespiratory fitness and hospitalization events in a cohort of large voluntary arm forces in Taiwan. METHODS The cardiorespiratory fitness and hospitalization events in armed forces(CHIEF) is a retrospective cohort consisting of more than 4000 professional military members aged 18-50 years in Eastern Taiwan. All participants received history taking, physical examination, chest radiography, 12-lead electrocardiography, blood tests for cell counts and fasting glucose, lipid profiles, uric acid, renal function and liver function in the Hualien Armed Forces General Hospital during 2014. In addition, participants were required to undergo two indoor resistant exercise tests including 2-min push-up and 2-min sit-up, both scored by infrared sensing, and one outdoor endurance 3000-m none weight-bearing running test, the main indicator of cardiorespiratory fitness in the Military Physical Training and Testing Center in Eastern Taiwan in 2014. RESULTS Hospitalization events for cardiovascular disease, acute kidney injury, rhabdomyolysis, severe infectious disease, acute psychiatric illness, diabetes, orthopedic surgery and mortality will be identified in the National Insurance Research Database for 10 years. CONCLUSION CHIEF will be among the largest Eastern Asian armed forces cohort, in which physical status was strictly evaluated to follow up the hospitalization events for severe illness.

从对干涉的分析看国际社会的民主化

一引言"干涉"是国际法当中存有难点较多的概念之一。纵观当代国际法发展的历史,干涉在不同的时期有着不同的含义。比如说,在19世纪其最初出现时,干涉经常是以"武力干涉"(armed intervention)的含义而被指称;发展到今天,每当提及干涉,人们较多的是指"人道主义干涉"(humanitarian intervention)。本文试图从"干涉"的定义出发。

Impact of the Armed Conflict of 2015-2016 in Aden on Health Services and the Availability of Medicines

To assess the impact of the armed conflict of 2015-2016 on the availability of medicines and health service in Aden Governorate whilst the rebels over-run the city. A cross sectional survey was done during the period, September-November 2016. The survey included 63 medicinal preparations as marker medicines in 142 public health facilities including private pharmacies. Direct questions and a retrospective study of the United Nations and other organizations that were working in area reporting were studied. I.V. fluids had the highest availability in the market whilst vaccines had the lowest average availability at 60%. Medicine prices were increased by 71%. The function of health facilities was almost on the verge of collapse. The four districts containing the main hospital and the medical stores were inaccessible and completely controlled by the rebels. Two out of six hospitals remain functional. Dengue and malaria rampantly spread and approximately 65,250 civilians were affected. The situation was further aggravated by the absence of basic services such as electricity, water and food.

Economic and Political Aspects of Wars and Armed Conflicts

War,as a social phenomenon,is studied unofficially by most disciplines of social sciences.This is due to the nature of the war itself,which is an extremely interdisciplinary phenomenon.In common thought,war is associated exclusively with the science of history,but in its essence,this phenomenon also includes economics and political sciences.War undeniably affects the political and economic processes in the state,both in a negative and positive way.Often,also the strategies of the state’s political activities and plans for economic development are conditioned by the occurrence of wars and armed conflicts.

A Rising Star on World Stage

The birth of the new South Africa signifies the end of international isolation ofthe old racist regime, the return of the country to the global community anda rising role for the republic in African and world affairs. The old racist regime was a regional hegemonic power, the root cause of eviland instability in Southern Africa, It occupied Namibia for a long time,

Rape and Medical Consequences among Girls and Women Victims during the Post-Armed Conflict Context in Congo

Rape is a criminal, aggressive and violent act to have sexual intercourse with a person without her consent. Few studies have been conducted on rape and sexual assaults related to armed conflict in developing countries. The objective of this study was to assess the magnitude of rape and its medical consequences among victims during armed post-conflict period in Brazzaville from January to December 1999. Rape victim was defined as woman or girl having received medical care from January to December 1999 in care units following reporting having incident of rape. SPSS V 20 software was used for the analyses. A total of 1282 victims were assessed. We documented 106 post-rape pregnancies, of which 58 (54.7%) ended in abortion, 15 (14.2%) in miscarriage and 33 (31.1%) in childbirth. Sexually transmitted infections (STIs) were common, with 560 (44%) cases among the 1282 victims. Of these, 301 (23%) had trichomoniasis, 123 (10%) had salpingitis, 89 (7%) had vaginal candidiasis and 38 (3%) had gonorrhea. A large proportion of morbidity 362 (28%) was attributed to vulvovaginal injuries and traumatic pelvic pains. In conclusion, our study highlights that rape practice was common in context of armed conflict in Congo. Medical consequences were unwanted pregnancies leading to unsafe abortions, STIs and physical injuries. Results argue in favor of effective public health interventions for a better prevention and care of victims during and after armed conflict.

The Influence of the Gentry on Rural Political Construction

Based on some former studies of Chinese rural society, this paper summerizes the achievements and limitations of general Chinese rural studies and then proposes a social operation model in rural areas which is dominated by the squires. It uses some specific historical data and discoveries of feild sduty to further examine the profound influence of the squires on rural politcal construction in three different aspects： the model of clan and religion, the role as inter-mediator and the growth of basic armed forces. The study found that this special social group played a center role in Chinese rural political system from ancient to modem times, particularly, the research considers the decline of the squire society since the establishment of the new government in 1949. In the end, this paper points out the cultural guiding significance of this social model in the study to the rural construction in contemporay China by predicting the possiblity of renaissance

Communicating Agencies＇ Humanitarianism in Natural Disaster and Armed Conflicts＂ Differences, Challenges, and Dilemmas

The literature on disasters mainly focuses on natural disasters and looks at their coverage by the media. The paper argues that armed conflicts are also disasters and that Western relief agencies intervening in natural disasters and conflict are also proactive communicators. Taking a different approach from much of the available research, it explores agencies＇ communication work in these two types of crises and analyses the differences, challenges and dilemmas that they face in communicating their humanitarianism. It outlines the distinguished inherent characteristics of natural disasters and conflicts, and examines their impact on the understanding of the crises, the perception of affected populations, and the implementation of agencies＇ actions. It also investigates how, in turn, all these features influence agencies＇ communication practices that in natural disasters emergencies and conflict-related crises perform a different role and show different parameters. In this sense, the paper distinguishes between ＂humanitarian communication＂ to refer to the former, and ＂humanitarian advocacy＂ to refer to the latter. The paper briefly explores the operational challenges engendered by the contested interpretations of humanitarian advocacy, shows that the use of the parameters of humanitarian communication in conflict-related crises to overcome these problems caused additional concern, and presents two forms of humanitarian advocacy engendering less challenges and dilemmas.

NMET97完形填空题解析

Todd was working at his gas station(加油站)at night when heheard over the radio that a 26 in Long Island had been 27 byan armed man who had killed the night guard and got away with $150,000.“One hundred and fifty thousand,”Todd whistled.Here’s a fellowwho just 28 into a bank and helps himself 29 so much money.

Shen Congwen,Literary Genius from Hunan

SHEN Congwen(1902-1988)was born in Fenghuang Coun-ty in western Hunan Prov-ince.His father was a military man,and at the age of 13 Shen himselfjoined one of the warlord armiesthat roamed much of China at thetime.He saw a lot of China whilewandering around the country withthis force—more than 20 countieshere and there across the borders ofHunan,Guizhou,Sichuan and Hu-bei provinces.As time went on,hecame to recognize that armed forceas used by the warlords who em-ployed him was incredibly destruc-tive,slaughtering the innocent anddestroying the fascinating folkloreand customs of the ordinary peoplearound him.By 1923 he had hadenough.He left the army and ranoff to Beijing,where he came underthe influence.of new ideas andbegan a course in

Neighbors

Jiro Ninomiya name to the United States ,from Japan .at the tum of the century and bought a few acres of land just northeast,of SanFrrincisco. There,next to a palm tree,

Analysis of Uncontrollable Variables to the Performance of Predefined Tasks

The aim of this research was to investigate the impacts of changing environmental factors on pilots by implementing the effective flight procedure that we found from the previous research. During the experiments, camcorders were used to monitor and analyze the tasks and physical exhaustion of the pilot. NASA-TLX was also used to collect the data of the workload. Through this experiment, we were able to approach the experiment from a different angle regarding the optimal assigned work of the pilot, unlike the previous studies. Also, we were able to find out the impacts of environmental factors on the pilot’s workload.

Appreciating Ancient Chinese Poetry

LU You ws a native of Shan-yin in Yuezhou(now inShaoxing,Zhejian Prov-ince).Born at the time of destruc-tion of the Northern Song Dynasty,he was a successfUl candidate in thehighest imperial examinations andonce served as a local official inZhenjiang and Longxing.Becausehe was nurtured in the spirit ofpatriotism when he was young。

The Swiss Public Opinion Towards the Tasks of the Swiss Armed Forces and the Constitutional Role

After the Cold War, all European armed forces have transformed to be prepared for the new geopolitical environment and have taken new tasks. Since then, the European armed forces are more active in international conflict management. Whereas most of the European states have suspended the conscription, the Swiss Armed Forces still hold on conscription. However, the Swiss Armed Forces have changed also. The reform ＂Armee 95＂ in 1995 and the reform ＂Armee XXI＂ in 2004 have transformed the Swiss Armed Forces and extended their range of tasks. Which of these tasks are legitimated by the Swiss population？ To answer this question, the Swiss population had been interviewed about the tasks of the Swiss Armed Forces as part of the study ＂Sicherheit 2016＂. The tasks which the Swiss population mentioned are displayed in this paper with regard to the transformation process classified and discussed. The evaluation shows that 93% of the interviewees have named one of Switzerland＇s constitutional duties （defense, support of the civilian authorities, and promotion of peace within an international context） as the most important task of the Swiss Armed Forces. Mainly the national defense order and the subsidiary support of the civilian authorities are approved by the Swiss population.