The derivatives of 4-alkyl-2-quinolones possess a variety of biological activities. The general synthetic method of 4-alkyl-2-quinolones is the reaction of aryl amines with β-ketoesters to form β-ketoamides, which a...The derivatives of 4-alkyl-2-quinolones possess a variety of biological activities. The general synthetic method of 4-alkyl-2-quinolones is the reaction of aryl amines with β-ketoesters to form β-ketoamides, which are then heated in concentrated sulfuric acid to complete the ring closure. Although a number of its 4-methyl and aryl derivatives have been obtained, other 4-alkyl-2-quinolones are rarely mentioned for lack of a convenient method to prepare the appropriate β-ketoesters used in condensation.展开更多
A Rh(Ⅰ)-catalyzed highly regio-and enantioselective allylic alkylation of Meldrum acid with racemic allylic substrates bearing alkyl groups has been developed.The applying of chiral bisoxazopinephosphine ligand is es...A Rh(Ⅰ)-catalyzed highly regio-and enantioselective allylic alkylation of Meldrum acid with racemic allylic substrates bearing alkyl groups has been developed.The applying of chiral bisoxazopinephosphine ligand is essential for the high yields and selectivities.This method provides a rapid access to various chiral β-alkyl-γ,δ-unsaturated carboxylic acids and their derivatives.展开更多
An efficient ultrasound-assisted preparation of a series of novel 4-aryl-3-methyl-4,5-dihydro-l//-pyrazolo[34-b]pyridin-6（7H）ones via the reaction of 5-amino-3-methyl-1H-pyrazole,Meldrum＇s acid and various arylalde...An efficient ultrasound-assisted preparation of a series of novel 4-aryl-3-methyl-4,5-dihydro-l//-pyrazolo[34-b]pyridin-6（7H）ones via the reaction of 5-amino-3-methyl-1H-pyrazole,Meldrum＇s acid and various arylaldehydes using one-pot three-component approach is described.This rapid method produced the products in short reaction times（3-4 min） and excellent yields（87-95%）.展开更多
基金Supported by the National Natural Science Foundation of China
文摘The derivatives of 4-alkyl-2-quinolones possess a variety of biological activities. The general synthetic method of 4-alkyl-2-quinolones is the reaction of aryl amines with β-ketoesters to form β-ketoamides, which are then heated in concentrated sulfuric acid to complete the ring closure. Although a number of its 4-methyl and aryl derivatives have been obtained, other 4-alkyl-2-quinolones are rarely mentioned for lack of a convenient method to prepare the appropriate β-ketoesters used in condensation.
基金financially supported by the National Natural Science Foundation of China(NSFC,Nos.21602130 and 21961023)the startup funding from Shanghai Jiao Tong University.
文摘A Rh(Ⅰ)-catalyzed highly regio-and enantioselective allylic alkylation of Meldrum acid with racemic allylic substrates bearing alkyl groups has been developed.The applying of chiral bisoxazopinephosphine ligand is essential for the high yields and selectivities.This method provides a rapid access to various chiral β-alkyl-γ,δ-unsaturated carboxylic acids and their derivatives.
基金Financial support from the Research Council of University of Guilan is sincerely acknowledged
文摘An efficient ultrasound-assisted preparation of a series of novel 4-aryl-3-methyl-4,5-dihydro-l//-pyrazolo[34-b]pyridin-6（7H）ones via the reaction of 5-amino-3-methyl-1H-pyrazole,Meldrum＇s acid and various arylaldehydes using one-pot three-component approach is described.This rapid method produced the products in short reaction times（3-4 min） and excellent yields（87-95%）.
