Correlation of S100A13 and FOXA1 expression with cell cycle and cell invasion in fine needle aspiration thyroid carcinoma tissue

Objective: To study the correlation of S100A13 and FOXA1 expression with cell cycle and cell invasion in fine needle aspiration thyroid carcinoma tissue. Methods: Patients who received ultrasound-guided thyroid nodule fine needle aspiration in Haiyang People's Hospital between April 2015 and February 2017 were selected, and the tissues were divided into malignant thyroid tissue and benign thyroid nodules according to the pathological results after biopsy. The expression of S100A13, FOXA1, cell cycle molecules and cell invasion molecules were measured. Results: S100A13, FOXA1, CDK2, CyclinD1, MCM2, MCM7, SKP2, CLOCK, STAT3, STAT5, N-cadherin, MT1-MMP and ADAM17 mRNA expression in thyroid carcinoma tissue were significantly higher than those in benign thyroid nodule;CDK2, CyclinD1, MCM2, MCM7, SKP2 and CLOCK mRNA expression in thyroid carcinoma tissue with high FOXA1 expression were significantly higher than those in thyroid carcinoma tissue with low FOXA1 expression;STAT3, STAT5, N-cadherin, MT1-MMP and ADAM17 mRNA expression in thyroid carcinoma tissue with high S100A13 expression were significantly higher than those in thyroid cancer tissue with low S100A13 expression. Conclusions: High expression of S100A13 and FOXA1 in thyroid carcinoma can promote cell invasion and cell cycle progression.

Rural Women's Aspirations through Art Work

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Some Unresolved Issues in Ocean Pipes Aspirating Fluid

This paper reviews the dynamics of ocean pipes aspirating fluid and presents a selective review of the research undertaken on it. It focuses on the equations of motion, fluid-solid interaction at the inlet of the free end of the pipe, the stability mechanism of pipes aspirating steady fluid, etc. In particular, some unresolved or partly resolved issues on these important aspects are discussed. Finally, the promising future development in this area is discussed.

升级版小强 宠碁Aspire 4752G-2332G50Mncc

如果MI没有记错，2011年的宏碁（Acer）旗下最耀眼的笔记本并不是国内首个发布的蜂鸟S3，而是为其销量作出巨大贡献的4750G。鉴于前作的成功，宏碁在年终的时候又带来了4750G的升级之作—4752G。

刀锋战士 Acer Aspire蜂鸟S3-951

超极本（Ultrabook）终于来了！这个被英特尔（Intel）赋予“开启全新笔记本系列”神圣使命的产品终于来到了我们面前。

超极本时代开启——Acer Aspire S3蜂鸟铸就标杆

蜂鸟是全世界最小最轻的鸟类,正如这一名字所包含的韵味一样,Acer蜂鸟笔记本拥有着与生俱来的轻盈特质：在外观上,Acer蜂鸟采用了镁铝合金材质,独特的金属拉丝设计简洁优雅,开合角度可达到180度的设计更显轻盈。

超极本的开山之作——Acer Aspire S3蜂鸟笔记本电脑

在当前的轻薄笔记本电脑市场中，最受关注的产品非苹果MacBook Air莫属，其全金属外观和纤薄的外形令很多消费者垂涎不已。不过对大多数消费者来说，苹果产品显然是有一些距离感的。针对这一奇怪的市场状况，Intel抛出3亿美元基金，用来推广自己的Ultrabook（超级本）概念。超极本其实就是具有更轻重量、更长续航时间的笔记本电脑，具备即时唤醒、即时更新等特征。

Successful endovascular treatment in patients with acute thromboembolic ischemia of the lower limb including the crural arteries

AIM To examine the efficacy and safety of the 6 French(6F) Rotarex~S catheter system in patients with acute limb ischemia(ALI) involving thromboembolic occlusion of the proximal and mid-crural vessels.METHODS The files of patients in our department with ALI between 2015 and 2017 were examined. In seven patients, the Rotarex~S catheter was used in the proximal segment of the crural arteries. Data related to the clinical examination, Doppler sonography, angiography and followup from these patients were further used for analysis.RESULTS Two patients(29%) had thrombotic occlusion of the common femoral artery, and the remaining five exhibited thrombosis of the superficial femoral artery and popliteal artery. Mechanical thrombectomy was performed in all cases using a 6F Rotarex~S catheter. Additional Rotarex~S catheter thrombectomy due to remaining thrombus formation with no reflow was performed in the anterior tibial artery in two of seven cases(29%), in the tibiofibular tract and posterior tibial artery in two of seven cases(29%) and in the tibiofibular tract and fibular artery in the remaining three of seven cases(43%). Ischemic symptoms resolved promptly in all, and none of the patients experienced a procedural complication, such as crural vessel dissection, perforation or thrombus embolization.CONCLUSION Mechanical debulking using the 6F Rotarex~S catheter system may be a safe and effective treatment option in case of thrombotic or thromboembolic occlusion of the proximal and mid-portion of crural arteries.

Three cases of retroperitoneal schwannoma diagnosed by EUS-FNA

Schwannomas are peripheral nerve tumors that are typically solitary and benign.Their diagnosis is largely based on surgically resected specimens.Recently,a number of case reports have indicated that retroperitoneal schwannomas could be diagnosed with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA).We report the diagnosis of three cases of schwannoma using EUS-FNA.Subjects were two males and one female,ages 22,40,and 46 years,respectively,all of whom were symptom-free.Imaging findings showed well-circumscribed round tumors.However,as the tumors could not be diagnosed using these findings alone,EUS-FNA was performed.Hematoxylin-eosin staining of the resulting tissue fragments revealed bland spindle cells with nuclear palisading.There was no disparity in nuclear sizes.Immunostaining revealed S-100 protein positivity and all cases were diagnosed as schwannomas.Ki-67 indexes were 3%-15%,2%-3%,and 3%,respectively.No case showed any signs of malignancy.As most schwannomas are benign tumors and seldom become malignant,we observed these patients without therapy.All tumors demonstrated no enlargement and no change in characteristics.Schwannomas are almost always benign and can be observed following diagnosis by EUS-FNA.

Clinical implications of doubling time of gastrointestinal submucosal tumors

AIM To evaluate the efficacy of doubling time(DT) of gastrointestinal submucosal tumors(GIST).METHODS From April 1987 through November 2012, a total of 323 patients were given a final histopathological diagnosis of GISTs on surgical resection or endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) in Kitasato University East Hospital or Kitasato University Hospital. We studied 53 of these patients(34 with resected tumors and 19 with unresected tumors) whose tumors could be measured on EUS on at least two successive occasions. The histopathological diagnosis was GIST in 34 patients, leiomyoma in 5, schwannoma in 3, ectopic pancreas in 1, hamartoma in 1, cyst in 1, Brunner's adenoma in 1, and spindle-cell tumor in 7. We retrospectively calculated the DT of GISTs on the basis of the time course of EUS findings to estimate the growth rate of such tumors.RESULTS The DT was 17.2 mo for GIST, as compared with 231.2 mo for leiomyoma, 104.7 mo for schwannoma, 274.9mo for ectopic pancreas, 61.2 mo for hamartoma, 49.0 mo for cyst, and 134.7 mo for Brunner's adenoma. The GISTs were divided into risk classes on the basis of tumor diameters and mitotic figures(Fletcher's classification). The classification was extremely low risk or low risk in 28 patients, intermediate risk in 3, and high risk in 3. DT of GIST according to risk was 24.0 mo for extremely low-risk plus low-risk GIST, 17.1 mo for intermediate-risk GIST, and 3.9 mo for high-risk GIST. DT of GIST was significantly shorter than that of leiomyoma plus schwannoma(P < 0.05), and DT of high-risk GIST was significantly shorter than that of extremely low-risk plus low-risk GIST(P < 0.05).CONCLUSION For GIST, a higher risk grade was associated with a significantly shorter DT. Small SMTs should initially be followed up within 6 mo after detection.

Progressively Enlarging Goiter:Case Reports of Primary Thyroid Lymphoma and Literature Review

Primary thyroid lymphoma(PTL)is an exceptionally rare and highly aggressive potentially curable malignant disease.We report three typical cases of PTL referred to our hospital.All three cases had long history of Hashimoto’s thyroiditis,and presented with progressively enlarging neck mass.The first two cases were confirmed by surgical biopsy to be diffuse large B cell lymphoma,and received radiotherapy combined with chemotherapy,or received only chemotherapy.The third case was confirmed by core needle biopsy to be mucosa-associated lymphoid tissue lymphoma,and received radiotherapy.In summary,confirmation of PTL diagnosis is essential for further clinical decisions.Core biopsy should be one of the most important methods to make the diagnosis of PTL,while the use of fine needle aspiration cytology alone is still limited in diagnosing PTL.

Asherman's综合征16例分析

对１６例Ａｓｈｅｒｍａｎ′ｓ综合征的临床资料进行了分析，发现该病与吸刮宫史关系密切．１６例均有吸刮宫史，最少１次，最多４次，人均２．８次．１６例中９５％患者有周期性腹痛、闭经或经量减少，１３例经阴道钝性分离宫颈、宫腔粘连，３例结合锐性分离治愈．本文认为加强计划生育宣教。

Laparoscopic hepatectomy by curettage and aspiration:a new technique

Background Laparoscopic surgery is advantageous for minimal invasiveness and rapid postoperative recovery. Since the use of laparoscopic hepatectomy in liver resection in the 1990s, it has been performed in a few institutions worldwide, Lack of efficient and safe techniques for liver transaction is the major obstacle preventing from its further development, We developed a new technique for laparoscopic hepatectomy by curettage and aspiration in 1998. In this paper we analyze the clinical outcomes of this technique after 7 years of practice.Methods Altogether 59 consecutive patients underwent laparoscopic hepatectomy by curettage and aspiration from August 1998 to January 2005 at our institution. These patients included 33 males and 26 females, with a mean age of 47 years. For liver transecsion laparoscopic Peng＇s multifunctional operative dissector （LPMOD） was used. Lesions included malignant liver tumors in 19 patients, benign liver tumors in 17, intrahepatic calculus in 18, and other liver lesions in 5. Procedures included local resections in 30 patients, left lateral segmentectomy in 28, and right hemihepatectomy in 1.Results Laparoscopic operation was completed in 57 patients. Two patients （3.4%） had the operation converted to laparotomy. The mean operating time was 143 minutes and the mean intraoperative blood loss was 456 ml. The mean length of postoperative hospital stay was 7 days. Complications occurred in 2 patients （3.4%）, and there was no pedoperative death.Conclusion Laparoscopic hepatectomy by curettage and aspiration is efficient and safe for liver resection.

Shi Yan Zhi: From Ideological Construction to Moral Education

During the pre-Qin period,shi yan zhi(poetry expressing aspirations)was not a poetic concept.It primarily served to shape Confucian ideology,carrying significant discourse implications.The practices of shi yan zhi and bi zhi in religious rituals held important implications for poem reciting,a prevalent activity during the banquet ceremonies in the Spring and Autumn Period and its various forms.Together,they established the rites and music tradition characterized by yanshuo(speeches).This tradition further established the status of The Book of Odes as a classic,furnishing high-ranking officials and Confucian scholars with legitimacy and rich discourse resources to develop new ideologies.The different interpretations and applications of shi yan zhi resulted in diverse discourse models,such as duanzhang-quyi(to interpret out of context),xin’er youzheng(being reliable and borne out by evidence),wenwang yinyan(no word,no expression of thoughts)and yiyi-nizhi(interpreting a writing from one’s perspective).Through these different interpretations and applications,the scholarly-official class established multiple values and objectives,such as liyan buxiu(advocating lasting noble ideas untouched by time),xing-guan-qun yuan(stimulation,contemplation,communication,and criticism),shang you(befriending those superior to oneself),fa hu qing,zhi hu li yi(starting with feelings and control with propriety).In the process of building a unified ideology in the Han Dynasty,the“Introduction to Mao’s Version of The Book of Odes”advocated the unity of qing(sentiment)and zhi(aspiration),infusing shi yan zhi with connotations of enlightenment as well as extolment and satirical criticism.This advocacy redefined the political authority and discourse models of the scholar-official class,objectively unveiling the literary features of poetry,such as evoking an emotional response and commencing the practice of education through poetry teaching.

Lancaster’s prophecy and i School’s aspiration: A cross-time discourse analysis

Against the increasing marginalization of libraries and the Library and Information Science discipline(LIS)in the iSchool movement,this paper performs a Foucauldian discourse analysis of Lancaster’s famous prophecy of the extinction of libraries.

HIGH AMBITIONS CHINA'S BOOMING HEMP INDUSTRY HAS GLOBAL ASPIRATIONS

Though there are many industries where China now commands a leading presence,cannabis production probably isn’t the first that comes to mind.The South China Morning Post recently shone a light on the relatively low-key hemp industry,and how China now accounts for approximately half of the world’s legal

刮吸解剖法在急性胆囊炎腹腔镜胆囊切除术中的应用

目的探讨刮吸解剖法在急性胆囊炎腹腔镜胆囊切除术（laparoscopic cholecystectomy,LC）中的应用价值。方法2002年8月-2008年1月,借助腹腔镜多功能手术解剖器（laparoscopic Peng,s multifunctional operative dissector,LPMOD）应用刮吸解剖法对820例急性胆囊炎施行LC。对有胆道相对探查指征的158例（143例有胆总管扩张）行术中胆道造影,发现胆总管结石17例,其中14例完成腹腔镜下胆总管探查术（laparoscopic common bile duct exploration,LCBDE）。结果812例LC成功,8例中转开腹。LC平均手术时间55 min（25-120 min）,LC＋LCBDE平均手术时间95 min（80-130min）,术中平均出血量25 ml（0.5-80 ml）,术后平均住院5 d（3-9 d）。无胆管损伤、胆漏、术后出血等并发症。804例随访2-18个月,平均11个月,2例胆总管残余结石（1例行开腹胆总管切开取石,1例行EST取石）,其余患者未发现与手术相关并发症。结论在急性胆囊炎腹腔镜胆囊切除术中应用刮吸解剖法能有效防止术中胆道损伤,安全可靠,值得临床推广。

鼠成骨细胞力学特性的理论与实验

利用微管吸吮技术对乳鼠颅盖骨成骨细胞进行了吸吮实验，测量了吸入长度随负压的变化关系；详细推导了基于微管吸吮技术的均质线弹性半无限体模型，给出吸入长度与负压的理论关系；测量了成骨细胞的杨氏模量，并研究了秋水仙素对成骨细胞弹性性质的影响，发现经秋水仙素处理后的成骨细胞的杨氏模量较正常组成骨细胞高。本研究工作为进一步研究成骨细胞的离体及在体的主动变形机制提供了基础数据。

非何杰金氏淋巴瘤针吸细胞学及电镜观察

目的 探讨非何杰金氏淋巴瘤的针吸细胞学形态特征及诊断中的意义。方法 对 17例淋巴瘤及 2例淋巴结反应性增生用细针吸取细胞学诊断 ,并将针吸标本用 2 0 %琼脂作依托再按常规扫描电镜 ,透射电镜技术分别制样观察 ,部分手术切除标本用石腊切片HE染色 ,常规透射电镜制样供观察。结果 淋巴结反应性增生 ,细胞形态多样呈弥漫分布 ,有T、B细胞来源的 ,可见大、小淋巴细胞及浆细胞等。结论 瘤细胞形态具有明显异型性以及单一性 ,T细胞淋巴瘤和B细胞淋巴瘤瘤细胞各有不同的超微病理学特征 。

护士主导的吞咽管理门诊在帕金森病吞咽障碍患者中的实践

目的探讨护士主导的吞咽管理门诊在帕金森病吞咽障碍患者中实施的可行性和效果。方法将217例门诊就诊的帕金森病吞咽障碍患者按门诊ID号奇偶数分为对照组100例和观察组117例。对照组按照常规由门诊医生给予吞咽障碍康复指导,观察组接受护士主导的吞咽管理门诊系统管理。干预6个月后评价效果。结果观察组吞咽障碍康复有效率显著高于对照组,误吸发生率显著低于对照组(均P<0.01)。结论护士主导的吞咽管理门诊可有效促进帕金森病患者吞咽功能恢复,降低误吸的发生。