According to the Buddhist philosophy, hatred （dosa） is considered as one of the three unwholesome roots which determine the actual immoral quality of volitional states and a conscious thought with its mental factors...According to the Buddhist philosophy, hatred （dosa） is considered as one of the three unwholesome roots which determine the actual immoral quality of volitional states and a conscious thought with its mental factors. Hatred, then, comprises all degrees of repulsion from the faintest trace of ill-humour up to the highest pitch of hate and wrath. Thus, ill-will, evil intention, wickedness, corruption and malice are various expressions and degrees ofdosa. A hateful temperament is said to be due to a predominance of the type of dosa, apo, vayu and semha. Vedic psychology forms the clinical core of mental health counseling in the Ayurvedic medical tradition. According to Ayurvedic medical practises, a person is dominated on one of constitutes type （type ofdosa） namely vata （vayu）, pita （apo） or kapha （semha）. This is known as prakurthi pariksha. Important aspect of identification of constitute type is for diagnosis of mental diseases, because each of constituent type has a list of probable mental diseases. An important area of expertise for many clinical psychologists is psychological assessment. Constructions of information systems using psychological assessment in clinical psychology have a problem of effective communication because of implicit knowledge. This complicates the effective communication of clinical data to the psychologist. In this paper, it presents an approach to modeling commonsense knowledge in clinical psychology in Ayurvedic medicine. It gives three-phase an approach for modeling commonsense knowledge in psychological assessment which enables holistic approach for clinical psychology. Evaluation of the system has shown 77% accuracy.展开更多
BACKGROUND Enteral nutrition(EN)is essential for critically ill patients.However,some patients will have enteral feeding intolerance(EFI)in the process of EN.AIM To develop a clinical prediction model to predict the r...BACKGROUND Enteral nutrition(EN)is essential for critically ill patients.However,some patients will have enteral feeding intolerance(EFI)in the process of EN.AIM To develop a clinical prediction model to predict the risk of EFI in patients receiving EN in the intensive care unit.METHODS A prospective cohort study was performed.The enrolled patients’basic information,medical status,nutritional support,and gastrointestinal(GI)symptoms were recorded.The baseline data and influencing factors were compared.Logistic regression analysis was used to establish the model,and the bootstrap resampling method was used to conduct internal validation.RESULTS The sample cohort included 203 patients,and 37.93%of the patients were diagnosed with EFI.After the final regression analysis,age,GI disease,early feeding,mechanical ventilation before EN started,and abnormal serum sodium were identified.In the internal validation,500 bootstrap resample samples were performed,and the area under the curve was 0.70(95%CI:0.63-0.77).CONCLUSION This clinical prediction model can be applied to predict the risk of EFI.展开更多
Early-and late-onset narcolepsy constitutes two distinct diagnostic subgroups.However,it is not clear whether symptomology and genetic risk factors differ between early-and late-onset narcoleptics.This study compared ...Early-and late-onset narcolepsy constitutes two distinct diagnostic subgroups.However,it is not clear whether symptomology and genetic risk factors differ between early-and late-onset narcoleptics.This study compared clinical data and single-nucleotide polymorphisms(SNPs)between early-and late-onset patients in a large cohort of 899 Han Chinese narcolepsy patients.Blood,cerebrospinal fluid,and clinical data were prospectively collected from patients,and patients were genotyped for 40 previously reported narcolepsy risk-conferring SNPs.Genetic risk scores(GRSs),associations of five different sets of SNPs(GRS1–GRS5)with early-and late-onset narcolepsy,were evaluated using logistic regression and receiver operating characteristic curves.Mean sleep latency was significantly shorter in early-onset cases than in late-onset cases.Symptom severity was greater among late-onset patients,with higher rates of sleep paralysis,hypnagogic hallucinations,health-related quality of life impairment,and concurrent presentation with four or more symptoms.Hypocretin levels did not differ significantly between early-and late-onset cases.Only rs3181077(CCR1/CCR3)and rs9274477(HLA-DQB1)were more prevalent among early-onset cases.Only GRS1(26 SNPs;OR=1.513,95%CI:0.893–2.585;P<0.05)and GRS5(6 SNPs;OR=1.893,95%CI:1.204–2.993;P<0.05)were associated with early-onset narcolepsy,with areas under the receiver operating characteristic curves of 0.731 and 0.732,respectively.Neither GRS1 nor GRS5 included SNPs in HLA regions.Our results indicate that symptomology and genetic risk factors differ between early-and late-onset narcolepsy.This protocol was approved by the Institutional Review Board(IRB)Panels on Medical Human Subjects at Peking University People’s Hospital,China(approval No.Yuanlunshenlinyi 86)in October 2011.展开更多
目的:系统收集中药治疗紧张性头痛(TTH)临床研究的现有证据,评价中药治疗紧张性头痛临床研究的现状。方法:计算机检索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、中国生物医学文献数据库(CBM)...目的:系统收集中药治疗紧张性头痛(TTH)临床研究的现有证据,评价中药治疗紧张性头痛临床研究的现状。方法:计算机检索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、中国生物医学文献数据库(CBM)、EMbase、PubMed、Cochrane Library、Web of science、ClinicalTrials.gov和中国临床试验注册中心共10个数据库,检索时限为建库至2020年10月,纳入有关中药治疗TTH的临床研究,采用证据图方法呈现临床研究的证据分布情况。结果:共纳入471项临床研究,其中随机对照试验378项,非随机对照试验41项,队列研究1项,病例系列研究51项,文献总发表数量在总体上随时间变化呈增长趋势,但呈“锯齿状”波动;方法学质量评价结果显示目前中药治疗紧张性头痛的临床研究质量较低;中药治疗紧张性头痛对总有效率、安全性事件、头痛持续时间、头痛强度、头痛发作频率、焦虑抑郁量表关注度较高,对经济学指标及远期预后指标关注较低。疗程集中在15~30 d。结论:目前中药治疗TTH的临床研究质量较低,未来需要开展更多高质量的临床研究为中药治疗TTH提供更充分的证据。展开更多
文摘According to the Buddhist philosophy, hatred （dosa） is considered as one of the three unwholesome roots which determine the actual immoral quality of volitional states and a conscious thought with its mental factors. Hatred, then, comprises all degrees of repulsion from the faintest trace of ill-humour up to the highest pitch of hate and wrath. Thus, ill-will, evil intention, wickedness, corruption and malice are various expressions and degrees ofdosa. A hateful temperament is said to be due to a predominance of the type of dosa, apo, vayu and semha. Vedic psychology forms the clinical core of mental health counseling in the Ayurvedic medical tradition. According to Ayurvedic medical practises, a person is dominated on one of constitutes type （type ofdosa） namely vata （vayu）, pita （apo） or kapha （semha）. This is known as prakurthi pariksha. Important aspect of identification of constitute type is for diagnosis of mental diseases, because each of constituent type has a list of probable mental diseases. An important area of expertise for many clinical psychologists is psychological assessment. Constructions of information systems using psychological assessment in clinical psychology have a problem of effective communication because of implicit knowledge. This complicates the effective communication of clinical data to the psychologist. In this paper, it presents an approach to modeling commonsense knowledge in clinical psychology in Ayurvedic medicine. It gives three-phase an approach for modeling commonsense knowledge in psychological assessment which enables holistic approach for clinical psychology. Evaluation of the system has shown 77% accuracy.
文摘BACKGROUND Enteral nutrition(EN)is essential for critically ill patients.However,some patients will have enteral feeding intolerance(EFI)in the process of EN.AIM To develop a clinical prediction model to predict the risk of EFI in patients receiving EN in the intensive care unit.METHODS A prospective cohort study was performed.The enrolled patients’basic information,medical status,nutritional support,and gastrointestinal(GI)symptoms were recorded.The baseline data and influencing factors were compared.Logistic regression analysis was used to establish the model,and the bootstrap resampling method was used to conduct internal validation.RESULTS The sample cohort included 203 patients,and 37.93%of the patients were diagnosed with EFI.After the final regression analysis,age,GI disease,early feeding,mechanical ventilation before EN started,and abnormal serum sodium were identified.In the internal validation,500 bootstrap resample samples were performed,and the area under the curve was 0.70(95%CI:0.63-0.77).CONCLUSION This clinical prediction model can be applied to predict the risk of EFI.
基金supported by the Research Project of Central Health Care Special Fund,China,No.W2017BJ52(to JZ)
文摘Early-and late-onset narcolepsy constitutes two distinct diagnostic subgroups.However,it is not clear whether symptomology and genetic risk factors differ between early-and late-onset narcoleptics.This study compared clinical data and single-nucleotide polymorphisms(SNPs)between early-and late-onset patients in a large cohort of 899 Han Chinese narcolepsy patients.Blood,cerebrospinal fluid,and clinical data were prospectively collected from patients,and patients were genotyped for 40 previously reported narcolepsy risk-conferring SNPs.Genetic risk scores(GRSs),associations of five different sets of SNPs(GRS1–GRS5)with early-and late-onset narcolepsy,were evaluated using logistic regression and receiver operating characteristic curves.Mean sleep latency was significantly shorter in early-onset cases than in late-onset cases.Symptom severity was greater among late-onset patients,with higher rates of sleep paralysis,hypnagogic hallucinations,health-related quality of life impairment,and concurrent presentation with four or more symptoms.Hypocretin levels did not differ significantly between early-and late-onset cases.Only rs3181077(CCR1/CCR3)and rs9274477(HLA-DQB1)were more prevalent among early-onset cases.Only GRS1(26 SNPs;OR=1.513,95%CI:0.893–2.585;P<0.05)and GRS5(6 SNPs;OR=1.893,95%CI:1.204–2.993;P<0.05)were associated with early-onset narcolepsy,with areas under the receiver operating characteristic curves of 0.731 and 0.732,respectively.Neither GRS1 nor GRS5 included SNPs in HLA regions.Our results indicate that symptomology and genetic risk factors differ between early-and late-onset narcolepsy.This protocol was approved by the Institutional Review Board(IRB)Panels on Medical Human Subjects at Peking University People’s Hospital,China(approval No.Yuanlunshenlinyi 86)in October 2011.
文摘目的:系统收集中药治疗紧张性头痛(TTH)临床研究的现有证据,评价中药治疗紧张性头痛临床研究的现状。方法:计算机检索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、中国生物医学文献数据库(CBM)、EMbase、PubMed、Cochrane Library、Web of science、ClinicalTrials.gov和中国临床试验注册中心共10个数据库,检索时限为建库至2020年10月,纳入有关中药治疗TTH的临床研究,采用证据图方法呈现临床研究的证据分布情况。结果:共纳入471项临床研究,其中随机对照试验378项,非随机对照试验41项,队列研究1项,病例系列研究51项,文献总发表数量在总体上随时间变化呈增长趋势,但呈“锯齿状”波动;方法学质量评价结果显示目前中药治疗紧张性头痛的临床研究质量较低;中药治疗紧张性头痛对总有效率、安全性事件、头痛持续时间、头痛强度、头痛发作频率、焦虑抑郁量表关注度较高,对经济学指标及远期预后指标关注较低。疗程集中在15~30 d。结论:目前中药治疗TTH的临床研究质量较低,未来需要开展更多高质量的临床研究为中药治疗TTH提供更充分的证据。
