A spotlight on dosage and subject selection for effective neuroprotection: exploring the central role of mitochondria

Neurons are notoriously vulnerable cell types.Even the slightest change in their internal and/or external environments will cause much distress and dysfunction,leading often to their death.A range of pathological conditions,including stroke,head trauma,and neurodegenerative disease,can generate stress in neurons,affecting their survival and proper function.In most neural pathologies,mitochondria become dysfunctional and this plays a pivotal role in the process of cell death.The challenge over the last few decades has been to develop effective interventions that improve neuronal homeostasis under pathological conditions.Such interventions,often referred to as disease-modifying or neuroprotective,have,however,proved frustratingly elusive,at both preclinical and,in particular,clinical levels.In this perspective,we highlight two factors that we feel are key to the development of effective neuroprotective treatments.These are:firstly,the choice of dose of intervention and method of application,and secondly,the selection of subjects,whether they be patients or the animal model.

Formation and ecological response of sand patches in the protection system of Shapotou section of the Baotou-Lanzhou railway,China

The development of bare patches typically signifies a process of ecosystem degradation.Within the protection system of Shapotou section of the Baotou-Lanzhou railway,the extensive emergence of bare sand patches poses a threat to both stability and sustainability.However,there is limited knowledge regarding the morphology,dynamic changes,and ecological responses associated with these sand patches.Therefore,we analyzed the formation and development process of sand patches within the protection system and its effects on herbaceous vegetation growth and soil nutrients through field observation,survey,and indoor analysis methods.The results showed that sand patch development can be divided into three stages,i.e.,formation,expansion,and stabilization,which correspond to the initial,actively developing,and semi-fixed sand patches,respectively.The average dimensions of all sand patch erosional areas were found to be 7.72 m in length,3.91 m in width,and 0.32 m in depth.The actively developing sand patches were the largest,and the initial sand patches were the smallest.Throughout the stage of formation and expansion,the herbaceous community composition changed,and the plant density decreased by more than 50.95%.Moreover,the coverage and height of herbaceous plants decreased in the erosional area and slightly increased in the depositional lobe;and the fine particles and nutrients of soils in the erosional area and depositional lobe showed a decreasing trend.In the stabilization phases of sand patches,the area from the inlet to the bottom of sand patches becomes initially covered with crusts.Vegetation and 0-2 cm surface soil condition improved in the erosional area,but this improvement was not yet evident in the depositional lobe.Factors such as disturbance,climate change,and surface resistance to erosion exert notable influences on the formation and dynamics of sand patches.The results can provide evidence for the future treatment of sand patches and the management of the protection system of Shapotou section of the Baotou-Lanzhou railway.

Hierarchical Privacy Protection Model in Advanced Metering Infrastructure Based on Cloud and Fog Assistance

The Advanced Metering Infrastructure(AMI),as a crucial subsystem in the smart grid,is responsible for measuring user electricity consumption and plays a vital role in communication between providers and consumers.However,with the advancement of information and communication technology,new security and privacy challenges have emerged for AMI.To address these challenges and enhance the security and privacy of user data in the smart grid,a Hierarchical Privacy Protection Model in Advanced Metering Infrastructure based on Cloud and Fog Assistance(HPPM-AMICFA)is proposed in this paper.The proposed model integrates cloud and fog computing with hierarchical threshold encryption,offering a flexible and efficient privacy protection solution that significantly enhances data security in the smart grid.The methodology involves setting user protection levels by processing missing data and utilizing fuzzy comprehensive analysis to evaluate user importance,thereby assigning appropriate protection levels.Furthermore,a hierarchical threshold encryption algorithm is developed to provide differentiated protection strategies for fog nodes based on user IDs,ensuring secure aggregation and encryption of user data.Experimental results demonstrate that HPPM-AMICFA effectively resists various attack strategies while minimizing time costs,thereby safeguarding user data in the smart grid.

Comprehensive Overview and Analytical Study on Automatic Bird Repellent Laser System for Crop Protection

Birds are a huge hazard to agriculture all around the world,causing harm to profitable field crops.Growers use a variety of techniques to keep them away,including visual,auditory,tactile,and olfactory deterrents. This study presents a comprehensive overview of current bird repellant approaches used in agricultural contexts,as well as potential new ways. The bird repellent techniques include Internet of Things technology,Deep Learning,Convolutional Neural Network,Unmanned Aerial Vehicles,Wireless Sensor Networks and Laser biotechnology. This study’s goal is to find and review about previous approach towards repellent of birds in the crop fields using various technologies.

Designing a Protection Scheme in Micro-Grid Systems with DG Using Central Protection Unite and Multiple Setting Group Protection Relays

Distributed generators now is widely used in electrical power networks, in some cases it works seasonally, and some types works at special weather conditions like photo voltaic systems and wind energy, and due to this continuous changes in generation condition, the fault current level in network will be affected, this changes in fault current level will affect in the coordination between protection relays and to keep the coordination at right way, an adaptive protection system is required that can adaptive its setting according to generation changes, the fault current level in each case is evaluated using ETAP software, and the required relay setting in each case is also evaluated using Grey Wolf Optimizer (GWO) algorithm, and to select suitable setting which required in each condition, to select the active setting group of protection relay according to generation capacity, central protection unite can be used, and to improve protection stability and minimizing relays tripping time, a proposed method for selecting suitable backup relay is used, which leads to decrease relays tripping time and increase system stability, output settings for relays in all cases achieved our constrains.

Assessment of ecological geological vulnerability in Mu Us Sandy Land based on GIS and suggestions of ecological protection and restoration

Eco-geological vulnerability assessment is a significant research topic within the field of eco-geology,but it remains poorly studied.The Mu Us Sandy Land,located in the central part of the farming-pastoral ecotone in northern China,plays a critical role in maintaining the ecological security pattern in this region.However,this sandy land also faces severe sandy desertification and ecological degradation.This study conducted a regional eco-geological vulnerability assessment of the Mu Us Sandy Land using a comprehensive index evaluation method based on eco-geological theories and survey results.To construct an appropriate index system for the eco-geological vulnerability assessment of the Mu Us Sandy Land,the study considered the sandy land’s unique characteristics and identified 15 factors of five categories,namely geology,meteorology,soil,topography,and vegetation.The paper calculated the comprehensive weights of all the indices using the analytic hierarchy process(AHP)and the entropy weight method(EWM).Furthermore,it established the eco-geological vulnerability index(EGVI)and obtained the assessment results.The results showed that the eco-geological vulnerability of the Mu Us Sandy Land gradually intensifies from east to west,manifested as vulnerable eco-geological conditions overall.Specifically,extremely vulnerable zones are found in the northwestern and southeastern parts of the study area,highly vulnerable zones in the western and southern parts,moderately vulnerable zones in the central part,and slightly and potentially vulnerable zones in the eastern and southern parts.Areas with high spatial autocorrelations include the northern Uxin Banner-Otog Banner-Angsu Town area,the surrounding areas of Hongdunjie Town in the southeastern part of the study area,the Hongshiqiao Township-Xiaohaotu Township area,Otog Front Banner,and Bainijing Town,which should be prioritized in the ecological conservation and restoration.Additionally,the paper proposed suggestions for the ecological conservation and restoration of county-level administrative areas in the study area.Overall,the findings provide a valuable reference for the ecological conservation and restoration of the Mu Us Sandy Land and other desert areas in arid and semi-arid regions.

Design analysis and its application of M out of N in reactor protection system

The reliability and availability of the reactor protection system （RPS） can be improved by using M out of N judg- ment system. By analyzing two quantitative indicators, the rate of refusal to operate and mal-operation rate, a strict math- ematical formula and an approximate calculation are stated. The differences of a series of judgment systems are discussed on condition that the unsafe failure probability and the security failure probability are both 0.1. Based on given parameters （A, B,P, Q）： A is upper limit of the refusal rate for the RPS, B is upper limit of the real-operation rate, P and Q are basic protection unit rates corresponding to refusal rate and mal-operation rate, respectively. According to these parameters, the values of N and M can be solved.

The future of artificial hibernation medicine:protection of nerves and organs after spinal cord injury

Spinal cord injury is a serious disease of the central nervous system involving irreversible nerve injury and various organ system injuries.At present,no effective clinical treatment exists.As one of the artificial hibernation techniques,mild hypothermia has preliminarily confirmed its clinical effect on spinal cord injury.However,its technical defects and barriers,along with serious clinical side effects,restrict its clinical application for spinal cord injury.Artificial hibernation is a futureoriented disruptive technology for human life support.It involves endogenous hibernation inducers and hibernation-related central neuromodulation that activate particular neurons,reduce the central constant temperature setting point,disrupt the normal constant body temperature,make the body adapt"to the external cold environment,and reduce the physiological resistance to cold stimulation.Thus,studying the artificial hibernation mechanism may help develop new treatment strategies more suitable for clinical use than the cooling method of mild hypothermia technology.This review introduces artificial hibernation technologies,including mild hypothermia technology,hibernation inducers,and hibernation-related central neuromodulation technology.It summarizes the relevant research on hypothermia and hibernation for organ and nerve protection.These studies show that artificial hibernation technologies have therapeutic significance on nerve injury after spinal co rd injury through inflammatory inhibition,immunosuppression,oxidative defense,and possible central protection.It also promotes the repair and protection of res pirato ry and digestive,cardiovascular,locomoto r,urinary,and endocrine systems.This review provides new insights for the clinical treatment of nerve and multiple organ protection after spinal cord injury thanks to artificial hibernation.At present,artificial hibernation technology is not mature,and research fa ces various challenges.Neve rtheless,the effort is wo rthwhile for the future development of medicine.

Network pharmacology and subsequent experimental validation reveal the synergistic myocardial protection mechanism of Salvia miltiorrhiza Bge.and Carthamus tinctorius L.

Objective:To reveal the molecular mechanism underlying the compatibility of Salvia miltiorrhiza Bge(S.miltiorrhiza,Dan Shen)and C.tinctorius L.(C.tinctorius,Hong Hua)as an herb pair through network pharmacology and subsequent experimental validation.Methods:Network pharmacology was applied to construct an active ingredient-efficacy target-disease protein network to reveal the unique regulation pattern of s.miltiorrhiza and C.tinctorius as herb pair.Molecular docking was used to verify the binding of the components of these herbs and their potential targets.An H9c2 glucose hypoxia model was used to evaluate the efficacy of the components and their synergistic effects,which were evaluated using the combination index.Western blot was performed to detect the protein expression of these targets.Results:Network pharmacology analysis revealed 5 pathways and 8 core targets of s.miltiorrhiza and C.tinctorius in myocardial protection.Five of the core targets were enriched in the hypoxia-inducible factor-1(HIF-1)signaling pathway.S.miltiorrhiza-C.tinctorius achieved vascular tone mainly by regulating the target genes of the HIF-1 pathway.As an upstream gene of the HIF-1 pathway,STAT3 can be activated by the active ingredients cryptotanshinone(Ctan),salvianolic acid B(Sal.B),and myricetin(Myric).Cell experiments revealed that Myric,Sal.B,and Ctan also exhibited synergistic myocardial protective activity.Molecular docking verified the strong binding of Myric,Sal.B,and Ctan to STAT3.Western blot further showed that the active ingredients synergistically upregulated the protein expressionof STAT3.Conclusion:The pharmacodynamic transmission analysis revealed that the active ingredients of S.miltiorrhiza and C.tinctorius can synergistically resist ischemia through various targets and pathways.This study provides a methodological reference for interpreting traditional Chinese medicine compatibility.

Effects of Water Stress on Reactive Oxygen Species Generation and Protection System in Rice During Grain-Filling Stage

Rice is one of the main staple food crops in the world, but it may suffer serious water stress during growth period. Water stress during grain filling results in decreased grain yeild, but its mechanism generating and scavenging the active oxygen is unclear under continuance of the water stress. The experiment was carried out in growth chamber to investigate the effects of water stress on the production of superoxide free radical （O2）, hydrogen peroxide （H202）, malondialdehyde （MDA）, reduced glutathione （GSH）, ascorbic acid （AsA）, and antioxidative enzyme activities in three rice hybrids with differing drought resistant under both normal and drought conditions during grain-filling stage. The results showed that water stress aggravated the membrane lipid peroxidation in rice leaves, which was more severe in less drought resistant hybrids than that in more tolerant ones. Also O2＇ and H2O2 accumulated more rapidly in less drought resistant hybrids than that in more tolerant ones. During water stress, decreases of GSH, AsA, chlorophyll, and relative water contents in more drought resistant hybrids were obvious less than those in less tolerant ones. Activities of superoxide dismutase （SOD）, catalase （CAT） and peroxidase （POD） in/eaves increased obviously in 0-14 d after heading and subsequently decreased rapidly, and those in more drought resistant hybrids were more than those in less tolerant ones. The results showed that changes of O2, H2O2, MDA, GSH, and AsA contents and antioxidative enzyme activities correlated significantly to drought resistance of rice hybrids, and more drought resistant hybrids possessed high ant oxidation capacity.

Preparation and Spectra Properties of BaO-Al_2O_3-P_2O_5-Sm_2O_3 System Protection Glasses

The forming-regions of phosphate glasses doped with high Sm2O3 contents were studied by two step melting method. The relationship between absorption spectrum and rare earth contents was also discussed. The spectra of BASP glasses were measured by spectrophotometer. The results show that the forming regions will shrink with the increase of Al2O3 and it is difficult to form glass when [PO4]/[AlO4] < 2. The forming regions tend to be a closed elliptical, and the intensity of characteristic absorption peak increases gradually with the increase of Sm2O3, the absorption lines broadens non-uniformly and there is approximate linear relation between optical density at the 1064 nm wavelength and Sm2O3 content.

Composite armor philosophy(CAP):Holistic design methodology of multi-layered composite protection systems for armored vehicles

A philosophy for the design of novel,lightweight,multi-layered armor,referred to as Composite Armor Philosophy(CAP),which can adapt to the passive protection of light-,medium-,and heavy-armored vehicles,is presented in this study.CAP can serve as a guiding principle to assist designers in comprehending the distinct roles fulfilled by each component.The CAP proposal comprises four functional layers,organized in a suggested hierarchy of materials.Particularly notable is the inclusion of a ceramic-composite principle,representing an advanced and innovative solution in the field of armor design.This paper showcases real-world defense industry applications,offering case studies that demonstrate the effectiveness of this advanced approach.CAP represents a significant milestone in the history of passive protection,marking an evolutionary leap in the field.This philosophical approach provides designers with a powerful toolset with which to enhance the protection capabilities of military vehicles,making them more resilient and better equipped to meet the challenges of modern warfare.

Architecture Design for Integrated Wide Area Protection and Control Systems

This paper firstly reviews the recent development in power system protection and control, with special attention paid to the wide-area and integrated protection, in order to look into future development of integration of protection and control for smart grids. This paper mainly reports on the development of integrated wide area protection and control for power systems. The concept of integrated wide area protection and control is introduced, in which a hierarchical protection and control system provides the protection and control of wide area or regional power substations/ plants and their associated power network. The system is mainly divided into three levels, the local, the substation/plant and the wide area/regional protection and control. The integrated functions at each level are described in details with an aim to develop an optimal coordination mechanism between the levels. One of the core elements in the system is the synchronised wide area communication network between the substations and the protection and control system, in which latest communication technology is employed. Another important player in the system is the wide area synchronized protection and control information platform, which not only enables the fusion three line of defence for power system protection and control, but also provides a perfect tool for the application of cloud computing to substations and power networks.

Cirsium japonicum mitigates allergic nasal inflammation by regulating NRF2-mediated mucin production: Systematic transcriptome and molecular docking analyses

Allergic rhinitis(AR)is an immunoglobulin(Ig)E-mediated allergic disease frequently recurring following seasonal changes and significantly impacting quality of life[1].Worsening AR symptoms can lead to more severe conditions.Cirsium japonicum(CSJ,milk thistle)is an edible and medicinal plant with anti-oxidant,anti-inflammatory,and hepatoprotective properties;however,its effects and mechanisms of action in AR remain unclear.Here,we investigated the CSJ targets in AR and the underlying mechanisms in an ovalbumin(OVA)-induced AR mouse model.

Research on the Spatial Distribution of Ecosystem Service Value in Guangxi and Its Ecological Protection Countermeasure

90 counties (cities) in Guangxi Province being taken as the tested region,the ecosystem service value of those counties (cities) was measured with the data of land-using in 2005 by means of the Table of Terrestrial Ecosystem Services Value in China.The result indicated that the value of the ecosystem services per unit was divided into 3 categories:the first category with high ecosystem services value,the second category with medium ecosystem services value and the third category with low ecosystem services value.The region of the first category was mainly distributed in the mountain area of northern,northwestern,eastern and northeast part of Guangxi;the second category,in the hilly area of southern part and the mountain area in the southwestern part of Guangxi and the third category,in the basin area of central Guangxi,the karst area of western and northwestern Guangxi Province.

Advances in magnetic-assisted triboelectric nanogenerators:structures,materials and self-sensing systems

Triboelectric nanogenerators(TENG),renowned for their remarkable capability to harness weak mechanical energy from the environment,have gained considerable attention owing to their cost-effectiveness,high output,and adaptability.This review provides a unique perspective by conducting a comprehensive and in-depth analysis of magnetically assisted TENGs that encompass structures,materials,and self-powered sensing systems.We systematically summarize the diverse functions of the magnetic assistance for TENGs,including system stiffness,components of the hybrid electromagnetic-triboelectric generator,transmission,and interaction forces.In the material domain,we review the incorporation of magnetic nano-composites materials,along with ferrofluid-based TENG and microstructure verification,which have also been summarized based on existing research.Furthermore,we delve into the research progress on physical quantity sensing and human-machine interface in magnetic-assisted TENGs.Our analysis highlights that magnetic assistance extends beyond the repulsive and suction forces under a magnetic field,thereby playing multifaceted roles in improving the output performance and environmental adaptability of the TENGs.Finally,we present the prevailing challenges and offer insights into the future trajectory of the magnetic-assisted TENGs development.

Enhancing Identity Protection in Metaverse-Based Psychological Counseling System

Non-face-to-face psychological counseling systems rely on network technologies to anonymize information regard-ing client identity.However,these systems often face challenges concerning voice data leaks and the suboptimal communication of the client’s non-verbal expressions,such as facial cues,to the counselor.This study proposes a metaverse-based psychological counseling system designed to enhance client identity protection while ensuring efficient information delivery to counselors during non-face-to-face counseling.The proposed systemincorporates a voicemodulation function that instantlymodifies/masks the client’s voice to safeguard their identity.Additionally,it employs real-time client facial expression recognition using an ensemble of decision trees to mirror the client’s non-verbal expressions through their avatar in the metaverse environment.The system is adaptable for use on personal computers and smartphones,offering users the flexibility to access metaverse-based psychological counseling across diverse environments.The performance evaluation of the proposed system confirmed that the voice modulation and real-time facial expression replication consistently achieve an average speed of 48.32 frames per second or higher,even when tested on the least powerful smartphone configurations.Moreover,a total of 550 actual psychological counseling sessions were conducted,and the average satisfaction rating reached 4.46 on a 5-point scale.This indicates that clients experienced improved identity protection compared to conventional non-face-to-face metaverse counseling approaches.Additionally,the counselor successfully addressed the challenge of conveying non-verbal cues from clients who typically struggled with non-face-to-face psychological counseling.The proposed systemholds significant potential for applications in interactive discussions and educational activities in the metaverse.

Assistive Robotics for Upper Limb Physical Rehabilitation:A Systematic Review and Future Prospects

Physical assistive robotics are oriented to support and improve functional capacities of people.In physical rehabilitation,robots are indeed useful for functional recovery of affected limb.However,there are still open questions related to technological aspects.This work presents a systematic review of upper limb rehabilitation robotics in order to analyze and establish technological challenges and future directions in this area.A bibliometric analysis was performed for the systematic literature review.Literature from the last six years,conducted between August 2020 and May 2021,was reviewed.The methodology for the literature search and a bibliometric analysis of the metadata are presented.After a preliminary search resulted in 820 articles,a total of 66 articles were included.A concurrency network and bibliographic analysis were provided.And an analysis of occurrences,taxonomy,and rehabilitation robotics reported in the literature is presented.This review aims to provide to the scientific community an overview of the state of the art in assistive robotics for upper limb physical rehabilitation.The literature analysis allows access to a gap of unexplored options to define the technological prospects applied to upper limb physical rehabilitation robotics.

Evaluation of a Suspended Personal Radiation Protection System vs. Conventional Apron and Shields in Clinical Interventional Procedures

Purpose: This clinical study compares conventional lead aprons and ancillary shields to a functionally weightless personal overhead-supported system with expanded coverage. Materials and Methods: Primary operators performed procedures (N = 126, fluoroscopy minutes = 1209) using one of 2 methods of radiation protection and wearing dosimeters on multiple body locations. Method “LAS” (Lead-Apron+Shields): lead skirt, vest, thyroid shield, with 100% use of under-table shield, side shield, and mobile suspended lead-acrylic shield. Method “Zgrav”: ZeroGravity system (CFI Medical Solutions) with variable use of shielding. The studied early model moving with the operator had a curved lead-acrylic head shield (0.5 mm Pb) and expansive lead apron (0.5 - 1.0 mm Pb) that covered leg to distal calf and proximal arm to elbow, and a drape that permitted sterile entry and exit. Study was institutional review board approved and HIPPA-compliant. Results: Measured with a sensitive electronic dosimeter, eye exposures were 99% (P 0.001) reduced for Zgrav with upgraded face shield vs. LAS, regardless of use or non-use of suspended shield with Zgrav. With optically stimulated luminescence (OSL) dosimeters, operator exposures, standardized to minutes of fluoroscopy and Fluoroscopic Patient Dose Area Product, were reduced by 87% - 100% for eye & head, neck, humerus, and tibia (Zgrav vs. LAS). Overall eye & head exposure reduction for entire study was 94%. Non-equivalence of torso exposures was not demonstrated. A brief user survey showed ergonomic advantages of Zgrav. Conclusion: Compared to conventional lead aprons with shields, the suspended system provided superior operator protection during interventional fluoroscopy, allowing operators to perform procedures without potentially obstructive shields.

Multiple Tin Compounds Modified Carbon Fibers to Construct Heterogeneous Interfaces for Corrosion Prevention and Electromagnetic Wave Absorption

Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly urgent.Multi-component interface engineering is considered an effective means to achieve high-efficiency EMW absorption.However,interface modulation engineering has not been fully discussed and has great potential in the field of EMW absorption.In this study,multi-component tin compound fiber composites based on carbon fiber(CF)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal reduction.By utilizing the different properties of different substances,rich heterogeneous interfaces are constructed.This effectively promotes charge transfer and enhances interfacial polarization and conduction loss.The prepared SnS/SnS_(2)/SnO_(2)/CF composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy resin.The minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 GHz.Moreover,SnS/SnS_(2)/SnO_(2)/CF epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel surfaces.Therefore,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.