BACKGROUND Esophageal foreign bodies are common around the world.Newer approaches,such as cap-assisted endoscopy,have been introduced as an alternative to conventional methods.Therefore,we performed a meta-analysis on...BACKGROUND Esophageal foreign bodies are common around the world.Newer approaches,such as cap-assisted endoscopy,have been introduced as an alternative to conventional methods.Therefore,we performed a meta-analysis ono cap-assisted endoscopy versus conventional endoscopy for removal of esophageal foreign bodies.AIM To investigated the effectiveness of cap-assisted endoscopy with conventional endoscopy.METHODS An extensive literature search was performed(December 2021).For esophageal foreign body removal,cap-assisted endoscopy was compared to conventional endoscopy for procedure time,technical success of the procedure,time of foreign body retrieval,en bloc removal,and adverse event rate using odds ratio and mean difference.RESULTS Six studies met the inclusion criteria(n=1305).Higher odds of technical success(P=0.002)and en bloc removal(P<0.01)and lower odds of adverse events(P=0.02)and foreign body removal time(P<0.01)were observed with cap-assisted endoscopy as compared to conventional techniques.CONCLUSION For esophageal foreign bodies,the technique of cap-assisted endoscopy demonstrated increased en bloc removal and technical success with decreased time and adverse events as compared to conventional techniques.展开更多
目的:比较机器人辅助腹腔镜与传统腹腔镜关于全子宫切除术在不同体质指数患者中的安全性及可行性。方法:回顾性收集2016年2月至2021年4月于重庆医科大学附属第一医院接受了机器人辅助腹腔镜全子宫切除术(n=416)和传统腹腔镜全子宫切除术...目的:比较机器人辅助腹腔镜与传统腹腔镜关于全子宫切除术在不同体质指数患者中的安全性及可行性。方法:回顾性收集2016年2月至2021年4月于重庆医科大学附属第一医院接受了机器人辅助腹腔镜全子宫切除术(n=416)和传统腹腔镜全子宫切除术(n=725)患者的病例资料。按照不同等级体质指数(body mass index,BMI)对患者进行分层(非超重、超重和肥胖),比较2组中各BMI亚组间患者的围术期情况、术中及术后并发症。结果:机器人组中超重亚组的手术时间短于传统腹腔镜组[(125.37±50.92) min vs.(135.68±44.55) min],机器人组中3个BMI亚组的术中出血量均少于传统腹腔镜组[(60.46±45.20) mL vs.(92.88±105.13) mL、(72.01±62.03) mL vs.(115.02±123.38) mL及(65.59±37.92) mL vs.(125.16±96.07) mL],机器人组中超重亚组和肥胖亚组的首次排气时间均短于传统腹腔镜组[(2.04±0.83) d vs.(2.19±0.63) d和(1.97±0.54) d vs.(2.19±0.54) d],差异均有统计学意义(P<0.05)。机器人组中各BMI亚组术中及术后总体并发症发生率仍低于腹腔镜组,但差异无统计学意义(P>0.05)。结论:超重和肥胖患者的全子宫切除术,机器人辅助腹腔镜相较于传统腹腔镜在围术期降低并发症等方面有一定优势。展开更多
It is well-documented that male overweight and obesity causes endocrine disorders that might diminish the male reproductive capacity; however, reports have been conflicting regarding the influence of male body mass in...It is well-documented that male overweight and obesity causes endocrine disorders that might diminish the male reproductive capacity; however, reports have been conflicting regarding the influence of male body mass index (BMI) on semen quality and the outcome of assisted reproductive technology (ART). The aim of this study was to investigate whether increased male BMI affects sperm quality and the outcome of assisted reproduction in couples with an overweight or obese man and a non-obese partner. Data was prospectively collected from 612 infertile couples undergoing ART at a Danish fertility center. Self-reported information on paternal height and weight were recorded and BMI was calculated. The men were divided into four BMI categories: underweight BMI 〈 20 kgm^-2, normal BMI 20-24.9 kg m^-2, overweight BMI 25-29.9 kgm^-2 and obese BMI 〉 30 kgm^-2. Conventional semen analysis was performed according to the World Health Organization guideline and sperm DNA integrity was analyzed by the Sperm Chromatin Structure Assay (SCSA). No statistically significant effect of male BMI was seen on conventional semen parameters (sperm concentration, total sperm count, seminal volume and motility) or on SCSA-results. Furthermore, the outcome of ART regarding fertilization rate, number of good quality embryos (GQE), implantation and pregnancy outcome was not influenced by the increasing male BMIo展开更多
Multiparity amongst women with a body mass index (BMI) ≥ 30 Kg/m2 is a common occurrence despite there being a known clear association with a decline in fecundity in women who are overweight or obese. These women, al...Multiparity amongst women with a body mass index (BMI) ≥ 30 Kg/m2 is a common occurrence despite there being a known clear association with a decline in fecundity in women who are overweight or obese. These women, also pose further concerns, as they are at increased risk of antenatal complications such as preeclampsia and gestational diabetes. Over the years, a number of different modalities of fertility treatments have been tried and tested in this cohort of women to find the optimal treatment to improve their reproductive capacity. There has been an exponential increase in knowledge and understanding towards managing patients with a raised BMI, particularly through assisted reproductive treatments. Although the efficacies of various forms of fertility treatments have been shown to be affected by a rise in BMI, there is yet to be a definitive understanding as to the optimal management of these patients. The literature supports weight loss alone as an effective intervention in improving the reproductive capacity of women with a raised BMI with unexplained infertility. Furthermore, if live birth rate is taken as the desired outcome measure, then ovarian drilling and in vitro fertilisation (IVF) treatment have been shown to yield the best results in overweight and obese patients when comparisons are drawn to other interventions such as natural conception and treatment with clomiphene citrate.展开更多
There can be little argument that embryo quality is one of the most critical factors in the success of assisted reproductive techniques. Yet the current methods of grading embryos are subjective at best. While a numbe...There can be little argument that embryo quality is one of the most critical factors in the success of assisted reproductive techniques. Yet the current methods of grading embryos are subjective at best. While a number of different groups have described more qualitative means of assessing embryo quality, the current standard remains morphology. Morphology has proven a good standard, but it does not allow for the detection of chromosomal abnormalities nor can it assess the biochemical status of the embryo prior to transfer. This laboratory recently described a method to estimate embryo weight and suggested weight might be a good indicator of biochemical status. The objective of the present study was to determine the relationship between maternal body composition and embryo weight and determine the influence maternal chemistry had on embryo development. The data continue to suggest that maternal body composition, especially body fat, influences the chemical nature of the embryo and may play a critical role in long-term survival.展开更多
<strong>Background:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> Intraoperative surgical planning tools (ISPTs) used in curren...<strong>Background:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> Intraoperative surgical planning tools (ISPTs) used in current-generation robotic arm-assisted total knee arthroplasty (RTKA) systems (such as Navio</span><sup><span style="font-size:12px;font-family:Verdana;"><span lang="ZH-CN" style="font-size:12pt;font-family:宋体;">®</span></span></sup><span style="font-family:Verdana;"> and MAKO</span><sup><span style="font-size:12px;font-family:Verdana;"><span lang="ZH-CN" style="font-size:12pt;font-family:宋体;">®</span></span></sup><span style="font-family:Verdana;">) involve employment of postoperative passive joint balancing. This results in improper ligament tension, which may negatively impact joint stability, which, in turn, may adversely affect patient function after TKA. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> A simulation-enhanced ISPT (SEISPT) that provides insights relating to postoperative active joint mechanics was developed. This involved four steps: 1) validation of a multi-body musculoskeletal model;2) optimization of the validated model;3) use of the validated and optimized model to derive knee performance equations (KPEs), which are equations that relate implant component characteristics to implant component biomechanical responses;and 4) optimization of the KPEs with respect to these responses. In a proof-of-concept study, KPEs that involved two</span></span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">com</span><span style="font-family:Verdana;">- </span><span style="font-family:;" "=""><span style="font-family:Verdana;">ponent biomechanical responses that have been shown to strongly correlate with poor proprioception (a common patient complaint post-TKA) were used to calculate optimal positions and orientations of the femoral and tibial components in the TKA design implanted in one subject (as reported in a publicly-available dataset). </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The differences between the calculated implant positions and orientations and the corresponding achieved values for the implant components in the subject were not similar to component position and orientation errors reported in biomechanical literature studies involving Navio</span><sup><span style="font-size:12px;font-family:Verdana;"><span lang="ZH-CN" style="font-size:12pt;font-family:宋体;">®</span></span></sup><span style="font-family:Verdana;"> and MAKO</span><sup><span style="font-size:12px;font-family:Verdana;"><span lang="ZH-CN" style="font-size:12pt;font-family:宋体;">®</span></span></sup><span style="font-family:Verdana;">. Also, we indicate how SEISPT could be incorporated into the surgical workflow of Navio</span><sup><span style="font-size:12px;font-family:Verdana;"><span lang="ZH-CN" style="font-size:12pt;font-family:宋体;">®</span></span></sup><span style="font-family:Verdana;"> with minimal disruption and increase in cost. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> SEISPT is a plausible alternative to current-gen</span></span><span style="font-family:Verdana;">- </span><span style="font-family:Verdana;">eration ISPTs.</span>展开更多
目的系统检索并筛选NICU神经调节辅助通气新生儿体位管理的系列证据,并对最佳证据进行总结。方法检索PubMed、Web of Science、Elsevier、Cochrane Library、中国知网、万方、维普等数据库关于NICU神经调节辅助通气新生儿体位管理的相...目的系统检索并筛选NICU神经调节辅助通气新生儿体位管理的系列证据,并对最佳证据进行总结。方法检索PubMed、Web of Science、Elsevier、Cochrane Library、中国知网、万方、维普等数据库关于NICU神经调节辅助通气新生儿体位管理的相关证据,包括指南、专家共识、护理方案、病例对照研究、Meta分析、随机对照试验(RCT)等,检索时限为2000年1月—2022年8月。由2名拥有循证护理背景研究者对纳入的文献进行质量独立评价并互相核对,出现争议时由第3方进行裁决,对符合纳入排除标准的文献进行证据提取。结果共纳入18篇文献,其中指南4篇,专家共识1篇,护理方案2篇,系统评价2篇,Meta分析3篇,病例对照研究1篇,RCT 5篇,从体位和风险评估、新生儿复苏时的体位摆放及其操作要点、新生儿NAVA过程中的体位转换及其操作要点、特殊疾病或情境下的体位管理、体位辅助工具的使用及皮肤保护5个方面对NICU神经调节辅助通气新生儿体位管理进行证据汇总,共形成最佳证据。结论该研究总结了NICU神经调节辅助通气的新生儿体位管理的最佳证据,为规范NICU神经调节辅助通气的新生儿体位管理提供了循证依据,建议护理人员在应用证据时综合考虑临床实际情况选择性应用最佳证据,提高新生儿存活率。展开更多
目的:探讨育龄期女性体重指数对胚胎发育及助孕结局的影响,旨在为不同体重指数的患者提供更好的助孕治疗,为临床诊疗提供参考。方法:回顾性收集2015年1月~2021年10月在海南医学院第一附属医院生殖医学中心首次接受鲜胚移植且通过长方案...目的:探讨育龄期女性体重指数对胚胎发育及助孕结局的影响,旨在为不同体重指数的患者提供更好的助孕治疗,为临床诊疗提供参考。方法:回顾性收集2015年1月~2021年10月在海南医学院第一附属医院生殖医学中心首次接受鲜胚移植且通过长方案促排的患者资料,共3783例。按照体重指数(body mass index,BMI)将患者分为:低体重组(BMI<18.5 kg/m^(2))、正常体重组(18.5≤BMI<24 kg/m^(2))、超重组(24≤BMI<28 kg/m^(2))和肥胖组(BMI≥28 kg/m^(2))。比较四组的基本情况、助孕过程、胚胎发育以及助孕结局。结果:分析患者基本情况发现,四组女性年龄无显著差异(P>0.05),但肥胖女性的不孕时间显著延长(P=0.007)。超重及肥胖组的基础内分泌水平低于正常组(P<0.05)。肥胖组基础卵泡刺激素(follicle-stimulating hormone,FSH)、基础黄体生成素(luteinizing hormone,LH)、基础雌二醇(estradiol,E2)、基础孕酮(progesterone,P)、抗缪勒管激素(anti-mullerian hormone,AMH)均低于正常体重组(P<0.05),肥胖组基础窦卵泡数(antral follicle counting,AFC)减少(P=0.011)。超重组仅表现为E2、P水平降低(P<0.05)。在助孕过程中,肥胖组促性腺激素(gonadotropin,Gn)用量最多,超重组次之,低体重组最少(P<0.001)。肥胖组的Gn天数延长(P<0.001)。超重、肥胖组扳机日LH、E2、P均低于正常体重组(P<0.05)。比较胚胎发育过程得出,肥胖组囊胚在原核消失(time of pronuclei disappearance,tPNf)、四细胞(time of four cells,t4)及囊胚形成(time of full blastocyst,tB)阶段均出现发育延迟(P<0.05)。肥胖组助孕结局较差,表现为临床妊娠率(P=0.044)及活产率(P=0.036)降低。行二分类Logistic回归分析后发现,肥胖是临床妊娠(OR=0.683,95%CI:0.479-0.973,P=0.035)及活产(OR=0.662,95%CI:0.459-0.954,P=0.027)的危险因素。年龄为生化妊娠、临床妊娠和活产的危险因素(P<0.05)。结论:女性肥胖延长不孕时间,引起内分泌紊乱,增加Gn用量及天数。女性肥胖能延迟囊胚发育过程,为临床妊娠及活产的危险因素。展开更多
Objective:To investigate the effects of female body mass index on embryo development and assisted reproductive technology outcomes,aiming to provide better treatment for patients with different body mass index and pro...Objective:To investigate the effects of female body mass index on embryo development and assisted reproductive technology outcomes,aiming to provide better treatment for patients with different body mass index and provide reference for clinical treatment.Methods:The study retrospectively collected data of 3783 patients who received their first fresh embryo transfer and were ovulated by a long protocol at the Reproductive Medicine Center of the First Affiliated Hospital of Hainan Medical University from January 2015 to October 2021.Patients were divided into four groups based on body mass index(BMI):low weight group,normal weight group,overweight group and obese group.The normal weight group was used as a control to compare the basic information,assisted reproductive technology process,embryo development and assisted reproductive technology outcomes between different groups.Results:Analyzing patients'basic information,we found that the duration of infertility was significantly longer in obese women(P=0.007).Basal hormone levels in the overweight and obese groups were lower than those in the normal group(P<0.05).Basal Follicle-stimulating hormone(FSH),basal Luteinizing hormone(LH),basal Estradiol(E2),basal Progesterone(P),and anti-Mullerian hormone(AMH)in the obese group were lower than the normal weight group(P<0.05),and the number of antral follicle counting(AFC)was reduced in the obese group(P=0.011).The overweight group only showed a decrease in E2 and P levels(P<0.05).During the ART,there was a significant difference in Gonadotropin(Gn)dosage among the four groups,with the obese group was the most,followed by the overweight group,and the low weight group was the least(P<0.001).Gn days were increased in the obese group(P<0.001).LH,E2,and P on trigger day were all lower in the overweight and obese groups than in the normal weight group(P<0.05).Comparing the embryo development process,we found that the blastocysts of the obese group showed delayed development at the stages of pronuclei disappearance,four-cell and blastocyst formation(P<0.05).The ART outcomes were worse in the obese group,the clinical pregnancy rate(P=0.044)and live birth rate(P=0.036)were reduced in the obese group.After logistic regression,obesity was found to be a risk factor for clinical pregnancy(OR=0.683,95%CI:0.479-0.973,P=0.035)and live birth(OR=0.662,95%CI:0.459-0.954,P=0.027).Female age was a risk factor for biochemical pregnancy,clinical pregnancy and live birth(P<0.05).Conclusion:Female obesity prolongs the duration of infertility,causes endocrine disorders,increases Gn dosage and days,and leads to poorer assisted reproductive technology outcomes.Female obesity delays the blastocyst development process and presents as a risk factor for clinical pregnancy and live birth.展开更多
文摘BACKGROUND Esophageal foreign bodies are common around the world.Newer approaches,such as cap-assisted endoscopy,have been introduced as an alternative to conventional methods.Therefore,we performed a meta-analysis ono cap-assisted endoscopy versus conventional endoscopy for removal of esophageal foreign bodies.AIM To investigated the effectiveness of cap-assisted endoscopy with conventional endoscopy.METHODS An extensive literature search was performed(December 2021).For esophageal foreign body removal,cap-assisted endoscopy was compared to conventional endoscopy for procedure time,technical success of the procedure,time of foreign body retrieval,en bloc removal,and adverse event rate using odds ratio and mean difference.RESULTS Six studies met the inclusion criteria(n=1305).Higher odds of technical success(P=0.002)and en bloc removal(P<0.01)and lower odds of adverse events(P=0.02)and foreign body removal time(P<0.01)were observed with cap-assisted endoscopy as compared to conventional techniques.CONCLUSION For esophageal foreign bodies,the technique of cap-assisted endoscopy demonstrated increased en bloc removal and technical success with decreased time and adverse events as compared to conventional techniques.
文摘目的:比较机器人辅助腹腔镜与传统腹腔镜关于全子宫切除术在不同体质指数患者中的安全性及可行性。方法:回顾性收集2016年2月至2021年4月于重庆医科大学附属第一医院接受了机器人辅助腹腔镜全子宫切除术(n=416)和传统腹腔镜全子宫切除术(n=725)患者的病例资料。按照不同等级体质指数(body mass index,BMI)对患者进行分层(非超重、超重和肥胖),比较2组中各BMI亚组间患者的围术期情况、术中及术后并发症。结果:机器人组中超重亚组的手术时间短于传统腹腔镜组[(125.37±50.92) min vs.(135.68±44.55) min],机器人组中3个BMI亚组的术中出血量均少于传统腹腔镜组[(60.46±45.20) mL vs.(92.88±105.13) mL、(72.01±62.03) mL vs.(115.02±123.38) mL及(65.59±37.92) mL vs.(125.16±96.07) mL],机器人组中超重亚组和肥胖亚组的首次排气时间均短于传统腹腔镜组[(2.04±0.83) d vs.(2.19±0.63) d和(1.97±0.54) d vs.(2.19±0.54) d],差异均有统计学意义(P<0.05)。机器人组中各BMI亚组术中及术后总体并发症发生率仍低于腹腔镜组,但差异无统计学意义(P>0.05)。结论:超重和肥胖患者的全子宫切除术,机器人辅助腹腔镜相较于传统腹腔镜在围术期降低并发症等方面有一定优势。
文摘It is well-documented that male overweight and obesity causes endocrine disorders that might diminish the male reproductive capacity; however, reports have been conflicting regarding the influence of male body mass index (BMI) on semen quality and the outcome of assisted reproductive technology (ART). The aim of this study was to investigate whether increased male BMI affects sperm quality and the outcome of assisted reproduction in couples with an overweight or obese man and a non-obese partner. Data was prospectively collected from 612 infertile couples undergoing ART at a Danish fertility center. Self-reported information on paternal height and weight were recorded and BMI was calculated. The men were divided into four BMI categories: underweight BMI 〈 20 kgm^-2, normal BMI 20-24.9 kg m^-2, overweight BMI 25-29.9 kgm^-2 and obese BMI 〉 30 kgm^-2. Conventional semen analysis was performed according to the World Health Organization guideline and sperm DNA integrity was analyzed by the Sperm Chromatin Structure Assay (SCSA). No statistically significant effect of male BMI was seen on conventional semen parameters (sperm concentration, total sperm count, seminal volume and motility) or on SCSA-results. Furthermore, the outcome of ART regarding fertilization rate, number of good quality embryos (GQE), implantation and pregnancy outcome was not influenced by the increasing male BMIo
文摘Multiparity amongst women with a body mass index (BMI) ≥ 30 Kg/m2 is a common occurrence despite there being a known clear association with a decline in fecundity in women who are overweight or obese. These women, also pose further concerns, as they are at increased risk of antenatal complications such as preeclampsia and gestational diabetes. Over the years, a number of different modalities of fertility treatments have been tried and tested in this cohort of women to find the optimal treatment to improve their reproductive capacity. There has been an exponential increase in knowledge and understanding towards managing patients with a raised BMI, particularly through assisted reproductive treatments. Although the efficacies of various forms of fertility treatments have been shown to be affected by a rise in BMI, there is yet to be a definitive understanding as to the optimal management of these patients. The literature supports weight loss alone as an effective intervention in improving the reproductive capacity of women with a raised BMI with unexplained infertility. Furthermore, if live birth rate is taken as the desired outcome measure, then ovarian drilling and in vitro fertilisation (IVF) treatment have been shown to yield the best results in overweight and obese patients when comparisons are drawn to other interventions such as natural conception and treatment with clomiphene citrate.
文摘There can be little argument that embryo quality is one of the most critical factors in the success of assisted reproductive techniques. Yet the current methods of grading embryos are subjective at best. While a number of different groups have described more qualitative means of assessing embryo quality, the current standard remains morphology. Morphology has proven a good standard, but it does not allow for the detection of chromosomal abnormalities nor can it assess the biochemical status of the embryo prior to transfer. This laboratory recently described a method to estimate embryo weight and suggested weight might be a good indicator of biochemical status. The objective of the present study was to determine the relationship between maternal body composition and embryo weight and determine the influence maternal chemistry had on embryo development. The data continue to suggest that maternal body composition, especially body fat, influences the chemical nature of the embryo and may play a critical role in long-term survival.
文摘<strong>Background:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> Intraoperative surgical planning tools (ISPTs) used in current-generation robotic arm-assisted total knee arthroplasty (RTKA) systems (such as Navio</span><sup><span style="font-size:12px;font-family:Verdana;"><span lang="ZH-CN" style="font-size:12pt;font-family:宋体;">®</span></span></sup><span style="font-family:Verdana;"> and MAKO</span><sup><span style="font-size:12px;font-family:Verdana;"><span lang="ZH-CN" style="font-size:12pt;font-family:宋体;">®</span></span></sup><span style="font-family:Verdana;">) involve employment of postoperative passive joint balancing. This results in improper ligament tension, which may negatively impact joint stability, which, in turn, may adversely affect patient function after TKA. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> A simulation-enhanced ISPT (SEISPT) that provides insights relating to postoperative active joint mechanics was developed. This involved four steps: 1) validation of a multi-body musculoskeletal model;2) optimization of the validated model;3) use of the validated and optimized model to derive knee performance equations (KPEs), which are equations that relate implant component characteristics to implant component biomechanical responses;and 4) optimization of the KPEs with respect to these responses. In a proof-of-concept study, KPEs that involved two</span></span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">com</span><span style="font-family:Verdana;">- </span><span style="font-family:;" "=""><span style="font-family:Verdana;">ponent biomechanical responses that have been shown to strongly correlate with poor proprioception (a common patient complaint post-TKA) were used to calculate optimal positions and orientations of the femoral and tibial components in the TKA design implanted in one subject (as reported in a publicly-available dataset). </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The differences between the calculated implant positions and orientations and the corresponding achieved values for the implant components in the subject were not similar to component position and orientation errors reported in biomechanical literature studies involving Navio</span><sup><span style="font-size:12px;font-family:Verdana;"><span lang="ZH-CN" style="font-size:12pt;font-family:宋体;">®</span></span></sup><span style="font-family:Verdana;"> and MAKO</span><sup><span style="font-size:12px;font-family:Verdana;"><span lang="ZH-CN" style="font-size:12pt;font-family:宋体;">®</span></span></sup><span style="font-family:Verdana;">. Also, we indicate how SEISPT could be incorporated into the surgical workflow of Navio</span><sup><span style="font-size:12px;font-family:Verdana;"><span lang="ZH-CN" style="font-size:12pt;font-family:宋体;">®</span></span></sup><span style="font-family:Verdana;"> with minimal disruption and increase in cost. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> SEISPT is a plausible alternative to current-gen</span></span><span style="font-family:Verdana;">- </span><span style="font-family:Verdana;">eration ISPTs.</span>
文摘目的系统检索并筛选NICU神经调节辅助通气新生儿体位管理的系列证据,并对最佳证据进行总结。方法检索PubMed、Web of Science、Elsevier、Cochrane Library、中国知网、万方、维普等数据库关于NICU神经调节辅助通气新生儿体位管理的相关证据,包括指南、专家共识、护理方案、病例对照研究、Meta分析、随机对照试验(RCT)等,检索时限为2000年1月—2022年8月。由2名拥有循证护理背景研究者对纳入的文献进行质量独立评价并互相核对,出现争议时由第3方进行裁决,对符合纳入排除标准的文献进行证据提取。结果共纳入18篇文献,其中指南4篇,专家共识1篇,护理方案2篇,系统评价2篇,Meta分析3篇,病例对照研究1篇,RCT 5篇,从体位和风险评估、新生儿复苏时的体位摆放及其操作要点、新生儿NAVA过程中的体位转换及其操作要点、特殊疾病或情境下的体位管理、体位辅助工具的使用及皮肤保护5个方面对NICU神经调节辅助通气新生儿体位管理进行证据汇总,共形成最佳证据。结论该研究总结了NICU神经调节辅助通气的新生儿体位管理的最佳证据,为规范NICU神经调节辅助通气的新生儿体位管理提供了循证依据,建议护理人员在应用证据时综合考虑临床实际情况选择性应用最佳证据,提高新生儿存活率。
文摘目的:探讨育龄期女性体重指数对胚胎发育及助孕结局的影响,旨在为不同体重指数的患者提供更好的助孕治疗,为临床诊疗提供参考。方法:回顾性收集2015年1月~2021年10月在海南医学院第一附属医院生殖医学中心首次接受鲜胚移植且通过长方案促排的患者资料,共3783例。按照体重指数(body mass index,BMI)将患者分为:低体重组(BMI<18.5 kg/m^(2))、正常体重组(18.5≤BMI<24 kg/m^(2))、超重组(24≤BMI<28 kg/m^(2))和肥胖组(BMI≥28 kg/m^(2))。比较四组的基本情况、助孕过程、胚胎发育以及助孕结局。结果:分析患者基本情况发现,四组女性年龄无显著差异(P>0.05),但肥胖女性的不孕时间显著延长(P=0.007)。超重及肥胖组的基础内分泌水平低于正常组(P<0.05)。肥胖组基础卵泡刺激素(follicle-stimulating hormone,FSH)、基础黄体生成素(luteinizing hormone,LH)、基础雌二醇(estradiol,E2)、基础孕酮(progesterone,P)、抗缪勒管激素(anti-mullerian hormone,AMH)均低于正常体重组(P<0.05),肥胖组基础窦卵泡数(antral follicle counting,AFC)减少(P=0.011)。超重组仅表现为E2、P水平降低(P<0.05)。在助孕过程中,肥胖组促性腺激素(gonadotropin,Gn)用量最多,超重组次之,低体重组最少(P<0.001)。肥胖组的Gn天数延长(P<0.001)。超重、肥胖组扳机日LH、E2、P均低于正常体重组(P<0.05)。比较胚胎发育过程得出,肥胖组囊胚在原核消失(time of pronuclei disappearance,tPNf)、四细胞(time of four cells,t4)及囊胚形成(time of full blastocyst,tB)阶段均出现发育延迟(P<0.05)。肥胖组助孕结局较差,表现为临床妊娠率(P=0.044)及活产率(P=0.036)降低。行二分类Logistic回归分析后发现,肥胖是临床妊娠(OR=0.683,95%CI:0.479-0.973,P=0.035)及活产(OR=0.662,95%CI:0.459-0.954,P=0.027)的危险因素。年龄为生化妊娠、临床妊娠和活产的危险因素(P<0.05)。结论:女性肥胖延长不孕时间,引起内分泌紊乱,增加Gn用量及天数。女性肥胖能延迟囊胚发育过程,为临床妊娠及活产的危险因素。
基金Hainan Provincial Science and Technology Plan(Clinical Medical Research Center)Project(No.LCYX202102)。
文摘Objective:To investigate the effects of female body mass index on embryo development and assisted reproductive technology outcomes,aiming to provide better treatment for patients with different body mass index and provide reference for clinical treatment.Methods:The study retrospectively collected data of 3783 patients who received their first fresh embryo transfer and were ovulated by a long protocol at the Reproductive Medicine Center of the First Affiliated Hospital of Hainan Medical University from January 2015 to October 2021.Patients were divided into four groups based on body mass index(BMI):low weight group,normal weight group,overweight group and obese group.The normal weight group was used as a control to compare the basic information,assisted reproductive technology process,embryo development and assisted reproductive technology outcomes between different groups.Results:Analyzing patients'basic information,we found that the duration of infertility was significantly longer in obese women(P=0.007).Basal hormone levels in the overweight and obese groups were lower than those in the normal group(P<0.05).Basal Follicle-stimulating hormone(FSH),basal Luteinizing hormone(LH),basal Estradiol(E2),basal Progesterone(P),and anti-Mullerian hormone(AMH)in the obese group were lower than the normal weight group(P<0.05),and the number of antral follicle counting(AFC)was reduced in the obese group(P=0.011).The overweight group only showed a decrease in E2 and P levels(P<0.05).During the ART,there was a significant difference in Gonadotropin(Gn)dosage among the four groups,with the obese group was the most,followed by the overweight group,and the low weight group was the least(P<0.001).Gn days were increased in the obese group(P<0.001).LH,E2,and P on trigger day were all lower in the overweight and obese groups than in the normal weight group(P<0.05).Comparing the embryo development process,we found that the blastocysts of the obese group showed delayed development at the stages of pronuclei disappearance,four-cell and blastocyst formation(P<0.05).The ART outcomes were worse in the obese group,the clinical pregnancy rate(P=0.044)and live birth rate(P=0.036)were reduced in the obese group.After logistic regression,obesity was found to be a risk factor for clinical pregnancy(OR=0.683,95%CI:0.479-0.973,P=0.035)and live birth(OR=0.662,95%CI:0.459-0.954,P=0.027).Female age was a risk factor for biochemical pregnancy,clinical pregnancy and live birth(P<0.05).Conclusion:Female obesity prolongs the duration of infertility,causes endocrine disorders,increases Gn dosage and days,and leads to poorer assisted reproductive technology outcomes.Female obesity delays the blastocyst development process and presents as a risk factor for clinical pregnancy and live birth.