MBHA resin-supported tripeptide catalyst system containing L-proline unit has been developed for use in the direct asymmetric aldol reaction of acetone and aldehydes, which afford the corresponding products with satis...MBHA resin-supported tripeptide catalyst system containing L-proline unit has been developed for use in the direct asymmetric aldol reaction of acetone and aldehydes, which afford the corresponding products with satisfactory isolated yields and enantiomeric excesses. 2009 Hong Bin Zou. Published by E]sevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
The 4,5-methano-L-proline was used as chiral organocatalysts in direct asymmetric aldol reactions.Under the optimal conditions,excellent enantioselectivities(up to 99%ee)were obtained with high chemical yields(up to 9...The 4,5-methano-L-proline was used as chiral organocatalysts in direct asymmetric aldol reactions.Under the optimal conditions,excellent enantioselectivities(up to 99%ee)were obtained with high chemical yields(up to 95%)for a series of aldehydes using only 5 mol%catalyst loading.To show the practicality of the method,the reaction was tested at a large scale.The reaction was complete in 16 h,and the aldol product was obtained in 86%yield and 93%ee.展开更多
文摘MBHA resin-supported tripeptide catalyst system containing L-proline unit has been developed for use in the direct asymmetric aldol reaction of acetone and aldehydes, which afford the corresponding products with satisfactory isolated yields and enantiomeric excesses. 2009 Hong Bin Zou. Published by E]sevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
基金support by the NSFC(No.21402065)the start-up fund of Shanghai Institute of Technology is gratefully acknowledged.
文摘The 4,5-methano-L-proline was used as chiral organocatalysts in direct asymmetric aldol reactions.Under the optimal conditions,excellent enantioselectivities(up to 99%ee)were obtained with high chemical yields(up to 95%)for a series of aldehydes using only 5 mol%catalyst loading.To show the practicality of the method,the reaction was tested at a large scale.The reaction was complete in 16 h,and the aldol product was obtained in 86%yield and 93%ee.
