A series of substituted chiral benzhydrols were synthesized by the reaction of aromatic aldehydes with chiral intermediates formed from chiral titanates and arylmagnesium halides.
The asymmetric reaction of the chiron 2(5H)-furanones (4a-4c) with the Homer-Emmons reagents (5a-5b) has been investigated. The newly chiral organophosphorus derivatives 6 and 7 were obtained using the phosphoryl-stab...The asymmetric reaction of the chiron 2(5H)-furanones (4a-4c) with the Homer-Emmons reagents (5a-5b) has been investigated. The newly chiral organophosphorus derivatives 6 and 7 were obtained using the phosphoryl-stabilized carbanion as a building block in DMSO under mild conditions. Through the asymmetric introduction, the Horner-Emmons reagent could be transformed to a chiral building block to afford the novel functionalized phosphorus derivatives. The structures of the synthesized compounds 6 and 7 were identified on the basis of their elementary and spectroscopic data, such as IR, 1H NMR, 13C NMR, MS and X-ray crystallography. These results provided a valuable approach to the synthesis of potentially interesting chiral organophosphorus derivatives and probing their biological activities.展开更多
Subject Code:B02 With the support by the National Natural Science Foundation of China,the research group led by Prof.Tang Pingping(汤平平)from Nankai University reported the asymmetric and direct trifluoromethoxylatio...Subject Code:B02 With the support by the National Natural Science Foundation of China,the research group led by Prof.Tang Pingping(汤平平)from Nankai University reported the asymmetric and direct trifluoromethoxylation with trifluoromethyl aryl sulfonate(TFMS)as a new展开更多
Asymmetric epoxidation of methyl gibberellate by the modified Sharpless reagent at various temperature is described.Compound 8 and 9 can be used as the key intermediates for the syntheses of the polyhydroxygibberellins.
The asymmetric desymmetrization of cyclic anhydrides via the addition of carbon-based nucleophiles has been the focus of considerable levels of interest because it leads to optically active products. Over the past 20 ...The asymmetric desymmetrization of cyclic anhydrides via the addition of carbon-based nucleophiles has been the focus of considerable levels of interest because it leads to optically active products. Over the past 20 years, a variety of different catalytic asymmetric alkylation reactions have been developed for the desymmetrization of cyclic anhydrides using different metal reagents as nucleophiles and using chiral ligands. The purpose of this review is to provide an overview of significant developments in this field. ~ 2013 Fen-Er Chen. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
文摘A series of substituted chiral benzhydrols were synthesized by the reaction of aromatic aldehydes with chiral intermediates formed from chiral titanates and arylmagnesium halides.
基金Project supported by the National Natural Science Foundation of China(No.29672004).
文摘The asymmetric reaction of the chiron 2(5H)-furanones (4a-4c) with the Homer-Emmons reagents (5a-5b) has been investigated. The newly chiral organophosphorus derivatives 6 and 7 were obtained using the phosphoryl-stabilized carbanion as a building block in DMSO under mild conditions. Through the asymmetric introduction, the Horner-Emmons reagent could be transformed to a chiral building block to afford the novel functionalized phosphorus derivatives. The structures of the synthesized compounds 6 and 7 were identified on the basis of their elementary and spectroscopic data, such as IR, 1H NMR, 13C NMR, MS and X-ray crystallography. These results provided a valuable approach to the synthesis of potentially interesting chiral organophosphorus derivatives and probing their biological activities.
文摘Subject Code:B02 With the support by the National Natural Science Foundation of China,the research group led by Prof.Tang Pingping(汤平平)from Nankai University reported the asymmetric and direct trifluoromethoxylation with trifluoromethyl aryl sulfonate(TFMS)as a new
文摘Asymmetric epoxidation of methyl gibberellate by the modified Sharpless reagent at various temperature is described.Compound 8 and 9 can be used as the key intermediates for the syntheses of the polyhydroxygibberellins.
文摘The asymmetric desymmetrization of cyclic anhydrides via the addition of carbon-based nucleophiles has been the focus of considerable levels of interest because it leads to optically active products. Over the past 20 years, a variety of different catalytic asymmetric alkylation reactions have been developed for the desymmetrization of cyclic anhydrides using different metal reagents as nucleophiles and using chiral ligands. The purpose of this review is to provide an overview of significant developments in this field. ~ 2013 Fen-Er Chen. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
