A six-axis force sensor with parallel 8/4-4 structure is introduced and its measurement principle is analyzed.Based on condition numbers of Jacobian matrix spectral norm of the sensor,the relationship between the forc...A six-axis force sensor with parallel 8/4-4 structure is introduced and its measurement principle is analyzed.Based on condition numbers of Jacobian matrix spectral norm of the sensor,the relationship between the force and moment isotropy and some structural parameters is deduced.Orthogonal test methods are used to determine the degree of primary and secondary factors that have significant effect on sensor characteristics.Furthermore,the relationship between each performance index and the structural parameters of the sensor is analyzed by the method of the atlas,which lays a foundation for structural optimization design of the force sensor.展开更多
Generalized geothermal data was used to produce two electronic atlases for Asian Russia,Geothermal Atlas of Siberia(GAS)(1995-2000) and Geothermal Atlas for Siberia and Russian Far East(GASRFE)(2009-2012).The ...Generalized geothermal data was used to produce two electronic atlases for Asian Russia,Geothermal Atlas of Siberia(GAS)(1995-2000) and Geothermal Atlas for Siberia and Russian Far East(GASRFE)(2009-2012).The atlases include heat flow maps,temperatures at depths of 0.5,1,2,3,5 km and lower boundary of permafrost.Quantitative values of parameters are presented as isolines(GAS) and symbols(GASRFE).GAS website is located at the Trofimuk Institute(www.ipgg.sbras.ru/ru/institute/structure/geophysics/natural-fields).GASRFE provides the most complete geothermal data on Asian Russia,which has been growing for the last 50 years,and is published on the Internet at http://maps.nrcgit.ru/geoterm.In this atlas,data about the depth of permafrost lower boundary( "zero" isotherm) are presented for the first time.展开更多
The servomotor drive turret punch press is attracting more attentions and being developed more intensively due to the advantages of high speed,high accuracy,high flexibility,high productivity,low noise,cleaning and en...The servomotor drive turret punch press is attracting more attentions and being developed more intensively due to the advantages of high speed,high accuracy,high flexibility,high productivity,low noise,cleaning and energy saving.To effectively improve the performance and lower the cost,it is necessary to develop new mechanisms and establish corresponding optimal design method with uniform performance indices.A new patented main driving mechanism and a new optimal design method are proposed.In the optimal design,the performance indices,i.e.,the local motion/force transmission indices ITI,OTI,good transmission workspace good transmission workspace(GTW) and the global transmission indices GTIs are defined.The non-dimensional normalization method is used to get all feasible solutions in dimensional synthesis.Thereafter,the performance atlases,which can present all possible design solutions,are depicted.As a result,the feasible solution of the mechanism with good motion/force transmission performance is obtained.And the solution can be flexibly adjusted by designer according to the practical design requirements.The proposed mechanism is original,and the presented design method provides a feasible solution to the optimal design of the main driving mechanism for servo punch press.展开更多
The integration of remote sensing and geographic information system(GIS)was employed in this study to delineate the structural lineaments within the eastern section of the Ouarzazate Basin,situated between the souther...The integration of remote sensing and geographic information system(GIS)was employed in this study to delineate the structural lineaments within the eastern section of the Ouarzazate Basin,situated between the southern front of the Central High Atlas and the northern slopes of the Eastern Anti-Atlas(also known as the Saghro Massif).To achieve this objective,Landsat 8 Operational Land Imager(OLI)and Shuttle Radar Topography Mission(SRTM)data were used.Principal Component Analysis(PCA)was computed and a directional filter was applied to the first PCA and the panchromatic band(B8).Additionally,shading was applied to the SRTM data in four directions;N0°,N45°,N90°,N135°.After removing of the non-geological linear structures,the results obtained,using the automatic extraction method,allowed us to produce a synthetic map that included 1251 lineaments with an average length of 1331 m and was dominated by NE-SW,ENE-WSW and E-W directions,respectively.However,the high lineament density is clearly noted in the Anti-Atlas(Saghro Massif)and at the level of the northern part,extending from the Ait Ibrirne to Arg-Ali Oubourk villages.High lineament density can always be found around the major faults affecting this area.The data collected during the field investigations and from geological maps show that the major direction of the faults and structural accidents range mostly between N45°,N70°and N75°.The correlation of remote sensing results with those collected in the field shows a similarity and coincidence with each other.From these results,it is possible to consider the automatic extraction method as a supplementary kind that can serve classical geology by quickly enriching it with additional data.As shown in this work,this method provides more information when applied in arid areas where the fields are well outcropped.展开更多
Plant morphogenesis relies on precise gene expression programs at the proper time and position which is orchestrated by transcription factors(TFs)in intricate regulatory networks in a cell-type specific manner.Here we...Plant morphogenesis relies on precise gene expression programs at the proper time and position which is orchestrated by transcription factors(TFs)in intricate regulatory networks in a cell-type specific manner.Here we introduced a comprehensive single-cell transcriptomic atlas of Arabidopsis seedlings.This atlas is the result of meticulous integration of 63 previously published scRNA-seq datasets,addressing batch effects and conserving biological variance.This integration spans a broad spectrum of tissues,including both below-and above-ground parts.Utilizing a rigorous approach for cell type annotation,we identified 47 distinct cell types or states,largely expanding our current view of plant cell compositions.We systematically constructed cell-type specific gene regulatory networks and uncovered key regulators that act in a coordinated manner to control cell-type specific gene expression.Taken together,our study not only offers extensive plant cell atlas exploration that serves as a valuable resource,but also provides molecular insights into gene-regulatory programs that varies from different cell types.展开更多
BACKGROUND Breast cancer(BC),a leading malignant disease,affects women all over the world.Cancer associated fibroblasts(CAFs)stimulate epithelial-mesenchymal transition,and induce chemoresistance and immunosuppression...BACKGROUND Breast cancer(BC),a leading malignant disease,affects women all over the world.Cancer associated fibroblasts(CAFs)stimulate epithelial-mesenchymal transition,and induce chemoresistance and immunosuppression.AIM To establish a CAFs-associated prognostic signature to improve BC patient out-come estimation.METHODS We retrieved the transcript profile and clinical data of 1072 BC samples from The Cancer Genome Atlas(TCGA)databases,and 3661 BC samples from the The Gene Expression Omnibus.CAFs and immune cell infiltrations were quantified using CIBERSORT algorithm.CAF-associated gene identification was done by weighted gene co-expression network analysis.A CAF risk signature was established via univariate,least absolute shrinkage and selection operator regression,and mul-tivariate Cox regression analyses.The receiver operating characteristic(ROC)and Kaplan-Meier curves were employed to evaluate the predictability of the model.Subsequently,a nomogram was developed with the risk score and patient clinical signature.Using Spearman's correlations analysis,the relationship between CAF risk score and gene set enrichment scores were examined.Patient samples were collected to validate gene expression by quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS Employing an 8-gene(IL18,MYD88,GLIPR1,TNN,BHLHE41,DNAJB5,FKBP14,and XG)signature,we attemp-ted to estimate BC patient prognosis.Based on our analysis,high-risk patients exhibited worse outcomes than low-risk patients.Multivariate analysis revealed the risk score as an independent indicator of BC patient prognosis.ROC analysis exhibited satisfactory nomogram predictability.The area under the curve showed 0.805 at 3 years,and 0.801 at 5 years in the TCGA cohort.We also demonstrated that a reduced CAF risk score was strongly associated with enhanced chemotherapeutic outcomes.CAF risk score was significantly correlated with most hallmark gene sets.Finally,the prognostic signature were further validated by qRT-PCR.CONCLUSION We introduced a newly-discovered CAFs-associated gene signature,which can be employed to estimate BC patient outcomes conveniently and accurately.展开更多
Introduction:DNA polymerases are crucial for maintaining genome stability and influencing tumorigenesis.However,the clinical implications of DNA polymerases in tumorigenesis and their potential as anti-cancer therapy ...Introduction:DNA polymerases are crucial for maintaining genome stability and influencing tumorigenesis.However,the clinical implications of DNA polymerases in tumorigenesis and their potential as anti-cancer therapy targets are not well understood.Methods:We conducted a systematic analysis using TCGA Pan-Cancer Atlas data and Gene Set Cancer Analysis results to examine the expression profiles of 15 DNA polymerases(POLYs)and their clinical correlations.We also evaluated the prognostic value of POLYs by analyzing their expression levels in relation to overall survival time(OS)using Kaplan-Meier survival curves.Additionally,we investigated the correlations between POLY expression and immune cells,DNA damage repair(DDR)pathways,and ubiquitination.Drug sensitivity analysis was performed to assess the relationship between POLY expression and drug response.Results:Our analysis revealed that 14 out of 15 POLYs exhibited significantly distinct expression patterns between tumor and normal samples across most cancer types,except for DNA nucleotidylexotransferase(DNTT).Specifically,POLD1 and POLE showed elevated expression in almost all cancers,while POLQ exhibited high expression levels in all cancer types.Some POLYs showed heightened expression in specific cancer subtypes,while others exhibited low expression.Kaplan-Meier survival curves demonstrated significant prognostic value of POLYs in multiple cancers,including PAAD,KIRC,and ACC.Cox analysis further validated these findings.Alteration patterns of POLYs varied significantly among different cancer types and were associated with poorer survival outcomes.Significant correlations were observed between the expression of POLY members and immune cells,DDR pathways,and ubiquitination.Drug sensitivity analysis indicated an inverse relationship between POLY expression and drug response.Conclusion:Our comprehensive study highlights the significant role of POLYs in cancer development and identifies them as promising prognostic and immunological biomarkers for various cancer types.Additionally,targeting POLYs therapeutically holds promise for tumor immunotherapy.展开更多
背景与目的 肺癌是全球最常见的恶性肿瘤,大多数患者初次诊断时已发生转移,因此寻找肺癌新的诊断标志物并探索其在肺癌发生中的作用具有重要价值。基于生物信息数据探讨分析肺癌中GINS1基因与肺癌预后的相关性具有重要意义。方法 检索On...背景与目的 肺癌是全球最常见的恶性肿瘤,大多数患者初次诊断时已发生转移,因此寻找肺癌新的诊断标志物并探索其在肺癌发生中的作用具有重要价值。基于生物信息数据探讨分析肺癌中GINS1基因与肺癌预后的相关性具有重要意义。方法 检索Oncomine、EGPIA、TCGA、Human protein atlas等基因数据库,分析GINS1基因在肺癌中的表达差异。应用蛋白质免疫印记法检测肺癌及癌旁组织中GINS1蛋白的表达水平,应用Kaplan-Meier进行患者生存分析,并利用String-DB数据库分析GINS1蛋白相互作用网络。结果 对Oncomine、GEPIA和The Human Protein Atlas数据库中肺癌与癌旁组织蛋白表达数据进行差异性分析,发现GINS1蛋白在肺癌组织中显著高表达,特别以肺腺癌、肺鳞癌中表达明显增加;通过生存分析发现高表达GINS1肺腺癌患者生存期明显低于低表达者,高表达患者预后更差;利用String-DB数据库发现与GINS1蛋白关联最为密切的为GINS蛋白家族(GINS2、GINS3、GINS4),其次为CDC45、MCM蛋白家族(MCM2、MCM3、MCM4、MCM5、MCM6、MCM7),富集分析发现互作蛋白主要参与DNA复制和细胞周期。结论GINS1基因在肺癌组织中显著高表达,与患者预后相关,其有可能成为肺癌诊断及药物治疗的新靶点。展开更多
由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中...由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中文170万字。此书分为Overview、Diagnosis of Uveitis、Treatment of Uveitis.Uveitisentities,Scleritis and Episcleritis四大部分,详细介绍了葡萄膜炎类疾病的疾病谱,常见类型的临床特征、进展和致盲规律,疾病诊疗的思想、原则、策略,并使用大量精美图片展现了常见葡萄膜炎类型的表现谱,即从发病到疾病后期,从最细微的异常到最严重的改变,从罕见的表现到典型的特征,展示出葡萄膜炎的全貌和细节,既可使临床医师快速掌握疾病要点,又不至于遗漏细微之处。这也是中国眼科医师首次向国际介绍葡萄膜炎诊疗的中国标准、方案和经验。展开更多
Objective:Understanding how brain changes over lifetime provides the basis for new insights into neurophysiology and neuropathology.In this study,we carried out a pseudo-longitudinal study based on age-related Chinese...Objective:Understanding how brain changes over lifetime provides the basis for new insights into neurophysiology and neuropathology.In this study,we carried out a pseudo-longitudinal study based on age-related Chinese brain atlases(i.e.,Chinese2020)constructed from large-scale volumetric brain MRI data collected in normal Han Chinese adults at varying ages.Methods:In order to quantify the deformation and displacement of brains for each voxel as age increases,optical flow algorithm was employed to compute motion vectors between every two consecutive brain templates of the age-related brain atlas,i.e.,Chinese2020.Results:Dynamic age-related neuroanatomical changes in a standardized brain space were shown.Overall,our results demonstrate that brain inward deformation(mainly due to atrophy)can appear in adulthood and this trend generally accelerates as age increases,affecting multiple regions including frontal cortex,temporal cortex,parietal cortex,and cerebellum,whereas occipital cortex is least affected by aging,and even showed some degree of outward deformation in the midlife.Conclusion:Our findings indicated more complicated age-related changes instead of a simple trend of brain volume decrease,which may be in line with the recently increasing interests in the age-related cortical complexity with other morphometry measures.展开更多
基金supported by the Open Foundation of Graduate Innovation Base(Laboratory)of Nanjing University of Aeronautics and Astronautics (No.kfjj20170512)the National Natural Science Foundation of China(No. 51175263)
文摘A six-axis force sensor with parallel 8/4-4 structure is introduced and its measurement principle is analyzed.Based on condition numbers of Jacobian matrix spectral norm of the sensor,the relationship between the force and moment isotropy and some structural parameters is deduced.Orthogonal test methods are used to determine the degree of primary and secondary factors that have significant effect on sensor characteristics.Furthermore,the relationship between each performance index and the structural parameters of the sensor is analyzed by the method of the atlas,which lays a foundation for structural optimization design of the force sensor.
基金The Project VIII.70.2.3 of IPGG SB RAS and Project 7.1 of Department of Earth Sciences of Russian Academy of Sciences (Program 7) were supported this work
文摘Generalized geothermal data was used to produce two electronic atlases for Asian Russia,Geothermal Atlas of Siberia(GAS)(1995-2000) and Geothermal Atlas for Siberia and Russian Far East(GASRFE)(2009-2012).The atlases include heat flow maps,temperatures at depths of 0.5,1,2,3,5 km and lower boundary of permafrost.Quantitative values of parameters are presented as isolines(GAS) and symbols(GASRFE).GAS website is located at the Trofimuk Institute(www.ipgg.sbras.ru/ru/institute/structure/geophysics/natural-fields).GASRFE provides the most complete geothermal data on Asian Russia,which has been growing for the last 50 years,and is published on the Internet at http://maps.nrcgit.ru/geoterm.In this atlas,data about the depth of permafrost lower boundary( "zero" isotherm) are presented for the first time.
基金supported by National Natural Science Foundation of China(Grant No.51021064)National Key Scientific and Technological Program of China(Grant No.2010ZX04004-116)
文摘The servomotor drive turret punch press is attracting more attentions and being developed more intensively due to the advantages of high speed,high accuracy,high flexibility,high productivity,low noise,cleaning and energy saving.To effectively improve the performance and lower the cost,it is necessary to develop new mechanisms and establish corresponding optimal design method with uniform performance indices.A new patented main driving mechanism and a new optimal design method are proposed.In the optimal design,the performance indices,i.e.,the local motion/force transmission indices ITI,OTI,good transmission workspace good transmission workspace(GTW) and the global transmission indices GTIs are defined.The non-dimensional normalization method is used to get all feasible solutions in dimensional synthesis.Thereafter,the performance atlases,which can present all possible design solutions,are depicted.As a result,the feasible solution of the mechanism with good motion/force transmission performance is obtained.And the solution can be flexibly adjusted by designer according to the practical design requirements.The proposed mechanism is original,and the presented design method provides a feasible solution to the optimal design of the main driving mechanism for servo punch press.
文摘The integration of remote sensing and geographic information system(GIS)was employed in this study to delineate the structural lineaments within the eastern section of the Ouarzazate Basin,situated between the southern front of the Central High Atlas and the northern slopes of the Eastern Anti-Atlas(also known as the Saghro Massif).To achieve this objective,Landsat 8 Operational Land Imager(OLI)and Shuttle Radar Topography Mission(SRTM)data were used.Principal Component Analysis(PCA)was computed and a directional filter was applied to the first PCA and the panchromatic band(B8).Additionally,shading was applied to the SRTM data in four directions;N0°,N45°,N90°,N135°.After removing of the non-geological linear structures,the results obtained,using the automatic extraction method,allowed us to produce a synthetic map that included 1251 lineaments with an average length of 1331 m and was dominated by NE-SW,ENE-WSW and E-W directions,respectively.However,the high lineament density is clearly noted in the Anti-Atlas(Saghro Massif)and at the level of the northern part,extending from the Ait Ibrirne to Arg-Ali Oubourk villages.High lineament density can always be found around the major faults affecting this area.The data collected during the field investigations and from geological maps show that the major direction of the faults and structural accidents range mostly between N45°,N70°and N75°.The correlation of remote sensing results with those collected in the field shows a similarity and coincidence with each other.From these results,it is possible to consider the automatic extraction method as a supplementary kind that can serve classical geology by quickly enriching it with additional data.As shown in this work,this method provides more information when applied in arid areas where the fields are well outcropped.
基金supported by the National Natural Science Foundation of China (No.32070656)the Nanjing University Deng Feng Scholars Program+1 种基金the Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions,China Postdoctoral Science Foundation funded project (No.2022M711563)Jiangsu Funding Program for Excellent Postdoctoral Talent (No.2022ZB50)
文摘Plant morphogenesis relies on precise gene expression programs at the proper time and position which is orchestrated by transcription factors(TFs)in intricate regulatory networks in a cell-type specific manner.Here we introduced a comprehensive single-cell transcriptomic atlas of Arabidopsis seedlings.This atlas is the result of meticulous integration of 63 previously published scRNA-seq datasets,addressing batch effects and conserving biological variance.This integration spans a broad spectrum of tissues,including both below-and above-ground parts.Utilizing a rigorous approach for cell type annotation,we identified 47 distinct cell types or states,largely expanding our current view of plant cell compositions.We systematically constructed cell-type specific gene regulatory networks and uncovered key regulators that act in a coordinated manner to control cell-type specific gene expression.Taken together,our study not only offers extensive plant cell atlas exploration that serves as a valuable resource,but also provides molecular insights into gene-regulatory programs that varies from different cell types.
文摘BACKGROUND Breast cancer(BC),a leading malignant disease,affects women all over the world.Cancer associated fibroblasts(CAFs)stimulate epithelial-mesenchymal transition,and induce chemoresistance and immunosuppression.AIM To establish a CAFs-associated prognostic signature to improve BC patient out-come estimation.METHODS We retrieved the transcript profile and clinical data of 1072 BC samples from The Cancer Genome Atlas(TCGA)databases,and 3661 BC samples from the The Gene Expression Omnibus.CAFs and immune cell infiltrations were quantified using CIBERSORT algorithm.CAF-associated gene identification was done by weighted gene co-expression network analysis.A CAF risk signature was established via univariate,least absolute shrinkage and selection operator regression,and mul-tivariate Cox regression analyses.The receiver operating characteristic(ROC)and Kaplan-Meier curves were employed to evaluate the predictability of the model.Subsequently,a nomogram was developed with the risk score and patient clinical signature.Using Spearman's correlations analysis,the relationship between CAF risk score and gene set enrichment scores were examined.Patient samples were collected to validate gene expression by quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS Employing an 8-gene(IL18,MYD88,GLIPR1,TNN,BHLHE41,DNAJB5,FKBP14,and XG)signature,we attemp-ted to estimate BC patient prognosis.Based on our analysis,high-risk patients exhibited worse outcomes than low-risk patients.Multivariate analysis revealed the risk score as an independent indicator of BC patient prognosis.ROC analysis exhibited satisfactory nomogram predictability.The area under the curve showed 0.805 at 3 years,and 0.801 at 5 years in the TCGA cohort.We also demonstrated that a reduced CAF risk score was strongly associated with enhanced chemotherapeutic outcomes.CAF risk score was significantly correlated with most hallmark gene sets.Finally,the prognostic signature were further validated by qRT-PCR.CONCLUSION We introduced a newly-discovered CAFs-associated gene signature,which can be employed to estimate BC patient outcomes conveniently and accurately.
基金supported by the project of funds by the Consultation of Provincial Department and University for S&T Innovation granted by Hebei Provincial Department of Science and Technology and Hebei Medical University(2020TXZH04).
文摘Introduction:DNA polymerases are crucial for maintaining genome stability and influencing tumorigenesis.However,the clinical implications of DNA polymerases in tumorigenesis and their potential as anti-cancer therapy targets are not well understood.Methods:We conducted a systematic analysis using TCGA Pan-Cancer Atlas data and Gene Set Cancer Analysis results to examine the expression profiles of 15 DNA polymerases(POLYs)and their clinical correlations.We also evaluated the prognostic value of POLYs by analyzing their expression levels in relation to overall survival time(OS)using Kaplan-Meier survival curves.Additionally,we investigated the correlations between POLY expression and immune cells,DNA damage repair(DDR)pathways,and ubiquitination.Drug sensitivity analysis was performed to assess the relationship between POLY expression and drug response.Results:Our analysis revealed that 14 out of 15 POLYs exhibited significantly distinct expression patterns between tumor and normal samples across most cancer types,except for DNA nucleotidylexotransferase(DNTT).Specifically,POLD1 and POLE showed elevated expression in almost all cancers,while POLQ exhibited high expression levels in all cancer types.Some POLYs showed heightened expression in specific cancer subtypes,while others exhibited low expression.Kaplan-Meier survival curves demonstrated significant prognostic value of POLYs in multiple cancers,including PAAD,KIRC,and ACC.Cox analysis further validated these findings.Alteration patterns of POLYs varied significantly among different cancer types and were associated with poorer survival outcomes.Significant correlations were observed between the expression of POLY members and immune cells,DDR pathways,and ubiquitination.Drug sensitivity analysis indicated an inverse relationship between POLY expression and drug response.Conclusion:Our comprehensive study highlights the significant role of POLYs in cancer development and identifies them as promising prognostic and immunological biomarkers for various cancer types.Additionally,targeting POLYs therapeutically holds promise for tumor immunotherapy.
文摘背景与目的 肺癌是全球最常见的恶性肿瘤,大多数患者初次诊断时已发生转移,因此寻找肺癌新的诊断标志物并探索其在肺癌发生中的作用具有重要价值。基于生物信息数据探讨分析肺癌中GINS1基因与肺癌预后的相关性具有重要意义。方法 检索Oncomine、EGPIA、TCGA、Human protein atlas等基因数据库,分析GINS1基因在肺癌中的表达差异。应用蛋白质免疫印记法检测肺癌及癌旁组织中GINS1蛋白的表达水平,应用Kaplan-Meier进行患者生存分析,并利用String-DB数据库分析GINS1蛋白相互作用网络。结果 对Oncomine、GEPIA和The Human Protein Atlas数据库中肺癌与癌旁组织蛋白表达数据进行差异性分析,发现GINS1蛋白在肺癌组织中显著高表达,特别以肺腺癌、肺鳞癌中表达明显增加;通过生存分析发现高表达GINS1肺腺癌患者生存期明显低于低表达者,高表达患者预后更差;利用String-DB数据库发现与GINS1蛋白关联最为密切的为GINS蛋白家族(GINS2、GINS3、GINS4),其次为CDC45、MCM蛋白家族(MCM2、MCM3、MCM4、MCM5、MCM6、MCM7),富集分析发现互作蛋白主要参与DNA复制和细胞周期。结论GINS1基因在肺癌组织中显著高表达,与患者预后相关,其有可能成为肺癌诊断及药物治疗的新靶点。
文摘由杨培增教授独自完成的大型英文葡萄膜炎专著《Atlas of Uveitis:Diagnosis and Treatment》已于2020年12月由Springer出版社和人民卫生出版社联合出版。此书是目前国际上单人完成的最大葡萄膜炎专著,共860页、3000余张患者图片,约合中文170万字。此书分为Overview、Diagnosis of Uveitis、Treatment of Uveitis.Uveitisentities,Scleritis and Episcleritis四大部分,详细介绍了葡萄膜炎类疾病的疾病谱,常见类型的临床特征、进展和致盲规律,疾病诊疗的思想、原则、策略,并使用大量精美图片展现了常见葡萄膜炎类型的表现谱,即从发病到疾病后期,从最细微的异常到最严重的改变,从罕见的表现到典型的特征,展示出葡萄膜炎的全貌和细节,既可使临床医师快速掌握疾病要点,又不至于遗漏细微之处。这也是中国眼科医师首次向国际介绍葡萄膜炎诊疗的中国标准、方案和经验。
基金supported by grants from the Innovation and Technology Commission(Project Nos.GHP-025-17SZ and GHP/028/14SZ)of the Hong Kong Special Administrative RegionShenzhen Science and Technology Innovation Committee(Project NoCYZZ20160421160735632)+2 种基金Beijing Nova Program(No.2016000021223TD07)Capacity Building for Sci-Tech Innovation£-Fundamental Scientific Research Funds(No.19530050157,No.19530050184)the Beijing Brain Initiative of Beijing Municipal Science&Technology Commission.
文摘Objective:Understanding how brain changes over lifetime provides the basis for new insights into neurophysiology and neuropathology.In this study,we carried out a pseudo-longitudinal study based on age-related Chinese brain atlases(i.e.,Chinese2020)constructed from large-scale volumetric brain MRI data collected in normal Han Chinese adults at varying ages.Methods:In order to quantify the deformation and displacement of brains for each voxel as age increases,optical flow algorithm was employed to compute motion vectors between every two consecutive brain templates of the age-related brain atlas,i.e.,Chinese2020.Results:Dynamic age-related neuroanatomical changes in a standardized brain space were shown.Overall,our results demonstrate that brain inward deformation(mainly due to atrophy)can appear in adulthood and this trend generally accelerates as age increases,affecting multiple regions including frontal cortex,temporal cortex,parietal cortex,and cerebellum,whereas occipital cortex is least affected by aging,and even showed some degree of outward deformation in the midlife.Conclusion:Our findings indicated more complicated age-related changes instead of a simple trend of brain volume decrease,which may be in line with the recently increasing interests in the age-related cortical complexity with other morphometry measures.