Brainstem auditory evoked potentials in patients with delayed encephalopathy after acute carbon monoxide poisoning

Objective:To evaluate the changes of brainstem auditory evoked potential (BAEP) in patients with delayed encephalopathy after acute carbon monoxide poisoning. Methods: BAEPs were performed in 32 controls and 40 patients. Wave Ⅰ , Ⅱ , Ⅲ ,Ⅳ, Ⅴ latencies and Ⅰ-Ⅲ , Ⅲ-Ⅴ , Ⅰ-Ⅴ interpeak latencies were measured, respectively. Results: Abnormalities of BAEPs in 13 patients (13/40, 32 ％). Among the13 abnormal BAEPs, 3 displayed prolongation of latency to waves in one side, no potential in another side; 5 displayed a similar abnormality which was bilateral prolongation of latency to waves ;and another 5 displayed unilateral latency delay. Compared wave Ⅰ , Ⅱ , Ⅲ , Ⅳ, Ⅴ latencies and Ⅰ-Ⅲ , Ⅲ-Ⅴ , Ⅰ-Ⅴ interpeak latencies in the patients and the controls, there were no significant differences (P＞0.05). Conclusion: BAEPs can be used for evaluating the diagnostic and prognostic values in the cases of delayed encephalopathy after acute carbon monoxide poisoning.

Characteristics of brainstem auditory evoked potentials of students studying folk dance

BACKGROUND： Previous experiments have demonstrated that brainstem auditory evoked potential is affected by exercise, exercise duration, and frequency. OBJECTIVE： Comparing the brainstem auditory evoked potential of students studying folk dance to students studying other subjects. DESIGN： Observational contrast study. SETTING： Physical Education College, Shandong Normal University PARTICIPANTS： Fifty-five female students were enrolled at Shandong Normal University between September and December in 2005, including 21 students that studied folk dance and 34 students that studied other subjects. The age of the folk dance students averaged （19 ± 1） years and dance training length was （6.0 ± 1.5） years. The students that studied other subjects had never taken part in dance training or other physical training, and their age averaged （22 ± 1） years, body height averaged （162 ± 5） cm, body mass averaged （51 ± 6） kg. All subjects had no prior ear disease or history of other neurological disorders. All students provided informed consent for the experimental project. METHODS： The neural electricity tester, NDI-200 （Shanghai Poseidon Medical Electronic Instrument Factory） was used to examine and record Brainstem Auditory Evoked Potential values of the subjects during silence, as well as to transversally analyze the Brainstem Auditory Evoked Potential values. The electrode positions were cleaned and degreased with soapy water, followed by ethanol. The selected bipolar electrodes were situated on the head： recording electrodes were placed at the Baihui acupoint, and the reference electrode was placed at the mastoid of the measured ear, with grounding electrodes in the center of the forehead. Brainstem Auditory Evoked Potential values were elicited by monaural stimulation of a ＂click＂ though an earphone; the other ear was sheltered by the white noise. The click intensity was 102 db, the stimulation frequency was 30 Hz, the bandpass filters were 1 000-3 000 Hz, the sensitivity was 5 ta V, and a total of 2 000 sweeps were averaged. Waveform identification and analysis： various components of the Brainstem Auditory Evoked Potential values were identified, and the peak latencies and peak-peak values were analyzed. MAIN OUTCOME MEASURES： Latency of Ⅰ , Ⅱ, Ⅲ, Ⅳ, Ⅴ and Peak-Peak Value of Ⅰ, Ⅲ, Ⅴwere measured. RESULTS： Fifty-five subjects were enrolled in the final analysis, without any loss. Compared to the students who studied other subjects ① Ⅰ -Ⅴ peak latencies （PL）： Ⅳ PL of the right ear of the folk dance students was obviously longer （P 〈 0.05）; ② Ⅰ, Ⅲ, V peak-peak values：Ⅰ peak-peak values of the right ear were obviously higher （P 〈 0.05）. CONCUSION： ① PL of the right ear of the folk dance students was obviously longer, which indicates that dancing results in a stronger sensibility to auditory stimuli. ②. Peak-peak values were obviously higher, which indicates that long-term exercise enhances the music senses and synchrony of auditory nerve impulses.

Enhanced auditory evoked potentials in musicians:A review of recent findings

Auditory evoked potentials serve as an objective mode for assessment to check the functioning of the auditory system and neuroplasticity.Literature has reported enhanced electrophysiological responses in musicians, which shows neuroplasticity in musicians. Various databases including Pub Med, Google, Google Scholar and Medline were searched for references related to auditory evoked potentials in musicians from 1994 till date. Different auditory evoked potentials in musicians have been summarized in the present article. The findings of various studies may support as evidences for music-induced neuroplasticity which can be used for the treatment of various clinical disorders. The search results showed enhanced auditory evoked potentials in musicians compared to non-musicians from brainstem to cortical levels. Also, the present review showed enhanced attentive and pre-attentive skills in musicians compared to non-musicians.

Effect of Qiangli Dingxuan Tablet on Cerebral Hemodynamics and Brainstem Auditory Evoked Potentials in Vertigo Patients with Posterior Circulation Ischemia

OBJECTIVE: To observe the effect of Qiangli Dingxuan Tablet on cerebral hemodynamics and brainstem auditory evoked potentials in vertigo patients with posterior circulation ischemia. METHODS: A total of 120 vertigo patients with posterior circulation ischemia were randomly divided into observation group and control group. 60 patients in the control group were treated with conventional western medicine. 60 patients in the observation group were treated with Qiangli Dingxuan Tablet on the basis of the control group. After 2 weeks of treatment, the improvement of vertigo(dizziness handicap inventory(DHI), dizziness handicap inventory(DHI)), the hemodynamic index(Basilar artery blood flow velocity(BA), left vertebroarterial artery(LVA), and the average blood flow velocity of right vertebroarterial artery(RVA)) and the changes in brain stem auditory evoked potential(BAEP) of two groups were observed. And statistical analysis was conducted for the clinical efficacy and adverse reactions during treatment of two groups. RESULTS: The total effective rate of the observation group was significantly higher than that of the control group(P < 0.05). The DHI and DARS scores of the two groups were significantly lower than those before treatment(P < 0.05), and the degree of reduction was more obvious in the observation group(P < 0.05). The levels of BA, LVA and RVA in the two groups were significantly higher than those before treatment(P < 0.05), and the levels of BA, LVA and RVA in the observation group were significantly higher than those in the control group(P < 0.05). The indexes of BAEP latency I, II, III and indexes of BAEP peak latency I-III, III-V, IV were obviously lower than those before treatment(P < 0.05). Besides, the decrease of BAEP index in the observation group was significantly lower than that in the control group(P < 0.05). No adverse reactions occurred during the treatment of the two groups. CONCLUSION: Qiangli Dingxuan Tablet is able to significantly improve the cerebral hemodynamics and brainstem auditory evoked potentials of patients with PCIV, and quickly relieve vertigo. It is safe and reliable and worthy of clinical application.

Effect of Acupuncture on the Auditory Evoked Brain Stem Potential in Parkinson's Disease

Under the auditory evoked brain stem potential (ABP) examination, the latent period of V wave and the intermittent periods of III-V peak and I-V peak were significantly shortened in Parkinson's disease patients of the treatment group (N=29) after acupuncture treatment. The difference of cumulative scores in Webster's scale was also decreased in correlation analysis. The increase of dopamine in the brain and the excitability of the dopamine neurons may contribute to the therapeutic effects, in TCM terms, of subduing the pathogenic wind and tranquilizing the mind.……

EFFECTS OF ACUPUNCTURE ON SENSORY EVOKED CORTICAL POTENTIALS IN RABBITS

The effects of acupuncture on the sensory evoked cortical potentials were investigated in 31 rabbits anaesthetized with urethane of conscious, so as to see what happened to the functional state of cerebral cortex in the meantime. The visual, auditory and somatosensory evoked potentials as well as raw EEGs were recorded from the animal’s scalp. In most cases, an electro-acupuncture instrument was used instead of manual acupuncture. The main component amplitudes of evoked potentials,the frequency band powers and the total integral values of raw EEGs were analyzed. Results showed that during acupuncture the main components of evoked potentials were significantly depressed and the raw EEGs appeared desynchronized while the experimental animals were slightly activated. Moreover,both the total integral values of raw EEGs and the powers of lower frequency waves (1 - 3. 99 Hz)were decreased and positively correlated well with the amplitudes of main components of the evoked potentials. Therefore, the possibility that the effects of acupuncture on the evoked potentials are secondary to the changes of raw EEGs remains to be ruled out, and it is suggested that the inhibition of evoked potentials during acupuncture does not necessarily mean that the cerebral cortex is in an inhibitory

Characteristics of brainstem auditory evoked potential of neonates with mild or moderate hyperbilirubinemia

BACKGROUND： Brainstem auditory evoked potential （BAEP） has been widely used to evaluate the functional integrity and development of injured auditory system and brain, especially to objectively evaluate the function of auditory system and brain stem of very young babies, such as neonates and sick babies. OBJECTIVE： To observe the changes of BAEP of neonates with hyperbilirubinemia, and to investigate the relationship of bilirubin concentration and BAEP. DESIGN： An observation experiment. SETTING： Department of Pediatrics, the 309 Clinical Division, General Hospital of Chinese PLA. PARTICIPANTS： Fifty-eight neonates with mild or moderate hyperbilirubinemia exhibiting jaundice within 24 hours after born, who received the treatment in the Department of Pediatrics, the 309 Clinical Division, General Hospital of Chinese PLA between January 2004 and May 2007, were recruited in this study. The involved neonates, 31 boys and 27 girls, had gestational age of 37 to 46 weeks. They had no history of birth asphyxia, and were scored 8 to 10 points when born. Written informed consents of examination and treatment were obtained from the guardians of the neonates. This study was approved by the Hospital Ethics Committee. According to serum total bilirubin value, the neonates were assigned into 3 groups： low-concentration bilirubin group （n =16）, moderate-concentration bilirubin group （n =27） and high-concentration bilirubin group （n =15）. According to mean daily bilirubin increase, the subjects were sub-assigned into bilirubin rapid increase group （n =39） and bilirubin slow increase group （n = 19）. METHODS： After admission, all the neonates received drug treatment. Meanwhile, their 116 ears were examined with a myoelectricity evoked potential equipment （KEYPOINT） in latency, wave duration, amplitude and wave shape differentiation of each wave of BAEP. BAEP abnormal type was observed and abnormal rate of BAEP was calculated. MAIN OUTCOME MEASURES： ①Abnormal rate and abnormal type of BAEP. ② Latency of waves Ⅰ , Ⅲ and Ⅴ, and wave duration of waves Ⅰ to Ⅲ,Ⅲ to Ⅴ, and Ⅰ to Ⅴ. RESULTS： Fifty-eight neonates with mild or moderate hyperbilirubinemia were involved in the final analysis. ①Abnormal type and abnormal rate of BAEP of neonates with hyperbilirubinemia： Among the 116 ears, unilateral or bilateral waves Ⅰ, Ⅲ,Ⅴ still existed. The latency of waves Ⅰ, Ⅲ and Ⅴ was ＋2.5 s longer than the normal level in 8, 4 and 15 ears, respectively. The wave duration of waves Ⅰ to Ⅲ and waves Ⅲ to Ⅴ was ＋2.5 s longer than the normal level in 6 and 14 ears, respectively. The wave duration of waves Ⅲ to Ⅴ was longer than that of ipsilateral waves Ⅰ to Ⅲ in 24 ears. The latency difference of wave Ⅴ between two ears was larger than 0.4 ms in 31 neonates with hyperbilirubinemia; The amplitude of wave Ⅴ to that of ipsilateral wave 1 was lower than 0.5 in 29 neonates. Totally 52 ears were abnormal, and the abnormal rate was 44.8%. One to two months later, 98% abnormal neonates with hyperbilirubinemia recovered. The abnormal rate in the low-, moderate-, and high-concentration bilirubin groups was 37.5%, 44.4% and 53.3%, respectively. ② Comparison of latency and wave duration of each wave of BAEP： Latency of waves Ⅰ, Ⅲ and Ⅴ, and wave duration of waves Ⅰ to III and Ⅲ to Ⅴ were gradually prolonged in low-, moderate-, and high-concentration bilirubin groups, but significant difference did not exist between two groups （P 〉 0.05）. ③ There were no significant differences in latency of waves Ⅰ, Ⅲand Ⅴ, and wave duration of waves Ⅰ to Ⅲ, Ⅲto Ⅴ and Ⅰ to Ⅴ between bilirubin rapid increase group and bilirubin slow increase group （P 〉 0.05）. CONCLUSION： Auditory acuity and brainstem of neonates with mild or moderate hyperbilirubinemia are damaged to some extent. High-concentration bilirubin causes BAEP abnormality easily. Bilirubin increase and its concentration change are not consistent with nervous lesion degree.

Electroencephalogram and brainstem auditory evoked potential in 539 patients with central coordination disorder

BACKGROUND： Electroencephalogram （EEG） and brainstem auditory evoked potential （BAEP） are objective non-invasive means of measuring brain electrophysiology. OBJECTIVE： To analyze the value of EEG and BAEP in early diagnosis, treatment and prognostic evaluation of central coordination disorder. DESIGN, TIME AND SETTING： This case analysis study was performed at the Rehabilitation Center of Hunan Children＇s Hospital from January 2002 to January 2006. PARTICIPANTS： A total of 593 patients with severe central coordination disorder, comprising 455 boys and 138 girls, aged 1-6 months were enrolled for this study. METHODS： EEG was monitored using electroencephalography. BAEP was recorded using a Keypoint electromyogram device. Intelligence was tested by professionals using the Gesell scale. MAIN OUTCOME MEASURES： （1） The rate of abnormal EEG and BAEP, （2） correlation of abnormalities of EEG and BAEP with associated injuries, （3） correlation of abnormalities of EEG and BAEP with high risk factors. RESULTS： The rate of abnormal EEG was 68.6% （407/593 patients）, and was increased in patients who also had mental retardation （P 〈 0.05）. The rate of abnormal BAEP was 21.4% （127/593 patients）. These 127 patients included 67 patients （52.8%） with peripheral auditory damage and 60 patients （47.2%） with central and mixed auditory damage. The rate of abnormal BAEP was significantly increased in patients who also had mental retardation （P 〈 0.01 ）. Logistic regression analysis showed that asphyxia （P 〈 0.05）, jaundice, preterm delivery, low birth weight and the umbilical cord around the neck were closely correlated with abnormal EEG in patients with central coordination disorder, lntracranial hemorrhage, jaundice （P 〈 0.05）, low birth weight and intrauterine infection （P 〈 0.05） were closely correlated with abnormal BAEP in patients with central coordination disorder. CONCLUSION： Central coordination disorder is often associated with abnormal EEG and BAEP. The rate of EEG or BAEP abnormality is positively associated with the size of the brain injury. Asphyxia is a high risk factor for abnormal EEG in central coordination disorder. Jaundice and intrauterine infection are high risk factors for abnormal BAEP in central coordination disorder.

Otoacoustic Emissions and Evoked Potentials in Infants after Breast-Feeding Jaundice——Hearing Dysfunction in Breast-Feeding Jaundice

We study hearing in a group of infants with Breast-feeding jaundice (BFJ) by means of Transient-evoked otoacoustic emissions (T-EOE) and Brainstem auditory evoked potentials (BAEP) searching for relationship between bilirubin serum levels and auditory dysfunction. Eleven infants born at-term with BFJ were selected for the study. We studied also 11 control age- and gender matched healthy at-term infants without signs of jaundice. T-EOAE studies were performed between 5-7 days after birth, and 3 months later. BAEP studies were performed once. BFJ group infants exhibited lower amplitudes in T-EOE than infants in the control group. These differences disappear at the 3-month evaluation. In BAEP, we observed a significant latency delay of waves I and V in Breast-feeding jaundice group infants. All infants in both groups demonstrated reproducible wave V response at 30 decibels. No significant correlation values were observed between bilirubin serum levels and T-EOE and BAEP variables. Our data suggest that BFJ can result in transient peripheral and central auditory dysfunction. Dysfunction is reversible after treatment of infants with BFJ.

Intraoperative Auditory Evoked Potential Monitoring for Anaesthesia Depth and Utilization of Inhaled Isoflurane

Background: Hypnosis monitoring has been shown to reduce the incidence of awareness. A-line ARX-IndexTM (AAI) derived from auditory evoked potentials (AEP) represents as a numerical variable depth of anaesthesia. Objectives: To study the efficacy of AEP as an indicator of anaesthetic depth and monitor intraoperative awareness in neurosurgical patients by using the AAI scale. Design: Prospective cohort study is used. Setting: The study is in Neurosurgical centre of Tertiary care hospital. Participants: Neurosurgical patients requiring general anaesthesia with duration of surgery between 90 - 150 minutes were enrolled for the study. Intervention: Patients in Group 1 (control) were monitored by conventional methods. Patients in Group 2 (study) underwent intraoperative monitoring by using the AEP monitor. Primary outcome: To study the efficacy of AEP monitoring and AAI index for monitoring the depth of anaesthesia and reducing the incidence of awareness. Results: There was no significant difference in the intraoperative haemodynamic responses measured between the two study groups (p > 0.5). There was no significant difference in the identification of intraoperative awareness by using conventional parameters between the two groups (p > 0.5). There was also a significantly faster time to recovery for patients in Group 2 (p < 0.05). Conclusion: Hypnosis monitoring using AEP monitor/AAI in neurosurgical patients under general anaesthesia did not show any significant difference in haemodynamic response and intraoperative awareness but had significant lower consumption of volatile anaesthetic with cost sparing effect and a faster recovery time as compared to conventional monitoring.

Clinical Study on Effect of Electro-acupuncture Combined with Different Anesthetics on Auditory-evoked Potential Index

To observe the effect of electro-acupuncture （EA） on auto regressive with exogenous input model （ARX-model） auditory evoked index （AAI） in patients anesthetized with different anesthetics. Methods： Forty-eight adult patients undergoing scheduled surgical operation were enrolled and divided into two groups （24 in each group） according to the anesthetics applied, Group A was anesthetized with propofol sedation and Group B with Isoflurane-epidural anesthesia. Group A was subdivided into three groups of low, middle and high concentration of target effect-site of 1.0 μg/ml, 1.5 μg/ml and 2.0 μg/ml through target controlled infusion （TCI） and Group B into 3 subgroups of minimum alveolar effective concentration of isoflurane （0.4 MAC, 0.6 MAC and 0.8 MAC for B1, B2 and B3 subgroups） respectively, with 8 patients in every subgroup. EA on acupoints of Hegu （LI4） and Neiguan （P6） was applied on all the patients during anesthesia, and the change of AAI at various time points was recorded. Results： In the three subgroups of Group A, levels of AAI were significantly elevated in the first few minutes after EA, and significantly lowered 20 min after EA in subgroup A2. While in the subgroups of Group B, except the elevating in Group B11 - 2 rain after EA, levels of AAI remained unchanged at other time points. Conclusion： Pain response could be reflected by AAI during EA. EA could enhance the sedative effect of propofol in middle concentration, but its effect on isoflurane epidural anesthesia is insignificant.

The effect of lead on brainstem auditory evoked potentials in children

To determine whether lead affects brainstem auditory evoked potentials (BAEPs) in low-to-moderate lead exposed children Methods BAEPs were recorded from 114 asymptomatic children aged 1-6 years Average values were calculated for peak latency (PL) and amplitude (Amp) Whole blood lead (PbB) levels were assessed by graphite furnace atomic absorption spectroscopy Based on their PbB levels, subjects were divided into low lead (PbB<100 μg/L) and high lead subgroups (PbB ≥100 μg/L) Results The PbB levels of the 114 subjects ranged from 32 0 to 380 0 μg/L in a positively skewed distribution The median of PbB levels was 90 0 μg/L while the arithmetic average was 88 0 μg/L Of the subjects, 43 0% (49/114) had levels equal to or greater than 100 μg/L Bilateral PLs Ⅰ, Ⅴ, and Ⅲ of the left ear in the high lead subgroup were significantly longer than those in the low lead subgroup (P<0 05) A positive correlation was found between PbB levels and bilateral PLs Ⅰ, Ⅴ and Ⅲ of the left ear (P<0 05), after controlling for age and gender as confounding factors A significant and positive correlation between PbB levels and PL Ⅰ of the left ear, even when PbB levels were lower than 100 μg/L, in the low subgroup (r=0 295, P=0 019) was also found Conclusions Lead poisoning in children younger than 6 years old is a very serious problem to which close attention should be paid The indications that lead prolongs partial PLs may imply that lead, even at PbB levels lower than 100 μg/L, impairs both the peripheral and the central portions of the auditory system BAEPs may be a sensitive detector of subclinical lead exposure effects on the nervous system in children

BIS和AEPI监测镇静深度的评价

目的比较脑电双频指数(BIS)和听觉诱发电位指数(AEPI)在丙酚靶控镇静深度的临床价值。方法45例腰-硬联合麻醉术中需丙泊酚镇静病人,ASAⅠ级,腰麻平面确定后开始丙泊酚靶控输注镇静。结果(1)丙泊酚镇静期BIS、AEPI逐渐降低,苏醒期逐渐升高(P<0.01),而AEPI则在意识转换过程中变化更敏感(P<0.01)。(2)在丙泊酚镇静期和苏醒期BIS、AEPI与丙泊酚EC密切相关。(3)在丙泊酚镇静期,联合监测当BIS≤63和AEPI≤30时敏感度即可达100%。结论BIS和AEPI是监测麻醉镇静深度的良好指标,BIS和AEPI联合监测提高了诊断的敏感度。

柴胡疏肝散对原发性抑郁症患者BAEP、VEP的影响

目的:观察柴胡疏肝散对原发性抑郁症患者脑干听觉诱发电位(BAEP)和视觉诱发电位(VEP)的影响。方法:将100例原发性抑郁症患者随机分为中药组、西药组,分别给予中药柴胡疏肝散和盐酸帕罗西汀治疗,采用脑诱发电位仪,记录治疗前后BAEP和VEP。结果:两组经治疗后,BAEP的I、V波治疗前后无明显改变(P>0.05),Ⅲ波潜伏期较治疗前明显缩短(P<0.05),VEP各波潜伏期均显著缩短(P<0.05);治疗后两组BAEP、VEP相比无统计学差异(P>0.05)。结论:柴胡疏肝散可缩短原发性抑郁症患者BAEP和VEP的潜伏期,减轻患者临床症状,具有应用价值。

希尔伯特-黄变换增强高刺激率AEP的信噪比

针对高刺激率模式下运用连续循环去卷积的方法提取的听觉诱发电位(AEP)可能需要比常规方法更长的记录时间,受试者要忍受大量的声音刺激的问题,本文提出运用希尔伯特-黄变换的去噪方法来减少刺激个数。首先对采集到的每个扫程的脑电信号进行经验模态分解,得到一组固有模态函数(IMFs),然后将这些IMFs分为有用信号层和噪声层,采取非线性阈值方法分层进行去噪处理,以提高信号去卷积前的信噪比。处理结果的评估以1 014个扫程的脑电数据按照常规方法处理的提取AEP为基准,计算去噪后AEP和基准AEP的信噪比与相关系数。结果表明该方法能够有效减少约2/3的刺激个数,是一种十分有前景的高刺激率下AEP信号的提取方法。

家兔椎基底动脉供血不足动物模型的BAEP变化

目的 为了探讨家兔椎基底动脉缺血后的脑干听觉诱发电位 (brainstem auditory evoked poten-tials,BAEP)变化及其在临床工作中的意义。方法 通过结扎家兔单侧椎动脉从而造成脑干缺血 ,并连续记录结扎后一小时内的 BAEP的变化过程。结果 、 、 潜伏期逐渐延长 ,以 波延长最明显 , ～ 、 ～ 、 ～ 峰间期均明显延长 , 波、 波波幅改变无统计意义。结论 本实验表明在椎基底动脉供血不全时 BAEP有显著异常 ,可作为椎基底动脉梗死溶栓治疗后脑干功能变化的观察指标。

Sensory evoked potentials in patients with affective disorders accompanying suicidal behavior

OBJECTIVE: To investigate the variations of sensory evoked potentials (SEPs) in patients with affective disorders accompanying suicidal behavior. METHODS: 39 depressive patients, 22 manic patients and 33 normal controls were included in the study. Visual, auditory and somatosensory evoked potentials (VEP, AEP & SSEP) were recorded from every subject using a Nicolet Spirit Instrument. RESULTS: Both the depressive and manic groups presented prolonged latencies and decreased amplitudes of major components of SEPs as compared to that of normal controls. Depressive patients with suicidal behavior had decreased P(3) amplitude of VEP (P

电刺激双耳后乳突部治疗椎动脉型颈椎病的TCD和BAEP观察

目的:观察电刺激治疗椎动脉型颈椎病患者的经颅多普勒超声(TCD)和脑干听觉诱发电位(BAEP)变化,从血流速度及神经电生理角度探讨电刺激双耳后乳突部的作用机制。方法:将40例椎动脉型颈椎病患者随机分为电刺激组和常规组,电刺激组20例,常规组20例,与30例健康人对照组比较。治疗前及治疗2周后检查TCD及BAEP,观察电刺激治疗对椎动脉型颈椎病患者血流速度及脑电生理的影响。结果:治疗前电刺激组与常规组椎基底动脉(VBA)流速明显低于对照组(P<0.05)。TCD异常的比例为75%(30/40例),以VBA流速降低为主要特点。BAEP异常的比例为77.5%(31/40例),以脑干型异常为主。治疗后两组血流速度均有改善,与常规组比较,电刺激组椎动脉流速改善更显著(P<0.05)。治疗后两组神经传导功能均有改善,与常规组相比,电刺激组Ⅴ波的峰潜伏期(PL)、Ⅲ-Ⅴ和Ⅰ-Ⅴ波的峰间潜伏期改善更显著(P<0.05)。结论:电刺激双耳后乳突部可改善椎动脉型颈椎病椎基循环的血流速度及脑干神经传导功能。

BAEP、BR及MEP联合检测在脑死亡诊断中的应用

目的探讨神经电生理在脑死亡判定中的应用价值。方法通过瞬间反射(BR)、脑干听觉诱发电位(BAEP)、运动诱发电位(MEP)三项联合检查对22例脑死亡患者进行评定,并与GCS评分结果进行比较。结果BAEP、BR和MEP三项联合检查对脑死亡判断准确率为100%,与GCS评分比较差异显著(P<0.05)。结论BAEP、BR和MEP三项联合检测对评价脑死亡患者的脑功能状态、预测预后提供了客观可靠的依据。

重症肌无力患者IgG脑室内注射对大鼠EEG及BAEP的影响

目的 观察重症肌无力 (myasthenia gravis,MG)患者 Ig G(ACh RAb)经大鼠脑室内注入对其脑电图 (elec-troencephalography,EEG)及脑干听觉诱发电位 (brain stem auditory evoked potential,BAEP)的影响 ,并探讨ACh RAb影响大鼠中枢神经系统 (CNS)的机制。方法 将从确诊的、ACh RAb阳性的 MG患者血清中提纯的Ig G(ACh RAb) ,注射到实验组大鼠侧脑室 ,对照组大鼠则注射健康人 Ig G,观察大鼠行为学、 BAEP、 EEG改变。结果 实验组大鼠术后出现类似于实验性自身免疫性 MG的行为学改变 ,部分大鼠出现癫痫发作 ;BAEP峰间潜伏期 (IPLs)延长 ;EEG异常 ,即δ、θ增多与痫性波发放增加。结论 MG ACh RAb可致大鼠 CNS损害 ,ACh RAb与大鼠 CNS神经元型乙酰胆碱受体结合 ,可能是其病理生理机制。