<strong>Purpose:</strong> Allergen immunotherapy (AIT) while usually safe, is not without risk. Both sublingual (SLIT) and subcutaneous immunotherapy (SCIT) have the potential for systemic reactions includ...<strong>Purpose:</strong> Allergen immunotherapy (AIT) while usually safe, is not without risk. Both sublingual (SLIT) and subcutaneous immunotherapy (SCIT) have the potential for systemic reactions including anaphylaxis. <strong>Materials and Methods:</strong> A short survey was distributed to fellows of the American Academy of Otolaryngic Allergy (AAOA) (n = 553) in July of 2019 to determine current prescribing practices. <strong>Results:</strong> A total of 103/553 surveys were completed, giving a response rate of 18.6%. Prescribing patterns for SCIT showed 79.6% prescribed auto-injectable epinephrine (AIE) to all patients, 11.7% prescribed only to high risk patients, while 1.9% did not prescribe AIE at all. SLIT showed similar patterns with 71.8% prescribing AIE to all, 11.7% to high risk or letting patient choose, and 6.8% did not prescribe to anyone. Just under half of the physicians responded affirmatively to giving a written anaphylaxis plan to patients on immunotherapy. 48.5% physicians reported treating in-office anaphylaxis due to SCIT or skin testing in the past year, while 6% reported anaphylaxis due to SLIT. <strong>Conclusions:</strong> A majority of otolaryngic allergists are still prescribing AIE for both SCIT and SLIT. With the recent higher costs attributed to AIE as well as drug shortages, some physicians are risk-stratifying patients. While SCIT has a higher risk for treatment related systemic reactions, anaphylaxis does occur with SLIT, thus making it imperative to counsel patients on a clear anaphylaxis protocol in all forms of AIT.展开更多
虚假数据注入攻击(false data injection attack,FDIA)是威胁电网运行安全的主要因素之一,其主要通过攻击电网中的一些通信环节,误导电力系统的状态估计结果,给电网安全运行带来巨大威胁。针对FDIA难以有效检测及电力系统状态估计中过...虚假数据注入攻击(false data injection attack,FDIA)是威胁电网运行安全的主要因素之一,其主要通过攻击电网中的一些通信环节,误导电力系统的状态估计结果,给电网安全运行带来巨大威胁。针对FDIA难以有效检测及电力系统状态估计中过程噪声与量测噪声两者协方差矩阵非正定问题,将向量自回归(vector auto regression,VAR)模型引入电力系统状态估计,提出一种基于VAR和加权最小二乘法(weighted least squares,WLS)的FDIA检测方法。首先,建立VAR状态估计模型,将量测噪声视为稳定量,只对过程噪声进行估计,解决两者协方差矩阵的非正定问题;其次,分别采用VAR与WLS对电力系统进行状态估计,采用一致性检验与量测量残差检验对2种方法的结果进行检测,以判定是否存在FDIA;最后,IEEE 14节点和IEEE 30节点仿真结果表明,本文所提检测方法能够成功检测到FDIA,且检测成功率较高,从而验证了该方法的可行性及有效性。展开更多
目的:将SEAL Auto Analyzer3流动注射分析仪应用于水中氰化物检测。方法:自动进样器采集样品和标准样,数据处理系统自动处理分析数据。结果:0μg/L-100μg/L线性区间,检出限为0.086μg/L,加标回收率为98%-102%,精密度和准确度较高,检出...目的:将SEAL Auto Analyzer3流动注射分析仪应用于水中氰化物检测。方法:自动进样器采集样品和标准样,数据处理系统自动处理分析数据。结果:0μg/L-100μg/L线性区间,检出限为0.086μg/L,加标回收率为98%-102%,精密度和准确度较高,检出限也低于传统分光光度法。结论:SEAL Auto Analyzer3流动注射分析仪在水中氰化物测定应用中,快速省时、分析效率高,适用大规模样品检测,在水中氰化物测定应用中具有很好的推广应用价值。展开更多
文摘<strong>Purpose:</strong> Allergen immunotherapy (AIT) while usually safe, is not without risk. Both sublingual (SLIT) and subcutaneous immunotherapy (SCIT) have the potential for systemic reactions including anaphylaxis. <strong>Materials and Methods:</strong> A short survey was distributed to fellows of the American Academy of Otolaryngic Allergy (AAOA) (n = 553) in July of 2019 to determine current prescribing practices. <strong>Results:</strong> A total of 103/553 surveys were completed, giving a response rate of 18.6%. Prescribing patterns for SCIT showed 79.6% prescribed auto-injectable epinephrine (AIE) to all patients, 11.7% prescribed only to high risk patients, while 1.9% did not prescribe AIE at all. SLIT showed similar patterns with 71.8% prescribing AIE to all, 11.7% to high risk or letting patient choose, and 6.8% did not prescribe to anyone. Just under half of the physicians responded affirmatively to giving a written anaphylaxis plan to patients on immunotherapy. 48.5% physicians reported treating in-office anaphylaxis due to SCIT or skin testing in the past year, while 6% reported anaphylaxis due to SLIT. <strong>Conclusions:</strong> A majority of otolaryngic allergists are still prescribing AIE for both SCIT and SLIT. With the recent higher costs attributed to AIE as well as drug shortages, some physicians are risk-stratifying patients. While SCIT has a higher risk for treatment related systemic reactions, anaphylaxis does occur with SLIT, thus making it imperative to counsel patients on a clear anaphylaxis protocol in all forms of AIT.
文摘虚假数据注入攻击(false data injection attack,FDIA)是威胁电网运行安全的主要因素之一,其主要通过攻击电网中的一些通信环节,误导电力系统的状态估计结果,给电网安全运行带来巨大威胁。针对FDIA难以有效检测及电力系统状态估计中过程噪声与量测噪声两者协方差矩阵非正定问题,将向量自回归(vector auto regression,VAR)模型引入电力系统状态估计,提出一种基于VAR和加权最小二乘法(weighted least squares,WLS)的FDIA检测方法。首先,建立VAR状态估计模型,将量测噪声视为稳定量,只对过程噪声进行估计,解决两者协方差矩阵的非正定问题;其次,分别采用VAR与WLS对电力系统进行状态估计,采用一致性检验与量测量残差检验对2种方法的结果进行检测,以判定是否存在FDIA;最后,IEEE 14节点和IEEE 30节点仿真结果表明,本文所提检测方法能够成功检测到FDIA,且检测成功率较高,从而验证了该方法的可行性及有效性。
文摘目的:将SEAL Auto Analyzer3流动注射分析仪应用于水中氰化物检测。方法:自动进样器采集样品和标准样,数据处理系统自动处理分析数据。结果:0μg/L-100μg/L线性区间,检出限为0.086μg/L,加标回收率为98%-102%,精密度和准确度较高,检出限也低于传统分光光度法。结论:SEAL Auto Analyzer3流动注射分析仪在水中氰化物测定应用中,快速省时、分析效率高,适用大规模样品检测,在水中氰化物测定应用中具有很好的推广应用价值。
